@article{MTMT:36114880,
	title = {Avian Influenza Clade 2.3.4.4b: Global Impact and Summary Analysis of Vaccine Trials},
	url = {https://m2.mtmt.hu/api/publication/36114880},
	author = {Kovács, László and Farkas, Máté and Dobra, Péter Ferenc and Lennon, Georgia and Könyves, László and Rusvai, Miklós},
	doi = {10.3390/vaccines13050453},
	journal-iso = {VACCINES-BASEL},
	journal = {VACCINES (BASEL)},
	volume = {13},
	unique-id = {36114880},
	abstract = {Background: Avian influenza (AI), caused by orthomyxoviruses, is a globally significant disease affecting avian and non-avian species. It manifests in two variants, according to the two biovariants of the virus differentiated as highly pathogenic avian influenza (HPAI) and low pathogenic avian influenza (LPAI) strains, both of which compromise animal welfare, reduce productivity, and cause substantial economic loss. The zoonotic potential of HPAI strains, particularly the currently dominant clade 2.3.4.4b, raises concerns about public health and epidemic risks. This review assesses the results of current vaccine trials targeting HPAI clade 2.3.4.4b, emphasizing these studies because most outbreak strains in domestic poultry currently belong to this dominant clade. Methods: Multiple scientific databases comprised reports of research trials on vaccine efficacy against HPAI clade 2.3.4.4b. The Boolean term “Clade 2.3.4.4b AND vaccine” was entered into the following databases: PubMed, PubAg, Scopus, Cochrane Library, and ScienceDirect. Results: The resulting papers were analyzed. Studies revealed that antigenic similarity between vaccine and field strains enhances protective efficacy (PE), reduces viral shedding, and improves hemagglutination inhibition titers. While multivalent vaccines showed potential, results were inconsistent and varied depending on strain compatibility. Single-dose vaccines may provide sufficient PE for poultry, though ducks and geese often require multiple doses, and long-term PE is yet unknown. It was discovered that vector vaccines can provide appropriate PE against clade 2.3.4.4.b. Conclusions: Further analysis is needed as their effects may be short-lived, and subsequent doses may be required. Limited research exists on the long-term efficacy of these vaccines and their effectiveness in many avian species. Addressing these gaps is crucial for optimizing vaccination strategies. A re-evaluation of vaccination strategies is recommended but essential to implement adequate biosecurity measures on in poultry farms. This review synthesizes current evidence and may assist veterinarians and authorities in deciding whether to apply or license vaccines to reduce economic losses caused by AI.},
	year = {2025},
	eissn = {2076-393X}
}

@article{MTMT:36143456,
	title = {Dose–response study of a fenugreek-based antibiotic alternative in Bábolna Tetra-SL chicks (1–42 days old) with mixed bacterial infections},
	url = {https://m2.mtmt.hu/api/publication/36143456},
	author = {Kerek, Ádám and Szabó, Ábel and Dobra, Péter Ferenc and Bárdos, Krisztina and Paszerbovics, Bettina and Bata, Zsófia and Molnár-Nagy, Viviána and Jerzsele, Ákos and Ózsvári, László},
	doi = {10.3389/fvets.2025.1570387},
	journal-iso = {FRONT VET SCI},
	journal = {FRONTIERS IN VETERINARY SCIENCE},
	volume = {12},
	unique-id = {36143456},
	year = {2025},
	eissn = {2297-1769},
	orcid-numbers = {Kerek, Ádám/0000-0002-7837-2459}
}

@article{MTMT:36293974,
	title = {Molecular investigation of hindgut flagellates from turkeys and pheasants in Hungary confirms the endemicity of a new species closely related to Histomonas meleagridis},
	url = {https://m2.mtmt.hu/api/publication/36293974},
	author = {Szekeres, Sándor and Takács, Nóra and Ózsvári, László and Tuska-Szalay, Barbara and Bárdos, Krisztina and Kerek, Ádám and Dobra, Péter Ferenc and Kovács, László and Keve, Gergő and Molnár-Nagy, Viviána and Bata, Zsófia and Hornok, Sándor},
	doi = {10.1556/004.2025.01119},
	journal-iso = {ACTA VET HUNG},
	journal = {ACTA VETERINARIA HUNGARICA},
	volume = {73},
	unique-id = {36293974},
	issn = {0236-6290},
	abstract = {To compensate the lack of molecular-phylogenetic data on hindgut flagellates in Hungary, galliform birds were monitored in five regions for two years. Samples were collected from 11 turkeys (from 4 flocks) and 9 pheasants (from 3 farm-raised flocks) suspected to have histomonosis. These samples were molecularly and phylogenetically analysed. In nine turkeys, five 18S rRNA genes and two ITS sequence variants of Histomonas meleagridis were identified. These variants were identical between the caecum and liver of the same bird in most cases, but different 18S variants were identified between sampling sites. In one turkey, an unnamed species, here designated as “Dientamoebidae sp. HUN35”, was identified. Its 18S rRNA gene sequence was near-identical (99.6–99.3%) to the sequence reported previously; and the ITS-1/5.8S/ITS-2 region confirmed a close relationship with H. meleagridis and Dientamoeba fragilis . In one pheasant, Tetratrichomonas gallinarum was detected. Different 18S rRNA variants had either identical or different ITS sequences, thus optimally, both should be used for molecular epidemiological studies. Our results suggest the unnamed Dientamoebidae sp. has been present in Hungary since its first detection in 2010 and the host range of this species as well as that of T. gallinarum is broader than previously thought.},
	year = {2025},
	eissn = {1588-2705},
	pages = {199-206},
	orcid-numbers = {Kerek, Ádám/0000-0002-7837-2459}
}

@article{MTMT:36299597,
	title = {Development of a Clostridium Perfringens Challenge Model in Broiler Chickens to Evaluate the Effects of Feed Additives},
	url = {https://m2.mtmt.hu/api/publication/36299597},
	author = {Kollár, Anna and Selymes, Kinga and Tóth, Gergely and Szekeres, Sándor and Dobra, Péter Ferenc and Bárdos, Krisztina and Ózsvári, László and Bata, Zsófia and Molnár-Nagy, Viviána and Tenk, Miklós},
	doi = {10.3390/pathogens14070707},
	journal-iso = {PATHOGENS},
	journal = {PATHOGENS},
	volume = {14},
	unique-id = {36299597},
	abstract = {Necrotic enteritis, caused by Clostridium perfringens (C. perfringens) is a disease present worldwide and causes major economic losses. The re-emergence of the disease, in recent years, is mainly due to the ban of the usage of antibiotics as growth promoters in the EU. The aim of this study was to establish a reliable, robust challenge model. Ross hybrid broilers were divided into randomized groups: a positive and a negative control group, a group receiving antibiotic treatment and three groups fed with assorted feed supplements, all receiving the same basal diet. The birds in the treatment groups were vaccinated twice using a 10-times dose of an Infectious Bursitis live vaccine and the animals were challenged four times with a NetB toxin producing C. perfringens strain. The presence of clinical signs and body weight gain were monitored. At the end of the study necropsy was performed and the gut lesions were scored. During the experiment, clinical signs were absent in the negative control group and in the antibiotic treated group. The other animals displayed diarrhea and feather loss. These symptoms were the most pronounced in the positive control group. The gut lesion scores showed significant differences between the negative and positive control groups, with the former scoring the lowest. Based on these results, the challenge model establishment was successful and in this setup the assessment of the potency of feed additives is also possible.},
	year = {2025},
	eissn = {2076-0817},
	pages = {707-721},
	orcid-numbers = {Bata, Zsófia/0000-0002-4840-9433; Molnár-Nagy, Viviána/0000-0001-7672-8370; Tenk, Miklós/0000-0003-0399-8147}
}

@article{MTMT:35261801,
	title = {A csirkék mirigyesgyomor-elhalását okozó birnavírusa (Chicken Proventricular Necrosis Virus) okozta fertőzés első megállapítása pettyes fogasfürjben (Cyrtonyx montezumae)},
	url = {https://m2.mtmt.hu/api/publication/35261801},
	author = {Dobra, Péter Ferenc and Molnár, László and Hoitsy, Márton György and Ziszisz, Árisz and Mándoki, Míra and Sós, Endre and Sós-Koroknai, Viktória and Schönhardt, Kitti and Gál, János},
	doi = {10.56385/magyallorv.2024.09.529-536},
	journal-iso = {MAGY ALLATORVOSOK},
	journal = {MAGYAR ÁLLATORVOSOK LAPJA},
	volume = {146},
	unique-id = {35261801},
	issn = {0025-004X},
	abstract = {A csirkék mirigyesgyomor-elhalását okozó birnavírusa (chicken proventricular necrosis virus, CPNV) az elsősorban brojlercsirkékben ismert átoltható mirigyesgyomor- gyulladás nevű kórkép feltételezett kóroka. A szerzők tudomásuk szerint elsőként igazolták a CPNV-fertőzést pettyes fogasfürjben. Az esetleírás célja, hogy felhívja a figyelmet az egyéb, tyúkalakúak közé tartozó madárfajok esetleges szerepére a vírus járványtanában. A szerzők egy pettyes fogasfürj tetemét vizsgálták makroszkópos és mikroszkópos vizsgálattal, rutin bakteriológiai, ill. molekuláris biológiai módszerekkel. A mirigyesgyomor-mintát kilenc vírus jelenlétére vizsgálták, amelyek közül csak a CPNV-re adott pozitív eredményt a PCR-vizsgálat.},
	year = {2024},
	eissn = {3003-9924},
	pages = {529-536}
}

@article{MTMT:34113765,
	title = {A propolisz különböző kivonatainak in vivo hatékonysága brojlercsirke szalmonellózisa esetén},
	url = {https://m2.mtmt.hu/api/publication/34113765},
	author = {Olasz, Ákos and Jerzsele, Ákos and Balta, László and Dobra, Péter Ferenc and Kerek, Ádám},
	doi = {10.56385/magyallorv.2023.08.461-475},
	journal-iso = {MAGY ALLATORVOSOK},
	journal = {MAGYAR ÁLLATORVOSOK LAPJA},
	volume = {145},
	unique-id = {34113765},
	issn = {0025-004X},
	abstract = {A terjedő antimikrobiális rezisztencia következtében egyre nagyobb hangsúlyt kap az antibiotikumalternatívák fejlesztése és alkalmazása. Ilyen pl. a propolisz, amely a méhek által készített természetes bakteriosztatikus vagy baktericid hatásmódú anyag. Vizsgálatukban a szerzők a propolisz brojlercsirkék szalmonellózisának megelőzésében és kezelésében betöltött lehetséges szerepét vizsgálták. Kimutatták, hogy a propolisz szignifikánsan nem befolyásolja a testtömeg-gyarapodást, ill. a fajlagos takarmányértékesítést a kontrollhoz képest, de csökkenti a szalmonellózis megeredésének esélyét. Kijelenthető, hogy a propolisz biztonságosan alkalmazható takarmánykiegészítő brojlercsirkék számára.},
	year = {2023},
	eissn = {3003-9924},
	pages = {461-475},
	orcid-numbers = {Kerek, Ádám/0000-0002-7837-2459}
}

@article{MTMT:34443313,
	title = {Az átoltható vírusos mirigyesgyomor-gyulladás (transmissible viral proventriculitis, TVP) első hazai megállapítása fácánban (Phasianus colchicus, Linnaeus, 1758)},
	url = {https://m2.mtmt.hu/api/publication/34443313},
	author = {Gál, János and Dobra, Péter Ferenc and Tóth, Tamás and Dénes, Lilla and Schönhardt, Kitti and Marosán, Miklós and Hoitsy, Márton György and Ziszisz, Árisz and Mándoki, Míra},
	doi = {10.56385/magyallorv.2023.12.735-740},
	journal-iso = {MAGY ALLATORVOSOK},
	journal = {MAGYAR ÁLLATORVOSOK LAPJA},
	volume = {145},
	unique-id = {34443313},
	issn = {0025-004X},
	abstract = {A szerzők hazánkban elsőként diagnosztizáltak Chicken Proventricular Necrosis Virus (CPNV) okozta félheveny, elhalásos mirigyesgyomor-gyulladást növendék fácánban (Phasianus colchicus). A 3–4 hetes életkorú fácáncsibékben szétnövés, kiegyenlítetlen fejlődés mellett a mirigyesgyomor interglandularis régióinak lympho-histiocytás beszűrődését, ill. a mirigyhámsejtek solitaer ill. multiplex, gócos degenerációját/elhalását figyelték meg. A munka során a kimutatott vírusgenom szekvenciájának meghatározásával és annak elemzésével azonosították az átoltható, vírusos mirigyesgyomor-gyulladást (Chicken Proventricular Necrosis Virus, CPNV) örökítő anyagát.},
	year = {2023},
	eissn = {3003-9924},
	pages = {735-740}
}

@article{MTMT:34443323,
	title = {A háziállatok haemophagocytás histiocytás sarcomája : Irodalmi összefoglaló és esetbemutatók},
	url = {https://m2.mtmt.hu/api/publication/34443323},
	author = {Dobra, Péter Ferenc and Szilasi, Anna and Vajdovich, Péter and Erdélyi, Ildikó and Horváth, Dávid Géza},
	doi = {10.56385/magyallorv.2023.12.725-734},
	journal-iso = {MAGY ALLATORVOSOK},
	journal = {MAGYAR ÁLLATORVOSOK LAPJA},
	volume = {145},
	unique-id = {34443323},
	issn = {0025-004X},
	abstract = {A szerzők szakirodalmi adatok felhasználásával áttekintést nyújtanak a háziállatok haemophagocytás histiocytás sarcomájának előfordulásáról, kóroktanáról és kórfejlődéséről, ismertetik a megbetegedés klinikumát, patológiáját, valamint a diagnosztikai megközelítést és a kórjóslatot. A kórképhez kötődő, jellegzetes makroszkópos és mikroszkópos elváltozásokat saját eseteiket felhasználva szemléltetik. Ez az esetbemutatásokkal kiegészített szakirodalmi áttekintés rávilágít a kórkép, mint differenciáldiagnózis fontosságára háziállatok regeneratív anaemiája és thrombocytopeniája esetén.},
	year = {2023},
	eissn = {3003-9924},
	pages = {725-734}
}

@article{MTMT:34516912,
	title = {Determining the In Vivo Efficacy of Plant-Based and Probiotic-Based Antibiotic Alternatives against Mixed Infection with Salmonella enterica and Escherichia coli in Domestic Chickens},
	url = {https://m2.mtmt.hu/api/publication/34516912},
	author = {Kerek, Ádám and Szabó, Á. and Dobra, Péter Ferenc and Bárdos, Krisztina and Ózsvári, László and Fehérvári, Péter and Bata, Zsófia and Molnár-Nagy, V. and Jerzsele, Ákos},
	doi = {10.3390/vetsci10120706},
	journal-iso = {VET SCI},
	journal = {VETERINARY SCIENCES},
	volume = {10},
	unique-id = {34516912},
	issn = {2306-7381},
	abstract = {Restrictions on the use of antimicrobial compounds have led to a surge of interest in alternative solutions, such as natural, plant-based compounds. In our study, we investigated the efficacy of three feed supplements containing different additives, namely, probiotics (Lactobacillus spp., “Test substance A”), turmeric (Curcuma longa L., “Test substance B”), and fenugreek (Trigonella foenum graecum, “Test substance C”). In the experiment, we tested 180 birds of the Bábolna Tetra-SL laying hybrid breed that were infected with Salmonella enteritidis strains. The birds were randomly divided into six groups: three groups treated with the different additives, a negative control group, a positive control group, and an antibiotic-treated group using enrofloxacin. We examined the maturation and the time course of shedding of Salmonella; at the end of rearing, pathological and histopathological examinations were performed. When Salmonella was isolated from the cloacal swab samples, the enrofloxacin-treated group had a high number of animals shedding Salmonella by day 9, which was like the group treated with test material C. The greatest reduction in Salmonella shedding was observed in the groups treated with test materials A and B. In terms of pathological parameters, villus length and crypt depth were significantly better in the group treated with test material C compared to the positive and negative controls, and when comparing the body weight of the tested animals, the group treated with test material B had a significantly larger absorption surface area compared to the positive control group. Overall, the supplement with test material C proved to be the most effective. In the future, it is worthwhile to investigate the combination of the tested active substances for their possible synergistic effects and to perform a dose-response study to select the optimal dosage. © 2023 by the authors.},
	keywords = {Body Weight; ARTICLE; Triticum aestivum; Triticum aestivum; Escherichia coli; controlled study; nonhuman; dose response; animal tissue; animal model; animal experiment; Histopathology; pathology; Histology; diet supplementation; antibiotic agent; Salmonella enteritidis; bacterial strain; Small intestine; optimal drug dose; colony forming unit; health hazard; egg laying; hen; Gallus gallus; Surface area; Probiotics; Cloaca; Synergistic effect; Escherichia coli infection; body weight gain; Curcuma longa; typhoid fever; bacterial shedding; Curcuma longa extract; Lactobacillus casei; fenugreek; Laying hens; Enrofloxacin; Antibiotic alternatives; Salmonella enterica serovar Enteritidis; fenugreek extract; Trigonella foenum graecum; Curcuma longaL; Bifidobacterium breve extract; Lactobacillus casei extract},
	year = {2023},
	eissn = {2306-7381},
	orcid-numbers = {Kerek, Ádám/0000-0002-7837-2459; Bata, Zsófia/0000-0002-4840-9433}
}

@article{MTMT:30795986,
	title = {Vírusos bélgyulladások egyes tyúkalakú madárfajokban : Irodalmi áttekintés és saját vizsgálatok fácánokban},
	url = {https://m2.mtmt.hu/api/publication/30795986},
	author = {Mándoki, Míra and Dénes, Lilla and Dobra, Péter Ferenc and Gál, János},
	journal-iso = {MAGY ALLATORVOSOK},
	journal = {MAGYAR ÁLLATORVOSOK LAPJA},
	volume = {141},
	unique-id = {30795986},
	issn = {0025-004X},
	year = {2019},
	eissn = {3003-9924},
	pages = {523-531}
}