TY - JOUR AU - Mészáros, Szilvia AU - Piroska, Márton AU - Leel-Őssy, Tamás AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Jokkel, Zsófia AU - Szabó, Helga AU - Hosszú, Éva AU - Csupor, Emőke AU - Kollár, Réka AU - Kézdi, Árpád AU - Tabák, Ádám AU - Horváth, Csaba TI - Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 46 PY - 2024 IS - 6 SP - 6419 EP - 6433 PG - 15 SN - 2509-2715 DO - 10.1007/s11357-024-01265-2 UR - https://m2.mtmt.hu/api/publication/35082580 ID - 35082580 AB - There is abundant evidence that bone mineral content is highly heritable, while the heritability of bone quality (i.e. trabecular bone score [TBS] and quantitative ultrasound index [QUI]) is rarely investigated. We aimed to disentangle the role of genetic, shared and unique environmental factors on TBS and QUI among Hungarian twins. Our study includes 82 twin (48 monozygotic, 33 same-sex dizygotic) pairs from the Hungarian Twin Registry. TBS was determined by DXA, QUI by calcaneal bone ultrasound. To estimate the genetic and environmental effects, we utilized ACE-variance decomposition. For the unadjusted model of TBS, an AE model provided the best fit with > 80% additive genetic heritability. Adjustment for age, sex, BMI and smoking status improved model fit with 48.0% of total variance explained by independent variables. Furthermore, there was a strong dominant genetic effect (73.7%). In contrast, unadjusted and adjusted models for QUI showed an AE structure. Adjustments improved model fit and 25.7% of the total variance was explained by independent variables. Altogether 70–90% of the variance in QUI was related to additive genetic influences. We found a strong genetic heritability of bone quality in unadjusted models. Half of the variance of TBS was explained by age, sex and BMI. Furthermore, the adjusted model suggested that the genetic component of TBS could be dominant or an epistasis could be present. In contrast, independent variables explained only a quarter of the variance of QUI and the additive heritability explained more than half of all the variance. LA - English DB - MTMT ER - TY - JOUR AU - Tárnoki, Dávid László AU - Piroska, Márton AU - Forgó, Bianka AU - Szabó, Helga AU - Zöldi, Luca AU - Melicher, Dóra AU - Metneki, Julia AU - Littvay, Levente AU - Tárnoki, Ádám Domonkos TI - The Population-Based Hungarian Twin Registry. An Update. TS - An Update. JF - TWIN RESEARCH AND HUMAN GENETICS J2 - TWIN RES HUM GENET VL - 27 PY - 2024 IS - 2 SP - 115 EP - 119 PG - 5 SN - 1832-4274 DO - 10.1017/thg.2024.15 UR - https://m2.mtmt.hu/api/publication/34868573 ID - 34868573 AB - Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University's innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register. The HTR's biobank was also established: 157,751 individuals with a likely twin-sibling living in Hungary (77,042 twins, 1194 triplets, 20 quadruplets, and one quintuplet) were contacted between February and March of 2021 via sealed letters. Until November 20, 2022, 12,001 twin individuals and their parents or guardians (6724 adult twins, 3009 parents/guardians and 5277 minor twins) registered, mostly online. Based on simple self-reports, 37.6% of the registered adults were MZ twins and 56.8% were DZ; 1.12% were triplets and 4.5% were unidentified. Of the registered children, 22.3% were MZ, 72.7% were DZ, 1.93% were triplets, and 3.05% were unidentified. Of the registered twins, 59.9% were female (including both the adult and minor twins). The registration questionnaire consists of eight parts, including socio-demographic and anthropometric data, smoking habits and medical questions (diseases, operations, therapies). Hungary's twin registry has become the sole and largest population-based twin registry in Central Eastern Europe. This new resource will facilitate performing world-class modern genetic research. LA - English DB - MTMT ER - TY - JOUR AU - Ujma, Przemyslaw Péter AU - Piroska, Márton AU - Szabó, Helga AU - Mladoneczki-Leszkó, Dóra AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - The genetics of intelligence and social outcomes in a Hungarian twin sample JF - PERSONALITY AND INDIVIDUAL DIFFERENCES J2 - PERS INDIV DIFFER VL - 225 PY - 2024 PG - 6 SN - 0191-8869 DO - 10.1016/j.paid.2024.112683 UR - https://m2.mtmt.hu/api/publication/34822630 ID - 34822630 N1 - Semmelweis University, Institute of Behavioural Sciences, Hungary Semmelweis University, Medical Imaging Centre, Budapest, Hungary Semmelweis University, School of PhD Studies, Hungary Hungarian Twin Registry, Budapest, Hungary Export Date: 24 September 2024 CODEN: PEIDD Correspondence Address: Ujma, P.P.; Semmelweis University, Hungary; email: ujma.peter@semmelweis.hu LA - English DB - MTMT ER - TY - THES AU - Szabó, Helga TI - ASSOCIATION BETWEEN ULTRASOUND MARKERS OF ATHEROSCLEROSIS AND THE GUT MICROBIOME IN TWINS PY - 2024 DO - 10.14753/SE.2024.2906 UR - https://m2.mtmt.hu/api/publication/34817947 ID - 34817947 LA - English DB - MTMT ER - TY - JOUR AU - Persely, Aliz AU - Beszedics, B. AU - Pálóczi, Krisztina AU - Piroska, Márton AU - Alijanpourotaghsara, Amirreza AU - Strelnikov, David AU - Vessal, A. AU - Szabó, Helga AU - Hernyes, Anita AU - Zöldi, Luca AU - Jokkel, Zsófia AU - Fekete, A. AU - Juhász, János AU - Makra, Nóra AU - Szabó, Dóra AU - Buzás, Edit Irén AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - Analysis of Genetic and MRI Changes, Blood Markers, and Risk Factors in a Twin Pair Discordant of Progressive Supranuclear Palsy JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 59 PY - 2023 IS - 10 PG - 18 SN - 1010-660X DO - 10.3390/medicina59101696 UR - https://m2.mtmt.hu/api/publication/34271363 ID - 34271363 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Neurology Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, 1085, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary Export Date: 23 January 2024 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com Chemicals/CAS: Biomarkers LA - English DB - MTMT ER - TY - JOUR AU - Jokkel, Zsófia AU - Szily, Marcell AU - Piroska, Márton AU - Szabó, Helga AU - Hernyes, Anita AU - Szabó, G. AU - Kalina, Ildikó AU - Maurovich-Horvat, Pál AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Parapharyngeal Fat Tissue Accumulation and Its Association with Carotid Intima-Media Thickness in Discordant Twin Pairs JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 13 PY - 2023 IS - 17 PG - 10 SN - 2076-3417 DO - 10.3390/app13179953 UR - https://m2.mtmt.hu/api/publication/34142302 ID - 34142302 N1 - Export Date: 28 October 2023 Correspondence Address: Jokkel, Z.; Medical Imaging Centre, Hungary; email: zsofijokkel@gmail.com LA - English DB - MTMT ER - TY - JOUR AU - Saeki, Soichiro AU - Yamamoto, Kouichi AU - Tomizawa, Rie AU - Mészáros, Szilvia AU - Horváth, Csaba AU - Zöldi, Luca AU - Szabó, Helga AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Ishida, Takayuki AU - Honda, Chika TI - Utilizing Graphical Analysis of Chest Radiographs for Primary Screening of Osteoporosis JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 58 PY - 2022 IS - 12 PG - 8 SN - 1010-660X DO - 10.3390/medicina58121765 UR - https://m2.mtmt.hu/api/publication/33501803 ID - 33501803 N1 - Center Hospital of the National Center for Global Health and Medicine, Tokyo, 162-8655, Japan Department of Global and Innovative Medicine, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan Department of Radiological Sciences, Faculty of Health Sciences, Morinomiya University of Medical Sciences, Osaka, 559-8611, Japan Center for Twin Research, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan School of Nursing, Graduate School of Nursing, Osaka Metropolitan University, Osaka, 545-8585, Japan Department of Internal Medicine and Oncology, Semmelweis University, Budapest, 1082, Hungary Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Department of Medical Physics & Engineering, Graduate School of Medicine, Osaka University, Osaka, 565-0871, Japan Department of Public Health Nursing, Shiga University of Medical Science, Otsu, 520-2192, Japan Export Date: 23 January 2024 Correspondence Address: Saeki, S.; Center Hospital of the National Center for Global Health and MedicineJapan; email: sosaeki@hosp.ncgm.go.jp Correspondence Address: Honda, C.; Center for Twin Research, Japan; email: chikah@belle.shiga-med.ac.jp AB - Background and Objectives: Osteoporosis is a major risk of fractures, harming patients’ quality of life. Dual-energy X-ray absorptiometry (DXA), which can detect osteoporosis early, is too expensive to be conducted on a regular basis. Therefore, we aimed to evaluate a screening method using chest radiographs developed in Japan applied to another population. Materials and Methods: Fifty-five patients who had a chest radiograph and DXA and applied within three months of each test were recruited from the patient database of Semmelweis University (Budapest, Hungary). Graphical analysis of the chest radiographs was conducted to identify the ratio of the cortical bone in the clavicle of each patient. Two researchers performed the analysis, and multiple regression was conducted to determine the bone mineral density of each patient provided by DXA. Results: The Pearson correlation between two examiners’ determinations of the cortical bone ratio was 0.769 (p < 0.001). The multiple regression model proved to be statistically significant in identifying osteoporosis, but the model adopted for the Hungarian population was different compared to the Japanese population. Conclusions: This simple, economic Japanese graphical analysis method for chest radiographs may be feasible in detecting osteoporosis. Further studies with a larger population of patients with greater variety of ethnicity would be of value in improving the accuracy of this model. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Helga AU - Piroska, Márton AU - Hernyes, Anita AU - Zöldi, Luca AU - Juhász, János AU - Ligeti, Balázs AU - Makra, Nóra AU - Szabó, Dóra AU - Bikov, András AU - Kunos, Laszlo AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László TI - The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 12 PY - 2022 IS - 22 PG - 18 SN - 2076-3417 DO - 10.3390/app122211484 UR - https://m2.mtmt.hu/api/publication/33291618 ID - 33291618 N1 - Medical Imaging Centre, Semmelweis University, Budapest, 1082, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary North West Lung Centre, Wythenshawe Hospital, Manchester University Foundation Trust, Manchester, M23 9LT, United Kingdom Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, M13 9NT, United Kingdom Institute of Pulmonology, Torokbalint, 2045, Hungary Cited By :1 Export Date: 20 July 2023 Correspondence Address: Tarnoki, D.L.; Medical Imaging Centre, Hungary; email: tarnoki4@gmail.com Funding details: Manchester Biomedical Research Centre, BRC Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-20-5 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Magyarország Kormánya, OTKA 138055 Funding details: Innovációs és Technológiai Minisztérium Funding details: Magyar Tüdőgyógyász Társaság, MTT Funding text 1: This research was funded by the Semmelweis Science and Innovation Fund—Research and Development Application; Hungarian Respiratory Society—Scientific Research Application; Dean’s Fund—Research Application between Theoretical and Clinical Institutes; Bólyai scholarship of the Hungarian Academy of Sciences; ÚNKP-20-5 and ÚNKP-21-5 New National Excellence Program of the Ministry for Innovation and Technology, from the source of the National Research, Development, and Innovation Fund. The bioinformatics analysis was supported by the Hungarian Government grant OTKA 138055 (Large scale surveying of bacteriophages in the human microbiome with pangenomic and machine learning approaches). Funding text 2: The Samsung ultrasound equipment was provided by Sonarmed Ltd., a Samsung Medison representative. Colleagues of the Medical Imaging Centre and Institute of Medical Microbiology, Semmelweis University, provided administrative and technical support. The authors are grateful to Electro-oxygen for providing equipment for this study and Monika Banlaky for her support with the sleep tests as well as Peter Fussy and Szonja Galyasz for their help during the microbiome measurements, and Bianka Forgo, Marcell Szily and Daniel Tamas Kovacs for their help in the OSA study. Andras Bikov is supported by the NIHR Manchester BRC. AB - Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of Peptostreptococcaceae was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: Bilophila, Romboutsia, Slackia, and Veillonella in the non-atherosclerotic group; and Escherichia-Shigella, Prevotella, and Ruminococcaceae in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample. LA - English DB - MTMT ER - TY - JOUR AU - Saeki, Soichiro AU - Szabó, Helga AU - Tomizawa, Rie AU - Tárnoki, Ádám Domonkos AU - Tárnoki, Dávid László AU - Watanabe, Yoshiyuki AU - Honda, Chika TI - Lobular Difference in Heritability of Brain Atrophy among Elderly Japanese: A Twin Study JF - MEDICINA-LITHUANIA J2 - MED LITH VL - 58 PY - 2022 IS - 9 PG - 9 SN - 1010-660X DO - 10.3390/medicina58091250 UR - https://m2.mtmt.hu/api/publication/33116118 ID - 33116118 AB - Background and Objectives: Brain atrophy is related to cognitive decline. However, the heritability of brain atrophy has not been fully investigated in the Eastern Asian population. Materials and Methods: Brain imaging of 74 Japanese twins registered in the Osaka University Twin Registry was conducted with voxel-based morphometry SPM12 and was processed by individual voxel-based morphometry adjusting covariates (iVAC) toolbox. The atrophy of the measured lobes was obtained by comparing the focal volume to the average of healthy subjects. Classical twin analysis was used to measure the heritability of its z-scores. Results: The heritability of brain atrophy ranged from 0.23 to 0.97, depending upon the lobes. When adjusted to age, high heritability was reported in the frontal, frontal-temporal, and parietal lobes, but the heritability in other lobes was lower than 0.70. Conclusions: This study revealed a relatively lower heritability in brain atrophy compared to other ethnicities. This result suggests a significant environmental impact on the susceptibility of brain atrophy the Japanese. Therefore, environmental factors may have more influence on the Japanese than in other populations. LA - English DB - MTMT ER - TY - JOUR AU - Bikov, András AU - Szabó, Helga AU - Piroska, Márton AU - Kunos, László AU - Szily, Marcell AU - Ligeti, Balázs AU - Makra, Nóra AU - Szabó, Dóra AU - Tárnoki, Dávid László AU - Tárnoki, Ádám Domonkos TI - Gut Microbiome in Patients with Obstructive Sleep Apnoea JF - APPLIED SCIENCES-BASEL J2 - APPL SCI-BASEL VL - 12 PY - 2022 IS - 4 PG - 12 SN - 2076-3417 DO - 10.3390/app12042007 UR - https://m2.mtmt.hu/api/publication/32687570 ID - 32687570 N1 - North West Lung Centre, Wythenshawe Hospital, Manchester University Foundation Trust, Manchester, M23 9LT, United Kingdom Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester, M13 9NT, United Kingdom Department of Pulmonology, Semmelweis University, Budapest, 1085, Hungary Medical Imaging Centre, Semmelweis University, Budapest, 1085, Hungary Central Radiological Diagnostic Department, Medical Centre Hungarian Defence Forces, Budapest, 1134, Hungary Institute of Medical Microbiology, Semmelweis University, Budapest, 1085, Hungary Faculty of Information Technology and Bionics, Pazmany Peter Catholic University, Budapest, 1085, Hungary Cited By :3 Export Date: 20 July 2023 Correspondence Address: Tarnoki, A.D.; Medical Imaging Centre, Hungary; email: tarnoki2@gmail.com LA - English DB - MTMT ER -