@article{MTMT:35082580,
	title = {Genetic and environmental determinants of bone quality: a cross-sectional analysis of the Hungarian Twin Registry},
	url = {https://m2.mtmt.hu/api/publication/35082580},
	author = {Mészáros, Szilvia and Piroska, Márton and Leel-Őssy, Tamás and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Jokkel, Zsófia and Szabó, Helga and Hosszú, Éva and Csupor, Emőke and Kollár, Réka and Kézdi, Árpád and Tabák, Ádám and Horváth, Csaba},
	doi = {10.1007/s11357-024-01265-2},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {46},
	unique-id = {35082580},
	issn = {2509-2715},
	abstract = {There is abundant evidence that bone mineral content is highly heritable, while the heritability of bone quality (i.e. trabecular bone score [TBS] and quantitative ultrasound index [QUI]) is rarely investigated. We aimed to disentangle the role of genetic, shared and unique environmental factors on TBS and QUI among Hungarian twins. Our study includes 82 twin (48 monozygotic, 33 same-sex dizygotic) pairs from the Hungarian Twin Registry. TBS was determined by DXA, QUI by calcaneal bone ultrasound. To estimate the genetic and environmental effects, we utilized ACE-variance decomposition. For the unadjusted model of TBS, an AE model provided the best fit with > 80% additive genetic heritability. Adjustment for age, sex, BMI and smoking status improved model fit with 48.0% of total variance explained by independent variables. Furthermore, there was a strong dominant genetic effect (73.7%). In contrast, unadjusted and adjusted models for QUI showed an AE structure. Adjustments improved model fit and 25.7% of the total variance was explained by independent variables. Altogether 70–90% of the variance in QUI was related to additive genetic influences. We found a strong genetic heritability of bone quality in unadjusted models. Half of the variance of TBS was explained by age, sex and BMI. Furthermore, the adjusted model suggested that the genetic component of TBS could be dominant or an epistasis could be present. In contrast, independent variables explained only a quarter of the variance of QUI and the additive heritability explained more than half of all the variance.},
	year = {2024},
	eissn = {2509-2723},
	pages = {6419-6433},
	orcid-numbers = {Mészáros, Szilvia/0000-0002-4871-6986; Piroska, Márton/0000-0002-6000-5044; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Jokkel, Zsófia/0000-0002-5407-6540; Hosszú, Éva/0000-0002-7420-4861; Kollár, Réka/0000-0002-0085-8029; Tabák, Ádám/0000-0002-6234-3936; Horváth, Csaba/0000-0002-0490-7932}
}

@article{MTMT:34868573,
	title = {The Population-Based Hungarian Twin Registry. An Update.},
	url = {https://m2.mtmt.hu/api/publication/34868573},
	author = {Tárnoki, Dávid László and Piroska, Márton and Forgó, Bianka and Szabó, Helga and Zöldi, Luca and Melicher, Dóra and Metneki, Julia and Littvay, Levente and Tárnoki, Ádám Domonkos},
	doi = {10.1017/thg.2024.15},
	journal-iso = {TWIN RES HUM GENET},
	journal = {TWIN RESEARCH AND HUMAN GENETICS},
	volume = {27},
	unique-id = {34868573},
	issn = {1832-4274},
	abstract = {Between 2006 and 2021, the Hungarian Twin Registry (HTR) operated a volunteer twin registry of all age groups (50% monozygotic [MZ], 50% dizygotic [DZ], 70% female, average age 34 ± 22 years), including 1044 twin pairs, 24 triplets and one quadruplet set. In 2021, the HTR transformed from a volunteer registry into a population-based one, and it was established in the Medical Imaging Centre of Semmelweis University in Budapest. Semmelweis University's innovation fund supported the development of information technology, a phone bank and voicemail infrastructure, administrative materials, and a new website was established where twins and their relatives (parent, foster parent or caregiver) can register. The HTR's biobank was also established: 157,751 individuals with a likely twin-sibling living in Hungary (77,042 twins, 1194 triplets, 20 quadruplets, and one quintuplet) were contacted between February and March of 2021 via sealed letters. Until November 20, 2022, 12,001 twin individuals and their parents or guardians (6724 adult twins, 3009 parents/guardians and 5277 minor twins) registered, mostly online. Based on simple self-reports, 37.6% of the registered adults were MZ twins and 56.8% were DZ; 1.12% were triplets and 4.5% were unidentified. Of the registered children, 22.3% were MZ, 72.7% were DZ, 1.93% were triplets, and 3.05% were unidentified. Of the registered twins, 59.9% were female (including both the adult and minor twins). The registration questionnaire consists of eight parts, including socio-demographic and anthropometric data, smoking habits and medical questions (diseases, operations, therapies). Hungary's twin registry has become the sole and largest population-based twin registry in Central Eastern Europe. This new resource will facilitate performing world-class modern genetic research.},
	keywords = {Central Eastern Europe; genetic research; twin registry},
	year = {2024},
	eissn = {1839-2628},
	pages = {115-119},
	orcid-numbers = {Tárnoki, Dávid László/0000-0002-7001-7647; Piroska, Márton/0000-0002-6000-5044; Zöldi, Luca/0000-0003-4187-1673; Melicher, Dóra/0000-0003-4848-1424; Littvay, Levente/0000-0003-2022-6886; Tárnoki, Ádám Domonkos/0000-0001-5909-3780}
}

@article{MTMT:34822630,
	title = {The genetics of intelligence and social outcomes in a Hungarian twin sample},
	url = {https://m2.mtmt.hu/api/publication/34822630},
	author = {Ujma, Przemyslaw Péter and Piroska, Márton and Szabó, Helga and Mladoneczki-Leszkó, Dóra and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László},
	doi = {10.1016/j.paid.2024.112683},
	journal-iso = {PERS INDIV DIFFER},
	journal = {PERSONALITY AND INDIVIDUAL DIFFERENCES},
	volume = {225},
	unique-id = {34822630},
	issn = {0191-8869},
	year = {2024},
	eissn = {1873-3549},
	orcid-numbers = {Ujma, Przemyslaw Péter/0000-0002-7981-3009; Piroska, Márton/0000-0002-6000-5044; Mladoneczki-Leszkó, Dóra/0000-0003-3343-7746; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647}
}

@mastersthesis{MTMT:34817947,
	title = {ASSOCIATION BETWEEN ULTRASOUND MARKERS OF ATHEROSCLEROSIS AND THE GUT MICROBIOME IN TWINS},
	url = {https://m2.mtmt.hu/api/publication/34817947},
	author = {Szabó, Helga},
	doi = {10.14753/SE.2024.2906},
	unique-id = {34817947},
	year = {2024}
}

@article{MTMT:34271363,
	title = {Analysis of Genetic and MRI Changes, Blood Markers, and Risk Factors in a Twin Pair Discordant of Progressive Supranuclear Palsy},
	url = {https://m2.mtmt.hu/api/publication/34271363},
	author = {Persely, Aliz and Beszedics, B. and Pálóczi, Krisztina and Piroska, Márton and Alijanpourotaghsara, Amirreza and Strelnikov, David and Vessal, A. and Szabó, Helga and Hernyes, Anita and Zöldi, Luca and Jokkel, Zsófia and Fekete, A. and Juhász, János and Makra, Nóra and Szabó, Dóra and Buzás, Edit Irén and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László},
	doi = {10.3390/medicina59101696},
	journal-iso = {MED LITH},
	journal = {MEDICINA-LITHUANIA},
	volume = {59},
	unique-id = {34271363},
	issn = {1010-660X},
	year = {2023},
	eissn = {1648-9144},
	orcid-numbers = {Pálóczi, Krisztina/0000-0001-7065-3582; Piroska, Márton/0000-0002-6000-5044; Strelnikov, David/0000-0002-5911-9335; Hernyes, Anita/0000-0001-5875-4006; Zöldi, Luca/0000-0003-4187-1673; Jokkel, Zsófia/0000-0002-5407-6540; Szabó, Dóra/0000-0002-8601-3923; Buzás, Edit Irén/0000-0002-3744-206X; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647}
}

@article{MTMT:34142302,
	title = {Parapharyngeal Fat Tissue Accumulation and Its Association with Carotid Intima-Media Thickness in Discordant Twin Pairs},
	url = {https://m2.mtmt.hu/api/publication/34142302},
	author = {Jokkel, Zsófia and Szily, Marcell and Piroska, Márton and Szabó, Helga and Hernyes, Anita and Szabó, G. and Kalina, Ildikó and Maurovich-Horvat, Pál and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos},
	doi = {10.3390/app13179953},
	journal-iso = {APPL SCI-BASEL},
	journal = {APPLIED SCIENCES-BASEL},
	volume = {13},
	unique-id = {34142302},
	year = {2023},
	eissn = {2076-3417},
	orcid-numbers = {Jokkel, Zsófia/0000-0002-5407-6540; Szily, Marcell/0000-0003-3298-9231; Piroska, Márton/0000-0002-6000-5044; Hernyes, Anita/0000-0001-5875-4006; Kalina, Ildikó/0000-0002-2647-9123; Maurovich-Horvat, Pál/0000-0003-0885-736X; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780}
}

@article{MTMT:33501803,
	title = {Utilizing Graphical Analysis of Chest Radiographs for Primary Screening of Osteoporosis},
	url = {https://m2.mtmt.hu/api/publication/33501803},
	author = {Saeki, Soichiro and Yamamoto, Kouichi and Tomizawa, Rie and Mészáros, Szilvia and Horváth, Csaba and Zöldi, Luca and Szabó, Helga and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Ishida, Takayuki and Honda, Chika},
	doi = {10.3390/medicina58121765},
	journal-iso = {MED LITH},
	journal = {MEDICINA-LITHUANIA},
	volume = {58},
	unique-id = {33501803},
	issn = {1010-660X},
	abstract = {Background and Objectives: Osteoporosis is a major risk of fractures, harming patients’ quality of life. Dual-energy X-ray absorptiometry (DXA), which can detect osteoporosis early, is too expensive to be conducted on a regular basis. Therefore, we aimed to evaluate a screening method using chest radiographs developed in Japan applied to another population. Materials and Methods: Fifty-five patients who had a chest radiograph and DXA and applied within three months of each test were recruited from the patient database of Semmelweis University (Budapest, Hungary). Graphical analysis of the chest radiographs was conducted to identify the ratio of the cortical bone in the clavicle of each patient. Two researchers performed the analysis, and multiple regression was conducted to determine the bone mineral density of each patient provided by DXA. Results: The Pearson correlation between two examiners’ determinations of the cortical bone ratio was 0.769 (p < 0.001). The multiple regression model proved to be statistically significant in identifying osteoporosis, but the model adopted for the Hungarian population was different compared to the Japanese population. Conclusions: This simple, economic Japanese graphical analysis method for chest radiographs may be feasible in detecting osteoporosis. Further studies with a larger population of patients with greater variety of ethnicity would be of value in improving the accuracy of this model.},
	keywords = {Hungary; Japan; PREVENTION; bone mineral density; aging society; bone fractures},
	year = {2022},
	eissn = {1648-9144},
	orcid-numbers = {Mészáros, Szilvia/0000-0002-4871-6986; Horváth, Csaba/0000-0002-0490-7932; Zöldi, Luca/0000-0003-4187-1673; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647}
}

@article{MTMT:33291618,
	title = {The Relationship between Atherosclerosis and Gut Microbiome in Patients with Obstructive Sleep Apnoea},
	url = {https://m2.mtmt.hu/api/publication/33291618},
	author = {Szabó, Helga and Piroska, Márton and Hernyes, Anita and Zöldi, Luca and Juhász, János and Ligeti, Balázs and Makra, Nóra and Szabó, Dóra and Bikov, András and Kunos, Laszlo and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László},
	doi = {10.3390/app122211484},
	journal-iso = {APPL SCI-BASEL},
	journal = {APPLIED SCIENCES-BASEL},
	volume = {12},
	unique-id = {33291618},
	abstract = {Background: Obstructive sleep apnoea (OSA) and gut dysbiosis are known risk factors for atherosclerosis. However, only very few studies have been focused on the relationship between OSA, atherosclerosis, and the intestinal microbiome, all in animal models. Methods: Twenty-two patients with OSA, 16 with and 6 without carotid atherosclerosis were involved in the study. After a diagnostic sleep examination, the intima media thickness (IMT) was measured and plaques were found using carotid ultrasound. Blood was also drawn for metabolic profile, and a stool sample was provided for 16S ribosomal RNA microbiome investigation. Results: An increased maximal common carotid artery (CCA) IMT was significantly associated with decreased phylum-level diversity. The level of Peptostreptococcaceae was significantly lower in atherosclerotic subjects. Some other candidate microbes appeared in the two groups at the genus level as well: Bilophila, Romboutsia, Slackia, and Veillonella in the non-atherosclerotic group; and Escherichia-Shigella, Prevotella, and Ruminococcaceae in the atherosclerotic group. Conclusions: This is the first pilot research to analyze the association between the gut microbiome and atherosclerosis in adult patients with OSA with and without carotid atherosclerosis. Dysbiosis and individual bacteria may contribute to the development of carotid atherosclerosis in patients with OSA. Further investigations are necessary to reveal a more precise background in a larger sample.},
	year = {2022},
	eissn = {2076-3417},
	orcid-numbers = {Piroska, Márton/0000-0002-6000-5044; Hernyes, Anita/0000-0001-5875-4006; Zöldi, Luca/0000-0003-4187-1673; Szabó, Dóra/0000-0002-8601-3923; Bikov, András/0000-0002-8983-740X; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647}
}

@article{MTMT:33116118,
	title = {Lobular Difference in Heritability of Brain Atrophy among Elderly Japanese: A Twin Study},
	url = {https://m2.mtmt.hu/api/publication/33116118},
	author = {Saeki, Soichiro and Szabó, Helga and Tomizawa, Rie and Tárnoki, Ádám Domonkos and Tárnoki, Dávid László and Watanabe, Yoshiyuki and Honda, Chika},
	doi = {10.3390/medicina58091250},
	journal-iso = {MED LITH},
	journal = {MEDICINA-LITHUANIA},
	volume = {58},
	unique-id = {33116118},
	issn = {1010-660X},
	abstract = {Background and Objectives: Brain atrophy is related to cognitive decline. However, the heritability of brain atrophy has not been fully investigated in the Eastern Asian population. Materials and Methods: Brain imaging of 74 Japanese twins registered in the Osaka University Twin Registry was conducted with voxel-based morphometry SPM12 and was processed by individual voxel-based morphometry adjusting covariates (iVAC) toolbox. The atrophy of the measured lobes was obtained by comparing the focal volume to the average of healthy subjects. Classical twin analysis was used to measure the heritability of its z-scores. Results: The heritability of brain atrophy ranged from 0.23 to 0.97, depending upon the lobes. When adjusted to age, high heritability was reported in the frontal, frontal-temporal, and parietal lobes, but the heritability in other lobes was lower than 0.70. Conclusions: This study revealed a relatively lower heritability in brain atrophy compared to other ethnicities. This result suggests a significant environmental impact on the susceptibility of brain atrophy the Japanese. Therefore, environmental factors may have more influence on the Japanese than in other populations.},
	year = {2022},
	eissn = {1648-9144},
	orcid-numbers = {Saeki, Soichiro/0000-0002-3288-423X; Tárnoki, Ádám Domonkos/0000-0001-5909-3780; Tárnoki, Dávid László/0000-0002-7001-7647; Watanabe, Yoshiyuki/0000-0003-3906-3730}
}

@article{MTMT:32687570,
	title = {Gut Microbiome in Patients with Obstructive Sleep Apnoea},
	url = {https://m2.mtmt.hu/api/publication/32687570},
	author = {Bikov, András and Szabó, Helga and Piroska, Márton and Kunos, László and Szily, Marcell and Ligeti, Balázs and Makra, Nóra and Szabó, Dóra and Tárnoki, Dávid László and Tárnoki, Ádám Domonkos},
	doi = {10.3390/app12042007},
	journal-iso = {APPL SCI-BASEL},
	journal = {APPLIED SCIENCES-BASEL},
	volume = {12},
	unique-id = {32687570},
	year = {2022},
	eissn = {2076-3417},
	orcid-numbers = {Bikov, András/0000-0002-8983-740X; Piroska, Márton/0000-0002-6000-5044; Szily, Marcell/0000-0003-3298-9231; Szabó, Dóra/0000-0002-8601-3923; Tárnoki, Dávid László/0000-0002-7001-7647; Tárnoki, Ádám Domonkos/0000-0001-5909-3780}
}