@article{MTMT:34824081,
	title = {Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches},
	url = {https://m2.mtmt.hu/api/publication/34824081},
	author = {Molnár, Tihamér and Lehoczki, Andrea Marianna and Fekete, Mónika and Várnai, Réka and Zavori, Laszlo and Erdő-Bonyár, Szabina and Simon, Diána and Berki, Tímea and Csécsei, Péter and Ezer, Erzsébet},
	doi = {10.1007/s11357-024-01165-5},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {In press},
	unique-id = {34824081},
	issn = {2509-2715},
	abstract = {The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition characterized by persistent symptoms following the resolution of the acute phase of infection. Among the myriad of symptoms reported by long COVID sufferers, chronic fatigue, cognitive disturbances, and exercise intolerance are predominant, suggesting systemic alterations beyond the initial viral pathology. Emerging evidence has pointed to mitochondrial dysfunction as a potential underpinning mechanism contributing to the persistence and diversity of long COVID symptoms. This review aims to synthesize current findings related to mitochondrial dysfunction in long COVID, exploring its implications for cellular energy deficits, oxidative stress, immune dysregulation, metabolic disturbances, and endothelial dysfunction. Through a comprehensive analysis of the literature, we highlight the significance of mitochondrial health in the pathophysiology of long COVID, drawing parallels with similar clinical syndromes linked to post-infectious states in other diseases where mitochondrial impairment has been implicated. We discuss potential therapeutic strategies targeting mitochondrial function, including pharmacological interventions, lifestyle modifications, exercise, and dietary approaches, and emphasize the need for further research and collaborative efforts to advance our understanding and management of long COVID. This review underscores the critical role of mitochondrial dysfunction in long COVID and calls for a multidisciplinary approach to address the gaps in our knowledge and treatment options for those affected by this condition.},
	year = {2024},
	eissn = {2509-2723},
	orcid-numbers = {Fekete, Mónika/0000-0001-8632-2120; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34796888,
	title = {Decidual γδT cells of early human pregnancy produce angiogenic and immunomodulatory proteins while also possessing cytotoxic potential},
	url = {https://m2.mtmt.hu/api/publication/34796888},
	author = {Nörenberg, Jasper Maximilian and Vida, P. and Bösmeier, I. and Forró, B. and Nörenberg, A. and Buda, Á. and Simon, Diána and Erdő-Bonyár, Szabina and Jáksó, Pál and Kovács, Kálmán András and Mikó, Éva and Berki, Tímea and Mezősi, Emese and Barakonyi, Alíz},
	doi = {10.3389/fimmu.2024.1382424},
	journal-iso = {FRONT IMMUNOL},
	journal = {FRONTIERS IN IMMUNOLOGY},
	volume = {15},
	unique-id = {34796888},
	issn = {1664-3224},
	year = {2024},
	eissn = {1664-3224},
	orcid-numbers = {Berki, Tímea/0000-0002-0134-8127; Mezősi, Emese/0000-0001-9367-3877}
}

@article{MTMT:34538798,
	title = {Altered Levels of Natural Autoantibodies against Heat Shock Proteins in Pregnant Women with Hashimoto’s Thyroiditis},
	url = {https://m2.mtmt.hu/api/publication/34538798},
	author = {Simon, Diána and Erdő-Bonyár, Szabina and Böröcz, Katalin and Balázs, Noémi and Badawy, Ahmed and Bajnok, Anna and Nörenberg, Jasper Maximilian and Litvai, Tímea and Várnagy, Ákos and Kovács, Kálmán András and Hantosi, Eszter and Mezősi, Emese and Németh, Péter and Berki, Tímea},
	doi = {10.3390/ijms25031423},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {25},
	unique-id = {34538798},
	issn = {1661-6596},
	abstract = {The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto’s thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study’s objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP). Serum samples collected from HTP and healthy pregnant (HP) women in the first and third trimesters were tested using in-house-developed enzyme-linked immunosorbent assays (ELISAs). Our findings indicate the stability of nAAbs against CS and Hsps throughout the pregnancies of both healthy women and those with HT. However, during both trimesters, HTP patients displayed elevated levels of IgM isotype nAAbs against Hsp60 and Hsp70 compared to HP women, suggesting a regulatory role of IgM nAAbs during the pregnancies of patients with HT. Nonetheless, levels of IgG isotype nAAbs against Hsps were lower solely in the third trimester among HTP patients, resulting in a higher IgM/IgG ratio, which indicates their importance in alterations of the nAAb network during pregnancy in patients with HT.},
	year = {2024},
	eissn = {1422-0067},
	orcid-numbers = {Bajnok, Anna/0000-0002-0647-4149; Mezősi, Emese/0000-0001-9367-3877; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34747030,
	title = {Természetes autoantitestek változásai egészséges és Hashimoto thyreoiditises nők terhessége során},
	url = {https://m2.mtmt.hu/api/publication/34747030},
	author = {Simon, Diána and Erdő-Bonyár, Szabina and Balázs, Noémi and Böröcz, Katalin and Bajnok, Anna and Nörenberg, Jasper Maximilian and Litvai, Tímea and Várnagy, Ákos and Kovács, Kálmán András and Mezősi, Emese and Németh, Péter and Berki, Tímea},
	journal-iso = {IMMUNOLÓGIAI SZEMLE},
	journal = {IMMUNOLÓGIAI SZEMLE},
	volume = {15},
	unique-id = {34747030},
	issn = {2061-0203},
	year = {2023},
	pages = {49-58},
	orcid-numbers = {Bajnok, Anna/0000-0002-0647-4149; Mezősi, Emese/0000-0001-9367-3877; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34214743,
	title = {Following Natural Autoantibodies : Further Immunoserological Evidence Regarding Their Silent Plasticity and Engagement in Immune Activation},
	url = {https://m2.mtmt.hu/api/publication/34214743},
	author = {Szinger, Dávid and Berki, Tímea and Németh, Péter and Erdő-Bonyár, Szabina and Simon, Diána and Drenjančević, Ines and Samardzic, Senka and Zelić, Marija and Sikora, Magdalena and Požgain, Arlen and Böröcz, Katalin},
	doi = {10.3390/ijms241914961},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34214743},
	issn = {1661-6596},
	abstract = {Contradictory reports are available on vaccine-associated hyperstimulation of the immune system, provoking the formation of pathological autoantibodies. Despite being interconnected within the same network, the role of the quieter, yet important non-pathological and natural autoantibodies (nAAbs) is less defined. We hypothesize that upon a prompt immunological trigger, physiological nAAbs also exhibit a moderate plasticity. We investigated their inducibility through aged and recent antigenic triggers. Anti-viral antibodies (anti-MMR n = 1739 and anti-SARS-CoV-2 IgG n = 330) and nAAbs (anti-citrate synthase IgG, IgM n = 1739) were measured by in-house and commercial ELISAs using Croatian (Osijek) anonymous samples with documented vaccination backgrounds. The results were subsequently compared for statistical evaluation. Interestingly, the IgM isotype nAAb showed a statistically significant connection with anti-MMR IgG seropositivity (p < 0.001 in all cases), while IgG isotype nAAb levels were elevated in association with anti-SARS CoV-2 specific seropositivity (p = 0.019) and in heterogeneous vaccine regimen recipients (unvaccinated controls vector/mRNA vaccines p = 0.002). Increasing evidence supports the interplay between immune activation and the dynamic expansion of nAAbs. Consequently, further questions may emerge regarding the ability of nAAbs silently shaping the effectiveness of immunization. We suggest re-evaluating the impact of nAAbs on the complex functioning of the immunological network.},
	keywords = {IMMUNIZATION; IGG; VACCINE; PLASTICITY; Serology; ELISA; autoantibody; MMR; SARS-CoV-2; natural autoantibody; anti-viral antibody; immunological network},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34141504,
	title = {Multiplex anti-cytokine autoantibody detection during pregnancy},
	url = {https://m2.mtmt.hu/api/publication/34141504},
	author = {Erdő-Bonyár, Szabina and Simon, Diána and Bajnok, A. and Nörenberg, J. and Sereny-Litvai, T. and Várnagy, Á. and Kovács, K. and Hantosi, E. and Mezősi, E. and Berki, T.},
	journal-iso = {CLIN CHEM LAB MED},
	journal = {CLINICAL CHEMISTRY AND LABORATORY MEDICINE},
	volume = {61},
	unique-id = {34141504},
	issn = {1434-6621},
	year = {2023},
	eissn = {1437-4331},
	pages = {eA91-eA91}
}

@article{MTMT:34118587,
	title = {Physiological Changes in the Levels of Anti-Cytokine Autoantibodies in Early Pregnancy Are Missing in Pregnant Women with Hashimoto’s Thyroiditis},
	url = {https://m2.mtmt.hu/api/publication/34118587},
	author = {Erdő-Bonyár, Szabina and Simon, Diána and Bajnok, Anna and Nörenberg, Jasper Maximilian and Litvai, Tímea and Várnagy, Ákos and Kovács, Kálmán András and Hantosi, Eszter and Mezősi, Emese and Berki, Tímea},
	doi = {10.1155/2023/5221658},
	journal-iso = {J IMMUNOL RES},
	journal = {JOURNAL OF IMMUNOLOGY RESEARCH},
	volume = {2023},
	unique-id = {34118587},
	issn = {2314-8861},
	abstract = {T helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto’s thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in several autoimmune disorders. Yet, no data are available on anti-cytokine autoantibodies either during early pregnancy or in patients with HT. The aim of the study was to measure autoantibodies to inflammatory-, Th1- and Th22-cytokines in serum samples in healthy pregnancy (HP) and in pregnant women with HT (HTP). As pathological autoantibodies are hallmarks of HT, in addition we also measured anti-B-cell activator factor (BAFF) autoantibodies. The measurement was carried out with a Luminex multiplex assay and the Luminex MAGPIX Instrument, age-matched healthy women (HC) and women with HT (HT) were used as controls. In the first trimester of HP, anti-TNFα, anti-IL-8, and anti-IFNγ autoantibodies were significantly decreased, while autoantibodies to BAFF were significantly elevated compared to the HC. However, these alterations were not present in the HTP. Moreover, the levels of autoantibodies to IL-22 and TNFα were significantly increased in HTP compared to the HP. All differences in the levels of the investigated autoantibodies could be detected in the first trimester of pregnancies except for anti-IL-22 autoantibodies. According to our results we can conclude that alterations in the levels of autoantibodies to inflammatory and Th1 cytokines are physiological in the first trimester of pregnancy and their disturbance can be associated with autoimmune conditions such as HT.},
	year = {2023},
	eissn = {2314-7156},
	orcid-numbers = {Bajnok, Anna/0000-0002-0647-4149; Mezősi, Emese/0000-0001-9367-3877; Berki, Tímea/0000-0002-0134-8127}
}

@article{MTMT:34043095,
	title = {Different Kinetics of Serum ADAMTS13, GDF-15, and Neutrophil Gelatinase-Associated Lipocalin in the Early Phase of Aneurysmal Subarachnoid Hemorrhage},
	url = {https://m2.mtmt.hu/api/publication/34043095},
	author = {Csécsei, Péter and Oláh, Csaba Zsolt and Várnai, Réka and Simon, Diána and Erdő-Bonyár, Szabina and Berki, Tímea and Czabajszki, Mate and Závori, László and Schwarcz, Attila and Molnár, Tihamér},
	doi = {10.3390/ijms241311005},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {34043095},
	issn = {1661-6596},
	abstract = {Growth differentiation factor 15 (GDF-15), neutrophil gelatinase-associated lipocalin (NGAL), and ADAMTS13 have previously been implicated in the pathophysiological processes of SAH. In the present study, we aim to examine their role in the early period of SAH and their relationship to primary and secondary outcomes. Serum samples were collected at five time periods after SAH (at 24 h (D1), at 72 h (D3), at 120 h (D5), at 168 h (D7) and at 216 h (D9), post-admission) and) were measured by using MILLIPLEX Map Human Cardiovascular Disease (CVD) Magnetic Bead Panel 2. We included 150 patients with SAH and 30 healthy controls. GDF-15 levels at D1 to D9 were significantly associated with a 3-month unfavorable outcome. Based on the ROC analysis, in patients with a good clinical grade at admission (WFNS I-III), the GDF-15 value measured at time point D3 predicted a 3-month unfavorable outcome (cut-off value: 3.97 ng/mL, AUC:0.833, 95%CI: 0.728–0.938, sensitivity:73.7%, specificity:82.6%, p < 0.001). Univariate binary logistic regression analysis showed that serum NGAL levels at D1-D5 and ADAMTS13 levels at D7-D9 were associated with MVS following SAH. GDF-15 is an early indicator of a poor 3-month functional outcome even in patients with mild clinical conditions at admission.},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Berki, Tímea/0000-0002-0134-8127; Závori, László/0000-0002-1715-4167}
}

@article{MTMT:33754872,
	title = {Complexity of the Immune Response Elicited by Different COVID-19 Vaccines, in the Light of Natural Autoantibodies and Immunomodulatory Therapies},
	url = {https://m2.mtmt.hu/api/publication/33754872},
	author = {Böröcz, Katalin and Kinyó, Ágnes and Simon, Diána and Erdő-Bonyár, Szabina and Németh, Péter and Berki, Tímea},
	doi = {10.3390/ijms24076439},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33754872},
	issn = {1661-6596},
	abstract = {Despite the abundance of data on the COVID-19 vaccine-induced immune activation, the impact of natural autoantibodies (nAAbs) on these processes is less well defined. Therefore, we investigated potential connections between vaccine efficacy and nAAb levels. We were also interested in the impact of immunomodulatory therapies on vaccine efficacy. Clinical residual samples were used for the assessment of the COVID-19 vaccine-elicited immune response (IR) (n=255), as well as for the investigation of the immunization-associated expansion of the nAAb pool (n=185). In order to study the potential interaction between immunomodulatory therapies and the vaccine-induced IR, untreated, healthy individuals and patients receiving anti-TNFα or anti-IL-17 therapies were compared (n total =45). In-house ELISAs (anticitrate synthase, anti-HSP60 and-70) and commercial ELISAs (anti-SARS-CoV-2 ELISAs IgG, IgA, NeutraLISA and IFN-γ release assay 'IGRA') were applied. We found significant differences in the IR given to different vaccines. Moreover, nAAb levels showed plasticity in response to anti-COVID-19 immunization. We conclude that our findings may support the theorem about the non-specific beneficial 'side effects' of vaccination, including the broadening of the nAAb repertoire. Considering immunomodulation, we suggest that anti-TNFα and anti-IL17 treatments may interfere negatively with MALT-associated IR, manifested as decreased IgA titers; however, the modest sample numbers of the herein presented model might be a limiting factor of reaching a more comprehensive conclusion.},
	keywords = {IMMUNOMODULATION; NATURAL AUTOANTIBODIES; VACCINE; ELISA; Cellular response; humoral; COVID-19},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Kinyó, Ágnes/0000-0002-9827-2690; Berki, Tímea/0000-0002-0134-8127}
}

@mastersthesis{MTMT:33682914,
	title = {A Toll-like receptor homológ CD180 molekula által közvetített B-sejt funkciók vizsgálata szisztémás sclerosisban},
	url = {https://m2.mtmt.hu/api/publication/33682914},
	author = {Erdő-Bonyár, Szabina},
	unique-id = {33682914},
	year = {2023}
}