@mastersthesis{MTMT:34117484,
	title = {Strategies for development of antimicrobial peptides and proteins},
	url = {https://m2.mtmt.hu/api/publication/34117484},
	author = {Manteghi, Reihaneh},
	doi = {10.14232/phd.11284},
	publisher = {Universití of Szeged},
	unique-id = {34117484},
	abstract = {Many researches have been done with the aim of overcoming AMPs challenges. Different modification strategies as well as different delivery development ideas were offered by these researches. However, peptide modifications and formulation of peptide delivery systems are challenging tasks and hide several risks. Understanding and evaluating the cause - effect relations within the initial Risk Assessment (RA) step in case of all attributes is novelty since it gives the basis for the experimental design as the next step, and aids the formulation development in order to get the final product in the targeted quality range. It also helps to focus on the resources (human, financial, time) related to the final product quality aimed at. By means of RA method within QbD approach of early pharmaceutical development we monitored the factors with highly risk potential in the PEGylation process and risks such as loosing antimicrobial activity of peptide are prevented. The selection of CQAs, CQAs, QTPPs, CQAs and CPPs/CMAs of a PEGylated PGLa formula was performed and interdependence rating among the QTPP elements and CQAs, as well as among the CPPs and CQAs was performed. This careful theoretical study led to the selection of the right methodologies and materials in the synthesis of PEGylated AMPs and their formulation and consequently resulted in obtaining optimized formulation. In our second work, LYZ encapsulated in a novel polyelectrolyte core-shell nanoparticles through the LBL technique utilized as a carrier system to control the release of protein. The preparation of LYZ NPs was made according to 23 full factorial design with QbD approach. Our aim was to understand the effect of process parameters through the determination of mathematical equations, based on which the optimization parameters can be predicted under different process parameters. The optimization parameters were encapsulation efficiency, particle size, enzyme activity, and the amount of α-helix structure. The nanoparticles were analyzed with transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR), and circular dichroism (CD) spectroscopy. Based on our results, we found that pH was the most important factor and pH 10 was recommended during the formulation. Enzyme activity and α-helix content correlated with each other very well, and particle size and encapsulation efficiency also showed a very good correlation with each other. The results of the α-helix content of FTIR and CD measurements were very similar for the precipitated lysozyme due to the solid-state of lysozyme.},
	year = {2022}
}

@article{MTMT:32793624,
	title = {Recent insight into strategies for the design of antimicrobial peptides (AMPs)},
	url = {https://m2.mtmt.hu/api/publication/32793624},
	author = {Manteghi, Reihaneh and Kristó, Katalin and Szakonyi, Gerda and Pannonhalminé Csóka, Ildikó},
	doi = {10.33892/aph.2022.92.20-37},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {92},
	unique-id = {32793624},
	issn = {0001-6659},
	year = {2022},
	eissn = {1587-1495},
	pages = {20-37},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@{MTMT:32639674,
	title = {Optimization of layering technique and the secondary structure analysis during formulation of nanoparticles containing lysozyme by Quality by Design approach},
	url = {https://m2.mtmt.hu/api/publication/32639674},
	author = {Manteghi, Reihaneh and Kristó, Katalin and Pannonhalminé Csóka, Ildikó},
	booktitle = {IV. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science : book of abstracts},
	doi = {10.14232/syrptbrs.2022.34},
	unique-id = {32639674},
	year = {2022},
	pages = {34-34},
	orcid-numbers = {Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@{MTMT:32640325,
	title = {Strategies for development of antimicrobial peptides and proteins},
	url = {https://m2.mtmt.hu/api/publication/32640325},
	author = {Manteghi, Reihaneh and Kristó, Katalin and Szakonyi, Gerda and Csóka, Ildikó},
	booktitle = {III. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science},
	doi = {10.14232/syrptbrs.2021.op8},
	unique-id = {32640325},
	year = {2021},
	pages = {20-20},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:32531578,
	title = {Optimization of layering technique and secondary structure analysis during the formulation of nanoparticles containing lysozyme by quality by design approach},
	url = {https://m2.mtmt.hu/api/publication/32531578},
	author = {Kristó, Katalin and Manteghi, Reihaneh and Ibrahim, Yousif and Ungor, Ditta Anita and Csapó, Edit and Berkesi, Dániel Simon and Kónya, Zoltán and Pannonhalminé Csóka, Ildikó},
	doi = {10.1371/journal.pone.0260603},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {16},
	unique-id = {32531578},
	issn = {1932-6203},
	abstract = {In our study, core-shell nanoparticles containing lysozyme were formulated with precipitation and layering self-assembly. Factorial design (DoE) was applied by setting the process parameters during the preparation with Quality by Design (QbD) approach. The factors were the concentration of lysozyme and sodium alginate, and pH. Our aim was to understand the effect of process parameters through the determination of mathematical equations, based on which the optimization parameters can be predicted under different process parameters. The optimization parameters were encapsulation efficiency, particle size, enzyme activity and the amount of α-helix structure. The nanoparticles were analysed with transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FTIR) and circular dichroism (CD) spectroscopy. Based on our results, we found that pH was the most important factor and pH 10 was recommended during the formulation. Enzyme activity and α-helix content correlated with each other very well, and particle size and encapsulation efficiency also showed very good correlation with each other. The results of the α-helix content of FTIR and CD measurements were very similar for the precipitated lysozyme due to the solid state of lysozyme. The mixing time had the best influence on the encapsulation efficiency and the particle size, which leads to the conclusion that a mixing time of 1 h is recommended. The novelty in our study is the presentation of a mathematical model with which the secondary structure of the protein and other optimization parameters can be controlled in the future during development of nanoparticle based on the process parameters.},
	year = {2021},
	eissn = {1932-6203},
	orcid-numbers = {Kristó, Katalin/0000-0003-4127-6831; Ungor, Ditta Anita/0000-0002-7659-0428; Csapó, Edit/0000-0002-6980-9524; Kónya, Zoltán/0000-0002-9406-8596; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:31781555,
	title = {PEGylation and formulation strategies of antimicrobial peptides and proteins development},
	url = {https://m2.mtmt.hu/api/publication/31781555},
	author = {Manteghi, Reihaneh and Kristó, Katalin and Szakonyi, Gerda and Pannonhalminé Csóka, Ildikó},
	booktitle = {III. Fiatal Technológusok Fóruma},
	doi = {10.14232/ftf.2020.op10},
	unique-id = {31781555},
	year = {2020},
	pages = {15-15},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:31361067,
	title = {PEGylation and formulation strategies of antimicrobial peptides and proteins development},
	url = {https://m2.mtmt.hu/api/publication/31361067},
	author = {Manteghi, Reihaneh and Szakonyi, Gerda and Pannonhalminé Csóka, Ildikó},
	booktitle = {II. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science},
	unique-id = {31361067},
	year = {2020},
	pages = {42-42},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@article{MTMT:31042655,
	title = {Pegylation and formulation strategy of Anti-Microbial Peptide (AMP) according to the quality by design approach},
	url = {https://m2.mtmt.hu/api/publication/31042655},
	author = {Manteghi, Reihaneh and Pallagi, Edina and Olajos, Gábor and Pannonhalminé Csóka, Ildikó},
	doi = {10.1016/j.ejps.2019.105197},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {144},
	unique-id = {31042655},
	issn = {0928-0987},
	year = {2020},
	eissn = {1879-0720},
	orcid-numbers = {Olajos, Gábor/0000-0002-2479-4891; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}

@CONFERENCE{MTMT:30656699,
	title = {Potentials and threats of the colloidal systems as carriers for peptide drugs},
	url = {https://m2.mtmt.hu/api/publication/30656699},
	author = {Pannonhalminé Csóka, Ildikó and Katona, Gábor and Dobó, Dorina Gabriella and Ismail, Ruba and Manteghi, Reihaneh and Pallagi, Edina},
	booktitle = {Eufeps Annual Meeting 2019 : Personalized medicines, targeted therapies, precision drug delivery},
	unique-id = {30656699},
	year = {2019},
	pages = {5},
	orcid-numbers = {Katona, Gábor/0000-0003-1564-4813; Ismail, Ruba/0000-0002-5122-9513}
}

@article{MTMT:30656319,
	title = {Formulation strategy of anti-microbial peptide (AMP) delivery systems},
	url = {https://m2.mtmt.hu/api/publication/30656319},
	author = {Manteghi, Reihaneh and Szakonyi, Gerda and Pallagi, Edina and Pannonhalminé Csóka, Ildikó},
	journal-iso = {ACTA PHARM HUNG},
	journal = {ACTA PHARMACEUTICA HUNGARICA},
	volume = {88},
	unique-id = {30656319},
	issn = {0001-6659},
	year = {2018},
	eissn = {1587-1495},
	pages = {192-192},
	orcid-numbers = {Szakonyi, Gerda/0000-0002-4366-4283; Pannonhalminé Csóka, Ildikó/0000-0003-0807-2781}
}