TY - JOUR AU - Csontos, Armand AU - Németh, Dávid AU - Szakó, Lajos AU - Berke, Gergő AU - Sindler, Dóra Lili AU - Berki, Dávid AU - Papp, Csenge AU - Hegyi, Péter AU - Vereczkei, András AU - Papp, András TI - Intraoperative pyloric drainage is unnecessary during esophagectomies: a meta-analysis and systematic review of randomized controlled trials JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 30 PY - 2024 PG - 11 SN - 1219-4956 DO - 10.3389/pore.2024.1611823 UR - https://m2.mtmt.hu/api/publication/35169697 ID - 35169697 N1 - Export Date: 09 April 2025; CODEN: POREF AB - Objective: The topic of this meta-analysis is the comparison of gastric conduit esophageal reconstructions with or without pyloroplasty. LA - English DB - MTMT ER - TY - JOUR AU - Kelava, Leonardo AU - Németh, Dávid AU - Hegyi, Péter AU - Kéringer, Patrik AU - Kovács, Dóra Krisztina AU - Balaskó, Márta AU - Varjú-Solymár, Margit AU - Pákai, Eszter AU - Rumbus, Zoltán AU - Garami, András TI - Dietary supplementation of transient receptor potential vanilloid-1 channel agonists reduces serum total cholesterol level : a meta-analysis of controlled human trials JF - CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION J2 - CRIT REV FOOD SCI VL - 62 PY - 2022 IS - 25 SP - 7025 EP - 7035 PG - 11 SN - 1040-8398 DO - 10.1080/10408398.2021.1910138 UR - https://m2.mtmt.hu/api/publication/31963955 ID - 31963955 AB - Abnormal cholesterol level is a major risk factor in the development of atherosclerosis, which is a fundamental derangement in cardiovascular diseases. Any efforts should be undertaken to lower blood cholesterol levels. Among dietary interventions, capsaicinoid supplementation is also considered as a novel cholesterol-lowering approach, but human studies concluded contradictory results about its effectiveness. The present meta-analysis aimed at determining the effects of capsaicinoids on serum lipid profile in humans. We searched the PubMed, EMBASE, and CENTRAL databases from inception to February 2021. We included 10 controlled studies, which involved 398 participants. We found that dietary capsaicinoid supplementation alone or in combination with other substances significantly (p = 0.004 and 0.001, respectively) reduced serum total cholesterol level compared to controls with an overall standardized mean difference of -0.52 (95% confidence interval: -0.83, -0.21). Capsaicinoids also decreased low-density lipoprotein level significantly (p = 0.035), whereas no effect was observed on serum levels of high-density lipoprotein and triglycerides. Our findings provide novel quantitative evidence for the efficacy of dietary capsaicin supplementation in lowering serum total cholesterol and low-density lipoprotein levels in humans. To validate our conclusion, further randomized controlled trials in a diverse population of adult humans receiving dietary capsaicinoid supplementation are warranted. LA - English DB - MTMT ER - TY - JOUR AU - Eitmann, Szimonetta Éva AU - Mátrai, Péter AU - Németh, Dávid AU - Hegyi, Péter AU - Lukács, Anita AU - Bérczi, Bálint AU - Czumbel, László Márk AU - Kiss, István AU - Gyöngyi, Zoltán AU - Varga, Gábor AU - Balaskó, Márta AU - Pétervári, Erika TI - Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis JF - PAEDIATRIC AND PERINATAL EPIDEMIOLOGY J2 - PAEDIATR PERINAT EP VL - 36 PY - 2022 IS - 2 SP - 276 EP - 287 PG - 12 SN - 0269-5022 DO - 10.1111/ppe.12859 UR - https://m2.mtmt.hu/api/publication/32604750 ID - 32604750 AB - Maternal overnutrition during pregnancy predisposes the offspring to cardiometabolic diseases.This systematic review and meta-analysis aimed to investigate the association between maternal overnutrition and offspring's blood pressure (BP) and the effect of offspring's obesity on this association.PubMed, EMBASE, Clinicaltrials.gov, CENTRAL.Human studies published in English before October 2021 were identified that presented quantitative estimates of association between maternal overnutrition just before or during pregnancy and the offspring's BP.Random-effect model with the DerSimonian and Laird weighting method was used to analyse regression coefficients or mean differences.After selection, 17 observational studies (140,517 mother-offspring pairs) were included. Prepregnancy body mass index (ppBMI) showed positive correlation with BP in offspring (regression coefficient for systolic: 0.38 mmHg per kg/m2 , 95% confidence interval (CI) 0.17, 0.58; diastolic: 0.10 mmHg per kg/m2 , 95% CI 0.05, 0.14). These indicate 1.9 mmHg increase in systolic and 0.5 mmHg increase in diastolic BP of offspring with every 5 kg/m2 gain in maternal ppBMI. Results on coefficients adjusted for offspring's BMI also showed association (systolic: 0.08 mmHg per kg/m2 , 95% CI 0.04, 0.11; diastolic: 0.03 mmHg per kg/m2 , 95% CI 0.01, 0.04). Independent from ppBMI, gestational weight gain (GWG) showed positive correlation with systolic BP (systolic BP: 0.05 mmHg per kg, 95% CI 0.01, 0.09), but not after adjustment for offspring's BMI. Mean systolic BP was higher in children of mothers with excessive GWG than in those of mothers with optimal GWG (difference: 0.65 mmHg, 95% CI 0.25, 1.05).Independent from offspring's BMI, higher prepregnancy BMI may increase the risk for hypertension in offspring. The positive association between GWG and offspring's systolic BP is indirect via offspring's obesity. Reduction in maternal obesity and treatment of obesity in children of obese mothers are needed to prevent hypertension. LA - English DB - MTMT ER - TY - JOUR AU - Ruzsics, István AU - Mátrai, Péter AU - Hegyi, Péter AU - Németh, Dávid AU - Tenk, Judit AU - Csenkey, Alexandra AU - Erőss, Bálint Mihály AU - Varga, Gábor AU - Balaskó, Márta AU - Pétervári, Erika AU - Veres, Gábor AU - Sepp, Róbert AU - Rakonczay, Zoltán AU - Vincze, Áron AU - Garami, András AU - Rumbus, Zoltán TI - Noninvasive ventilation improves the outcome in patients with pneumonia-associated respiratory failure: Systematic review and meta-analysis JF - JOURNAL OF INFECTION AND PUBLIC HEALTH J2 - J INFECT PUBLIC HEALTH VL - 15 PY - 2022 IS - 3 SP - 349 EP - 359 PG - 11 SN - 1876-0341 DO - 10.1016/j.jiph.2022.02.004 UR - https://m2.mtmt.hu/api/publication/32692193 ID - 32692193 AB - Background Noninvasive ventilation (NIV) is beneficial in exacerbations of chronic obstructive pulmonary disease (COPD), but its effectiveness in pneumonia-associated respiratory failure is still controversial. In the current meta-analysis, we aimed to investigate whether the use of NIV before intubation in pneumonia improves the mortality and intubation rates of respiratory failure as compared to no use of NIV in adults. Methods We searched three databases from inception to December 2019. We included studies, in which pneumonia patients were randomized initially into either NIV-treated or non-NIV-treated groups. Five full-text publications, including 121 patients, reported eligible data for statistical analysis. Results With NIV the overall hospital mortality rate seemed lower in patients with pneumonia-associated respiratory failure, but this was not significant [odds ratio (OR) = 0.39; 95% confidence interval (CI): 0.13–1.14; P = 0.085]. In the intensive care unit, the mortality was significantly lower when NIV was applied compared to no NIV treatment (OR = 0.22; 95% CI: 0.07–0.75; P = 0.015). NIV also decreased mortality compared to no NIV in patient groups, which did not exclude patients with COPD (OR = 0.25; 95% CI: 0.08–0.74; P = 0.013). The need for intubation was significantly reduced in NIV-treated patients (OR = 0.22; 95% CI: 0.09–0.53; P = 0.001), which effect was more prominent in pneumonia patient groups not excluding patients with pre-existing COPD (OR = 0.13; 95% CI: 0.03–0.46; P = 0.002). Conclusion NIV markedly decreases the death rate in the intensive care unit and reduces the need for intubation in patients with pneumonia-associated respiratory failure. The beneficial effects of NIV seem more pronounced in populations that include patients with COPD. Our findings suggest that NIV should be considered in the therapeutic guidelines of pneumonia, given that future clinical trials confirm the results of our meta-analysis. Availability of data and materials All data and materials generated during the current study are available from the corresponding author on reasonable request. LA - English DB - MTMT ER - TY - JOUR AU - Leiner, Tamás AU - Németh, Dávid AU - Hegyi, Péter AU - Ocskay, Klementina AU - Virag, Marcell AU - Kiss, Szabolcs AU - Rottler, Máté AU - Vajda, Mátyás AU - Váradi, Alex AU - Molnár, Zsolt TI - Frailty and Emergency Surgery: Results of a Systematic Review and Meta-Analysis JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 9 PY - 2022 PG - 16 SN - 2296-858X DO - 10.3389/fmed.2022.811524 UR - https://m2.mtmt.hu/api/publication/32787246 ID - 32787246 AB - Frailty, a "syndrome of loss of reserves," is a decade old concept. Initially it was used mainly in geriatrics but lately its use has been extended into other specialties including surgery. Our main objective was to examine the association between frailty and mortality, between frailty and length of hospital stay (LOS) and frailty and readmission within 30 days in the emergency surgical population.Studies reporting on frailty in the emergency surgical population were eligible. MEDLINE (via PubMed), EMBASE, Scopus, CENTRAL, and Web of Science were searched with terms related to acute surgery and frail*. We searched for eligible articles without any restrictions on the 2nd of November 2020. Odds ratios (OR) and weighted mean differences (WMD) were calculated with 95% confidence intervals (CI), using a random effect model. Risk of bias assessment was performed according to the recommendations of the Cochrane Collaboration. As the finally selected studies were either prospective or retrospective cohorts, the "Quality In Prognosis Studies" (QUIPS) tool was used.At the end of the selection process 21 eligible studies with total 562.070 participants from 8 countries were included in the qualitative and the quantitative synthesis. Patients living with frailty have higher chance of dying within 30 days after an emergency surgical admission (OR: 1.99; CI: 1.76-2.21; p < 0.001). We found a tendency of increased LOS with frailty in acute surgical patients (WMD: 4.75 days; CI: 1.79-7.71; p = 0.002). Patients living with frailty have increased chance of 30-day readmission after discharge (OR: 1.36; CI: 1.06-1.75; p = 0.015).Although there is good evidence that living with frailty increases the chance of unfavorable outcomes, further research needs to be done to assess the benefits and costs of frailty screening for emergency surgical patients.The review protocol was registered on the PROSPERO International Prospective Register of Systematic Reviews (CRD42021224689). LA - English DB - MTMT ER - TY - JOUR AU - Zádori, Noémi AU - Németh, Dávid AU - Szakó, Lajos AU - Váncsa, Szilárd AU - Vörhendi, Nóra AU - Szakács, Zsolt AU - Frim, Levente AU - Hegyi, Péter AU - Czimmer, József TI - Prevalence of Autoimmune-phenomena behind Chronic Gastritis of Unknown Origin, and its Role in Poor Histological Outcome of the Stomach : A Single-centre, Retrospective Cross-sectional Study. JF - JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES J2 - J GASTROINTEST LIVER VL - 31 PY - 2022 IS - 2 SP - 168 EP - 175 PG - 8 SN - 1841-8724 DO - 10.15403/jgld-4218 UR - https://m2.mtmt.hu/api/publication/32827542 ID - 32827542 AB - The underlying aetiology of chronic gastritis (CG) often remains unknown due to its underrated significance in clinical practice. However, the role of chronic inflammation of the stomach in the development of atrophy, intestinal metaplasia (IM) and eventually of gastric cancer is well documented. We aimed to explore the possible aetiological factors of CG, determine the prevalence of systemic autoimmune disorders in patients with CG of unknown aetiology, and clarify the role of autoantibodies in the development of precancerous lesions in the stomach.This is a retrospective, cross-sectional study, conducted from January 2016 to January 2020, including data from 175 patients with CG. Exclusion criteria were: (1) acute gastritis; (2) reactive gastropathy; (3) gastric cancer; (4) subjects without any serology testing results; and (5) Helicobacter pylori positivity. The primary endpoint was a composite endpoint involving gastric atrophy and IM.Fifty-five per cent of patients with CG had autoantibodies. Systemic lupus erythematosus (SLE)-related antibodies were positive in most of the cases, including antinuclear antibody (ANA) positivity, which was found in 19.13% of the patients. Autoimmune positivity was shown to be associated with precancerous lesions in the stomach (p<0.001): IM, atrophy and IM with atrophy. Anti-parietal cell antibody positivity seems to be a significant risk factor for IM and IM with atrophy. Autoimmune thyroiditis-related antibodies and ANA positivity by itself were only associated with atrophy; SLE-related antibodies and inflammatory bowel diseases related antibodies (ASCA and ANCA) correlated either with IM or with atrophy. No significant relation was found between any other investigated autoimmune disease-related antibodies and precancerous lesions.Autoimmune positivity often underlies gastritis of unknown aetiology and predisposes to precancerous lesions in the stomach. These antibodies can serve as non-invasive markers for the of optimal timing of an endoscopic follow-up strategy. Furthermore, CG can be an early symptom of a systemic autoimmune disorder. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Norbert AU - Németh, Dávid AU - Földi, Mária AU - Nagy, Bernadette AU - Bunduc, Stefania AU - Hegyi, Péter AU - Bajor, Judit AU - Müller, Katalin Eszter AU - Vincze, Áron AU - Erőss, Bálint Mihály AU - Ábrahám, Szabolcs TI - Selective intraoperative cholangiography should be considered over routine intraoperative cholangiography during cholecystectomy : a systematic review and meta-analysis JF - SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES J2 - SURG ENDOSC VL - 36 PY - 2022 IS - 10 SP - 7126 EP - 7139 PG - 14 SN - 0930-2794 DO - 10.1007/s00464-022-09267-x UR - https://m2.mtmt.hu/api/publication/32925017 ID - 32925017 AB - Decades of debate surround the use of intraoperative cholangiography (IOC) during cholecystectomy. To the present day, the role of IOC is controversial as regards decreasing the rate of bile duct injury (BDI). We aimed to review and analyse the available literature on the benefits of IOC during cholecystectomy.A systematic literature search was performed until 19 October 2020 in five databases using the following search keys: cholangiogra* and cholecystectomy. The primary outcomes were BDI and retained stone rate. To investigate the differences between the groups (routine IOC vs selective IOC and IOC vs no IOC), we calculated weighted mean differences (WMD) for continuous outcomes and relative risks (RR) for dichotomous outcomes, with 95% confidence intervals (CI).Of the 19,863 articles, 38 were selected and 32 were included in the quantitative synthesis. Routine IOC showed no superiority compared to selective IOC in decreasing BDI (RR = 0.91, 95% CI 0.66; 1.24). Comparing IOC and no IOC, no statistically significant differences were found in the case of BDI, retained stone rate, readmission rate, and length of hospital stay. We found an increased risk of conversion rate to open surgery in the no IOC group (RR = 0.64, CI 0.51; 0.78). The operation time was significantly longer in the IOC group compared to the no IOC group (WMD = 11.25 min, 95% CI 6.57; 15.93).Our findings suggest that IOC may not be indicated in every case, however, the evidence is very uncertain. Further good quality research is required to address this question. LA - English DB - MTMT ER - TY - JOUR AU - Szakó, Lajos AU - Németh, Dávid AU - Borbásné Farkas, Kornélia AU - Kiss, Szabolcs AU - Dömötör, Réka Zsuzsa AU - Engh, Marie Anne AU - Hegyi, Péter AU - Erőss, Bálint Mihály AU - Papp, András TI - Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer: The superiority of minimally invasive surgery JF - WORLD JOURNAL OF GASTROENTEROLOGY J2 - WORLD J LGASTROENTEROL VL - 28 PY - 2022 IS - 30 SP - 4201 EP - 4210 PG - 10 SN - 1007-9327 DO - 10.3748/wjg.v28.i30.4201 UR - https://m2.mtmt.hu/api/publication/33126264 ID - 33126264 AB - Previous meta-analyses, with many limitations, have described the beneficial nature of minimal invasive procedures.To compare all modalities of esophagectomies to each other from the results of randomized controlled trials (RCTs) in a network meta-analysis (NMA).We conducted a systematic search of the MEDLINE, EMBASE, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and CENTRAL databases to identify RCTs according to the following population, intervention, control, outcome (commonly known as PICO): P: Patients with resectable esophageal cancer; I/C: Transthoracic, transhiatal, minimally invasive (thoracolaparoscopic), hybrid, and robot-assisted esophagectomy; O: Survival, total adverse events, adverse events in subgroups, length of hospital stay, and blood loss. We used the Bayesian approach and the random effects model. We presented the geometry of the network, results with probabilistic statements, estimated intervention effects and their 95% confidence interval (CI), and the surface under the cumulative ranking curve to rank the interventions.We included 11 studies in our analysis. We found a significant difference in postoperative pulmonary infection, which favored the minimally invasive intervention compared to transthoracic surgery (risk ratio 0.49; 95%CI: 0.23 to 0.99). The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery (mean difference -85 min; 95%CI: -150 to -29), hybrid intervention (mean difference -98 min; 95%CI: -190 to -9.4), minimally invasive technique (mean difference -130 min; 95%CI: -210 to -50), and robot-assisted esophagectomy (mean difference -150 min; 95%CI: -240 to -53). Other comparisons did not yield significant differences.Based on our results, the implication of minimally invasive esophagectomy should be favored. LA - English DB - MTMT ER - TY - JOUR AU - Zádori, Noémi AU - Németh, Dávid AU - Frim, Levente AU - Vörhendi, Nóra AU - Szakó, Lajos AU - Váncsa, Szilárd AU - Hegyi, Péter AU - Czimmer, József TI - Dyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study JF - INTERNATIONAL JOURNAL OF GENERAL MEDICINE J2 - INT J GEN MED VL - 15 PY - 2022 SP - 7789 EP - 7796 PG - 8 SN - 1178-7074 DO - 10.2147/IJGM.S380419 UR - https://m2.mtmt.hu/api/publication/33154300 ID - 33154300 LA - English DB - MTMT ER - TY - GEN AU - A., Csontos AU - Németh, Dávid AU - Szakó, Lajos AU - G., Berke AU - L., D. Sindler AU - Hegyi, Péter AU - Papp, András TI - The necessity of pyloric drainage in esophagectomies: protocol of a meta-analysis and a systematic review of randomized controlled trials. PY - 2022 UR - https://m2.mtmt.hu/api/publication/33588407 ID - 33588407 AB - Background: Esophageal carcinoma is the 8th most common malignant tumour in the world with more than 600 000 cases (3.1% of all), while being the 6th most common reason of tumour mortality, causing more than 500 000 deaths (5.5% of all) annually. The 1, 3 and 5 year-prevalence are 2.4%, 1.6% and 1.3% respectively. The question of this meta-analysis is whether pyloric drainage is preferable over the lack of pyloric drainage during elective esophagectomies in patients suffering from esophageal cancer, regarding mortality, anastomosis leakage, respiratory morbidity, vomiting, gastric emptying time. Methods: We plan to identify randomized controlled trials to investigate the question by performing extensive search in multiple databases. Based on of predefined criteria, two independent authors will perform the steps of selection, after which appropriate statistical analysis will be performed to identify potential significant differences. Cochrane Risk of Bias Tool 2, and GRADE approach will be used to estimate the risk of bias and quality of results. Dissemination plans: We plan to distribute our results in peer-reviewed journal. LA - English DB - MTMT ER -