@article{MTMT:35169697,
	title = {Intraoperative pyloric drainage is unnecessary during esophagectomies: a meta-analysis and systematic review of randomized controlled trials},
	url = {https://m2.mtmt.hu/api/publication/35169697},
	author = {Csontos, Armand and Németh, Dávid and Szakó, Lajos and Berke, Gergő and Sindler, Dóra Lili and Berki, Dávid and Papp, Csenge and Hegyi, Péter and Vereczkei, András and Papp, András},
	doi = {10.3389/pore.2024.1611823},
	journal-iso = {PATHOL ONCOL RES},
	journal = {PATHOLOGY AND ONCOLOGY RESEARCH},
	volume = {30},
	unique-id = {35169697},
	issn = {1219-4956},
	abstract = {Objective: The topic of this meta-analysis is the comparison of gastric conduit esophageal reconstructions with or without pyloroplasty.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {1532-2807},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:31963955,
	title = {Dietary supplementation of transient receptor potential vanilloid-1 channel agonists reduces serum total cholesterol level : a meta-analysis of controlled human trials},
	url = {https://m2.mtmt.hu/api/publication/31963955},
	author = {Kelava, Leonardo and Németh, Dávid and Hegyi, Péter and Kéringer, Patrik and Kovács, Dóra Krisztina and Balaskó, Márta and Varjú-Solymár, Margit and Pákai, Eszter and Rumbus, Zoltán and Garami, András},
	doi = {10.1080/10408398.2021.1910138},
	journal-iso = {CRIT REV FOOD SCI},
	journal = {CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION},
	volume = {62},
	unique-id = {31963955},
	issn = {1040-8398},
	abstract = {Abnormal cholesterol level is a major risk factor in the development of atherosclerosis, which is a fundamental derangement in cardiovascular diseases. Any efforts should be undertaken to lower blood cholesterol levels. Among dietary interventions, capsaicinoid supplementation is also considered as a novel cholesterol-lowering approach, but human studies concluded contradictory results about its effectiveness. The present meta-analysis aimed at determining the effects of capsaicinoids on serum lipid profile in humans. We searched the PubMed, EMBASE, and CENTRAL databases from inception to February 2021. We included 10 controlled studies, which involved 398 participants. We found that dietary capsaicinoid supplementation alone or in combination with other substances significantly (p = 0.004 and 0.001, respectively) reduced serum total cholesterol level compared to controls with an overall standardized mean difference of -0.52 (95% confidence interval: -0.83, -0.21). Capsaicinoids also decreased low-density lipoprotein level significantly (p = 0.035), whereas no effect was observed on serum levels of high-density lipoprotein and triglycerides. Our findings provide novel quantitative evidence for the efficacy of dietary capsaicin supplementation in lowering serum total cholesterol and low-density lipoprotein levels in humans. To validate our conclusion, further randomized controlled trials in a diverse population of adult humans receiving dietary capsaicinoid supplementation are warranted.},
	keywords = {CAPSAICIN; TRPV1; LDL; lipoprotein; Lipid profile; Chili; [Meta-analysis]},
	year = {2022},
	eissn = {1549-7852},
	pages = {7025-7035},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Kovács, Dóra Krisztina/0000-0001-5152-2069; Varjú-Solymár, Margit/0000-0001-6667-6263; Garami, András/0000-0003-2493-0571}
}

@article{MTMT:32604750,
	title = {Maternal overnutrition elevates offspring's blood pressure-A systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/32604750},
	author = {Eitmann, Szimonetta Éva and Mátrai, Péter and Németh, Dávid and Hegyi, Péter and Lukács, Anita and Bérczi, Bálint and Czumbel, László Márk and Kiss, István and Gyöngyi, Zoltán and Varga, Gábor and Balaskó, Márta and Pétervári, Erika},
	doi = {10.1111/ppe.12859},
	journal-iso = {PAEDIATR PERINAT EP},
	journal = {PAEDIATRIC AND PERINATAL EPIDEMIOLOGY},
	volume = {36},
	unique-id = {32604750},
	issn = {0269-5022},
	abstract = {Maternal overnutrition during pregnancy predisposes the offspring to cardiometabolic diseases.This systematic review and meta-analysis aimed to investigate the association between maternal overnutrition and offspring's blood pressure (BP) and the effect of offspring's obesity on this association.PubMed, EMBASE, Clinicaltrials.gov, CENTRAL.Human studies published in English before October 2021 were identified that presented quantitative estimates of association between maternal overnutrition just before or during pregnancy and the offspring's BP.Random-effect model with the DerSimonian and Laird weighting method was used to analyse regression coefficients or mean differences.After selection, 17 observational studies (140,517 mother-offspring pairs) were included. Prepregnancy body mass index (ppBMI) showed positive correlation with BP in offspring (regression coefficient for systolic: 0.38 mmHg per kg/m2 , 95% confidence interval (CI) 0.17, 0.58; diastolic: 0.10 mmHg per kg/m2 , 95% CI 0.05, 0.14). These indicate 1.9 mmHg increase in systolic and 0.5 mmHg increase in diastolic BP of offspring with every 5 kg/m2 gain in maternal ppBMI. Results on coefficients adjusted for offspring's BMI also showed association (systolic: 0.08 mmHg per kg/m2 , 95% CI 0.04, 0.11; diastolic: 0.03 mmHg per kg/m2 , 95% CI 0.01, 0.04). Independent from ppBMI, gestational weight gain (GWG) showed positive correlation with systolic BP (systolic BP: 0.05 mmHg per kg, 95% CI 0.01, 0.09), but not after adjustment for offspring's BMI. Mean systolic BP was higher in children of mothers with excessive GWG than in those of mothers with optimal GWG (difference: 0.65 mmHg, 95% CI 0.25, 1.05).Independent from offspring's BMI, higher prepregnancy BMI may increase the risk for hypertension in offspring. The positive association between GWG and offspring's systolic BP is indirect via offspring's obesity. Reduction in maternal obesity and treatment of obesity in children of obese mothers are needed to prevent hypertension.},
	keywords = {[Meta-analysis]},
	year = {2022},
	eissn = {1365-3016},
	pages = {276-287},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Lukács, Anita/0000-0002-0746-8920; Czumbel, László Márk/0000-0002-5915-0383; Gyöngyi, Zoltán/0000-0001-9330-9119; Varga, Gábor/0000-0002-5506-8198; Pétervári, Erika/0000-0002-3673-8491}
}

@article{MTMT:32692193,
	title = {Noninvasive ventilation improves the outcome in patients with pneumonia-associated respiratory failure: Systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/32692193},
	author = {Ruzsics, István and Mátrai, Péter and Hegyi, Péter and Németh, Dávid and Tenk, Judit and Csenkey, Alexandra and Erőss, Bálint Mihály and Varga, Gábor and Balaskó, Márta and Pétervári, Erika and Veres, Gábor and Sepp, Róbert and Rakonczay, Zoltán and Vincze, Áron and Garami, András and Rumbus, Zoltán},
	doi = {10.1016/j.jiph.2022.02.004},
	journal-iso = {J INFECT PUBLIC HEALTH},
	journal = {JOURNAL OF INFECTION AND PUBLIC HEALTH},
	volume = {15},
	unique-id = {32692193},
	issn = {1876-0341},
	abstract = {Background
		Noninvasive ventilation (NIV) is beneficial in exacerbations of chronic obstructive pulmonary disease (COPD), but its effectiveness in pneumonia-associated respiratory failure is still controversial. In the current meta-analysis, we aimed to investigate whether the use of NIV before intubation in pneumonia improves the mortality and intubation rates of respiratory failure as compared to no use of NIV in adults.
		
		Methods
		We searched three databases from inception to December 2019. We included studies, in which pneumonia patients were randomized initially into either NIV-treated or non-NIV-treated groups. Five full-text publications, including 121 patients, reported eligible data for statistical analysis.
		
		Results
		With NIV the overall hospital mortality rate seemed lower in patients with pneumonia-associated respiratory failure, but this was not significant [odds ratio (OR) = 0.39; 95% confidence interval (CI): 0.13–1.14; P = 0.085]. In the intensive care unit, the mortality was significantly lower when NIV was applied compared to no NIV treatment (OR = 0.22; 95% CI: 0.07–0.75; P = 0.015). NIV also decreased mortality compared to no NIV in patient groups, which did not exclude patients with COPD (OR = 0.25; 95% CI: 0.08–0.74; P = 0.013). The need for intubation was significantly reduced in NIV-treated patients (OR = 0.22; 95% CI: 0.09–0.53; P = 0.001), which effect was more prominent in pneumonia patient groups not excluding patients with pre-existing COPD (OR = 0.13; 95% CI: 0.03–0.46; P = 0.002).
		
		Conclusion
		NIV markedly decreases the death rate in the intensive care unit and reduces the need for intubation in patients with pneumonia-associated respiratory failure. The beneficial effects of NIV seem more pronounced in populations that include patients with COPD. Our findings suggest that NIV should be considered in the therapeutic guidelines of pneumonia, given that future clinical trials confirm the results of our meta-analysis.
		
		Availability of data and materials
		All data and materials generated during the current study are available from the corresponding author on reasonable request.},
	keywords = {MORTALITY; Meta-analysis; pneumonia; Noninvasive ventilation; INVASIVE VENTILATION; [Meta-analysis]},
	year = {2022},
	eissn = {1876-035X},
	pages = {349-359},
	orcid-numbers = {Ruzsics, István/0000-0002-6381-8884; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427; Varga, Gábor/0000-0002-5506-8198; Pétervári, Erika/0000-0002-3673-8491; Veres, Gábor/0000-0002-0911-1941; Sepp, Róbert/0000-0003-4964-1661; Rakonczay, Zoltán/0000-0002-1499-3416; Vincze, Áron/0000-0003-2217-7686; Garami, András/0000-0003-2493-0571}
}

@article{MTMT:32787246,
	title = {Frailty and Emergency Surgery: Results of a Systematic Review and Meta-Analysis},
	url = {https://m2.mtmt.hu/api/publication/32787246},
	author = {Leiner, Tamás and Németh, Dávid and Hegyi, Péter and Ocskay, Klementina and Virag, Marcell and Kiss, Szabolcs and Rottler, Máté and Vajda, Mátyás and Váradi, Alex and Molnár, Zsolt},
	doi = {10.3389/fmed.2022.811524},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {9},
	unique-id = {32787246},
	abstract = {Frailty, a "syndrome of loss of reserves," is a decade old concept. Initially it was used mainly in geriatrics but lately its use has been extended into other specialties including surgery. Our main objective was to examine the association between frailty and mortality, between frailty and length of hospital stay (LOS) and frailty and readmission within 30 days in the emergency surgical population.Studies reporting on frailty in the emergency surgical population were eligible. MEDLINE (via PubMed), EMBASE, Scopus, CENTRAL, and Web of Science were searched with terms related to acute surgery and frail*. We searched for eligible articles without any restrictions on the 2nd of November 2020. Odds ratios (OR) and weighted mean differences (WMD) were calculated with 95% confidence intervals (CI), using a random effect model. Risk of bias assessment was performed according to the recommendations of the Cochrane Collaboration. As the finally selected studies were either prospective or retrospective cohorts, the "Quality In Prognosis Studies" (QUIPS) tool was used.At the end of the selection process 21 eligible studies with total 562.070 participants from 8 countries were included in the qualitative and the quantitative synthesis. Patients living with frailty have higher chance of dying within 30 days after an emergency surgical admission (OR: 1.99; CI: 1.76-2.21; p < 0.001). We found a tendency of increased LOS with frailty in acute surgical patients (WMD: 4.75 days; CI: 1.79-7.71; p = 0.002). Patients living with frailty have increased chance of 30-day readmission after discharge (OR: 1.36; CI: 1.06-1.75; p = 0.015).Although there is good evidence that living with frailty increases the chance of unfavorable outcomes, further research needs to be done to assess the benefits and costs of frailty screening for emergency surgical patients.The review protocol was registered on the PROSPERO International Prospective Register of Systematic Reviews (CRD42021224689).},
	keywords = {[Meta-analysis]},
	year = {2022},
	eissn = {2296-858X},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Ocskay, Klementina/0000-0001-5848-2506; Rottler, Máté/0000-0003-0743-5595; Váradi, Alex/0000-0001-8229-6340}
}

@article{MTMT:32827542,
	title = {Prevalence of Autoimmune-phenomena behind Chronic Gastritis of Unknown Origin, and its Role in Poor Histological Outcome of the Stomach : A Single-centre, Retrospective Cross-sectional Study.},
	url = {https://m2.mtmt.hu/api/publication/32827542},
	author = {Zádori, Noémi and Németh, Dávid and Szakó, Lajos and Váncsa, Szilárd and Vörhendi, Nóra and Szakács, Zsolt and Frim, Levente and Hegyi, Péter and Czimmer, József},
	doi = {10.15403/jgld-4218},
	journal-iso = {J GASTROINTEST LIVER},
	journal = {JOURNAL OF GASTROINTESTINAL AND LIVER DISEASES},
	volume = {31},
	unique-id = {32827542},
	issn = {1841-8724},
	abstract = {The underlying aetiology of chronic gastritis (CG) often remains unknown due to its underrated significance in clinical practice. However, the role of chronic inflammation of the stomach in the development of atrophy, intestinal metaplasia (IM) and eventually of gastric cancer is well documented. We aimed to explore the possible aetiological factors of CG, determine the prevalence of systemic autoimmune disorders in patients with CG of unknown aetiology, and clarify the role of autoantibodies in the development of precancerous lesions in the stomach.This is a retrospective, cross-sectional study, conducted from January 2016 to January 2020, including data from 175 patients with CG. Exclusion criteria were: (1) acute gastritis; (2) reactive gastropathy; (3) gastric cancer; (4) subjects without any serology testing results; and (5) Helicobacter pylori positivity. The primary endpoint was a composite endpoint involving gastric atrophy and IM.Fifty-five per cent of patients with CG had autoantibodies. Systemic lupus erythematosus (SLE)-related antibodies were positive in most of the cases, including antinuclear antibody (ANA) positivity, which was found in 19.13% of the patients. Autoimmune positivity was shown to be associated with precancerous lesions in the stomach (p<0.001): IM, atrophy and IM with atrophy. Anti-parietal cell antibody positivity seems to be a significant risk factor for IM and IM with atrophy. Autoimmune thyroiditis-related antibodies and ANA positivity by itself were only associated with atrophy; SLE-related antibodies and inflammatory bowel diseases related antibodies (ASCA and ANCA) correlated either with IM or with atrophy. No significant relation was found between any other investigated autoimmune disease-related antibodies and precancerous lesions.Autoimmune positivity often underlies gastritis of unknown aetiology and predisposes to precancerous lesions in the stomach. These antibodies can serve as non-invasive markers for the of optimal timing of an endoscopic follow-up strategy. Furthermore, CG can be an early symptom of a systemic autoimmune disorder.},
	year = {2022},
	eissn = {1842-1121},
	pages = {168-175},
	orcid-numbers = {Váncsa, Szilárd/0000-0002-9347-8163; Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259; Czimmer, József/0000-0001-7831-3523}
}

@article{MTMT:32925017,
	title = {Selective intraoperative cholangiography should be considered over routine intraoperative cholangiography during cholecystectomy : a systematic review and meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/32925017},
	author = {Kovács, Norbert and Németh, Dávid and Földi, Mária and Nagy, Bernadette and Bunduc, Stefania and Hegyi, Péter and Bajor, Judit and Müller, Katalin Eszter and Vincze, Áron and Erőss, Bálint Mihály and Ábrahám, Szabolcs},
	doi = {10.1007/s00464-022-09267-x},
	journal-iso = {SURG ENDOSC},
	journal = {SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES},
	volume = {36},
	unique-id = {32925017},
	issn = {0930-2794},
	abstract = {Decades of debate surround the use of intraoperative cholangiography (IOC) during cholecystectomy. To the present day, the role of IOC is controversial as regards decreasing the rate of bile duct injury (BDI). We aimed to review and analyse the available literature on the benefits of IOC during cholecystectomy.A systematic literature search was performed until 19 October 2020 in five databases using the following search keys: cholangiogra* and cholecystectomy. The primary outcomes were BDI and retained stone rate. To investigate the differences between the groups (routine IOC vs selective IOC and IOC vs no IOC), we calculated weighted mean differences (WMD) for continuous outcomes and relative risks (RR) for dichotomous outcomes, with 95% confidence intervals (CI).Of the 19,863 articles, 38 were selected and 32 were included in the quantitative synthesis. Routine IOC showed no superiority compared to selective IOC in decreasing BDI (RR = 0.91, 95% CI 0.66; 1.24). Comparing IOC and no IOC, no statistically significant differences were found in the case of BDI, retained stone rate, readmission rate, and length of hospital stay. We found an increased risk of conversion rate to open surgery in the no IOC group (RR = 0.64, CI 0.51; 0.78). The operation time was significantly longer in the IOC group compared to the no IOC group (WMD = 11.25 min, 95% CI 6.57; 15.93).Our findings suggest that IOC may not be indicated in every case, however, the evidence is very uncertain. Further good quality research is required to address this question.},
	keywords = {[Meta-analysis]},
	year = {2022},
	eissn = {1432-2218},
	pages = {7126-7139},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Müller, Katalin Eszter/0000-0001-5355-4224; Vincze, Áron/0000-0003-2217-7686; Erőss, Bálint Mihály/0000-0003-3658-8427; Ábrahám, Szabolcs/0000-0002-2191-1714}
}

@article{MTMT:33126264,
	title = {Network meta-analysis of randomized controlled trials on esophagectomies in esophageal cancer: The superiority of minimally invasive surgery},
	url = {https://m2.mtmt.hu/api/publication/33126264},
	author = {Szakó, Lajos and Németh, Dávid and Borbásné Farkas, Kornélia and Kiss, Szabolcs and Dömötör, Réka Zsuzsa and Engh, Marie Anne and Hegyi, Péter and Erőss, Bálint Mihály and Papp, András},
	doi = {10.3748/wjg.v28.i30.4201},
	journal-iso = {WORLD J LGASTROENTEROL},
	journal = {WORLD JOURNAL OF GASTROENTEROLOGY},
	volume = {28},
	unique-id = {33126264},
	issn = {1007-9327},
	abstract = {Previous meta-analyses, with many limitations, have described the beneficial nature of minimal invasive procedures.To compare all modalities of esophagectomies to each other from the results of randomized controlled trials (RCTs) in a network meta-analysis (NMA).We conducted a systematic search of the MEDLINE, EMBASE, Reference Citation Analysis (https://www.referencecitationanalysis.com/) and CENTRAL databases to identify RCTs according to the following population, intervention, control, outcome (commonly known as PICO): P: Patients with resectable esophageal cancer; I/C: Transthoracic, transhiatal, minimally invasive (thoracolaparoscopic), hybrid, and robot-assisted esophagectomy; O: Survival, total adverse events, adverse events in subgroups, length of hospital stay, and blood loss. We used the Bayesian approach and the random effects model. We presented the geometry of the network, results with probabilistic statements, estimated intervention effects and their 95% confidence interval (CI), and the surface under the cumulative ranking curve to rank the interventions.We included 11 studies in our analysis. We found a significant difference in postoperative pulmonary infection, which favored the minimally invasive intervention compared to transthoracic surgery (risk ratio 0.49; 95%CI: 0.23 to 0.99). The operation time was significantly shorter for the transhiatal approach compared to transthoracic surgery (mean difference -85 min; 95%CI: -150 to -29), hybrid intervention (mean difference -98 min; 95%CI: -190 to -9.4), minimally invasive technique (mean difference -130 min; 95%CI: -210 to -50), and robot-assisted esophagectomy (mean difference -150 min; 95%CI: -240 to -53). Other comparisons did not yield significant differences.Based on our results, the implication of minimally invasive esophagectomy should be favored.},
	keywords = {[Meta-analysis]},
	year = {2022},
	eissn = {2219-2840},
	pages = {4201-4210},
	orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Engh, Marie Anne/0000-0003-4269-5130; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427}
}

@article{MTMT:33154300,
	title = {Dyspepsia-Like Symptoms in Helicobacter pylori-Negative Chronic Gastritis are Associated with ASCA-, ANCA-, and Celiac Seropositivity but Not with Other Autoimmune Parameters: A Single-Centre, Retrospective Cross-Sectional Study},
	url = {https://m2.mtmt.hu/api/publication/33154300},
	author = {Zádori, Noémi and Németh, Dávid and Frim, Levente and Vörhendi, Nóra and Szakó, Lajos and Váncsa, Szilárd and Hegyi, Péter and Czimmer, József},
	doi = {10.2147/IJGM.S380419},
	journal-iso = {INT J GEN MED},
	journal = {INTERNATIONAL JOURNAL OF GENERAL MEDICINE},
	volume = {15},
	unique-id = {33154300},
	year = {2022},
	eissn = {1178-7074},
	pages = {7789-7796},
	orcid-numbers = {Frim, Levente/0000-0003-0097-6663; Váncsa, Szilárd/0000-0002-9347-8163; Hegyi, Péter/0000-0003-0399-7259; Czimmer, József/0000-0001-7831-3523}
}

@misc{MTMT:33588407,
	title = {The necessity of pyloric drainage in esophagectomies: protocol of a meta-analysis and a systematic review of randomized controlled trials.},
	url = {https://m2.mtmt.hu/api/publication/33588407},
	author = {A., Csontos and Németh, Dávid and Szakó, Lajos and G., Berke and L., D. Sindler and Hegyi, Péter and Papp, András},
	unique-id = {33588407},
	abstract = {Background: Esophageal carcinoma is the 8th most common malignant tumour in the world with more than 600 000 cases (3.1% of all), while being the 6th most common reason of tumour mortality, causing more than 500 000 deaths (5.5% of all) annually. The 1, 3 and 5 year-prevalence are 2.4%, 1.6% and 1.3% respectively. The question of this meta-analysis is whether pyloric drainage is preferable over the lack of pyloric drainage during elective esophagectomies in patients suffering from esophageal cancer, regarding mortality, anastomosis leakage, respiratory morbidity, vomiting, gastric emptying time. Methods: We plan to identify randomized controlled trials to investigate the question by performing extensive search in multiple databases. Based on of predefined criteria, two independent authors will perform the steps of selection, after which appropriate statistical analysis will be performed to identify potential significant differences. Cochrane Risk of Bias Tool 2, and GRADE approach will be used to estimate the risk of bias and quality of results. Dissemination plans: We plan to distribute our results in peer-reviewed journal.},
	year = {2022},
	orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259}
}