@article{MTMT:3339535,
	title = {Uric acid and allopurinol aggravate absence epileptic activity in Wistar Albino Glaxo Rijswijk rats},
	url = {https://m2.mtmt.hu/api/publication/3339535},
	author = {Lakatos, Renáta Krisztina and Dobolyi, Árpád and Kovács, Zsolt},
	doi = {10.1016/j.brainres.2018.02.012},
	journal-iso = {BRAIN RES},
	journal = {BRAIN RESEARCH},
	volume = {1686},
	unique-id = {3339535},
	issn = {0006-8993},
	keywords = {CEREBROSPINAL-FLUID; Indomethacin; Adenosine receptors; DOUBLE-BLIND; PLACEBO-CONTROLLED TRIAL; Allopurinol; RADICAL SCAVENGERS; inosine; XANTHINE-OXIDASE; ABSENCE EPILEPSY; uric acid; INTRACTABLE EPILEPSY; Seizure activity; WAG/Rij rats; WAVE DISCHARGE ACTIVITY; GLAXO/RIJSWIJK RATS},
	year = {2018},
	eissn = {1872-6240},
	pages = {1-9},
	orcid-numbers = {Dobolyi, Árpád/0000-0003-0397-2991; Kovács, Zsolt/0000-0001-8571-5686}
}

@CONFERENCE{MTMT:3314738,
	title = {Guanosine may increase absence epileptic activity in Wistar Albino Glaxo Rijswijk rats},
	url = {https://m2.mtmt.hu/api/publication/3314738},
	author = {Lakatos, Renáta Krisztina and Dobolyi, A and Kekesi, KA and Aleksza, M and Kovács, Zsolt},
	booktitle = {5th FENS Regional Meeting 2017},
	unique-id = {3314738},
	year = {2017},
	pages = {266},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686}
}

@CONFERENCE{MTMT:3180977,
	title = {A guanozin hatása az abszensz epilepsziás aktivitásra WAG/Rij patkányban},
	url = {https://m2.mtmt.hu/api/publication/3180977},
	author = {Lakatos, Renáta Krisztina and Kovács, Zsolt},
	booktitle = {XII. Regionális Természettudományi Konferencia},
	unique-id = {3180977},
	abstract = {XII. Regionális Természettudományi Konferencia 2017. január 25.; Az előadások összefoglalói; Szerkesztő: Dr. Puskás János},
	year = {2017},
	pages = {12-12},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686}
}

@article{MTMT:3163629,
	title = {Absence epileptic activity in Wistar Albino Glaxo Rijswijk rat mothers},
	url = {https://m2.mtmt.hu/api/publication/3163629},
	author = {Kovács, Zsolt and Lakatos, Renáta Krisztina and Barna, János and Dobolyi, Árpád},
	doi = {10.1016/j.brainres.2017.01.005},
	journal-iso = {BRAIN RES},
	journal = {BRAIN RESEARCH},
	volume = {1657},
	unique-id = {3163629},
	issn = {0006-8993},
	abstract = {Abstract Absence epileptic activity was analyzed during pregnancy, the postpartum period and after weaning to establish alterations of seizures throughout the reproductive cycle. Wistar Albino Glaxo Rijswijk (WAG/Rij) rats were used in the study as a model of absence epilepsy and because their seizures do not interfere with rearing offspring. The number of spike-wave discharges (SWDs) was gradually elevated from the 19th pregnancy day to delivery. Meanwhile, the characteristics of individual SWDs did not change suggesting that SWD generation remained the same. In the postpartum and postweaning periods, the number of SWDs was not increased in the absence of pups. However, returning the pups to mothers resulted in a markedly elevated number of SWDs for 1 h. If pups were taken away after 30 min, the number of SWDs dropped immediately suggesting that the presence of pups increased the SWD number. The time mothers spent with the litter and in kyphosis suckling posture were in correlation with their SWD number further suggesting the importance of interaction with pups in SWD induction. Suckling elevates prolactin levels but surprisingly, its intracerebroventricular injection markedly reduced SWD number in suckled WAG/Rij mothers suggesting that the SWD-inducing effect of suckling is not mediated by prolactin. Rather, the elevated prolactin level may provide some protection against pro-epileptic effects of suckling. In conclusion, we first identified periods within the reproductive cycle with increased absence epileptic activity, implying that more attention should be devoted to epileptic activity changes in mothers.},
	keywords = {somatosensory cortex; PROLACTIN; suckling; ABSENCE EPILEPSY; Female WAG/Rij rats; Pregnant and lactating mother},
	year = {2017},
	eissn = {1872-6240},
	pages = {368-376},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686; Barna, János/0000-0002-4394-2175; Dobolyi, Árpád/0000-0003-0397-2991}
}

@CONFERENCE{MTMT:3064202,
	title = {Inosine, guanosine and uridine modulate the lipopolysaccharide-evoked changes in spike-wave discharge activity in Wistar Albino Glaxo/Rijswijk rats},
	url = {https://m2.mtmt.hu/api/publication/3064202},
	author = {Lakatos, Renáta Krisztina and Dobolyi, Árpád and Kékesi, Adrienna Katalin and Juhász, Gábor Dénes and Kovács, Zsolt},
	booktitle = {IBRO Workshop 2016},
	unique-id = {3064202},
	year = {2016},
	pages = {&},
	orcid-numbers = {Kékesi, Adrienna Katalin/0000-0003-3042-4878; Juhász, Gábor Dénes/0000-0002-0849-6931; Kovács, Zsolt/0000-0001-8571-5686}
}

@article{MTMT:3064172,
	title = {Guanosine may increase absence epileptic activity by means of A2A adenosine receptors in Wistar Albino Glaxo Rijswijk rats.},
	url = {https://m2.mtmt.hu/api/publication/3064172},
	author = {Lakatos, Renáta Krisztina and Dobolyi, Árpád and Todorov, Mihail and Kékesi, Adrienna Katalin and Juhász, Gábor Dénes and Aleksza, Magdolna and Kovács, Zsolt},
	doi = {10.1016/j.brainresbull.2016.05.001},
	journal-iso = {BRAIN RES BULL},
	journal = {BRAIN RESEARCH BULLETIN},
	volume = {124},
	unique-id = {3064172},
	issn = {0361-9230},
	abstract = {The non-adenosine nucleoside guanosine (Guo) was demonstrated to decrease quinolinic acid(QA)-induced seizures, spontaneously emerged absence epileptic seizures and lipopolysaccharide(LPS)-evoked induction of absence epileptic seizures suggesting its antiepileptic potential. It was also described previously that intraperitoneal (i.p.) injection of 20 and 50mg/kg Guo decreased the number of spike-wave discharges (SWDs) in a well investigated model of human absence epilepsy, the Wistar Albino Glaxo Rijswijk (WAG/Rij) rats during 4th (20mg/kg Guo) and 3rd as well as 4th (50mg/kg Guo) measuring hours. Guanosine can potentially decrease SWD number by means of its putative receptors but absence epileptic activity changing effects of Guo by means of increased extracellular adenosine (Ado) cannot be excluded. An increase in the dose of i.p. injected Guo is limited by its low solubility in saline, therefore, we addressed in the present study whether higher doses of Guo, diluted in sodium hydroxide (NaOH) solution, have more potent antiepileptic effect in WAG/Rij rats. We confirmed that i.p. 50mg/kg Guo decreased but, surprisingly, i.p. 100mg/kg Guo enhanced the number of SWDs in WAG/Rij rats. Combined i.p. injection of a non-selective Ado receptor antagonist theophylline (5mg/kg) or a selective Ado A2A receptor (A2AR) antagonist SCH 58261 (7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyri midine) (1mg/kg) and a cyclooxygenase 1 and 2/COX-1 and COX-2 inhibitor indomethacin (10mg/kg) with 100mg/kg Guo decreased the SWD number compared to i.p. 100mg/kg Guo alone. The results suggest that i.p. 100mg/kg Guo can increase SWD number by means of the adenosinergic system.},
	year = {2016},
	eissn = {1873-2747},
	pages = {172-181},
	orcid-numbers = {Dobolyi, Árpád/0000-0003-0397-2991; Todorov, Mihail/0000-0002-8627-1260; Kékesi, Adrienna Katalin/0000-0003-3042-4878; Juhász, Gábor Dénes/0000-0002-0849-6931; Kovács, Zsolt/0000-0001-8571-5686}
}

@CONFERENCE{MTMT:3006421,
	title = {A nem-adenozin nukleozidok hatása az LPS indukálta abszensz epilepsziás aktivitásra WAG/Rij patkányban},
	url = {https://m2.mtmt.hu/api/publication/3006421},
	author = {Lakatos, Renáta Krisztina and Kovács, Zsolt},
	booktitle = {XI. Regionális Természettudományi Konferencia},
	unique-id = {3006421},
	year = {2016},
	pages = {11-12},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686}
}

@CONFERENCE{MTMT:2920394,
	title = {Inosine, guanosine and uridine change the absence epileptic activity in Wistar Albino Glaxo/Rijswijk rats},
	url = {https://m2.mtmt.hu/api/publication/2920394},
	author = {Kovács, Zsolt and Katalin, A Kékesi and Árpád, Dobolyi and Lakatos, Renáta Krisztina and Gábor, Juhász},
	booktitle = {XV. Biannual Conference of the Hungarian Neuroscience Society},
	unique-id = {2920394},
	year = {2015},
	pages = {61-61},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686}
}

@article{MTMT:2915179,
	title = {Effects of nucleosides on glia - Neuron interactions open up new vistas in the development of more effective antiepileptic drugs},
	url = {https://m2.mtmt.hu/api/publication/2915179},
	author = {Kovács, Zsolt and Kardos, Julianna and Kékesi, Adrienna Katalin and Juhász, Gábor Dénes and Lakatos, Renáta Krisztina and Héja, László},
	doi = {10.2174/0929867322666150212153210},
	journal-iso = {CURR MED CHEM},
	journal = {CURRENT MEDICINAL CHEMISTRY},
	volume = {22},
	unique-id = {2915179},
	issn = {0929-8673},
	year = {2015},
	eissn = {1875-533X},
	pages = {1500-1514},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686; Kékesi, Adrienna Katalin/0000-0003-3042-4878; Juhász, Gábor Dénes/0000-0002-0849-6931}
}

@article{MTMT:2904124,
	title = {Absence epileptic activity changing effects of non-adenosine nucleoside inosine, guanosine and uridine in Wistar Albino Glaxo Rijswijk rats.},
	url = {https://m2.mtmt.hu/api/publication/2904124},
	author = {Kovács, Zsolt and Kékesi, Adrienna Katalin and Dobolyi, Árpád and Lakatos, Renáta Krisztina and Juhász, Gábor Dénes},
	doi = {10.1016/j.neuroscience.2015.05.054},
	journal-iso = {NEUROSCIENCE},
	journal = {NEUROSCIENCE},
	volume = {300},
	unique-id = {2904124},
	issn = {0306-4522},
	abstract = {Adenosine (Ado) and non-adenosine (non-Ado) nucleosides such as inosine (Ino), guanosine (Guo) and uridine (Urd) may have regionally different roles in the regulation of physiological and pathophysiological processes in the central nervous system (CNS) such as epilepsy. It was demonstrated previously that Ino and Guo decreased quinolinic acid (QA)-induced seizures and Urd reduced penicillin-, bicuculline- and pentylenetetrazole (PTZ)-induced seizures. It has also been demonstrated that Ino and Urd may exert their effects through GABAergic system by altering the function of GABAA type of gamma-aminobutyric acid receptors (GABAA receptors) whereas Guo decreases glutamate-induced excitability through glutamatergic system, which systems (GABAergic and glutamatergic) are involved in pathomechanisms of absence epilepsy. Thus, we hypothesized that Ino and Guo, similarly to the previously described effect of Urd, might also decrease absence epileptic activity. We investigated in the present study whether intraperitoneal (i.p.) application of Ino (500 and 1000mg/kg), Guo (20 and 50mg/kg), Urd (500 and 1000mg/kg), GABAA receptor agonist muscimol (1 and 3mg/kg), GABAA receptor antagonist bicuculline (2 and 4mg/kg), non-selective Ado receptor antagonist theophylline (5 and 10mg/kg) and non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist (+)-5-methyl-10,11-dihydro-5H-dibenzo (a,d) cyclohepten-5,10-imine maleate (MK-801, 0.0625 and 0.1250mg/kg) alone and in combination have modulatory effects on absence epileptic activity in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats. We found that Guo decreased the number of spike-wave discharges (SWDs) whereas Ino increased it dose-dependently. We strengthened that Urd can decrease absence epileptic activity. Our results suggest that Guo, Urd and their analogs could be potentially effective drugs for treatment of human absence epilepsy.},
	year = {2015},
	eissn = {1873-7544},
	pages = {593-608},
	orcid-numbers = {Kovács, Zsolt/0000-0001-8571-5686; Kékesi, Adrienna Katalin/0000-0003-3042-4878; Dobolyi, Árpád/0000-0003-0397-2991; Juhász, Gábor Dénes/0000-0002-0849-6931}
}