TY - THES AU - Pamlényi, Krisztián TI - Development of buccal mucoadhesive polymer films with sodium alginate and cetirizine dihydrochloride in allergy therapy [Allergiaterápiában alkalmazott cetirizin és nátrium-alginát tartalmú bukkális mukoadhezív polimer film fejlesztése] PB - Szegedi Tudományegyetem PY - 2023 SP - 50 DO - 10.14232/phd.11618 UR - https://m2.mtmt.hu/api/publication/34115930 ID - 34115930 LA - English DB - MTMT ER - TY - CHAP AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Jójártné Laczkovich, Orsolya AU - Nemes, Dániel AU - Bácskay, Ildikó AU - Kristó, Katalin ED - Varga, Patrícia Orsolya ED - Szalai, Boglárka ED - Uhljar, Luca Éva TI - Formulation of buccal films in Parkinson’s disease T2 - V. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science PB - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Faculty of Pharmacy CY - Szeged PY - 2023 SP - 34 EP - 34 PG - 1 DO - 10.14232/syrptbrs.2023.34 UR - https://m2.mtmt.hu/api/publication/34046049 ID - 34046049 LA - English DB - MTMT ER - TY - JOUR AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Jójártné Laczkovich, Orsolya AU - Nemes, Dániel AU - Bácskay, Ildikó AU - Kristó, Katalin TI - Formulation and characterization of pramipexole containing buccal films for using in Parkinson's disease JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 187 PY - 2023 PG - 12 SN - 0928-0987 DO - 10.1016/j.ejps.2023.106491 UR - https://m2.mtmt.hu/api/publication/34008857 ID - 34008857 N1 - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720, Szeged, Hungary Department of Pharmaceutical Technology, University of Debrecen, Nagyerdei krt. 98., H-4032, Debrecen, Hungary Export Date: 1 August 2023 CODEN: EPSCE Correspondence Address: Regdon, G.; Institute of Pharmaceutical Technology and Regulatory Affairs, Eötvös u. 6., H-6720, Hungary; email: geza.regdon@pharm.u-szeged.hu Chemicals/CAS: pramipexole, 104632-26-0, 104632-25-9, 191217-81-9; Drug Carriers; Pramipexole Funding details: 5991 Funding details: Richter Gedeon Talentum Alapítvány, 100822 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, ÚNKP-21-3 Funding details: Innovációs és Technológiai Minisztérium Funding text 1: The publication was funded by The University of Szeged Open Access Fund (FundRef, Grant No. 5991). This research work was supported by Richter Gedeon Talentum Foundation to help me participate in the PhD program (Grant No. 100822 ). This work was also supported by the New National Excellence Program of the Ministry for Innovation and Technology from the Source of the National Research, Development and Innovation Fund (Grant No. ÚNKP-21-3 ). LA - English DB - MTMT ER - TY - CONF AU - Pamlényi, Krisztián TI - Parkinson-kór kezelésében alkalmazható, pramipexolt tartalmazó innovatív bukkális polimer film formulálása és vizsgálata T2 - SZTE-GYTK ÚNKP előadóülés PY - 2022 SP - 10 UR - https://m2.mtmt.hu/api/publication/33550392 ID - 33550392 LA - Hungarian DB - MTMT ER - TY - GEN AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Bácskay, Ildikó AU - Nemes, Dániel AU - Kristó, Katalin TI - Pramipexolt tartalmazó innovatív bukkális polimer film formulálása és vizsgálata PY - 2022 UR - https://m2.mtmt.hu/api/publication/33550300 ID - 33550300 N1 - [előadás] LA - Hungarian DB - MTMT ER - TY - CHAP AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Nemes, Dániel AU - Bácskay, Ildikó AU - Kristó, Katalin ED - Aleš, Obreza ED - Rok, Dreu ED - Alenka, Zvonar Pobirk ED - Barbara, Sterle Zorec TI - Preparation of buccal films in Parkinson’s Diseasee T2 - 9th BBBB International Conference on Pharmaceutical Sciences - Pharma Sciences of Tomorrow: Book of Abstracts PB - Univerza v Ljubljani CY - Ljubljana SN - 9789619423042 PY - 2022 SP - 105 EP - 106 PG - 2 UR - https://m2.mtmt.hu/api/publication/33550245 ID - 33550245 LA - English DB - MTMT ER - TY - JOUR AU - Litauszki, Katalin AU - Igriczné, É.K. AU - Pamlényi, Krisztián AU - Szarka, Györgyi Éva AU - Kmetty, Ákos AU - Kovács, Zsolt TI - Controlled Drug Release from Laser Treated Polymeric Carrier JF - JOURNAL OF PHARMACEUTICAL SCIENCES J2 - J PHARM SCI VL - 111 PY - 2022 IS - 12 SP - 3297 EP - 3303 PG - 7 SN - 0022-3549 DO - 10.1016/j.xphs.2022.08.018 UR - https://m2.mtmt.hu/api/publication/33098362 ID - 33098362 N1 - Funding Agency and Grant Number: New National Excellence Program of the Ministry for Innovation and Technology [UNKP-19-3-I-BME-261, UNKP-19-3]; Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund [BME-NVA-02]; NRDI Fund; European Social Fund [EFOP-3.6.2-16-2017-00005]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences; National Research, Development and Innovation Office of Hungary [OTKA K138339]; Ministry for Innovation and Technology Funding text: This research was supported by the UNKP-19-3 New National Excellence Program of the Ministry for Innovation and Technology (UNKP-19-3-I-BME-261) . The research reported in this paper is part of project no. BME-NVA-02, implemented with the support provided by the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021 funding scheme. The research reported in this paper and carried out at BME has been supported by the NRDI Fund (TKP2020 NC, Grant No. BME-NCS) based on the charter of bolster issued by the NRDI Office under the auspices of the Ministry for Inno-vation and Technology. The authors would like to acknowledge the European Social Fund EFOP-3.6.2-16-2017-00005 entitled by Ultra-fast physical processes in atoms, molecules, nanostructures and biol-ogy structures grant, as it enabled us to use the laser facilities at University of Szeged. A. Kmetty is thankful for the support of Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. This work was also supported by the National Research, Development and Innovation Office (OTKA K138339 project) of Hungary. AB - In this study, we present the effect of laser treatment on polymeric poly(lactic acid) drug carrier films. Our goal was to demonstrate the control of the drug-release kinetics of a polymeric carrier as a function of total absorbed laser energy. The controlled drug release kinetic was achieved by modifying the amorphous polymeric carrier's molecular weight via low energy density laser-exposure. According to gel permeation chromatography results, the decrease of molecular weight correlates with an increasing laser-shot number and shows a distinct saturation-like behavior. The dissolution test also suggests the presence of such dependency, as the rate and amount of caffeine released from the sample shows an increasing tendency up to 2000 laser shots. This fact proves that the laser treatment modifies the drug release. The approach presented here may complement other methods used for controlled drug release in various medical and pharmacological applications. LA - English DB - MTMT ER - TY - JOUR AU - Pamlényi, Krisztián AU - Kristó, Katalin AU - Sovány, Tamás AU - Regdon, Géza (ifj.) TI - Development and evaluation of bioadhesive buccal films based on sodium alginate for allergy therapy JF - HELIYON J2 - HELIYON VL - 8 PY - 2022 IS - 8 PG - 10 SN - 2405-8440 DO - 10.1016/j.heliyon.2022.e10364 UR - https://m2.mtmt.hu/api/publication/33062910 ID - 33062910 N1 - Cited By :1 Export Date: 17 June 2023 Correspondence Address: Regdon jr., G.; University of Szeged, Eötvös u. 6., H-6720, Hungary; email: geza.regdon@pharm.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Nemes, Dániel AU - Fenyvesi, Ferenc AU - Bácskay, Ildikó AU - Kristó, Katalin TI - Stability, Permeability and Cytotoxicity of Buccal Films in Allergy Treatment JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 14 PY - 2022 IS - 8 PG - 15 SN - 1999-4923 DO - 10.3390/pharmaceutics14081633 UR - https://m2.mtmt.hu/api/publication/33049226 ID - 33049226 N1 - Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, H-6720, Hungary Department of Pharmaceutical Technology, University of Debrecen, Debrecen, H-4032, Hungary Cited By :2 Export Date: 17 June 2023 Correspondence Address: Kristó, K.; Institute of Pharmaceutical Technology and Regulatory Affairs, Hungary; email: kristo.katalin@szte.hu AB - Oral mucoadhesive systems, such as polymer films, are among innovative pharmaceutical products. These systems can be applied in swallowing problems and can also be used in geriatrics and paediatrics. In our earlier work, we successfully formulated buccal mucoadhesive polymer films, which contained cetirizine-hydrochloride (CTZ) as the API. The present study focused on investigating the stability and permeability of the prepared films. The stability of the films was studied with an accelerated stability test. During the stability test, thickness, breaking hardness and in vitro mucoadhesivity were analysed. Furthermore, the interactions were studied with FT-IR spectroscopy, and the changes in the amount of the API were also monitored. Cytotoxicity and cell line permeability studies were carried out on TR 146 buccal cells. Compositions that can preserve more than 85% of the API after 6 months were found. Most of the compositions had a high cell viability of more than 50%. Citric acid (CA) decreased the stability and reduced every physical parameter of the films. However, cell line studies showed that the permeability of the films was enhanced. In our work, we successfully formulated CTZ-containing buccal films with adequate stability, high cell viability and appropriate absorption properties. LA - English DB - MTMT ER - TY - CHAP AU - Pamlényi, Krisztián AU - Regdon, Géza (ifj.) AU - Nemes, Dániel AU - Bácskay, Ildikó AU - Kristó, Katalin ED - Uhljar, Luca Éva ED - Sipos, Bence TI - Stability and permeability properties of sodium alginate buccal films T2 - IV. Symposium of Young Researchers on Pharmaceutical Technology, Biotechnology and Regulatory Science : book of abstracts PB - University of Szeged CY - Szeged PY - 2022 SP - 26 EP - 26 PG - 1 DO - 10.14232/syrptbrs.2022.26 UR - https://m2.mtmt.hu/api/publication/32628560 ID - 32628560 LA - English DB - MTMT ER -