TY - JOUR AU - Bukva, Mátyás AU - Dobra, Gabriella AU - Gyukity-Sebestyén, Edina AU - Böröczky, Timea AU - Korsós, Marietta Margaréta AU - David G, Meckes AU - Horváth, Péter AU - Buzás, Krisztina AU - Harmati, Mária TI - Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation - A meta-analysis. JF - CELL COMMUNICATION AND SIGNALING J2 - CELL COMM SIGN VL - 21 PY - 2023 IS - 1 PG - 17 SN - 1478-811X DO - 10.1186/s12964-023-01344-5 UR - https://m2.mtmt.hu/api/publication/34417027 ID - 34417027 N1 - Video-Audio Media; Meta-Analysis; Journal Article AB - Although interest in the role of extracellular vesicles (EV) in oncology is growing, not all potential aspects have been investigated. In this meta-analysis, data regarding (i) the EV proteome and (ii) the invasion and proliferation capacity of the NCI-60 tumor cell lines (60 cell lines from nine different tumor types) were analyzed using machine learning methods.On the basis of the entire proteome or the proteins shared by all EV samples, 60 cell lines were classified into the nine tumor types using multiple logistic regression. Then, utilizing the Least Absolute Shrinkage and Selection Operator, we constructed a discriminative protein panel, upon which the samples were reclassified and pathway analyses were performed. These panels were validated using clinical data (n = 4,665) from Human Protein Atlas.Classification models based on the entire proteome, shared proteins, and discriminative protein panel were able to distinguish the nine tumor types with 49.15%, 69.10%, and 91.68% accuracy, respectively. Invasion and proliferation capacity of the 60 cell lines were predicted with R2 = 0.68 and R2 = 0.62 (p < 0.0001). The results of the Reactome pathway analysis of the discriminative protein panel suggest that the molecular content of EVs might be indicative of tumor-specific biological processes.Integrating in vitro EV proteomic data, cell physiological characteristics, and clinical data of various tumor types illuminates the diagnostic, prognostic, and therapeutic potential of EVs. Video Abstract. LA - English DB - MTMT ER - TY - JOUR AU - Korsós, Marietta Margaréta AU - Bellák, Tamás AU - Becskeházi, Eszter AU - Gál, Eleonóra AU - Veréb, Zoltán AU - Venglovecz, Viktória TI - Mouse esophaegal, organoid cultures are the novel model for studying the epithelial ion transport mechanisms JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 8 PY - 2022 IS - Suppl. 1 SP - 85 EP - 85 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32843357 ID - 32843357 LA - English DB - MTMT ER - TY - JOUR AU - Becskeházi, Eszter AU - Korsós, Marietta Margaréta AU - Gál, Eleonóra AU - Tiszlavicz, László AU - Hoyk, Z AU - Deli, M AU - Köhler, Zoltán Márton AU - Keller-Pintér, Anikó AU - Horváth, Attila AU - Csekő, K AU - Helyes, Z AU - Hegyi, Péter AU - Venglovecz, Viktória TI - NHE-1 plays a central role in the smoke-induced proliferation in barrett's esophageal cell line JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 8 PY - 2022 IS - Suppl 1 SP - 65 EP - 65 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32843331 ID - 32843331 LA - English DB - MTMT ER - TY - JOUR AU - Becskeházi, Eszter AU - Korsós, Marietta Margaréta AU - Gál, Eleonóra AU - Tiszlavicz, László AU - Hoyk, Zsófia AU - Deli, Mária Anna AU - Köhler, Zoltán Márton AU - Keller-Pintér, Anikó AU - Horváth, Attila AU - Csekő, Kata AU - Helyes, Zsuzsanna AU - Hegyi, Péter AU - Venglovecz, Viktória TI - Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett’s Esophageal Cell Line JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 19 PG - 16 SN - 1661-6596 DO - 10.3390/ijms221910581 UR - https://m2.mtmt.hu/api/publication/32258572 ID - 32258572 LA - English DB - MTMT ER - TY - JOUR AU - Korsós, Marietta Margaréta AU - Bellák, Tamás AU - Becskeházi, Eszter AU - Gál, Eleonóra AU - Veréb, Zoltán AU - Hegyi, Péter AU - Venglovecz, Viktória TI - Mouse organoid culture is a suitable model to study esophageal ion transport mechanisms JF - AMERICAN JOURNAL OF PHYSIOLOGY: CELL PHYSIOLOGY J2 - AM J PHYSIOL CELL PH VL - 321 PY - 2021 IS - 5 SP - C798 EP - C811 PG - 14 SN - 0363-6143 DO - 10.1152/ajpcell.00295.2021 UR - https://m2.mtmt.hu/api/publication/32204160 ID - 32204160 N1 - Export Date: 26 January 2024 CODEN: AJPCD Correspondence Address: Venglovecz, V.; Department of Pharmacology and Pharmacotherapy, Hungary; email: venglovecz.viktoria@med.u-szeged.hu AB - Altered esophageal ion transport mechanisms play a key role in inflammatory and cancerous diseases of the esophagus, but epithelial ion processes have been less studied in the esophagus because of the lack of a suitable experimental model. In this study, we generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs. EOs form a cell-filled structure with a diameter of 250-300 µm and generated from epithelial stem cells as shown by FACS analysis. Using conventional PCR and immunostaining, the presence of Slc26a6 Cl-/HCO3- anion exchanger (AE), Na+/H+ exchanger (NHE), Na+/HCO3- cotransporter (NBC), cystic fibrosis transmembrane conductance regulator (CFTR) and anoctamin 1 Cl- channels were detected in EOs. Microfluorimetric techniques revealed high NHE, AE, and NBC activities, whereas that of CFTR was relatively low. In addition, inhibition of CFTR led to functional interactions between the major acid-base transporters and CFTR. We conclude that EOs provide a relevant and suitable model system for studying the ion transport mechanisms of esophageal epithelial cells, and they can be also used as preclinical tools to assess the effectiveness of novel therapeutic compounds in esophageal diseases associated with altered ion transport processes. LA - English DB - MTMT ER - TY - JOUR AU - Korsós, Marietta Margaréta AU - Bellák, Tamás AU - Becskeházi, Eszter AU - Venglovecz, Viktória TI - Esophageal organoid culture is a novel model to study epithelial ion transport mechanisms JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 6 PY - 2020 IS - Suppl 2 SP - 62 EP - 62 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32104411 ID - 32104411 LA - English DB - MTMT ER - TY - JOUR AU - Becskeházi, Eszter AU - Gál, Eleonóra AU - Korsós, Marietta Margaréta AU - Venglovecz, Viktória TI - Smoking changes iontransport mechanisms of guinea pig esophageal epithelial cells and human esophageal cell lines JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 6 PY - 2020 IS - Suppl 2 SP - 35 EP - 35 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32104401 ID - 32104401 LA - English DB - MTMT ER - TY - JOUR AU - Becskeházi, Eszter AU - Korsós, Marietta Margaréta AU - Erőss, Bálint Mihály AU - Hegyi, Péter AU - Venglovecz, Viktória TI - OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions JF - FRONTIERS IN PHYSIOLOGY J2 - FRONT PHYSIOL VL - 11 PY - 2020 PG - 15 SN - 1664-042X DO - 10.3389/fphys.2020.00855 UR - https://m2.mtmt.hu/api/publication/31381996 ID - 31381996 N1 - * Megosztott szerzőség LA - English DB - MTMT ER - TY - JOUR AU - Szarka, Dóra AU - Elekes, Gréta AU - Korsós, Marietta Margaréta AU - Berczeli, Orsolya AU - Szalay, László AU - Török, Dénes AU - Tóth-Molnár, Edit TI - Role of aquaporin 4 in lacrimal gland ductal fluid secretion in mice JF - INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE J2 - INVEST OPHTH VIS SCI VL - 61 PY - 2020 IS - 7 PG - 1 SN - 0146-0404 UR - https://m2.mtmt.hu/api/publication/31374309 ID - 31374309 LA - English DB - MTMT ER - TY - JOUR AU - Korsós, Marietta Margaréta AU - Venglovecz, Viktória TI - Mouse organoid cultures are the novel model to study the esophageal ion transport mechanisms JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL VL - 7 PY - 2019 IS - S8 SP - 408 EP - 408 PG - 1 SN - 2050-6406 UR - https://m2.mtmt.hu/api/publication/31009570 ID - 31009570 N1 - [Poszter] LA - English DB - MTMT ER -