@article{MTMT:34417027,
	title = {Machine learning-based analysis of cancer cell-derived vesicular proteins revealed significant tumor-specificity and predictive potential of extracellular vesicles for cell invasion and proliferation - A meta-analysis.},
	url = {https://m2.mtmt.hu/api/publication/34417027},
	author = {Bukva, Mátyás and Dobra, Gabriella and Gyukity-Sebestyén, Edina and Böröczky, Timea and Korsós, Marietta Margaréta and David G, Meckes and Horváth, Péter and Buzás, Krisztina and Harmati, Mária},
	doi = {10.1186/s12964-023-01344-5},
	journal-iso = {CELL COMM SIGN},
	journal = {CELL COMMUNICATION AND SIGNALING},
	volume = {21},
	unique-id = {34417027},
	issn = {1478-811X},
	abstract = {Although interest in the role of extracellular vesicles (EV) in oncology is growing, not all potential aspects have been investigated. In this meta-analysis, data regarding (i) the EV proteome and (ii) the invasion and proliferation capacity of the NCI-60 tumor cell lines (60 cell lines from nine different tumor types) were analyzed using machine learning methods.On the basis of the entire proteome or the proteins shared by all EV samples, 60 cell lines were classified into the nine tumor types using multiple logistic regression. Then, utilizing the Least Absolute Shrinkage and Selection Operator, we constructed a discriminative protein panel, upon which the samples were reclassified and pathway analyses were performed. These panels were validated using clinical data (n = 4,665) from Human Protein Atlas.Classification models based on the entire proteome, shared proteins, and discriminative protein panel were able to distinguish the nine tumor types with 49.15%, 69.10%, and 91.68% accuracy, respectively. Invasion and proliferation capacity of the 60 cell lines were predicted with R2 = 0.68 and R2 = 0.62 (p < 0.0001). The results of the Reactome pathway analysis of the discriminative protein panel suggest that the molecular content of EVs might be indicative of tumor-specific biological processes.Integrating in vitro EV proteomic data, cell physiological characteristics, and clinical data of various tumor types illuminates the diagnostic, prognostic, and therapeutic potential of EVs. Video Abstract.},
	keywords = {CLASSIFICATION; PROLIFERATION; INVASION; PREDICTION; machine learning; Extracellular vesicles; NCI-60},
	year = {2023},
	eissn = {1478-811X},
	orcid-numbers = {Bukva, Mátyás/0000-0002-5225-0285; Dobra, Gabriella/0000-0002-2814-7720; Gyukity-Sebestyén, Edina/0000-0003-1383-6301; Böröczky, Timea/0009-0009-3390-7809; Buzás, Krisztina/0000-0001-8933-2033; Harmati, Mária/0000-0002-4875-5723}
}

@article{MTMT:32843357,
	title = {Mouse esophaegal, organoid cultures are the novel model for studying the epithelial ion transport mechanisms},
	url = {https://m2.mtmt.hu/api/publication/32843357},
	author = {Korsós, Marietta Margaréta and Bellák, Tamás and Becskeházi, Eszter and Gál, Eleonóra and Veréb, Zoltán and Venglovecz, Viktória},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {8},
	unique-id = {32843357},
	year = {2022},
	eissn = {2415-9107},
	pages = {85-85},
	orcid-numbers = {Veréb, Zoltán/0000-0002-9518-2155; Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:32843331,
	title = {NHE-1 plays a central role in the smoke-induced proliferation in barrett's esophageal cell line},
	url = {https://m2.mtmt.hu/api/publication/32843331},
	author = {Becskeházi, Eszter and Korsós, Marietta Margaréta and Gál, Eleonóra and Tiszlavicz, László and Hoyk, Z and Deli, M and Köhler, Zoltán Márton and Keller-Pintér, Anikó and Horváth, Attila and Csekő, K and Helyes, Z and Hegyi, Péter and Venglovecz, Viktória},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {8},
	unique-id = {32843331},
	year = {2022},
	eissn = {2415-9107},
	pages = {65-65},
	orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Köhler, Zoltán Márton/0000-0002-8299-105X; Keller-Pintér, Anikó/0000-0002-4105-8458; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:32258572,
	title = {Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett’s Esophageal Cell Line},
	url = {https://m2.mtmt.hu/api/publication/32258572},
	author = {Becskeházi, Eszter and Korsós, Marietta Margaréta and Gál, Eleonóra and Tiszlavicz, László and Hoyk, Zsófia and Deli, Mária Anna and Köhler, Zoltán Márton and Keller-Pintér, Anikó and Horváth, Attila and Csekő, Kata and Helyes, Zsuzsanna and Hegyi, Péter and Venglovecz, Viktória},
	doi = {10.3390/ijms221910581},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32258572},
	issn = {1661-6596},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Deli, Mária Anna/0000-0001-6084-6524; Köhler, Zoltán Márton/0000-0002-8299-105X; Keller-Pintér, Anikó/0000-0002-4105-8458; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:32204160,
	title = {Mouse organoid culture is a suitable model to study esophageal ion transport mechanisms},
	url = {https://m2.mtmt.hu/api/publication/32204160},
	author = {Korsós, Marietta Margaréta and Bellák, Tamás and Becskeházi, Eszter and Gál, Eleonóra and Veréb, Zoltán and Hegyi, Péter and Venglovecz, Viktória},
	doi = {10.1152/ajpcell.00295.2021},
	journal-iso = {AM J PHYSIOL CELL PH},
	journal = {AMERICAN JOURNAL OF PHYSIOLOGY: CELL PHYSIOLOGY},
	volume = {321},
	unique-id = {32204160},
	issn = {0363-6143},
	abstract = {Altered esophageal ion transport mechanisms play a key role in inflammatory and cancerous diseases of the esophagus, but epithelial ion processes have been less studied in the esophagus because of the lack of a suitable experimental model. In this study, we generated 3D esophageal organoids (EOs) from two different mouse strains and characterized the ion transport processes of the EOs. EOs form a cell-filled structure with a diameter of 250-300 µm and generated from epithelial stem cells as shown by FACS analysis. Using conventional PCR and immunostaining, the presence of Slc26a6 Cl-/HCO3- anion exchanger (AE), Na+/H+ exchanger (NHE), Na+/HCO3- cotransporter (NBC), cystic fibrosis transmembrane conductance regulator (CFTR) and anoctamin 1 Cl- channels were detected in EOs. Microfluorimetric techniques revealed high NHE, AE, and NBC activities, whereas that of CFTR was relatively low. In addition, inhibition of CFTR led to functional interactions between the major acid-base transporters and CFTR. We conclude that EOs provide a relevant and suitable model system for studying the ion transport mechanisms of esophageal epithelial cells, and they can be also used as preclinical tools to assess the effectiveness of novel therapeutic compounds in esophageal diseases associated with altered ion transport processes.},
	keywords = {ion transport; esophagus; CFTR},
	year = {2021},
	eissn = {1522-1563},
	pages = {C798-C811},
	orcid-numbers = {Veréb, Zoltán/0000-0002-9518-2155; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:32104411,
	title = {Esophageal organoid culture is a novel model to study epithelial ion transport mechanisms},
	url = {https://m2.mtmt.hu/api/publication/32104411},
	author = {Korsós, Marietta Margaréta and Bellák, Tamás and Becskeházi, Eszter and Venglovecz, Viktória},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {6},
	unique-id = {32104411},
	year = {2020},
	eissn = {2415-9107},
	pages = {62-62},
	orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:32104401,
	title = {Smoking changes iontransport mechanisms of guinea pig esophageal epithelial cells and human esophageal cell lines},
	url = {https://m2.mtmt.hu/api/publication/32104401},
	author = {Becskeházi, Eszter and Gál, Eleonóra and Korsós, Marietta Margaréta and Venglovecz, Viktória},
	journal-iso = {CENT EUR J GASTRO HEPATOL},
	journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE},
	volume = {6},
	unique-id = {32104401},
	year = {2020},
	eissn = {2415-9107},
	pages = {35-35},
	orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:31381996,
	title = {OEsophageal Ion Transport Mechanisms and Significance Under Pathological Conditions},
	url = {https://m2.mtmt.hu/api/publication/31381996},
	author = {Becskeházi, Eszter and Korsós, Marietta Margaréta and Erőss, Bálint Mihály and Hegyi, Péter and Venglovecz, Viktória},
	doi = {10.3389/fphys.2020.00855},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {11},
	unique-id = {31381996},
	year = {2020},
	eissn = {1664-042X},
	orcid-numbers = {Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247}
}

@article{MTMT:31374309,
	title = {Role of aquaporin 4 in lacrimal gland ductal fluid secretion in mice},
	url = {https://m2.mtmt.hu/api/publication/31374309},
	author = {Szarka, Dóra and Elekes, Gréta and Korsós, Marietta Margaréta and Berczeli, Orsolya and Szalay, László and Török, Dénes and Tóth-Molnár, Edit},
	journal-iso = {INVEST OPHTH VIS SCI},
	journal = {INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE},
	volume = {61},
	unique-id = {31374309},
	issn = {0146-0404},
	year = {2020},
	eissn = {1552-5783},
	orcid-numbers = {Szarka, Dóra/0000-0002-5117-2131; Szalay, László/0000-0002-8797-4291; Tóth-Molnár, Edit/0000-0001-7989-1616}
}

@article{MTMT:31009570,
	title = {Mouse organoid cultures are the novel model to study the esophageal ion transport mechanisms},
	url = {https://m2.mtmt.hu/api/publication/31009570},
	author = {Korsós, Marietta Margaréta and Venglovecz, Viktória},
	journal-iso = {UEG JOURNAL},
	journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL},
	volume = {7},
	unique-id = {31009570},
	issn = {2050-6406},
	year = {2019},
	eissn = {2050-6414},
	pages = {408-408}
}