TY - JOUR AU - Ébert, Attila AU - Gál, Eleonóra AU - Tóth, Emese AU - Szögi, Titanilla AU - Hegyi, Péter AU - Venglovecz, Viktória TI - Role of CFTR in diabetes‐induced pancreatic ductal fluid and HCO 3 − secretion JF - JOURNAL OF PHYSIOLOGY-LONDON J2 - J PHYSIOL-LONDON VL - 602 PY - 2024 IS - 6 SP - 1065 EP - 1083 PG - 19 SN - 0022-3751 DO - 10.1113/JP285702 UR - https://m2.mtmt.hu/api/publication/34677129 ID - 34677129 N1 - Funding Agency and Grant Number: CF-Trust CFRD-SRC [SRC 007]; National Research, Development and Innovation Office [SNN134497]; New National Excellence Program Of The Ministry Of Human Capacities [UNKP-18-4] Funding text: We are grateful for support for this study provided by the CF-Trust CFRD-SRC Grant (No.: SRC 007) and the National Research, Development and Innovation Office (SNN134497) and New National Excellence Program Of The Ministry Of Human Capacities (UNKP-18-4 to VV). LA - English DB - MTMT ER - TY - JOUR AU - Gál, Eleonóra AU - Menyhárt, I AU - Veréb, Z AU - Kemény, L AU - Tiszlavicz, L AU - Czakó, László AU - Takács, Tamás AU - Hegyi, P AU - Venglovecz, Viktória TI - Importance of MUC17 in the bile-induced pancreatic cancer progression JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 9 PY - 2023 IS - Suppl 1 SP - 79 EP - 79 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/34053506 ID - 34053506 LA - English DB - MTMT ER - TY - JOUR AU - Ébert, Attila AU - Gál, Eleonóra AU - Tóth, Emese AU - Hegyi, Péter AU - Venglovecz, Viktória TI - The role of CFTR in the diabetes-induced pancreatic ductal fluid and HCO3-secretion JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 9 PY - 2023 IS - Suppl 1 SP - 74 EP - 75 PG - 2 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/34053481 ID - 34053481 LA - English DB - MTMT ER - TY - CHAP AU - Parvaneh, Shahram AU - Lovászi, Borbála AU - Szűcs, Diána AU - Monostori, Tamás AU - Gál, Eleonóra AU - Venglovecz, Viktória AU - Kemény, Lajos AU - Veréb, Zoltán ED - Halász, Réka ED - Zimmermann, Ildikó TI - 3D bioprinting of human pancreas cancer model T2 - Abstract Book of the 1st International Conference of Biomedical Engineering and Innovation PB - PTE CY - Pécs SN - 9789636260538 PY - 2022 SP - 48 EP - 48 PG - 1 UR - https://m2.mtmt.hu/api/publication/34064907 ID - 34064907 LA - English DB - MTMT ER - TY - JOUR AU - Marolt, Urška AU - Paradiž Leitgeb, Eva AU - Pohorec, Viljem AU - Lipovšek, Saška AU - Venglovecz, Viktória AU - Gál, Eleonóra AU - Ébert, Attila AU - Menyhárt, István AU - Potrč, Stojan AU - Gosak, Marko AU - Dolenšek, Jurij AU - Stožer, Andraž TI - Calcium imaging in intact mouse acinar cells in acute pancreas tissue slices JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 6 PG - 26 SN - 1932-6203 DO - 10.1371/journal.pone.0268644 UR - https://m2.mtmt.hu/api/publication/32867137 ID - 32867137 N1 - Clinical department for abdominal and general surgery, University Medical Centre Maribor, Maribor, Slovenia Institute of Physiology, Faculty of Medicine, University of Maribor, Maribor, Slovenia Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia Faculty of Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary Cited By :1 Export Date: 21 August 2022 CODEN: POLNC Correspondence Address: Marolt, U.; Clinical department for abdominal and general surgery, Slovenia; email: ursusmarolt@gmail.com Correspondence Address: Dolenšek, J.; Institute of Physiology, Slovenia; email: jurij.dolensek@um.si Correspondence Address: Stožer, A.; Institute of Physiology, Slovenia; email: andraz.stozer@um.si AB - The physiology and pathophysiology of the exocrine pancreas are in close connection to changes in intra-cellular Ca2+ concentration. Most of our knowledge is based on in vitro experiments on acinar cells or acini enzymatically isolated from their surroundings, which can alter their structure, physiology, and limit our understanding. Due to these limitations, the acute pancreas tissue slice technique was introduced almost two decades ago as a complementary approach to assess the morphology and physiology of both the endocrine and exocrine pancreas in a more conserved in situ setting. In this study, we extend previous work to functional multicellular calcium imaging on acinar cells in tissue slices. The viability and morphological characteristics of acinar cells within the tissue slice were assessed using the LIVE/DEAD assay, transmission electron microscopy, and immunofluorescence imaging. The main aim of our study was to characterize the responses of acinar cells to stimulation with acetylcholine and compare them with responses to cerulein in pancreatic tissue slices, with special emphasis on inter-cellular and inter-acinar heterogeneity and coupling. To this end, calcium imaging was performed employing confocal microscopy during stimulation with a wide range of acetylcholine concentrations and selected concentrations of cerulein. We show that various calcium oscillation parameters depend monotonically on the stimulus concentration and that the activity is rather well synchronized within acini, but not between acini. The acute pancreas tissue slice represents a viable and reliable experimental approach for the evaluation of both intra- and inter-cellular signaling characteristics of acinar cell calcium dynamics. It can be utilized to assess many cells simultaneously with a high spatiotemporal resolution, thus providing an efficient and high-yield platform for future studies of normal acinar cell biology, pathophysiology, and screening pharmacological substances. LA - English DB - MTMT ER - TY - JOUR AU - Gál, Eleonóra AU - Veréb, Zoltán AU - Rakk, Dávid AU - Szekeres, András AU - Becskeházi, Eszter AU - Tiszlavicz, László AU - Czakó, László AU - Takács, Tamás AU - Hegyi, P AU - Venglovecz, Viktória TI - The effect of bile on pancreatic cancer, the importance of mucins JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 8 PY - 2022 IS - Suppl. 1 SP - 77 EP - 77 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32843481 ID - 32843481 LA - English DB - MTMT ER - TY - JOUR AU - Korsós, Marietta Margaréta AU - Bellák, Tamás AU - Becskeházi, Eszter AU - Gál, Eleonóra AU - Veréb, Zoltán AU - Venglovecz, Viktória TI - Mouse esophaegal, organoid cultures are the novel model for studying the epithelial ion transport mechanisms JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 8 PY - 2022 IS - Suppl. 1 SP - 85 EP - 85 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32843357 ID - 32843357 LA - English DB - MTMT ER - TY - JOUR AU - Becskeházi, Eszter AU - Korsós, Marietta Margaréta AU - Gál, Eleonóra AU - Tiszlavicz, László AU - Hoyk, Z AU - Deli, M AU - Köhler, Zoltán Márton AU - Keller-Pintér, Anikó AU - Horváth, Attila AU - Csekő, K AU - Helyes, Z AU - Hegyi, Péter AU - Venglovecz, Viktória TI - NHE-1 plays a central role in the smoke-induced proliferation in barrett's esophageal cell line JF - CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE J2 - CENT EUR J GASTRO HEPATOL VL - 8 PY - 2022 IS - Suppl 1 SP - 65 EP - 65 PG - 1 SN - 2415-9107 UR - https://m2.mtmt.hu/api/publication/32843331 ID - 32843331 LA - English DB - MTMT ER - TY - JOUR AU - Becskeházi, Eszter AU - Korsós, Marietta Margaréta AU - Gál, Eleonóra AU - Tiszlavicz, László AU - Hoyk, Zsófia AU - Deli, Mária Anna AU - Köhler, Zoltán Márton AU - Keller-Pintér, Anikó AU - Horváth, Attila AU - Csekő, Kata AU - Helyes, Zsuzsanna AU - Hegyi, Péter AU - Venglovecz, Viktória TI - Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett’s Esophageal Cell Line JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 19 PG - 16 SN - 1661-6596 DO - 10.3390/ijms221910581 UR - https://m2.mtmt.hu/api/publication/32258572 ID - 32258572 LA - English DB - MTMT ER - TY - JOUR AU - Gál, Eleonóra AU - Dolenšek, Jurij AU - Stožer, Andraž AU - Czakó, László AU - Ébert, Attila AU - Venglovecz, Viktória TI - Mechanisms of Post-Pancreatitis Diabetes Mellitus and Cystic Fibrosis-Related Diabetes. A Review of Preclinical Studies TS - A Review of Preclinical Studies JF - FRONTIERS IN ENDOCRINOLOGY J2 - FRONT ENDOCRINOL VL - 12 PY - 2021 SP - 715043 PG - 12 SN - 1664-2392 DO - 10.3389/fendo.2021.715043 UR - https://m2.mtmt.hu/api/publication/32246015 ID - 32246015 N1 - Journal Article; Review AB - Anatomical proximity and functional correlations between the exocrine and endocrine pancreas warrant reciprocal effects between the two parts. Inflammatory diseases of the exocrine pancreas, such as acute or chronic pancreatitis, or the presence of cystic fibrosis disrupt endocrine function, resulting in diabetes of the exocrine pancreas. Although novel mechanisms are being increasingly identified, the intra- and intercellular pathways regulating exocrine-endocrine interactions are still not fully understood, making the development of new and more effective therapies difficult. Therefore, this review sought to accumulate current knowledge regarding the pathogenesis of diabetes in acute and chronic pancreatitis, as well as cystic fibrosis. LA - English DB - MTMT ER -