TY - THES AU - Gáspár, Attila TI - Cognitive characterization of Long-Evans rats in a streptozotocin-induced Alzheimer's disease model PY - 2023 DO - 10.14753/SE.2023.2924 UR - https://m2.mtmt.hu/api/publication/34580784 ID - 34580784 LA - English DB - MTMT ER - TY - JOUR AU - Tajti, Tekla Brigitta AU - Ojin, Yoon AU - Ernyey, Alíz Judit AU - Gáspár, Attila AU - Varga, Bence Tamás AU - Gyertyán, István TI - Using appetitive motivation to train mice for spatial learning in the Barnes maze JF - BIOMED RESEARCH INTERNATIONAL J2 - BIOMED RES INT VL - 2023 PY - 2023 PG - 16 SN - 2314-6133 DO - 10.1155/2023/6625491 UR - https://m2.mtmt.hu/api/publication/34428826 ID - 34428826 LA - English DB - MTMT ER - TY - JOUR AU - Gáspár, Attila AU - Hutka, Barbara AU - Ernyey, Alíz Judit AU - Tajti, Tekla Brigitta AU - Varga, Bence Tamás AU - Zádori, Zoltán Sándor AU - Gyertyán, István TI - Corrigendum: Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 13 PY - 2023 PG - 2 SN - 1663-9812 DO - 10.3389/fphar.2022.1122260 UR - https://m2.mtmt.hu/api/publication/33626416 ID - 33626416 LA - English DB - MTMT ER - TY - JOUR AU - Gáspár, Attila AU - Hutka, Barbara AU - Ernyey, Alíz Judit AU - Tajti, Tekla Brigitta AU - Varga, Bence Tamás AU - Zádori, Zoltán Sándor AU - Gyertyán, István TI - Performance of the intracerebroventricularly injected streptozotocin Alzheimer’s disease model in a translationally relevant, aged and experienced rat population JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 12 PY - 2022 IS - 1 PG - 13 SN - 2045-2322 DO - 10.1038/s41598-022-24292-5 UR - https://m2.mtmt.hu/api/publication/33269705 ID - 33269705 AB - The intracerebroventricularly (icv) injected streptozotocin (STZ) induced brain state is a widely used model of sporadic Alzheimer-disease (AD). However, data have been generated in young, naive albino rats. We postulate that the translationally most relevant animal population of an AD model should be that of aged rats with substantial learning history. The objective of the study was thus to probe the model in old rats with knowledge in various cognitive domains. Long-Evans rats of 23 and 10 months age with acquired knowledge in five-choice serial reaction time task (5-CSRTT), a cooperation task, Morris water-maze (MWM) and “pot-jumping” exercise were treated with 3 × 1.5 mg/kg icv. STZ and their performance were followed for 3 months in the above and additional behavioral assays. Both STZ-treated age groups showed significant impairment in the MWM (spatial learning) and novel object recognition test (recognition memory) but not in passive avoidance and fear conditioning paradigms (fear memory). In young STZ treated rats, significant differences were also found in the 5CSRTT (attention) and pot jumping test (procedural learning) while in old rats a significant increase in hippocampal phospho-tau/tau protein ratio was observed. No significant difference was found in the cooperation (social cognition) and pairwise discrimination (visual memory) assays and hippocampal β-amyloid levels. STZ treated old animals showed impulsivity-like behavior in several tests. Our results partly coincide with partly deviate from those published on young, albino, unexperienced rats. Beside the age, strain and experience level of the animals differences can also be attributed to the increased dose of STZ, and the applied food restriction regime. The observed cognitive and non-cognitive activity pattern of icv. STZ in aged experienced rats call for more extensive studies with the STZ model to further strengthen and specify its translational validity. LA - English DB - MTMT ER - TY - JOUR AU - Varga, Bence Tamás AU - Gáspár, Attila AU - Ernyey, Alíz Judit AU - Hutka, Barbara AU - Tajti, Tekla Brigitta AU - Zádori, Zoltán Sándor AU - Gyertyán, István TI - Introduction of a pharmacological neurovascular uncoupling model in rats based on results of mice JF - PHYSIOLOGY INTERNATIONAL J2 - PHYSIOL INT VL - 109 PY - 2022 IS - 3 SP - 405 EP - 418 PG - 8 SN - 2498-602X DO - 10.1556/2060.2022.00226 UR - https://m2.mtmt.hu/api/publication/33086714 ID - 33086714 AB - Our aim was to establish a pharmacologically induced neurovascular uncoupling (NVU) method in rats as a model of human cognitive decline. Pharmacologically induced NVU with subsequent neurological and cognitive defects was described in mice, but not in rats so far. We used 32 male Hannover Wistar rats. NVU was induced by intraperitoneal administration of a pharmacological “cocktail” consisting of N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MSPPOH, a specific inhibitor of epoxyeicosatrienoic acid-producing epoxidases, 5 mg kg−1), L-NG-nitroarginine methyl ester (L-NAME, a nitric oxide synthase inhibitor, 10 mg kg−1) and indomethacin (a nonselective inhibitor of cyclooxygenases, 1 mg kg−1) and injected twice daily for 8 consecutive days. Cognitive performance was tested in the Morris water-maze and fear-conditioning assays. We also monitored blood pressure. In a terminal operation a laser Doppler probe was used to detect changes in blood-flow (CBF) in the barrel cortex while the contralateral whisker pad was stimulated. Brain and small intestine tissue samples were collected post mortem and examined for prostaglandin E2 (PGE2) level. Animals treated with the “cocktail” showed no impairment in their performance in any of the cognitive tasks. They had higher blood pressure and showed cca. 50% decrease in CBF. Intestinal bleeding and ulcers were found in some animals with significantly decreased levels of PGE2 in the brain and small intestine. Although we could evoke NVU by the applied mixture of pharmacons, it also induced adverse side effects such as hypertension and intestinal malformations while the treatment did not cause cognitive impairment. Thus, further refinements are still required for the development of an applicable model. LA - English DB - MTMT ER - TY - JOUR AU - Gyertyán, István AU - Kassai, Ferenc AU - Gáspár, Attila AU - Varga, Bence Tamás AU - Ernyey, Alíz Judit TI - P.0549 A complex experimental design for measuring the learning impairing effect of repeat dose scopolamine in experienced aged rats JF - EUROPEAN NEUROPSYCHOPHARMACOLOGY J2 - EUR NEUROPSYCHOPHARM VL - 53 PY - 2021 IS - Supplement 1 SP - S404 EP - S404 SN - 0924-977X DO - 10.1016/j.euroneuro.2021.10.519 UR - https://m2.mtmt.hu/api/publication/32576831 ID - 32576831 LA - English DB - MTMT ER - TY - JOUR AU - Varga, Bence Tamás AU - Ernyey, Alíz Judit AU - Tajti, Tekla Brigitta AU - Gáspár, Attila AU - Gyertyán, István TI - P.0849 Freezing and ultrasound vocalization in response to contextual and discrete conditional stimuli in a fear conditioning paradigm JF - EUROPEAN NEUROPSYCHOPHARMACOLOGY J2 - EUR NEUROPSYCHOPHARM VL - 53 PY - 2021 IS - Supplement 1 SP - S621 EP - S622 SN - 0924-977X DO - 10.1016/j.euroneuro.2021.10.708 UR - https://m2.mtmt.hu/api/publication/32576479 ID - 32576479 LA - English DB - MTMT ER - TY - JOUR AU - Gáspár, Attila AU - Ernyey, Alíz Judit AU - Hutka, Barbara AU - Tajti, Tekla Brigitta AU - Varga, Bence Tamás AU - Zádori, Zoltán Sándor AU - Gyertyán, István TI - Cognitive performance of aged, experienced Long-Evans rats after icv streptozotocin treatment JF - EUROPEAN NEUROPSYCHOPHARMACOLOGY J2 - EUR NEUROPSYCHOPHARM VL - 53 PY - 2021 IS - Suppl. 1 SP - S620 EP - S621 PG - 2 SN - 0924-977X DO - 10.1016/j.euroneuro.2021.10.707 UR - https://m2.mtmt.hu/api/publication/32576372 ID - 32576372 LA - English DB - MTMT ER - TY - JOUR AU - Gáspár, Attila AU - Hutka, Barbara AU - Ernyey, Alíz Judit AU - Tajti, Tekla Brigitta AU - Varga, Bence Tamás AU - Zádori, Zoltán Sándor AU - Gyertyán, István TI - Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats JF - FRONTIERS IN PHARMACOLOGY J2 - FRONT PHARMACOL VL - 12 PY - 2021 PG - 11 SN - 1663-9812 DO - 10.3389/fphar.2021.662173 UR - https://m2.mtmt.hu/api/publication/32007892 ID - 32007892 LA - English DB - MTMT ER - TY - JOUR AU - Gáspár, Attila AU - Ernyey, Alíz Judit AU - Hutka, Barbara AU - Tajti, Tekla Brigitta AU - Varga, Bence Tamás AU - Zádori, Zoltán Sándor AU - Gyertyán, István TI - P.376 Investigating the effect of intracerebroventricularly injected streptozotocin in various learning paradigms in long-evans rats JF - EUROPEAN NEUROPSYCHOPHARMACOLOGY J2 - EUR NEUROPSYCHOPHARM VL - 40 PY - 2020 IS - Suppl. 1 SP - S216 EP - S217 SN - 0924-977X DO - 10.1016/j.euroneuro.2020.09.282 UR - https://m2.mtmt.hu/api/publication/31850390 ID - 31850390 N1 - Supplement: 1 LA - English DB - MTMT ER -