@mastersthesis{MTMT:34580784,
	title = {Cognitive characterization of Long-Evans rats in a streptozotocin-induced Alzheimer's disease model},
	url = {https://m2.mtmt.hu/api/publication/34580784},
	author = {Gáspár, Attila},
	doi = {10.14753/SE.2023.2924},
	unique-id = {34580784},
	year = {2023},
	orcid-numbers = {Gáspár, Attila/0000-0001-5203-2109}
}

@article{MTMT:34428826,
	title = {Using appetitive motivation to train mice for spatial learning in the Barnes maze},
	url = {https://m2.mtmt.hu/api/publication/34428826},
	author = {Tajti, Tekla Brigitta and Ojin, Yoon and Ernyey, Alíz Judit and Gáspár, Attila and Varga, Bence Tamás and Gyertyán, István},
	doi = {10.1155/2023/6625491},
	journal-iso = {BIOMED RES INT},
	journal = {BIOMED RESEARCH INTERNATIONAL},
	volume = {2023},
	unique-id = {34428826},
	issn = {2314-6133},
	year = {2023},
	eissn = {2314-6141},
	orcid-numbers = {Tajti, Tekla Brigitta/0000-0001-6274-4775; Ernyey, Alíz Judit/0000-0003-1957-2239; Gáspár, Attila/0000-0001-5203-2109; Varga, Bence Tamás/0000-0003-1768-0439; Gyertyán, István/0000-0002-5727-1974}
}

@article{MTMT:33626416,
	title = {Corrigendum: Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats},
	url = {https://m2.mtmt.hu/api/publication/33626416},
	author = {Gáspár, Attila and Hutka, Barbara and Ernyey, Alíz Judit and Tajti, Tekla Brigitta and Varga, Bence Tamás and Zádori, Zoltán Sándor and Gyertyán, István},
	doi = {10.3389/fphar.2022.1122260},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {13},
	unique-id = {33626416},
	year = {2023},
	eissn = {1663-9812},
	orcid-numbers = {Gáspár, Attila/0000-0001-5203-2109; Hutka, Barbara/0000-0002-7692-2744; Ernyey, Alíz Judit/0000-0003-1957-2239; Tajti, Tekla Brigitta/0000-0001-6274-4775; Varga, Bence Tamás/0000-0003-1768-0439; Zádori, Zoltán Sándor/0000-0001-7312-618X; Gyertyán, István/0000-0002-5727-1974}
}

@article{MTMT:33269705,
	title = {Performance of the intracerebroventricularly injected streptozotocin Alzheimer’s disease model in a translationally relevant, aged and experienced rat population},
	url = {https://m2.mtmt.hu/api/publication/33269705},
	author = {Gáspár, Attila and Hutka, Barbara and Ernyey, Alíz Judit and Tajti, Tekla Brigitta and Varga, Bence Tamás and Zádori, Zoltán Sándor and Gyertyán, István},
	doi = {10.1038/s41598-022-24292-5},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {12},
	unique-id = {33269705},
	issn = {2045-2322},
	abstract = {The intracerebroventricularly (icv) injected streptozotocin (STZ) induced brain state is a widely used model of sporadic Alzheimer-disease (AD). However, data have been generated in young, naive albino rats. We postulate that the translationally most relevant animal population of an AD model should be that of aged rats with substantial learning history. The objective of the study was thus to probe the model in old rats with knowledge in various cognitive domains. Long-Evans rats of 23 and 10 months age with acquired knowledge in five-choice serial reaction time task (5-CSRTT), a cooperation task, Morris water-maze (MWM) and “pot-jumping” exercise were treated with 3 × 1.5 mg/kg icv. STZ and their performance were followed for 3 months in the above and additional behavioral assays. Both STZ-treated age groups showed significant impairment in the MWM (spatial learning) and novel object recognition test (recognition memory) but not in passive avoidance and fear conditioning paradigms (fear memory). In young STZ treated rats, significant differences were also found in the 5CSRTT (attention) and pot jumping test (procedural learning) while in old rats a significant increase in hippocampal phospho-tau/tau protein ratio was observed. No significant difference was found in the cooperation (social cognition) and pairwise discrimination (visual memory) assays and hippocampal β-amyloid levels. STZ treated old animals showed impulsivity-like behavior in several tests. Our results partly coincide with partly deviate from those published on young, albino, unexperienced rats. Beside the age, strain and experience level of the animals differences can also be attributed to the increased dose of STZ, and the applied food restriction regime. The observed cognitive and non-cognitive activity pattern of icv. STZ in aged experienced rats call for more extensive studies with the STZ model to further strengthen and specify its translational validity.},
	year = {2022},
	eissn = {2045-2322},
	orcid-numbers = {Gáspár, Attila/0000-0001-5203-2109; Hutka, Barbara/0000-0002-7692-2744; Ernyey, Alíz Judit/0000-0003-1957-2239; Tajti, Tekla Brigitta/0000-0001-6274-4775; Varga, Bence Tamás/0000-0003-1768-0439; Zádori, Zoltán Sándor/0000-0001-7312-618X; Gyertyán, István/0000-0002-5727-1974}
}

@article{MTMT:33086714,
	title = {Introduction of a pharmacological neurovascular uncoupling model in rats based on results of mice},
	url = {https://m2.mtmt.hu/api/publication/33086714},
	author = {Varga, Bence Tamás and Gáspár, Attila and Ernyey, Alíz Judit and Hutka, Barbara and Tajti, Tekla Brigitta and Zádori, Zoltán Sándor and Gyertyán, István},
	doi = {10.1556/2060.2022.00226},
	journal-iso = {PHYSIOL INT},
	journal = {PHYSIOLOGY INTERNATIONAL},
	volume = {109},
	unique-id = {33086714},
	issn = {2498-602X},
	abstract = {Our aim was to establish a pharmacologically induced neurovascular uncoupling (NVU) method in rats as a model of human cognitive decline. Pharmacologically induced NVU with subsequent neurological and cognitive defects was described in mice, but not in rats so far.
		
		We used 32 male Hannover Wistar rats. NVU was induced by intraperitoneal administration of a pharmacological “cocktail” consisting of N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MSPPOH, a specific inhibitor of epoxyeicosatrienoic acid-producing epoxidases, 5 mg kg−1), L-NG-nitroarginine methyl ester (L-NAME, a nitric oxide synthase inhibitor, 10 mg kg−1) and indomethacin (a nonselective inhibitor of cyclooxygenases, 1 mg kg−1) and injected twice daily for 8 consecutive days.
		
		Cognitive performance was tested in the Morris water-maze and fear-conditioning assays. We also monitored blood pressure. In a terminal operation a laser Doppler probe was used to detect changes in blood-flow (CBF) in the barrel cortex while the contralateral whisker pad was stimulated. Brain and small intestine tissue samples were collected post mortem and examined for prostaglandin E2 (PGE2) level.
		
		Animals treated with the “cocktail” showed no impairment in their performance in any of the cognitive tasks. They had higher blood pressure and showed cca. 50% decrease in CBF. Intestinal bleeding and ulcers were found in some animals with significantly decreased levels of PGE2 in the brain and small intestine.
		
		Although we could evoke NVU by the applied mixture of pharmacons, it also induced adverse side effects such as hypertension and intestinal malformations while the treatment did not cause cognitive impairment. Thus, further refinements are still required for the development of an applicable model.},
	year = {2022},
	eissn = {2677-0164},
	pages = {405-418},
	orcid-numbers = {Varga, Bence Tamás/0000-0003-1768-0439; Gáspár, Attila/0000-0001-5203-2109; Ernyey, Alíz Judit/0000-0003-1957-2239; Hutka, Barbara/0000-0002-7692-2744; Tajti, Tekla Brigitta/0000-0001-6274-4775; Zádori, Zoltán Sándor/0000-0001-7312-618X; Gyertyán, István/0000-0002-5727-1974}
}

@article{MTMT:32576831,
	title = {P.0549 A complex experimental design for measuring the learning impairing effect of repeat dose scopolamine in experienced aged rats},
	url = {https://m2.mtmt.hu/api/publication/32576831},
	author = {Gyertyán, István and Kassai, Ferenc and Gáspár, Attila and Varga, Bence Tamás and Ernyey, Alíz Judit},
	doi = {10.1016/j.euroneuro.2021.10.519},
	journal-iso = {EUR NEUROPSYCHOPHARM},
	journal = {EUROPEAN NEUROPSYCHOPHARMACOLOGY},
	volume = {53},
	unique-id = {32576831},
	issn = {0924-977X},
	year = {2021},
	eissn = {1873-7862},
	pages = {S404-S404},
	orcid-numbers = {Gyertyán, István/0000-0002-5727-1974; Kassai, Ferenc/0000-0003-4815-3527; Gáspár, Attila/0000-0001-5203-2109; Varga, Bence Tamás/0000-0003-1768-0439; Ernyey, Alíz Judit/0000-0003-1957-2239}
}

@article{MTMT:32576479,
	title = {P.0849 Freezing and ultrasound vocalization in response to contextual and discrete conditional stimuli in a fear conditioning paradigm},
	url = {https://m2.mtmt.hu/api/publication/32576479},
	author = {Varga, Bence Tamás and Ernyey, Alíz Judit and Tajti, Tekla Brigitta and Gáspár, Attila and Gyertyán, István},
	doi = {10.1016/j.euroneuro.2021.10.708},
	journal-iso = {EUR NEUROPSYCHOPHARM},
	journal = {EUROPEAN NEUROPSYCHOPHARMACOLOGY},
	volume = {53},
	unique-id = {32576479},
	issn = {0924-977X},
	year = {2021},
	eissn = {1873-7862},
	pages = {S621-S622},
	orcid-numbers = {Varga, Bence Tamás/0000-0003-1768-0439; Ernyey, Alíz Judit/0000-0003-1957-2239; Tajti, Tekla Brigitta/0000-0001-6274-4775; Gáspár, Attila/0000-0001-5203-2109; Gyertyán, István/0000-0002-5727-1974}
}

@article{MTMT:32576372,
	title = {Cognitive performance of aged, experienced Long-Evans rats after icv streptozotocin treatment},
	url = {https://m2.mtmt.hu/api/publication/32576372},
	author = {Gáspár, Attila and Ernyey, Alíz Judit and Hutka, Barbara and Tajti, Tekla Brigitta and Varga, Bence Tamás and Zádori, Zoltán Sándor and Gyertyán, István},
	doi = {10.1016/j.euroneuro.2021.10.707},
	journal-iso = {EUR NEUROPSYCHOPHARM},
	journal = {EUROPEAN NEUROPSYCHOPHARMACOLOGY},
	volume = {53},
	unique-id = {32576372},
	issn = {0924-977X},
	year = {2021},
	eissn = {1873-7862},
	pages = {S620-S621},
	orcid-numbers = {Gáspár, Attila/0000-0001-5203-2109; Ernyey, Alíz Judit/0000-0003-1957-2239; Hutka, Barbara/0000-0002-7692-2744; Tajti, Tekla Brigitta/0000-0001-6274-4775; Varga, Bence Tamás/0000-0003-1768-0439; Zádori, Zoltán Sándor/0000-0001-7312-618X; Gyertyán, István/0000-0002-5727-1974}
}

@article{MTMT:32007892,
	title = {Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats},
	url = {https://m2.mtmt.hu/api/publication/32007892},
	author = {Gáspár, Attila and Hutka, Barbara and Ernyey, Alíz Judit and Tajti, Tekla Brigitta and Varga, Bence Tamás and Zádori, Zoltán Sándor and Gyertyán, István},
	doi = {10.3389/fphar.2021.662173},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {12},
	unique-id = {32007892},
	year = {2021},
	eissn = {1663-9812},
	orcid-numbers = {Gáspár, Attila/0000-0001-5203-2109; Hutka, Barbara/0000-0002-7692-2744; Ernyey, Alíz Judit/0000-0003-1957-2239; Tajti, Tekla Brigitta/0000-0001-6274-4775; Varga, Bence Tamás/0000-0003-1768-0439; Zádori, Zoltán Sándor/0000-0001-7312-618X; Gyertyán, István/0000-0002-5727-1974}
}

@article{MTMT:31850390,
	title = {P.376 Investigating the effect of intracerebroventricularly injected streptozotocin in various learning paradigms in long-evans rats},
	url = {https://m2.mtmt.hu/api/publication/31850390},
	author = {Gáspár, Attila and Ernyey, Alíz Judit and Hutka, Barbara and Tajti, Tekla Brigitta and Varga, Bence Tamás and Zádori, Zoltán Sándor and Gyertyán, István},
	doi = {10.1016/j.euroneuro.2020.09.282},
	journal-iso = {EUR NEUROPSYCHOPHARM},
	journal = {EUROPEAN NEUROPSYCHOPHARMACOLOGY},
	volume = {40},
	unique-id = {31850390},
	issn = {0924-977X},
	year = {2020},
	eissn = {1873-7862},
	pages = {S216-S217},
	orcid-numbers = {Gáspár, Attila/0000-0001-5203-2109; Ernyey, Alíz Judit/0000-0003-1957-2239; Hutka, Barbara/0000-0002-7692-2744; Tajti, Tekla Brigitta/0000-0001-6274-4775; Varga, Bence Tamás/0000-0003-1768-0439; Zádori, Zoltán Sándor/0000-0001-7312-618X; Gyertyán, István/0000-0002-5727-1974}
}