TY  - JOUR
AU  - Jankó, Laura
AU  - Kovács, Tünde
AU  - Laczik, Miklós
AU  - Sári, Zsanett Mercédesz
AU  - Ujlaki, Gyula
AU  - Kis, Nikoletta Gréta
AU  - Horváth, Ibolya
AU  - Antal, Miklós
AU  - Vigh, László
AU  - Bálint, Bálint László
AU  - Uray (Davis), Karen L.
AU  - Bay, Péter
TI  - Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation
JF  - CELLS
J2  - CELLS-BASEL
VL  - 10
PY  - 2021
IS  - 6
PG  - 23
SN  - 2073-4409
DO  - 10.3390/cells10061387
UR  - https://m2.mtmt.hu/api/publication/32058440
ID  - 32058440
N1  - Funding Agency and Grant Number: NKFIHNational Research, Development & Innovation Office (NRDIO) - Hungary [K123975, GINOP-2.3.2-15-201600006, EFOP-3.6.2-16-2017-00006, K 129166]; Momentum fellowship of the Hungarian Academy of Sciences; University of Debrecen; Higher Education Institutional Excellence Program of the Ministry of Innovation and Technology in Hungary [NKFIH-1150-6/2019]; MOLMEDEX FUN-OMICS [GINOP-2.3.3-15-2016-00007]; Debrecen Venture Catapult Program [EFOP-3.6.1-16-2016-00022];  [UNKP-20-4-II-DE-68]
            Funding text: This research was funded by grants from the NKFIH (K123975, GINOP-2.3.2-15-201600006, EFOP-3.6.2-16-2017-00006), the Momentum fellowship of the Hungarian Academy of Sciences, and the University of Debrecen. The research was financed by the Higher Education Institutional Excellence Program (NKFIH-1150-6/2019) of the Ministry of Innovation and Technology in Hungary, within the framework of the biotechnology thematic program of the University of Debrecen. Tunde Kovacs was supported by the UNKP-20-4-II-DE-68 grant. B.L.B. was supported by MOLMEDEX FUN-OMICS (GINOP-2.3.3-15-2016-00007), Debrecen Venture Catapult Program (EFOP-3.6.1-16-2016-00022), NKFIH K 129166.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sári, Zsanett Mercédesz
AU  - Mikó, Edit
AU  - Kovács, Tünde
AU  - Boratkó, Anita
AU  - Ujlaki, Gyula
AU  - Jankó, Laura
AU  - Kiss, Borbála Katalin
AU  - Uray (Davis), Karen L.
AU  - Bay, Péter
TI  - Indoxylsulfate, a metabolite of the microbiome, has cytostatic effects in breast cancer via activation of AHR and PXR receptors and induction of oxidative stress
JF  - CANCERS
J2  - CANCERS
VL  - 12
PY  - 2020
IS  - 10
PG  - 23
SN  - 2072-6694
DO  - 10.3390/cancers12102915
UR  - https://m2.mtmt.hu/api/publication/31627406
ID  - 31627406
N1  - Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Egyetem tér 1., Debrecen, 4032, Hungary            
            MTA-DE Lendület Laboratory of Cellular Metabolism, Debrecen, 4032, Hungary            
            Department of Oncology, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary            
            Research Center for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, 4032, Hungary            
            Cited By :2            
            Export Date: 24 May 2021            
            Correspondence Address: Bai, P.; Department of Medical Chemistry, Egyetem tér 1., Hungary; email: baip@med.unideb.hu            
            Correspondence Address: Bai, P.; MTA-DE Lendület Laboratory of Cellular MetabolismHungary; email: baip@med.unideb.hu            
            Correspondence Address: Bai, P.; Research Center for Molecular Medicine, Hungary; email: baip@med.unideb.hu            
            Funding details: ÚNKP-19-4-DE-79, ÚNKP-20-5-DE-96            
            Funding details:            
            Funding details: ÚNKP-20-4-II-DE-68            
            Funding details: NKFIH-1150-6/2019
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sári, Zsanett Mercédesz
AU  - Kovács, Tünde
AU  - Csonka, Tamás
AU  - Török, M
AU  - Sebő, É
AU  - Toth, J
AU  - Tóth, Dezső
AU  - Mikó, Edit
AU  - Kiss, Borbála Katalin
AU  - Szeőcs, Dóra
AU  - Uray (Davis), Karen L.
AU  - Karányi, Zsolt
AU  - Kovács, Ilona
AU  - Méhes, Gábor
AU  - Árkosy, Péter
AU  - Bay, Péter
TI  - Fecal expression of Escherichia coli lysine decarboxylase (LdcC) is downregulated in E-cadherin negative lobular breast carcinoma
JF  - PHYSIOLOGY INTERNATIONAL
J2  - PHYSIOL INT
VL  - 107
PY  - 2020
IS  - 2
SP  - 349
EP  - 358
PG  - 10
SN  - 2498-602X
DO  - 10.1556/2060.2020.00016
UR  - https://m2.mtmt.hu/api/publication/31607797
ID  - 31607797
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Sári, Zsanett Mercédesz
AU  - Mikó, Edit
AU  - Kovács, Tünde
AU  - Jankó, Laura
AU  - Csonka, Tamás
AU  - Lente, G
AU  - Sebő, É
AU  - Toth, J
AU  - Tóth, Dezső
AU  - Árkosy, Péter
AU  - Boratkó, Anita
AU  - Ujlaki, Gyula
AU  - Török, M
AU  - Kovács, Ilona
AU  - Szabó, Judit
AU  - Kiss, Borbála Katalin
AU  - Méhes, Gábor
AU  - Goedert, JJ
AU  - Bay, Péter
TI  - Indolepropionic acid, a metabolite of the microbiome, has cytostatic properties in breast cancer by activating AHR and PXR receptors and inducing oxidative stress
JF  - CANCERS
J2  - CANCERS
VL  - 12
PY  - 2020
IS  - 9
PG  - 27
SN  - 2072-6694
DO  - 10.3390/cancers12092411
UR  - https://m2.mtmt.hu/api/publication/31408725
ID  - 31408725
LA  - English
DB  - MTMT
ER  - 

TY  - PAT
AU  - Bay, Péter
AU  - Goedert, JJ
AU  - Kovács, Tünde
AU  - Mikó, Edit
AU  - Sári, Zsanett Mercédesz
AU  - Sebő, É
AU  - Tóth, J
TI  - Treatment and diagnosis of breast cancer
PY  - 2020
UR  - https://m2.mtmt.hu/api/publication/31408665
ID  - 31408665
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Jankó, Laura
AU  - Sári, Zsanett Mercédesz
AU  - Kovács, Tünde
AU  - Kis, Nikoletta Gréta
AU  - Szántó, Magdolna
AU  - Antal, Miklós
AU  - Juhász, Gábor
AU  - Bay, Péter
TI  - Silencing of PARP2 blocks autophagic degradation
JF  - CELLS
J2  - CELLS-BASEL
VL  - 9
PY  - 2020
IS  - 2
SN  - 2073-4409
DO  - 10.3390/cells9020380
UR  - https://m2.mtmt.hu/api/publication/31156819
ID  - 31156819
N1  - Funding Agency and Grant Number: NKFIH [K123975, PD121138, KKP129797, GINOP-2.3.2-15-2016-00006]; Higher Education Institutional Excellence Programme of the Ministry of Innovation and Technology in Hungary [NKFIH-1150-6/2019]; Hungarian Academy of SciencesHungarian Academy of Sciences;  [NKM-26/2019]
            Funding text: Our work was supported by K123975, PD121138, KKP129797, GINOP-2.3.2-15-2016-00006 from NKFIH and NKM-26/2019 and a Bolyai fellowship (to M.S.) from the Hungarian Academy of Sciences. The research was financed by the Higher Education Institutional Excellence Programme (NKFIH-1150-6/2019) of the Ministry of Innovation and Technology in Hungary, within the framework of the Biotechnology thematic programme of the University of Debrecen.
LA  - English
DB  - MTMT
ER  - 

TY  - CHAP
AU  - Kovács, Tünde
AU  - Mikó, Edit
AU  - Ujlaki, Gyula
AU  - Sári, Zsanett Mercédesz
AU  - Bay, Péter
ED  - Birbrair, A
TI  - The microbiome as a component of the tumor microenvironment
T2  - Tumor Microenvironment: Recent advances
PB  - Springer Netherlands
CY  - Cham
SN  - 9783030357269
T3  - Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 1225.
PY  - 2020
SP  - 137
EP  - 153
PG  - 17
SN  - 9783030357269
DO  - 10.1007/978-3-030-35727-6_10
UR  - https://m2.mtmt.hu/api/publication/30941569
ID  - 30941569
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Kovács, Patrik Bence
AU  - Csonka, Tamás
AU  - Kovács, Tünde
AU  - Sári, Zsanett Mercédesz
AU  - Ujlaki, Gyula
AU  - Sipos, Adrienn
AU  - Karányi, Zsolt
AU  - Szeőcs, Dóra
AU  - Hegedűs, Csaba
AU  - Uray (Davis), Karen L.
AU  - Jankó, Laura
AU  - Kiss, M
AU  - Kiss, Borbála Katalin
AU  - Laoui, D
AU  - Virág, László
AU  - Méhes, Gábor
AU  - Bay, Péter
AU  - Mikó, Edit
TI  - Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer
JF  - CANCERS
J2  - CANCERS
VL  - 11
PY  - 2019
IS  - 9
PG  - 31
SN  - 2072-6694
DO  - 10.3390/cancers11091255
UR  - https://m2.mtmt.hu/api/publication/30774202
ID  - 30774202
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Mikó, Edit
AU  - Vida, András
AU  - Kovács, Tünde
AU  - Ujlaki, Gyula
AU  - Trencsényi, György
AU  - Márton, Judit
AU  - Sári, Zsanett Mercédesz
AU  - Kovács, Patrik Bence
AU  - Boratkó, Anita
AU  - Hujber, Zoltán
AU  - Csonka, Tamás
AU  - Antal-Szalmás, Péter
AU  - Watanabe, M
AU  - Gombos, Imre
AU  - Csoka, B
AU  - Kiss, Borbála Katalin
AU  - Vigh, László
AU  - Szabó, Judit
AU  - Méhes, Gábor
AU  - Sebestyén, Anna
AU  - Goedert, JJ
AU  - Bay, Péter
TI  - Lithocholic acid, a bacterial metabolite reduces breast cancer cell proliferation and aggressiveness
JF  - BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
J2  - BBA-BIOENERGETICS
VL  - 1859
PY  - 2018
IS  - 9
SP  - 958
EP  - 974
PG  - 17
SN  - 0005-2728
DO  - 10.1016/j.bbabio.2018.04.002
UR  - https://m2.mtmt.hu/api/publication/3357955
ID  - 3357955
AB  - Our study aimed at finding a mechanistic relationship between the gut microbiome and breast cancer. Breast cancer cells are not in direct contact with these microbes, but disease could be influenced by bacterial metabolites including secondary bile acids that are exclusively synthesized by the microbiome and known to enter the human circulation. In murine and bench experiments, a secondary bile acid, lithocholic acid (LCA) in concentrations corresponding to its tissue reference concentrations (< 1 mu M), reduced cancer cell proliferation (by 10-20%) and VEGF production (by 37%), aggressiveness and metastatic potential of primary tumors through inducing mesenchymal-to-epithelial transition, increased antitumor immune response, OXPHOS and the TCA cycle. Part of these effects was due to activation of TGR5 by LCA. Early stage breast cancer patients, versus control women, had reduced serum LCA levels, reduced chenodeoxycholic acid to LCA ratio, and reduced abundance of the baiH (7 alpha/beta-hydroxysteroid dehydroxylase, the key enzyme in LCA generation) gene in fecal DNA, all suggesting reduced microbial generation of LCA in early breast cancer.
LA  - English
DB  - MTMT
ER  -