@article{MTMT:34335469,
	title = {Efficacy of high dose systemic versus combined (systemic and intratympanic) corticosteroid therapy in idiopathic sudden sensorineural hearing loss : A prospective randomized trial and risk factor analysis},
	url = {https://m2.mtmt.hu/api/publication/34335469},
	author = {Kovács, Márton and Uzsaly, János Gáspár and Bodzai, G and Pap, István and Lippai, Bálint and Dergez, Tímea and Németh, Adrienn and Gerlinger, Imre and Szanyi, István and Bakó, Péter},
	doi = {10.1016/j.amjoto.2023.104099},
	journal-iso = {AM J OTOLARYNG},
	journal = {AMERICAN JOURNAL OF OTOLARYNGOLOGY},
	volume = {45},
	unique-id = {34335469},
	issn = {0196-0709},
	abstract = {The pathophysiology and the proper treatment of idiopathic sudden sensorineural hearing loss (ISSNHL) are an ongoing subject of debate. Locally or systemic administered corticosteroids are the most accepted drugs of treatment in reference to ISSNHL (idiopathic sudden sensorineural hearing loss), however, no strong evidence nor guidelines regarding their effectiveness yet exists. In our prospective, randomized, controlled trial 78 participants were enrolled. Patients were randomly assigned based on the day of admission to two groups according to treatment: group SS (n = 43) received intravenous systemic methylprednisolone alone, and group CT (n = 35) received intratympanic dexamethasone + systemic methylprednisolone. The primary outcome was to compare the hearing outcomes between the treatment groups based on different, widely accepted categories (Siegel, Kanzaki, modified Siegel and PTA4 gain). In consideration of the secondary outcome, we examined the effect of the various risk factors on the hearing improvement. No differences were detected regarding hearing improvement between the two groups, based on any criteria [Siegel's criteria (p = 0.604); Kanzaki's criteria (p = 0.720); modified Siegel's criteria (p = 0.524) and PTA 4 gain (p = 0.569)]. However, several clinical factors such as vertigo (p = 0.039), or cardiovascular comorbidity (p = 0.02) and the severity of initial hearing loss (p = 0.033) were found to bear a significant impact upon the hearing outcome. To the best of our knowledge, this is the first randomized controlled trial comparing high dose systemic and combination corticosteroid therapy in ISSNHL patients. Our findings suggest coexisting cardiovascular comorbidity, vertigo and severity of the initial hearing loss may bear a significantly higher impact upon hearing improvement, than the additional intratympanic steroid administration. The presented trial was registered in the European Union Drug Regulating Authorities Clinical Trials Database (name: Combinated systemic and intratympanic steroid therapy in idiopathic sudden sensorineural hearing loss, No.: 2017-000658-20) and with the ethical approval of The National Institute of Pharmacy and Nutrition (OGYÉI) (protocol No.: 7621, on 2017.02.16.).},
	keywords = {risk factor; steroid; Sudden hearing loss; Intratympanic injection},
	year = {2024},
	eissn = {1532-818X},
	orcid-numbers = {Lippai, Bálint/0009-0004-9117-1063}
}

@article{MTMT:33728524,
	title = {Quality-of-life outcomes with endoscopic and microscopic type I tympanoplasty-a prospective cohort study},
	url = {https://m2.mtmt.hu/api/publication/33728524},
	author = {Pap, István and Kovács, Márton and Bölcsföldi, Barbara and Szakács, Zsolt and Gerlinger, Imre and Imreh, Bence and Szántóné Csongor, Alexandra and Warta, Vilmos and Szanyi, István},
	doi = {10.1007/s00405-023-07938-6},
	journal-iso = {EUR ARCH OTO-RHINO-L},
	journal = {EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY},
	volume = {280},
	unique-id = {33728524},
	issn = {0937-4477},
	abstract = {Endoscopic type I tympanoplasty was originally introduced in the 1990s and the extensive spread of this practice can be easily observed. The conventional technique performed involves the repair of a tympanic membrane perforation and is defined as microscopic type I tympanoplasty. The aim of this study is the comparison of quality-of-life (QoL) outcomes with endoscopic to that with microscopic type I tympanoplasty.All patients, or in the case of children with the aid of a parent, were asked to complete a novel QoL questionnaire drafted by our study group. The analysis was performed with descriptive statistics-mean, SD and relative frequency-and with a mixed model (generalized least squares fit). A two-sided p value of < 0.05 was regarded as statistically significant.A total of 83 patients completed the questionnaire, 38 in the endoscopic group and 45 in the microscopic group. Every question represented a different. A statistically significant result was found in favor of the endoscopic approach regarding average hospitalization rate (p = 0.003) and cosmetic outcomes (p = 0.015). No statistically significant difference was otherwise observed between the groups.Based on our prospective cohort study, the QoL outcomes of endoscopic type I tympanoplasty in terms of postoperative pain, headache, nausea, vomiting, dizziness, taste disorder and hearing were comparable to the microscopic type I tympanoplasty. In regard to cosmetics, an increase in desirable results was achieved in the endoscopic group, particularly the average hospitalization rate proved to be statistically significantly lower than in the microscopic group.},
	keywords = {Quality of Life; Treatment Outcome; endoscopy; Cosmetics; tympanoplasty; myringoplasty},
	year = {2023},
	eissn = {1434-4726},
	pages = {4401-4408},
	orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X}
}

@article{MTMT:33079688,
	title = {A szelektív epitympanalis dysventilatiós szindróma műtéti megoldása.},
	url = {https://m2.mtmt.hu/api/publication/33079688},
	author = {Bölcsföldi, T Barbara and Pap, István and Tóth, Tamás Ferenc and Tóth, István and Révész, Péter and Gerlinger, Imre and Szanyi, István},
	doi = {10.1556/650.2022.32563},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {163},
	unique-id = {33079688},
	issn = {0030-6002},
	abstract = {The selective epitympanic dysventilation syndrome is a new theory of the cholesteatoma formation, the description of which was allowed by a minimally invasive surgical technique - the transcanal endoscopic ear surgery - some years ago. The transcanal endoscopic ear surgery provided the possibility of a certain amount of detailed anatomical knowledge to identify the new factor behind this process, namely obstruction of the ventilation pathways of the middle ear. Our goal was to draw the ear surgeons' attention to this clinical picture as cholesteatoma development and subsequent worsening of the quality of life caused by ear discharge and conductive hearing loss may be reversible or preventable. We make the syndrome more understandable by using our own anatomical drawings. In this paper, the authors present a case of selective epitympanic dysventilation syndrome, and emphasize the importance of recognition and the endoscopic ear surgical treatment as well as review the international literature. Orv Hetil. 2022; 163(36): 1440-1446.},
	keywords = {Minimally invasive; cholesteatoma; endoscopic ear surgery; dysventilatio; dysventilation; endoszkópos fülsebészet; minimálinvazív},
	year = {2022},
	eissn = {1788-6120},
	pages = {1440-1446}
}

@article{MTMT:32838757,
	title = {Mastoidobliterációhoz használt csontpor és bioaktív üveggranulátum a cholesteatoma sebészetében.},
	url = {https://m2.mtmt.hu/api/publication/32838757},
	author = {Gerlinger, Imre and Szabó, Éva and Szanyi, István and Rostás, Tamás and Pap, István and Révész, Péter and Kopjár, Eszter},
	doi = {10.1556/650.2022.32477},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {163},
	unique-id = {32838757},
	issn = {0030-6002},
	abstract = {Mastoid obliteration technique combines the advantages of canal wall-up (CWU) and canal wall-down (CWD) approaches in the surgery of chronic suppurative otitis media with cholesteatoma. We aim to demonstrate our experience with mastoid obliteration technique using bone dust and BonAlive® (S53P4) bioactive glass granule in a comparative prospective clinical study.Between 1st of March 2012 and 31st of November 2021, mastoid obliteration surgery was performed in 14 patients using bone dust (7 cases) and BonAlive® granule (7 cases). Prior to these interventions, the patients had undergone more than three ear surgeries (CWU and CWD) generally in both groups. Changes of complaints, audiological results, and changes in quality of life were analysed in both groups, postoperatively.Having performed the mastoid obliteration technique, cochlear damage did not occur in either patient group. Long-term ear discharge and vertigo were occasionally observed after performing obliteration with bone dust. However, these complaints disappeared after a while. Complications were not reported in the case of obliteration with BonAlive®. Outstanding improvement was experienced in both groups.In our practice, mastoid obliteration surgery, using either bone dust or BonAlive® granule, has proved to be a safe and effective method in the management of chronic suppurative otitis media with cholesteatoma, resulting in continuous putrid ear discharge after CWU or CWD tympanoplasty. Obliteration with BonAlive® granule provides several advantages for patients, such as antibacterial effect, osteoconductive effect ensuring frame for bone growth and osteoproductive effect stimulating the ossification. Orv Hetil. 2022; 163(21): 838-845.},
	keywords = {Sensorineural hearing loss; conductive hearing loss; Bone pate; vezetéses halláscsökkenés; BonAlive® granules; BonAlive® granulátum; canal wall-down tympanoplasty; canal wall-up tympanoplasty; csontpor; idegi halláscsökkenés; kevert típusú halláscsökkenés; mixed-type hearing loss; nyitott technikájú tympanoplastica; zárt technikájú tympnoplastica},
	year = {2022},
	eissn = {1788-6120},
	pages = {838-845}
}

@article{MTMT:32604752,
	title = {Transorbitomaxillaris percutan endoszkópos gastrostomia},
	url = {https://m2.mtmt.hu/api/publication/32604752},
	author = {Pap, István and Jakab-Péter, Kinga and Uzsaly, János Gáspár and Tóth, István and Barabás, Márta-Andrea and Fábián, György and Lujber, László},
	doi = {10.1556/650.2022.32286},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {163},
	unique-id = {32604752},
	issn = {0030-6002},
	abstract = {Összefoglaló. Fej-nyaki daganattal diagnosztizált és kezelt betegeknél a szájon keresztüli táplálás gyakran nem lehetséges vagy nehezítetté válik a kezelés valamelyik fázisában. A beteg enteralis táplálásának biztosítására tartós és hatékony megoldást kell nyújtanunk, erre megfelelő választás lehet a percutan endoszkópos gastrostomia. A fej-nyaki régióban a daganat elhelyezkedése, kiterjedtsége és a műtétek miatt megváltozott anatómiai viszonyok sokszor gátat szabnak a gasztroszkóp hagyományos, szájon át történő sikeres levezetésének, és így különleges megoldásokra lehet szükség. Közleményünkben egy, a szakirodalomban is ritkán alkalmazott percutan endoszkópos gastrostomakészítésről számolunk be. A bemutatott esetben egy kiterjedt, rosszindulatú fej-nyaki daganat miatt totális maxillectomián és orbitaexenteratión átesett betegben a műtét következtében kialakult arcdefektuson át történt a gastroscopia és a tápszonda levezetése, ugyanis komplett szájzár következtében a beteg a táplálkozásra képtelen volt. A fent említett módszerrel sikerült a beteg hosszú távú enteralis táplálását megoldani minimálinvazív módon. Az összetett kóros esetek gyakran állítják kihívások elé a gyakorló klinikust. Esetbemutatásunkkal szeretnénk felhívni a figyelmet a hagyományos, megszokott módszerek helyett sokszor nagyobb sikerrel alkalmazható, személyre szabott terápiás lehetőségekre. Orv Hetil. 2022; 163(3): 116-119. Summary. Peroral, enteral feeding is often impossible in patients with head and neck cancer. Percutaneous endoscopic gastrostomy is a well-established, quick, minimally invasive, and safe procedure for providing long-term enteral feeding. Space-occupying tumour mass and altered anatomy due to surgery inhibit the gastroscope's peroral introduction and the feeding tube's placement in some instances. Various access routes and modified insertion techniques are recommended to overcome the feeding tube insertion challenges. We present a rare case of a 64-year-old head and neck cancer patient who was unable to eat orally due to trismus and had a facial soft tissue defect following total maxillectomy and orbital exenteration. A complete oesophago-gastro-duodenoscopy and feeding tube insertion were performed transfacially. Percutaneous endoscopic gastrostomy was successful and uneventful via the maxillary and orbital soft tissue facial defect. No complication was noted, and long-term enteral feeding of the patient was provided in a minimally invasive way. Surgeons often face challenging cases when treating patients with head and neck cancer. The modification of standard procedures is sometimes required to adapt surgical techniques to the patient's specific case. Orv Hetil. 2022; 163(3): 116-119.},
	keywords = {Head and neck cancer; percutaneous endoscopic gastrostomy; orbital exenteration; fej-nyaki tumor; maxillectomia; maxillectomy; orbitalis exenteratio; percutan endoszkópos gastrostomia; transfacial; transfacialis},
	year = {2022},
	eissn = {1788-6120},
	pages = {116-119}
}

@article{MTMT:32508864,
	title = {Az endoszkópos I-es típusú tympanoplastica ugyanolyan hatékony, mint a mikroszkópos I-es típusú tympanoplastica, de kevésbé invazív - Metaanalízis},
	url = {https://m2.mtmt.hu/api/publication/32508864},
	author = {Pap, István and Tóth, István and Szakács, Zsolt and Gede, Noémi and Koukkoullis, Alexandros and Révész, Péter and Harmat, Kinga and Németh, Adrienn and Lujber, László and Bocskai, Tímea and Hegyi, Péter and Varga, Gábor and Gerlinger, Imre and Szanyi, István},
	journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT},
	journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT},
	volume = {67},
	unique-id = {32508864},
	issn = {0016-237X},
	year = {2021},
	pages = {139-146},
	orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259}
}

@article{MTMT:31641583,
	title = {A pars petrosa cholesteatomák korszerű ellátása Pécsi tapasztalatok},
	url = {https://m2.mtmt.hu/api/publication/31641583},
	author = {Gerlinger, Imre and Végh, Ildikó and Nepp, Nelli and Pap, István and Révész, Péter and Bakó, Péter and Szanyi, István and Rostás, Tamás and Tóth, István},
	doi = {10.1556/650.2020.31879},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {161},
	unique-id = {31641583},
	issn = {0030-6002},
	keywords = {dura mater; internal carotid artery; facial nerve; NERVUS FACIALIS; skull base surgery; hallásrehabilitáció; hearing rehabilitation; Jugular bulb; agyalapi sebészet; arteria carotis interna; bulbus venae jugularis; pars petrosa cholesteatoma; petrous bone cholesteatoma},
	year = {2020},
	eissn = {1788-6120},
	pages = {1840-1848}
}

@article{MTMT:31383609,
	title = {Cholesteatoma update 2019},
	url = {https://m2.mtmt.hu/api/publication/31383609},
	author = {Tóth, István and Pap, István and Gerlinger, Imre},
	journal-iso = {FÜL-ORR-GÉGEGYÓGYÁSZAT},
	journal = {FÜL-ORR-GÉGEGYÓGYÁSZAT},
	volume = {66},
	unique-id = {31383609},
	issn = {0016-237X},
	year = {2020},
	pages = {9-18}
}

@article{MTMT:31269089,
	title = {Subtotalis petrosectomia – javallatok, műtéti technika, pécsi tapasztalatok},
	url = {https://m2.mtmt.hu/api/publication/31269089},
	author = {Gerlinger, Imre and Molnár, Krisztián and Nepp, Nelli and Tóth, István and Tóth, Tamás Ferenc and Szanyi, István and Bakó, Péter and Pap, István},
	doi = {10.1556/650.2020.31691},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {161},
	unique-id = {31269089},
	issn = {0030-6002},
	abstract = {Introduction: Subtotal petrosectomy (STP) has been known for decades and it is considered being on the borderline between ear and skull-base surgery. Due to its excessive radicalism and adverse effects on hearing, it has been a forgotten surgical technique until recently. Over the last decade, due to its many benefits and the ability to combine it with modern hearing rehabilitation methods, STP has reappeared, providing a definitive solution to a number of problematic middl-ear disorders. Aim: In our retrospective clinical study, we wanted to highlight the effectiveness of STP, analyzing the efficiency of this surgery for the first time in domestic patient records, and to report our own experiences to date. Method: We processed data from 45 surgeries on our 44 patients. In addition to presenting the various surgical indications, we review the steps of the operation, analyze the audiological results, including the various methods of hearing rehabilitation, and also analyze the complications that have occurred. Our results are also summarized in the light of international professional literature. Results: Of our 44 patients, 23 were female and 21 were male. Patients had a mean age of 44.6 ± 20.5 years and a mean follow-up of 23 ± 16 months. Of our patients, 25 (57%) had undergone at least two previous unsuccessful ear operations, and 6 (14%) had deafness before surgery. The most common indication was chronic otitis media with cholesteatoma. 13 patients underwent 14 cochlear implantations (23%), in addition 6 patients received bone anchored hearing aids (BAHA) (14%), and 2 patients (5%) underwent VSB (Vibrant Soundbridge) placement against the round window membrane. Complications occurred in 11 of our patients, the most common of which was cerebrospinal fluid leak (5 cases, 11%) and wound dehiscence (3 cases, 7%). Data from 3 patients were available for processing the audiological results. Conclusion: STP is an extremely favorable surgical solution for a number of middle-ear pathologies that have previously caused major problems. The main reason for its growing popularity is that it can be combined with a number of modern, effective methods of hearing rehabilitation. Orv Hetil. 2020; 161(14): 544-553.},
	keywords = {cholesteatoma; Subtotal petrosectomy; hallásrehabilitáció; hearing rehabilitation; closure of external ear canal; hallójárat lezárása; műtéti üreg obliterációja; subtotalis petrosectomia; surgical cavity obliteration},
	year = {2020},
	eissn = {1788-6120},
	pages = {544-553}
}

@article{MTMT:31180137,
	title = {Is the bispectral index monitoring protective against postoperative cognitive decline? A systematic review with meta-analysis},
	url = {https://m2.mtmt.hu/api/publication/31180137},
	author = {Bocskai, Tímea and Kovács, Márton and Szakács, Zsolt and Gede, Noémi and Hegyi, Péter and Varga, Gábor and Pap, István and Tóth, István and Révész, Péter and Szanyi, István and Németh, Adrienn and Gerlinger, Imre and Karádi, Kázmér and Lujber, László},
	doi = {10.1371/journal.pone.0229018},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {15},
	unique-id = {31180137},
	issn = {1932-6203},
	year = {2020},
	eissn = {1932-6203},
	orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259; Varga, Gábor/0000-0002-5506-8198}
}