@article{MTMT:35629895, title = {Kvantummikroszkópia, anyagtudomány, kísérleti fúziós berendezések – fókuszban az ELFT ipari fizikusai}, url = {https://m2.mtmt.hu/api/publication/35629895}, author = {Hülber, Tímea Nóra and Szipőcs, Róbert}, journal-iso = {FIZIKAI SZEMLE}, journal = {FIZIKAI SZEMLE}, volume = {74}, unique-id = {35629895}, issn = {0015-3257}, year = {2024}, pages = {401-401}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339} } @{MTMT:33027964, title = {HARMONIZATION PROTOCOL ON THE QUALITY OF THE MICRONUCLEUS SAMPLES THAT ARE SCORED AUTOMATICALLY}, url = {https://m2.mtmt.hu/api/publication/33027964}, author = {Hülber, Tímea Nóra and Kocsis, Zsuzsa and Pesznyák, Csilla}, booktitle = {6th European Congress on Radiation Protection: Radiation Protection for Everyone}, unique-id = {33027964}, year = {2022}, pages = {246-246}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339; Kocsis, Zsuzsa/0000-0002-4336-3325; Pesznyák, Csilla/0000-0001-5815-0974} } @{MTMT:33027906, title = {AN OCT SCANNER FOR 3D ASSESMENT OF CLINICAL LINAC DOSE FIELDS AND DEVELOPMENTS OF SPECIFIC POLYMER GELS}, url = {https://m2.mtmt.hu/api/publication/33027906}, author = {Hülber, Tímea Nóra and Pesznyák, Csilla and Dávid, Fitala and Francesco, D’errico and Erik, Hülber}, booktitle = {6th European Congress on Radiation Protection: Radiation Protection for Everyone}, unique-id = {33027906}, year = {2022}, pages = {171-171}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339; Pesznyák, Csilla/0000-0001-5815-0974} } @mastersthesis{MTMT:32744456, title = {Automated analysis of chromosome damage}, url = {https://m2.mtmt.hu/api/publication/32744456}, author = {Hülber, Tímea Nóra}, publisher = {Budapest University of Technology and Economics}, unique-id = {32744456}, year = {2022}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339} } @article{MTMT:32150201, title = {Cytogenetic bio-dosimetry techniques in the detection of dicentric chromosomes induced by ionizing radiation: A review}, url = {https://m2.mtmt.hu/api/publication/32150201}, author = {Ludovici, G. M. and Cascone, M. G. and Hülber, Tímea Nóra and Chierici, A. and Gaudio, P. and de Souza, S. O. and d’Errico, F. and Malizia, A.}, doi = {10.1140/epjp/s13360-021-01447-3}, journal-iso = {EUR PHYS J PLUS}, journal = {EUROPEAN PHYSICAL JOURNAL PLUS}, volume = {136}, unique-id = {32150201}, issn = {2190-5444}, year = {2021}, eissn = {2190-5444}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339} } @article{MTMT:32127711, title = {Influence of sample preparation optimization on the accuracy of dose assessment of an automatic non-fluorescent MN scoring system.}, url = {https://m2.mtmt.hu/api/publication/32127711}, author = {Hülber, Tímea Nóra and Kocsis, Zsuzsa and Németh, J and Kis, Enikő and d'Errico, F and Sáfrány, Géza and Pesznyák, Csilla}, doi = {10.1080/09553002.2021.1962573}, journal-iso = {INT J RADIAT BIOL}, journal = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY}, volume = {97}, unique-id = {32127711}, issn = {0955-3002}, abstract = {Purpose - Automatizing the scoring of the cytokinesis-blocked micronucleus assay spares a lot of valuable time. The dose-effect relationship can be applied reliably for dose estimation, if the quality of the slides is the same from the perspective of the used image processing algorithm. This aspect brings in additional requirements against the quality of the slides compared to the conventional visual scoring.Materials and methods - An add-in software was created to the non-fluorescent RS-MN automatic MN scoring system which is capable of measuring quantitatively the degree of typical anomalies. The image processing is less reliable when the presence of these anomalies is more frequent. The behavior of the designed sample quality parameters (SQPs) was tested on in vitro irradiated peripheral blood samples (0, 1 and 2 Gy) obtained from a healthy donor and also on samples from patients undergoing low dose-rate brachytherapy.Results: We examined 20 different SQPs and identified two that are independent and correlate significantly with the error of the fully automatic MN frequency. One is related to the size of the cells and the other reflects the homogeneity of the environment. An equation was established which presents a connection between the error of the auto MN frequency and the SQPs. By adding a fourth cleaning step to the conventional sample preparation and changing the pre-dripping temperature of the slide, the SQP can be modified and consequently the sample quality can be improved. The gain in accuracy is 54 ± 10 MN per 1000 binucleated cells, which corresponds to the effects of 0.5 Gy. Around the lowest limit of detection (<0.5 Gy) it means a 50-100% drop in error of dose, which is significant. With sample quality harmonization, the positive predictive value was raised to 80 - 93% depending on the dose.Conclusions: With the technique described in this paper, the suitability for automated scoring of a micronucleus slide can be tested quantitatively and objectively. A method is presented with which in some cases the uncertainty of the assessed doses due to variance in sample quality can be decreased or if it is not possible its bias can be predicted. The proposed protocol leads to a more reliable estimation of dose. The SQPs are designed in a way that they have a potential to be adapted to similar systems.}, keywords = {biodosimetry; Automatic micronucleus assay (MN); quantified slide quality; sample preparation optimization}, year = {2021}, eissn = {1362-3095}, pages = {1470-1484}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339; Kocsis, Zsuzsa/0000-0002-4336-3325; Pesznyák, Csilla/0000-0001-5815-0974} } @article{MTMT:31169808, title = {A scanning and image processing system with integrated design for automated micronucleus scoring}, url = {https://m2.mtmt.hu/api/publication/31169808}, author = {Hülber, Tímea Nóra and Kocsis, Zsuzsa and Kis, Enikő and Sáfrány, Géza and Pesznyák, Csilla}, doi = {10.1080/09553002.2020.1722863}, journal-iso = {INT J RADIAT BIOL}, journal = {INTERNATIONAL JOURNAL OF RADIATION BIOLOGY}, volume = {96}, unique-id = {31169808}, issn = {0955-3002}, year = {2020}, eissn = {1362-3095}, pages = {628-641}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339; Kocsis, Zsuzsa/0000-0002-4336-3325; Pesznyák, Csilla/0000-0001-5815-0974} } @article{MTMT:30775666, title = {[P286] Study on semi-automatically evaluated micronucleus frequency changes in patients with prostate adenocarcinoma undergoing low and high dose rate brachytherapy}, url = {https://m2.mtmt.hu/api/publication/30775666}, author = {Hülber, Tímea Nóra and Kis, Enikő and Kocsis, Zsuzsa and Sáfrány, Géza and Pesznyák, Csilla}, doi = {10.1016/j.ejmp.2018.06.561}, journal-iso = {PHYS MEDICA}, journal = {PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS}, volume = {52}, unique-id = {30775666}, issn = {1120-1797}, year = {2018}, eissn = {1724-191X}, pages = {182-183}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339; Kocsis, Zsuzsa/0000-0002-4336-3325; Pesznyák, Csilla/0000-0001-5815-0974} } @article{MTMT:30763138, title = {Spectral characterization of laser-accelerated protons with CR-39 nuclear track detector}, url = {https://m2.mtmt.hu/api/publication/30763138}, author = {Seimetz, M. and Bellido, P. and García, P. and Mur, P. and Iborra, A. and Soriano, A. and Hülber, Tímea Nóra and García López, J. and Jiménez-Ramos, M. C. and Lera, R. and Ruiz-de la Cruz, A. and Sánchez, I. and Zaffino, R. and Roso, L. and Benlloch, J. M.}, doi = {10.1063/1.5009587}, journal-iso = {REV SCI INSTRUM}, journal = {REVIEW OF SCIENTIFIC INSTRUMENTS}, volume = {89}, unique-id = {30763138}, issn = {0034-6748}, year = {2018}, eissn = {1089-7623}, pages = {023302}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339} } @misc{MTMT:30649964, title = {Development of an image-processing based sample quality index for non-fluorescent micronucleus assay which offers extended robustness feature for automated scoring}, url = {https://m2.mtmt.hu/api/publication/30649964}, author = {Hülber, Tímea Nóra and Enikő, Kis and Kocsis, Zsuzsa and Sáfrány, Géza and Pesznyák, Csilla}, unique-id = {30649964}, year = {2018}, orcid-numbers = {Hülber, Tímea Nóra/0000-0002-0757-5339; Kocsis, Zsuzsa/0000-0002-4336-3325; Pesznyák, Csilla/0000-0001-5815-0974} }