@article{MTMT:33727646,
	title = {Investigation of the Antineoplastic Effects of 2-(4-Chlorophenyl)-13α-Estrone Sulfamate against the HPV16-Positive Human Invasive Cervical Carcinoma Cell Line SiHa},
	url = {https://m2.mtmt.hu/api/publication/33727646},
	author = {Ali, Hazhmat and Traj, Péter and Szebeni, Gábor and Gémes, Nikolett and Resch, Vivien Erzsébet and Paragi, Gábor and Mernyák, Erzsébet and Minorics, Renáta and Zupkó, István},
	doi = {10.3390/ijms24076625},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {24},
	unique-id = {33727646},
	issn = {1661-6596},
	abstract = {Cervical carcinoma is one of the most frequent malignant gynecological cancers in women of reproductive age. Because of the poor tolerability of currently available chemotherapeutic agents, efforts have been focused on developing innovative molecules, including steroids, that exert antineoplastic effects with a better safety profile. In addition to their endocrine properties, certain estrogens exhibit additional biological activities, such as antiangiogenic and anticancer effects. Based on previous studies, the antineoplastic properties of 13α-estrone sulfamate derivatives (13AES1-3) were investigated, and the mechanism of action for the most promising compound 13AES3 was explored. Based on their effects on the viability of different human adherent gynecological cancer cells, the SiHa cervical cell line was used for mechanistic experiments. The most active analog 13AES3 was shown to exert considerable proapoptotic effects, as evidenced by a colorimetric caspase-3 assay and fluorescent double staining. It also elicited antimigratory and anti-invasive effects in a concentration-dependent manner, as evidenced by wound healing and Boyden chamber assays, respectively. Regarding their mechanism of action, 13AES derivatives were shown to inhibit tubulin polymerization, and computer simulations provided a possible explanation for the importance of the presence of the chlorophenyl ring on the estrane skeleton. 13AES3 is considered to be the first 13α-estrone derivative with a significant antineoplastic potency against SiHa cancer cells. Therefore, it might serve as a valuable lead molecule for the design of anticancer agents targeting cervical carcinomas.},
	keywords = {APOPTOSIS; Antiproliferative; anti-invasive; 13α-estrone and cervical carcinoma; tubulin-microtubule system},
	year = {2023},
	eissn = {1422-0067},
	orcid-numbers = {Szebeni, Gábor/0000-0002-6998-5632; Resch, Vivien Erzsébet/0000-0003-0044-5731; Paragi, Gábor/0000-0001-5408-1748; Mernyák, Erzsébet/0000-0003-4494-1817; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300}
}

@article{MTMT:33594496,
	title = {Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers},
	url = {https://m2.mtmt.hu/api/publication/33594496},
	author = {Kovács, Édua and Ali, Hazhmat and Minorics, Renáta and Traj, Péter and Resch, Vivien Erzsébet and Paragi, Gábor and Bruszel, Bella and Zupkó, István and Mernyák, Erzsébet},
	doi = {10.3390/molecules28031196},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {33594496},
	issn = {1420-3049},
	abstract = {Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan–Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis. The antiproliferative activities of the newly synthesized diaryl ethers against a panel of human cancer cell lines (A2780, MCF-7, MDA-MB 231, HeLa, SiHa) were investigated by means of MTT assays. The quinoline derivative displayed substantial antiproliferative activity against MCF-7 and HeLa cell lines with low micromolar IC50 values. Disturbance of tubulin polymerization has been confirmed by microplate-based photometric assay. Computational calculations reveal significant interactions of the quinoline derivative with the taxoid binding site of tubulin.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Minorics, Renáta/0000-0001-9685-813X; Resch, Vivien Erzsébet/0000-0003-0044-5731; Paragi, Gábor/0000-0001-5408-1748; Zupkó, István/0000-0003-3243-5300; Mernyák, Erzsébet/0000-0003-4494-1817}
}

@{MTMT:33338885,
	title = {In Vitro Evaluation of Antiproliferative and Antimetastatic Activity of the Newly Synthesized 2-(4-Chlorophenyl)-13α-Estrone Sulfamate},
	url = {https://m2.mtmt.hu/api/publication/33338885},
	author = {Ali, Hazhmat and Mernyák, Erzsébet and Traj, Péter and Gábor, J. Szebeni and Minorics, Renáta and Zupkó, István},
	booktitle = {Natural vs. Artificial Networks: The Usefulness of the Concept in Health, Life, and Technical Sciences},
	unique-id = {33338885},
	year = {2022},
	pages = {81-82},
	orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300}
}

@CONFERENCE{MTMT:32585798,
	title = {Investigation of the anticancer potentials of the newly synthesized 13α- estrone derivatives},
	url = {https://m2.mtmt.hu/api/publication/32585798},
	author = {Ali, Hazhmat and Mernyák, Erzsébet and Traj, Péter and Szebeni, Gábor and Minorics, Renáta and Zupkó, István},
	booktitle = {11th ISCTICO – HUPHAR – IUPHAR – CONFERENCE},
	unique-id = {32585798},
	year = {2021},
	pages = {76-76},
	orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817; Szebeni, Gábor/0000-0002-6998-5632; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300}
}

@article{MTMT:31916683,
	title = {Transition metal-catalyzed A-ring C–H activations and C(sp2)–C(sp2) couplings in the 13α-estrone series and in vitro evaluation of antiproliferative properties},
	url = {https://m2.mtmt.hu/api/publication/31916683},
	author = {Traj, Péter and Ali, Hazhmat and Motzwickler-Németh, Anett and Dajcs, Sámuel Trisztán and Tömösi, Ferenc and Tea, Lanisnik-Rizner and Zupkó, István and Mernyák, Erzsébet},
	doi = {10.1080/14756366.2021.1900165},
	journal-iso = {J ENZYM INHIB MED CH},
	journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY},
	volume = {36},
	unique-id = {31916683},
	issn = {1475-6366},
	year = {2021},
	eissn = {1475-6374},
	pages = {895-902},
	orcid-numbers = {Tömösi, Ferenc/0000-0002-6657-5777; Zupkó, István/0000-0003-3243-5300; Mernyák, Erzsébet/0000-0003-4494-1817}
}

@inproceedings{MTMT:32585831,
	title = {Transition metal-catalyzed synthesis of 13α-estrone derivatives with potential anticancer properties},
	url = {https://m2.mtmt.hu/api/publication/32585831},
	author = {Traj, Péter and Ali, Hazhmat and Anett, Németh and Sámuel, Trisztán Dajcs and Zupkó, István and Mernyák, Erzsébet},
	booktitle = {Proceedings of the 26th International Symposium on Analytical and Environmental Problems},
	unique-id = {32585831},
	year = {2020},
	pages = {338-341},
	orcid-numbers = {Zupkó, István/0000-0003-3243-5300; Mernyák, Erzsébet/0000-0003-4494-1817}
}

@inproceedings{MTMT:32582948,
	title = {Átmenetifém-katalizált keresztkapcsolási és C-H aktiválási reakciók a 13α-ösztron sorban},
	url = {https://m2.mtmt.hu/api/publication/32582948},
	author = {Traj, Péter and Németh, Anett and Dajcs, Trisztán Sámuel and Mernyák, Erzsébet},
	booktitle = {XLIII. Kémiai Előadói Napok - Előadás összefoglalók},
	unique-id = {32582948},
	year = {2020},
	pages = {69-75},
	orcid-numbers = {Mernyák, Erzsébet/0000-0003-4494-1817}
}

@article{MTMT:31390677,
	title = {Mechanochemical and wet chemical syntheses of CaIn-layered double hydroxide and its performance in a transesterification reaction compared to those of other Ca2M(III) hydrocalumites (M: Al, Sc, V, Cr, Fe, Ga) and Mg(II)-, Ni(II)-, Co(II)- or Zn(II)-based hydrotalcites},
	url = {https://m2.mtmt.hu/api/publication/31390677},
	author = {Szabados, Márton and Ádám, Anna Adél and Traj, Péter and Muráth, Szabolcs and Baán, Kornélia and Bélteky, Péter and Kónya, Zoltán and Kukovecz, Ákos and Sipos, Pál Miklós and Pálinkó, István},
	doi = {10.1016/j.jcat.2020.07.038},
	journal-iso = {J CATAL},
	journal = {JOURNAL OF CATALYSIS},
	volume = {391},
	unique-id = {31390677},
	issn = {0021-9517},
	year = {2020},
	eissn = {1090-2694},
	pages = {282-297},
	orcid-numbers = {Szabados, Márton/0000-0002-7588-335X; Muráth, Szabolcs/0000-0002-7849-5678; Baán, Kornélia/0000-0001-7511-4422; Kónya, Zoltán/0000-0002-9406-8596; Kukovecz, Ákos/0000-0003-0716-9557; Sipos, Pál Miklós/0000-0003-1407-0950; Pálinkó, István/0000-0002-8508-309X}
}

@article{MTMT:30672179,
	title = {Synthesis, Biological Evaluation and Docking Studies of 13-Epimeric 10-fluoro- and 10-Chloroestra-1,4-dien-3-ones as Potential Aromatase Inhibitors},
	url = {https://m2.mtmt.hu/api/publication/30672179},
	author = {Jójárt, Rebeka and Traj, Péter and Kovács, Édua and Horváth, Ágnes and Schneider, Gyula and Szécsi, Mihály and Pál, Attila and Paragi, Gábor and Mernyák, Erzsébet},
	doi = {10.3390/molecules24091783},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {24},
	unique-id = {30672179},
	issn = {1420-3049},
	year = {2019},
	eissn = {1420-3049},
	orcid-numbers = {Szécsi, Mihály/0000-0002-4272-1362; Paragi, Gábor/0000-0001-5408-1748; Mernyák, Erzsébet/0000-0003-4494-1817}
}