@article{MTMT:35454226,
title = {Juvenile agile frogs spatially avoid ranavirus-infected conspecifics},
url = {https://m2.mtmt.hu/api/publication/35454226},
author = {Herczeg, Dávid and Horváth, Gergely and Bókony, Veronika and Herczeg, Gábor and Kásler, Andrea and Holly, Dóra and Mikó, Zsanett and Ujhegyi, Nikolett and Ujszegi, János and Papp, Tibor and Hettyey, Attila},
doi = {10.1038/s41598-024-74575-2},
journal-iso = {SCI REP},
journal = {SCIENTIFIC REPORTS},
volume = {14},
unique-id = {35454226},
year = {2024},
eissn = {2045-2322},
orcid-numbers = {Herczeg, Dávid/0000-0001-5098-961X; Horváth, Gergely/0000-0002-0485-333X; Bókony, Veronika/0000-0002-2136-5346; Herczeg, Gábor/0000-0003-0441-342X; Ujhegyi, Nikolett/0000-0001-9610-0353; Papp, Tibor/0000-0002-6402-3864}
}
@article{MTMT:34074949,
title = {Amphibian larvae benefit from a warm environment under simultaneous threat from chytridiomycosis and ranavirosis},
url = {https://m2.mtmt.hu/api/publication/34074949},
author = {Herczeg, Dávid and Holly, Dóra and Kásler, Andrea and Bókony, Veronika and Papp, Tibor and Takács-Vágó, Hunor and Ujszegi, János and Hettyey, Attila},
doi = {10.1111/oik.09953},
journal-iso = {OIKOS},
journal = {OIKOS},
volume = {2023},
unique-id = {34074949},
issn = {0030-1299},
abstract = {Rising temperatures can facilitate epizootic outbreaks, but disease outbreaks may be suppressed if temperatures increase beyond the optimum of the pathogens while still within the temperature range that allows for effective immune function in hosts. The two most devastating pathogens of wild amphibians, Batrachochytrium dendrobatidis (Bd) and ranaviruses (Rv), co‐occur in large areas, yet little is known about the consequences of their co‐infection and how these consequences depend on temperature. Here we tested how exposure to Bd and subsequent exposure to Rv, followed by treatment at elevated temperatures (28 and 30°C versus 22°C) affected Bd and Rv prevalence, infection intensities, and resulting mortalities in larval agile frogs and common toads. We found multiple pieces of evidence that the presence of one pathogen influenced the prevalence and/or infection intensity of the other pathogen in both species, depending on temperature and initial Rv concentration. Generally, the 30°C treatment lowered the prevalence and infection intensity of both pathogens and, in agile frogs, this was mirrored by higher survival. These results suggest that if temperatures naturally increase or are artificially elevated beyond what is ideal for both Bd and Rv, amphibians may be able to control infections and survive even the simultaneous presence of their most dangerous pathogenic enemies.},
year = {2023},
eissn = {1600-0706},
orcid-numbers = {Herczeg, Dávid/0000-0001-5098-961X; Bókony, Veronika/0000-0002-2136-5346; Papp, Tibor/0000-0002-6402-3864}
}
@article{MTMT:34010493,
title = {Does The Glucocorticoid Stress Response Make Toads More Toxic? An Experimental Study on The Regulation of Bufadienolide Toxin Synthesis},
url = {https://m2.mtmt.hu/api/publication/34010493},
author = {Üveges, Bálint and Kalina, C and Szabó, Krisztina and Móricz, Ágnes and Holly, Dóra and Gabor, C R and Hettyey, Attila and Bókony, Veronika},
doi = {10.1093/iob/obad021},
journal-iso = {INTEGR ORGAN BIOL},
journal = {INTEGRATIVE ORGANISMAL BIOLOGY},
volume = {5},
unique-id = {34010493},
abstract = {Chemical defence is a crucial component of fitness in many organisms, yet the physiological regulation of defensive toxin synthesis is poorly understood, especially in vertebrates. Bufadienolides, the main defensive compounds of toads, are toxic to many predators and other natural enemies, and their synthesis can be upregulated by stressors including predation risk, high conspecific density, and pollutants. Thus, higher toxin content may be the consequence of a general endocrine stress response in toads. Therefore, we hypothesized that bufadienolide synthesis may be stimulated by elevated levels of corticosterone (CORT), the main glucocorticoid hormone of amphibians, or by upstream regulators that stimulate CORT production. To test these alternatives, we treated common toad tadpoles with exogenous CORT (exoCORT) or metyrapone (MTP, a CORT-synthesis inhibitor that stimulates upstream regulators of CORT by negative feedback) in the presence or absence of predation cues for 2 or 6 days, and subsequently measured their CORT release rates and bufadienolide content. We found that CORT release rates were elevated by exoCORT, and to a lesser extent also by MTP, regardless of treatment length. Bufadienolide content was significantly decreased by treatment with exoCORT for 6 days, but was unaffected by exposure to exoCORT for 2 days or to MTP for either 6 or 2 days. Presence or absence of predation cues affected neither CORT release rate nor bufadienolide content. Our results suggest that changes in bufadienolide synthesis in response to environmental challenges are not driven by CORT but may rather be regulated by upstream hormones of the stress response.},
year = {2023},
eissn = {2517-4843},
orcid-numbers = {Üveges, Bálint/0000-0001-9234-9258; Gabor, C R/0000-0001-7584-1451; Bókony, Veronika/0000-0002-2136-5346}
}
@CONFERENCE{MTMT:33661348,
title = {A klímaváltozás és két piretroid rovarölőszer együttes hatásai juvenilis barna varangyok (Bufo bufo) fejlődésére és túlélésére},
url = {https://m2.mtmt.hu/api/publication/33661348},
author = {Kásler, Andrea and Bókony, Veronika and Mikó, Zsanett and Herczeg, Dávid and Ujszegi, János and Holly, Dóra and Hettyey, Attila},
booktitle = {69. NÖVÉNYVÉDELMI TUDOMÁNYOS NAPOK},
unique-id = {33661348},
year = {2023},
pages = {36},
orcid-numbers = {Bókony, Veronika/0000-0002-2136-5346; Herczeg, Dávid/0000-0001-5098-961X}
}
@CONFERENCE{MTMT:33661330,
title = {Ökotoxikológia egy komplex világban: peszticidek és patogének együttes hatásai erdei békákra (Rana dalmatina) a korai életszakaszban},
url = {https://m2.mtmt.hu/api/publication/33661330},
author = {Hettyey, Attila and Kásler, Andrea and Ujszegi, János and Holly, Dóra and Herczeg, Dávid},
booktitle = {69. NÖVÉNYVÉDELMI TUDOMÁNYOS NAPOK},
unique-id = {33661330},
year = {2023},
pages = {34},
orcid-numbers = {Herczeg, Dávid/0000-0001-5098-961X}
}
@article{MTMT:33582820,
title = {Chytridiomycosis and climate change: exposure to Batrachochytrium dendrobatidis and mild winter conditions do not increase mortality in juvenile agile frogs during hibernation},
url = {https://m2.mtmt.hu/api/publication/33582820},
author = {Kásler, Andrea and Holly, Dóra and Herczeg, Dávid and Ujszegi, János and Hettyey, Attila},
doi = {10.1111/acv.12851},
journal-iso = {ANIM CONSERV},
journal = {ANIMAL CONSERVATION},
volume = {26},
unique-id = {33582820},
issn = {1367-9430},
year = {2023},
eissn = {1469-1795},
pages = {654-662},
orcid-numbers = {Herczeg, Dávid/0000-0001-5098-961X}
}
@article{MTMT:32888499,
title = {In vitro thermal tolerance of a hypervirulent lineage of Batrachochytrium dendrobatidis : Growth arrestment by elevated temperature and recovery following thermal treatment},
url = {https://m2.mtmt.hu/api/publication/32888499},
author = {Kásler, Andrea and Ujszegi, János and Holly, Dóra and Jaloveczki, Boglárka and Gál, Zoltán and Hettyey, Attila},
doi = {10.1080/00275514.2022.2065443},
journal-iso = {MYCOLOGIA},
journal = {MYCOLOGIA},
volume = {114},
unique-id = {32888499},
issn = {0027-5514},
year = {2022},
eissn = {1557-2536},
pages = {661-669}
}
@article{MTMT:32837173,
title = {Metamorphic common toads keep chytrid infection under control, but at a cost},
url = {https://m2.mtmt.hu/api/publication/32837173},
author = {Kásler, Andrea and Ujszegi, János and Holly, Dóra and Üveges, Bálint and Móricz, Ágnes and Herczeg, Dávid and Hettyey, Attila},
doi = {10.1111/jzo.12974},
journal-iso = {J ZOOL},
journal = {JOURNAL OF ZOOLOGY},
volume = {317},
unique-id = {32837173},
issn = {0952-8369},
year = {2022},
eissn = {1469-7998},
pages = {159-169},
orcid-numbers = {Üveges, Bálint/0000-0001-9234-9258; Herczeg, Dávid/0000-0001-5098-961X}
}
@article{MTMT:32053850,
title = {Host–multiparasite interactions in amphibians: a review},
url = {https://m2.mtmt.hu/api/publication/32053850},
author = {Herczeg, Dávid and Ujszegi, János and Kásler, Andrea and Holly, Dóra and Hettyey, Attila},
doi = {10.1186/s13071-021-04796-1},
journal-iso = {PARASITE VECT},
journal = {PARASITES AND VECTORS},
volume = {14},
unique-id = {32053850},
issn = {1756-3305},
year = {2021},
eissn = {1756-3305},
orcid-numbers = {Herczeg, Dávid/0000-0001-5098-961X}
}
@article{MTMT:30740303,
title = {Mitigating Disease Impacts in Amphibian Populations: Capitalizing on the Thermal Optimum Mismatch Between a Pathogen and Its Host},
url = {https://m2.mtmt.hu/api/publication/30740303},
author = {Hettyey, Attila and Ujszegi, János and Herczeg, Dávid and Holly, Dóra and Vörös, Judit and Schmidt, Benedikt R. and Bosch, Jaime},
doi = {10.3389/fevo.2019.00254},
journal-iso = {FRONT ECOL EVOL},
journal = {FRONTIERS IN ECOLOGY AND EVOLUTION},
volume = {7},
unique-id = {30740303},
abstract = {Understanding how animal behavior can influence the susceptibility of endangered hosts to emerging pathogens and using this knowledge to ameliorate negative effects of infectious wildlife diseases is a promising avenue in conservation biology. Chytridiomycosis, an emerging infectious disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd) in amphibians has led to the most spectacular disease-borne loss of vertebrate biodiversity ever recorded in history. Unfortunately, the methods of mitigation that are available today are only practical in captive populations, and an effective method that could be applied in natural habitats without inflicting vast collateral damage is lacking. We suggest here that the thermal tolerance mismatch between Bd and its ectothermic hosts coupled with the thermoregulatory behavior of amphibians could be exploited in mitigation interventions combating Bd infection in situ. If microhabitats with elevated temperatures are made available in their natural environment, individuals taking advantage of the possibility to reach their preferred body temperature could critically lower their infection intensity or even clear the pathogen. We provide a basis for studying this approach by reviewing the evidence that supports the idea, describing how technical difficulties may be overcome, pointing out gaps in our knowledge that need to be filled by future studies, and listing presumable bene fits and probable limitations of localized heating. The proposed approach has good potential to become an effective in situ mitigation method that can be easily employed in a wide taxonomic range of amphibians, especially in species that are warm-adapted, while causing less collateral damage than any other method that is currently available. If so, it may quickly become a widely applicable tool of biodiversity conservation and may contribute to saving many amphibian populations and species from extinction in the next few decades.},
keywords = {Mitigation; THERMAL TOLERANCE; Batrachochytrium dendrobatidis; emerging infectious disease; Batrachochytrium salamandrivorans; heated shelter},
year = {2019},
eissn = {2296-701X},
orcid-numbers = {Herczeg, Dávid/0000-0001-5098-961X; Vörös, Judit/0000-0001-9707-1443}
}