@mastersthesis{MTMT:33628903,
	title = {A riluzol hatásmechanizmusának vizsgálata fotoaktiválható riluzol analóg segítségével},
	url = {https://m2.mtmt.hu/api/publication/33628903},
	author = {Földi, Mátyás Csaba},
	unique-id = {33628903},
	year = {2022}
}

@article{MTMT:32801600,
	title = {The Bradycardic Agent Ivabradine Acts as an Atypical Inhibitor of Voltage-Gated Sodium Channels},
	url = {https://m2.mtmt.hu/api/publication/32801600},
	author = {Hackl, Benjamin and Lukács, Péter and Ebner, Janine and Pesti, Krisztina and Haechl, Nicholas and Földi, Mátyás Csaba and Lilliu, Elena and Schicker, Klaus and Kubista, Helmut and Stary-Weinzinger, Anna and Hilber, Karlheinz and Mike, Árpád and Todt, Hannes and Koenig, Xaver},
	doi = {10.3389/fphar.2022.809802},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {13},
	unique-id = {32801600},
	year = {2022},
	eissn = {1663-9812},
	orcid-numbers = {Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:32676587,
	title = {Automated patch-clamp with automated analysis: extracting compound-specific, concentration-independent biophysical properties of inhibition for sodium channel inhibitors},
	url = {https://m2.mtmt.hu/api/publication/32676587},
	author = {Mike, Árpád and Pesti, Krisztina and Földi, Mátyás Csaba and Tóth, Ádám Viktor and Zboray, Katalin and Lukács, Péter},
	doi = {10.1016/j.bpj.2021.11.2238},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {121},
	unique-id = {32676587},
	issn = {0006-3495},
	year = {2022},
	eissn = {1542-0086},
	pages = {92-92},
	orcid-numbers = {Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:32468284,
	title = {An Advanced Automated Patch Clamp Protocol Design to Investigate Drug—Ion Channel Binding Dynamics},
	url = {https://m2.mtmt.hu/api/publication/32468284},
	author = {Lukács, Péter and Pesti, Krisztina and Földi, Mátyás Csaba and Zboray, Katalin and Tóth, Ádám Viktor and Papp, Gábor and Mike, Árpád},
	doi = {10.3389/fphar.2021.738260},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {12},
	unique-id = {32468284},
	year = {2021},
	eissn = {1663-9812},
	orcid-numbers = {Papp, Gábor/0000-0001-5038-678X; Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:32218209,
	title = {Characterization of Compound-Specific, Concentration-Independent Biophysical Properties of Sodium Channel Inhibitor Mechanism of Action Using Automated Patch-Clamp Electrophysiology},
	url = {https://m2.mtmt.hu/api/publication/32218209},
	author = {Pesti, Krisztina and Földi, Mátyás Csaba and Zboray, Katalin and Tóth, Ádám Viktor and Lukács, Péter and Mike, Árpád},
	doi = {10.3389/fphar.2021.738460},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {12},
	unique-id = {32218209},
	year = {2021},
	eissn = {1663-9812},
	orcid-numbers = {Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:31821613,
	title = {The mechanism of non-blocking inhibition of sodium channels revealed by conformation-selective photolabeling},
	url = {https://m2.mtmt.hu/api/publication/31821613},
	author = {Földi, Mátyás Csaba and Pesti, Krisztina and Zboray, Katalin and Tóth, Ádám Viktor and Hegedűs, Tamás and Málnási Csizmadia, András and Lukács, Péter and Mike, Árpád},
	doi = {10.1111/bph.15365},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	volume = {178},
	unique-id = {31821613},
	issn = {0007-1188},
	abstract = {Sodium channel inhibitors can be used to treat hyperexcitability-related diseases, including epilepsies, pain syndromes, neuromuscular disorders, and cardiac arrhythmias. The applicability of these drugs is limited by their nonspecific effect on physiological function. They act mainly by sodium channel block and in addition by modulation of channel kinetics. While channel block inhibits healthy and pathological tissue equally, modulation can preferentially inhibit pathological activity. An ideal drug designed to target the sodium channels of pathological tissue would act predominantly by modulation. Thus far, no such drug has been described.Patch-clamp experiments with ultra-fast solution exchange and photolabeling-coupled electrophysiology were applied to describe the unique mechanism of riluzole on Nav1.4 sodium channels. In silico docking experiments were used to study the molecular details of binding.We present evidence that riluzole acts predominantly by non-blocking modulation. We propose that, being a relatively small molecule, riluzole is able to stay bound to the binding site, but nonetheless stay off the conduction pathway, by residing in one of the fenestrations. We demonstrate how this mechanism can be recognized.Our results identify riluzole as the prototype of this new class of sodium channel inhibitors. Drugs of this class are expected to selectively prevent hyperexcitability, while having minimal effect on cells firing at a normal rate from a normal resting potential.},
	keywords = {EPILEPSY; PAIN; BINDING SITES; Sodium Channels; ARRHYTHMIAS; riluzole; local anesthetics},
	year = {2021},
	eissn = {1476-5381},
	pages = {1200-1217},
	orcid-numbers = {Hegedűs, Tamás/0000-0002-0331-9629; Málnási Csizmadia, András/0000-0002-2430-8398; Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:31180515,
	title = {Development of a Smell Biosensor System for Early Detection of Plant Diseases},
	url = {https://m2.mtmt.hu/api/publication/31180515},
	author = {Miskolczi, Tímea Dóra and Zboray, Katalin and Keszőcze, Anikó Zsófia and Quddoos, Zainab and Ambrózy, Zsuzsanna and Hamow, Kamirán Áron and Tóth, Ádám Viktor and Sági, László and Szelényi, Magdolna Olívia and Radványi, Dalma and Földi, Mátyás Csaba and Molnár, Béla Péter and Pesti, Krisztina and Mike, Árpád and Lukács, Péter},
	doi = {10.1016/j.bpj.2019.11.1774},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {118},
	unique-id = {31180515},
	issn = {0006-3495},
	year = {2020},
	eissn = {1542-0086},
	pages = {315A-315A},
	orcid-numbers = {Hamow, Kamirán Áron/0000-0002-7089-1078; Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:31179616,
	title = {Riluzole as a Prototype of a New Class of Sodium Channel Inhibitors},
	url = {https://m2.mtmt.hu/api/publication/31179616},
	author = {Földi, Mátyás Csaba and Lukács, Péter and Pesti, Krisztina and Málnási Csizmadia, András and Mike, Árpád},
	doi = {10.1016/j.bpj.2019.11.3130},
	journal-iso = {BIOPHYS J},
	journal = {BIOPHYSICAL JOURNAL},
	volume = {118},
	unique-id = {31179616},
	issn = {0006-3495},
	year = {2020},
	eissn = {1542-0086},
	pages = {576A-576A},
	orcid-numbers = {Málnási Csizmadia, András/0000-0002-2430-8398; Mike, Árpád/0000-0002-9095-8161}
}

@article{MTMT:3397475,
	title = {Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog},
	url = {https://m2.mtmt.hu/api/publication/3397475},
	author = {Lukács, Péter and Földi, Mátyás Csaba and Valanszki, L and Casanova, E and Biri-Kovács, Beáta and Nyitray, László and Málnási Csizmadia, András and Mike, Árpád},
	doi = {10.1038/s41598-018-26444-y},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {8},
	unique-id = {3397475},
	issn = {2045-2322},
	abstract = {Sodium channel inhibitor drugs decrease pathological hyperactivity in various diseases including pain syndromes, myotonia, arrhythmias, nerve injuries and epilepsies. Inhibiting pathological but not physiological activity, however, is a major challenge in drug development. Sodium channel inhibitors exert their effects by a dual action: they obstruct ion flow ("block"), and they alter the energetics of channel opening and closing ("modulation"). Ideal drugs would be modulators without blocking effect, because modulation is inherently activity-dependent, therefore selective for pathological hyperactivity. Can block and modulation be separated? It has been difficult to tell, because the effect of modulation is obscured by conformation-dependent association/dissociation of the drug. To eliminate dynamic association/dissociation, we used a photoreactive riluzole analog which could be covalently bound to the channel; and found, unexpectedly, that drug-bound channels could still conduct ions, although with modulated gating. The finding that non-blocking modulation is possible, may open a novel avenue for drug development because non-blocking modulators could be more specific in treating hyperactivity-linked diseases.},
	keywords = {NEURONS; MECHANISMS; RECEPTORS; RECOMBINATION; CONFORMATIONS; Electrophysiology; lidocaine; DRUG DISCOVERY; LOCAL-ANESTHETICS; DEPENDENT BLOCK},
	year = {2018},
	eissn = {2045-2322},
	orcid-numbers = {Biri-Kovács, Beáta/0000-0001-5803-9969; Nyitray, László/0000-0003-4717-5994; Málnási Csizmadia, András/0000-0002-2430-8398; Mike, Árpád/0000-0002-9095-8161}
}