TY - JOUR AU - Gyürkés, Martin AU - Tacsi, Kornélia AU - Pataki, Hajnalka AU - Farkas, Attila TI - Residence Time Distribution-Based Smith Predictor: an Advanced Feedback Control for Dead Time–Dominated Continuous Powder Blending Process JF - JOURNAL OF PHARMACEUTICAL INNOVATION J2 - J PHARM INNOV VL - 18 PY - 2023 IS - 3 SP - 1381 EP - 1394 PG - 14 SN - 1872-5120 DO - 10.1007/s12247-023-09728-3 UR - https://m2.mtmt.hu/api/publication/33813141 ID - 33813141 N1 - Funding Agency and Grant Number: Budapest University of Technology and Economics; OTKA [FK-143019]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund [UNKP-223-II-BME-171]; National Laboratory of Artificial Intelligence - NRDIO Funding text: Open access funding provided by Budapest University of Technology and Economics. This work was supported by OTKA grant FK-143019. This work was supported by the UNKP-22-3-II-BME-171. New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. The research reported in this paper and carried out at BME has been supported by the National Laboratory of Artificial Intelligence funded by the NRDIO under the auspices of the Ministry for Innovation and Technology. LA - English DB - MTMT ER - TY - JOUR AU - Záhonyi, Petra AU - Szabó, Edina AU - Domokos, A. AU - Péter-Haraszti, Anna AU - Gyürkés, Martin AU - Moharos, E. AU - Nagy, Zsombor Kristóf TI - Continuous integrated production of glucose granules with enhanced flowability and tabletability JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 626 PY - 2022 PG - 11 SN - 0378-5173 DO - 10.1016/j.ijpharm.2022.122197 UR - https://m2.mtmt.hu/api/publication/33126966 ID - 33126966 N1 - Export Date: 5 October 2022 CODEN: IJPHD Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Hungary; email: zsknagy@oct.bme.hu AB - Glucose is widely used in both the food and pharmaceutical industry. However, the application of industrially crystallized glucose in solid dosage forms is challenged by its poor flowability and tabletability. To improve these characteristics continuous twin-screw granulation was tested, which has the potential to be integrated into the continuous production of solid glucose from corn starch. A completely continuous manufacturing line (including drying and milling) was developed and the different production steps were examined and synchronized. Our line was supplemented with an in-line applicable near-infrared spectroscopic probe to monitor the moisture content of the milled granules in real-time. The flowability and tabletability of the powder improved significantly, and tablets with acceptable breaking force (greater than 100 N) could be prepared from the granules. The developed continuous line can be easily installed into the industrial solid glucose production process resulting in pure glucose granules with adequate flow properties and tabletability in a simple, continuous and efficient way. LA - English DB - MTMT ER - TY - JOUR AU - Gyürkés, Martin AU - Madarász, Lajos AU - Záhonyi, Petra AU - Köte, Ákos AU - Nagy, Brigitta AU - Pataki, Hajnalka AU - Nagy, Zsombor Kristóf AU - Domokos, András AU - Farkas, Attila TI - Soft sensor for content prediction in an integrated continuous pharmaceutical formulation line based on the residence time distribution of unit operations JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 624 PY - 2022 PG - 12 SN - 0378-5173 DO - 10.1016/j.ijpharm.2022.121950 UR - https://m2.mtmt.hu/api/publication/32918786 ID - 32918786 N1 - Export Date: 15 July 2022 CODEN: IJPHD Funding details: Hungarian Scientific Research Fund, OTKA, FK-132133, ÚNKP-21-3-II-BME-309, ÚNKP-21-4-I-BME-329 Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding details: Innovációs és Technológiai Minisztérium Funding text 1: A. Farkas acknowledges the financial support received through the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences, later Eötvös Loránd Research Network. This work was supported by OTKA grant FK-132133. This work was supported by the ÚNKP-21-3-II-BME-309 and ÚNKP-21-4-I-BME-329. New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. The research reported in this paper and carried out at BME has been supported by the National Laboratory of Artificial Intelligence funded by the NRDIO under the auspices of the Ministry for Innovation and Technology. AB - In this study, a concentration predicting soft sensor was achieved based on the Residence Time Distribution (RTD) of an integrated, three-step pharmaceutical formulation line. The RTD was investigated with color-based tracer experiments using image analysis. Twin-screw wet granulation (TSWG) was directly coupled with a horizontal fluid bed dryer and an oscillating mill. Based on integrated measurement, we proved that it is also possible to couple the unit operations in silico. Three surrogate tracers were produced with a coloring agent to investigate the separated unit operations and the solid and liquid inputs of the TSWG. The soft sensor’s prediction was compared to validating experiments of a 0.05 mg/g (15% of the nominal) concentration change with High-Performance Liquid Chromatography (HPLC) reference measurements of the active ingredient proving the adequacy of the soft sensor (RMSE < 4%). LA - English DB - MTMT ER - TY - JOUR AU - Domján, Júlia AU - Pantea, Eszter AU - Gyürkés, Martin AU - Madarász, Lajos AU - Kozák, Dóra AU - Farkas, Attila AU - Horváth, Balázs AU - Benkő, Zsuzsa AU - Nagy, Zsombor Kristóf AU - Marosi, György AU - Hirsch, Edit TI - Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using raman spectroscopy JF - BIOTECHNOLOGY JOURNAL J2 - BIOTECHNOL J VL - 17 PY - 2022 IS - 5 PG - 14 SN - 1860-6768 DO - 10.1002/biot.202100395 UR - https://m2.mtmt.hu/api/publication/32633240 ID - 32633240 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Fund of Hungary [FIEK_16-1-2016-0007]; Gedeon Richter's Talentum Foundation; PREMIUM post-doctorate research program of the Hungarian Academy of Sciences; New National Excellence Program of The Ministry for Innovation and Technology [UNKP-20-3-I-BME-306, UNKP-20-3-I-562 BME] Funding text: National Research, Development and Innovation Fund of Hungary, Grant/Award Number: FIEK_16-1-2016-0007; Ph.D. scholarship from Gedeon Richter's Talentum Foundation; PREMIUM post-doctorate research programof the Hungarian Academy of Sciences; UNKP-20-3-I-BME-306, UNKP-20-3-I-562 BME by New National Excellence Program of The Ministry for Innovation and Technology AB - An innovative, Raman spectroscopy-based monitoring and control system is introduced in this paper for designing dynamic feeding strategies that allow the maintenance of key cellular nutrients at an ideal level in Chinese hamster ovary cell culture. The Partial Least Squares calibration models built for glucose, lactate and 16 (out of 20) individual amino acids had very good predictive power with low root mean square errors values and high square correlation coefficients. The developed models used for real-time measurement of nutrient and by-product concentrations allowed us to gain better insight into the metabolic behavior and nutritional consumption of cells. To establish a more beneficial nutritional environment for the cells, two types of dynamic feeding strategies were used to control the delivery of two-part multi-component feed media according to the prediction of Raman models (glucose or arginine). As a result, instead of high fluctuations, the nutrients (glucose together with amino acids) were maintained at the desired level providing a more balanced environment for the cells. Moreover, the use of amino acid-based feeding control enabled to prevent the excessive nutrient replenishment and was economically beneficial by significantly reducing the amount of supplied feed medium compared to the glucose-based dynamic fed culture. LA - English DB - MTMT ER - TY - JOUR AU - Beke, Áron Kristóf AU - Gyürkés, Martin AU - Nagy, Zsombor Kristóf AU - Marosi, György AU - Farkas, Attila TI - Digital Twin of Low Dosage Continuous Powder Blending - Artificial Neural Networks and Residence Time Distribution Models JF - EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS J2 - EUR J PHARM BIOPHARM VL - 169 PY - 2021 SP - 64 EP - 77 PG - 14 SN - 0939-6411 DO - 10.1016/j.ejpb.2021.09.006 UR - https://m2.mtmt.hu/api/publication/32244801 ID - 32244801 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Fund of Hungary,under the FIEK_16 funding scheme [FIEK_16-1-2016-0007]; National Research, Development and Innovation Office of HungaryNational Research, Development & Innovation Office (NRDIO) - Hungary [KH-129584, FK-132133]; Eodtvods Lorand Research Network; New National Excellence Program of the Ministry for Innovation and Technology from National Research, Development, and Innovation Fund [uNKP-20-1] Funding text: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from grants by National Research, Development and Innovation Office of Hungary (grant numbers: KH-129584, FK-132133) . Attila Farkas ac-knowledges the financial support received through the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences, later Eodtvods Lorand Research Network. This project was supported by the uNKP-20-1 New National Excellence Program of the Ministry for Inno-vation and Technology from the source of the National Research, Development, and Innovation Fund. LA - English DB - MTMT ER - TY - JOUR AU - Szabó, Edina AU - Záhonyi, Petra AU - Gyürkés, Martin AU - Nagy, Brigitta AU - Galata, Dorián László AU - Madarász, Lajos AU - Hirsch, Edit AU - Farkas, Attila AU - Andersen, Sune K. AU - Vigh, Tamás AU - Verreck, Geert AU - Csontos, István AU - Marosi, György AU - Nagy, Zsombor Kristóf TI - Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy JF - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES J2 - EUR J PHARM SCI VL - 164 PY - 2021 PG - 12 SN - 0928-0987 DO - 10.1016/j.ejps.2021.105907 UR - https://m2.mtmt.hu/api/publication/32063872 ID - 32063872 N1 - Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), H-1111, Budapest, Műegyetem rakpart 3, Hungary Oral Solids Development, Janssen R&D, B-2340 Beerse, Turnhoutseweg 30, Belgium Export Date: 6 September 2021 CODEN: EPSCE Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, H-1111, Budapest, Műegyetem rakpart 3, Hungary; email: zsknagy@oct.bme.hu Chemicals/CAS: itraconazole, 84625-61-6; Excipients; Itraconazole; Tablets Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-20-2-I Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, FK-132133, KH-112644, PD-121143 Funding text 1: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from grants by National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644 , FK-132133 , PD-121143 ). Attila Farkas acknowledges the financial support received through the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. This project was supported by the ÚNKP-20-2-I and the ÚNKP-20-3-I New National Excellence Program of the Ministry of Human Capacities. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), H-1111, Budapest, Műegyetem rakpart 3, Hungary Oral Solids Development, Janssen R&D, B-2340 Beerse, Turnhoutseweg 30, Belgium Export Date: 7 September 2021 CODEN: EPSCE Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, H-1111, Budapest, Műegyetem rakpart 3, Hungary; email: zsknagy@oct.bme.hu Chemicals/CAS: itraconazole, 84625-61-6; Excipients; Itraconazole; Tablets Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-20-2-I Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, FK-132133, KH-112644, PD-121143 Funding text 1: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from grants by National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644 , FK-132133 , PD-121143 ). Attila Farkas acknowledges the financial support received through the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. This project was supported by the ÚNKP-20-2-I and the ÚNKP-20-3-I New National Excellence Program of the Ministry of Human Capacities. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), H-1111, Budapest, Műegyetem rakpart 3, Hungary Oral Solids Development, Janssen R&D, B-2340 Beerse, Turnhoutseweg 30, Belgium Export Date: 8 September 2021 CODEN: EPSCE Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, H-1111, Budapest, Műegyetem rakpart 3, Hungary; email: zsknagy@oct.bme.hu Chemicals/CAS: itraconazole, 84625-61-6; Excipients; Itraconazole; Tablets Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-20-2-I Funding details: Emberi Eroforrások Minisztériuma, EMMI Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, FK-132133, KH-112644, PD-121143 Funding text 1: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from grants by National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644 , FK-132133 , PD-121143 ). Attila Farkas acknowledges the financial support received through the PREMIUM post-doctorate research program of the Hungarian Academy of Sciences. This project was supported by the ÚNKP-20-2-I and the ÚNKP-20-3-I New National Excellence Program of the Ministry of Human Capacities. LA - English DB - MTMT ER - TY - JOUR AU - Domokos, András AU - Pusztai, Éva AU - Madarász, Lajos AU - Nagy, Brigitta AU - Gyürkés, Martin AU - Farkas, Attila AU - Fülöp, Gergő AU - Casian, Tibor AU - Szilágyi, Botond AU - Nagy, Zsombor Kristóf TI - Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line: Rapid and deep process understanding JF - POWDER TECHNOLOGY J2 - POWDER TECHNOL VL - 388 PY - 2021 SP - 70 EP - 81 PG - 12 SN - 0032-5910 DO - 10.1016/j.powtec.2021.04.059 UR - https://m2.mtmt.hu/api/publication/31994941 ID - 31994941 N1 - Budapest University of Technology and Economics, Organic Chemistry and Technology Department, Budapest, H-1111, Hungary Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Budapest, H-1111, Hungary Department of Pharmaceutical Technology and Biopharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, 400012, Romania Budapest University of Technology and Economics, Faculty of Chemical Technology and Biotechnology, Budapest, H-1111, Hungary Export Date: 17 June 2021 CODEN: POTEB Correspondence Address: Szilágyi, B.; Budapest University of Technology and Economics, Hungary; email: szilagyi.botond@vbk.bme.hu AB - Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw wet granulation, vibrational fluid-bed drying and milling. A Partial Least Squares (PLS) regression model was built using Near-infrared (NIR) spectroscopy for the real-time monitoring of the product moisture content after the milling step. A split-plot full factorial experimental design was set up and executed to help the understanding of the relationships between the moisture content and process parameters. Furthermore, a mechanistic model was built, involving heat transfer between the drying air and the solid material. The unknown kinetic model parameters were estimated using the results of the experimental study resulting in good calibration and validation performance. The simulations not only reinforced the experimental observations but also paves the way for model-based process monitoring and optimal control. LA - English DB - MTMT ER - TY - JOUR AU - Bordácsné Bocz, Katalin AU - Ronkay, Ferenc György AU - Molnár, Béla AU - Vadas, Dániel AU - Gyürkés, Martin AU - Gere, Dániel AU - Marosi, György AU - Czigány, Tibor TI - Recycled PET foaming: supercritical carbon dioxide assisted extrusion with real-time quality monitoring JF - ADVANCED INDUSTRIAL AND ENGINEERING POLYMER RESEARCH J2 - ADV INDUST ENGIN POLYMER RES VL - 4 PY - 2021 IS - 3 SP - 178 EP - 186 PG - 10 SN - 2542-5048 DO - 10.1016/j.aiepr.2021.03.002 UR - https://m2.mtmt.hu/api/publication/31916949 ID - 31916949 N1 - Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-1111, Hungary Imsys Ltd, Material Testing Laboratory, Mozaik Street 14/A., Budapest, H-1033, Hungary Department of Polymer Engineering, Faculty of Mechanical Engineering, Budapest University of Technology and Economics, Műegyetem rkp. 3., Budapest, H-1111, Hungary MTA-BME Research Group for Composite Science and Technology, H-1111 Budapest, Muegyetem rkp. 3., Budapest, H-1111, Hungary Cited By :2 Export Date: 14 October 2022 Correspondence Address: Czigany, T.; Department of Polymer Engineering, Műegyetem rkp. 3., Hungary; email: czigany@eik.bme.hu LA - English DB - MTMT ER - TY - JOUR AU - Fülöp, Gergő AU - Domokos, András AU - Galata, Dorián László AU - Szabó, Edina AU - Gyürkés, Martin AU - Szabó, B. AU - Farkas, Attila AU - Madarász, Lajos AU - Démuth, Balázs AU - Lendér, T. AU - Nagy, T. AU - Kovács-Kiss, D. AU - Van der Gucht, F. AU - Marosi, György AU - Nagy, Zsombor Kristóf TI - Integrated twin-screw wet granulation, continuous vibrational fluid drying and milling: A fully continuous powder to granule line JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 594 PY - 2021 PG - 12 SN - 0378-5173 DO - 10.1016/j.ijpharm.2020.120126 UR - https://m2.mtmt.hu/api/publication/31831437 ID - 31831437 N1 - Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 31111 Budapest, Hungary Gedeon Richter Plc., Formulation R&D, Gyömrői u. 19-21H-1103 Budapest, Hungary ProCepT N.V., Industriepark Rosteyne 4, Zelzate, 9060, Belgium Export Date: 9 February 2021 CODEN: IJPHD Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: zsknagy@oct.bme.hu Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 31111 Budapest, Hungary Gedeon Richter Plc., Formulation R&D, Gyömrői u. 19-21H-1103 Budapest, Hungary ProCepT N.V., Industriepark Rosteyne 4, Zelzate, 9060, Belgium Cited By :1 Export Date: 26 April 2021 CODEN: IJPHD Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: zsknagy@oct.bme.hu Department of Organic Chemistry and Technology, Budapest University of Technology and Economics (BME), Műegyetem rkp. 31111 Budapest, Hungary Gedeon Richter Plc., Formulation R&D, Gyömrői u. 19-21H-1103 Budapest, Hungary ProCepT N.V., Industriepark Rosteyne 4, Zelzate, 9060, Belgium Cited By :1 Export Date: 27 April 2021 CODEN: IJPHD Correspondence Address: Nagy, Z.K.; Department of Organic Chemistry and Technology, Műegyetem rkp. 3, Hungary; email: zsknagy@oct.bme.hu LA - English DB - MTMT ER - TY - JOUR AU - Gyürkés, Martin AU - Madarász, Lajos AU - Köte, Ákos AU - Domokos, András AU - Mészáros, Dániel AU - Beke, Áron Kristóf AU - Nagy, Brigitta AU - Marosi, György AU - Pataki, Hajnalka AU - Nagy, Zsombor Kristóf AU - Farkas, Attila TI - Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 12 PY - 2020 IS - 11 SN - 1999-4923 DO - 10.3390/pharmaceutics12111119 UR - https://m2.mtmt.hu/api/publication/31678236 ID - 31678236 N1 - Export Date: 9 February 2021 Correspondence Address: Farkas, A.; Department of Organic Chemistry and Technology, Műegyetem rakpart 3, Hungary; email: farkas.attila@mail.bme.hu Export Date: 18 March 2021 Correspondence Address: Farkas, A.; Department of Organic Chemistry and Technology, Műegyetem rakpart 3, Hungary; email: farkas.attila@mail.bme.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; microcrystalline cellulose, 39394-43-9, 51395-75-6 Funding details: Hungarian Scientific Research Fund, OTKA Funding details: Magyar Tudományos Akadémia, MTA Funding details: National Research, Development and Innovation Office, FK-132133, KH-112644, PD-121143 Funding text 1: Funding: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from OTKA grants by the National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644, FK-132133, PD-121143). H.P. is thankful for the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.F. acknowledges the financial support received through the PREMIUM postdoctorate research program of the Hungarian Academy of Sciences. Export Date: 26 April 2021 Correspondence Address: Farkas, A.; Department of Organic Chemistry and Technology, Műegyetem rakpart 3, Hungary; email: farkas.attila@mail.bme.hu Export Date: 27 April 2021 Correspondence Address: Farkas, A.; Department of Organic Chemistry and Technology, Műegyetem rakpart 3, Hungary; email: farkas.attila@mail.bme.hu Cited By :1 Export Date: 29 May 2021 Correspondence Address: Farkas, A.; Department of Organic Chemistry and Technology, Műegyetem rakpart 3, Hungary; email: farkas.attila@mail.bme.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; microcrystalline cellulose, 39394-43-9, 51395-75-6 Funding details: Hungarian Scientific Research Fund, OTKA Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: National Research, Development and Innovation Office, FK-132133, KH-112644, PD-121143 Funding text 1: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from OTKA grants by the National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644, FK-132133, PD-121143). H.P. is thankful for the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.F. acknowledges the financial support received through the PREMIUM postdoctorate research program of the Hungarian Academy of Sciences. Funding text 2: Funding: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from OTKA grants by the National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644, FK-132133, PD-121143). H.P. is thankful for the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.F. acknowledges the financial support received through the PREMIUM postdoctorate research program of the Hungarian Academy of Sciences. Funding Agency and Grant Number: National Research, Development and Innovation Fund of Hungary [FIEK_16-1-2016-0007]; OTKA grants by the National Research, Development and Innovation Office of Hungary [KH-112644, FK-132133, PD-121143]; Hungarian Academy of SciencesHungarian Academy of Sciences; PREMIUM postdoctorate research program of the Hungarian Academy of Sciences Funding text: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from OTKA grants by the National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644, FK-132133, PD-121143). H.P. is thankful for the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.F. acknowledges the financial support received through the PREMIUM postdoctorate research program of the Hungarian Academy of Sciences. Cited By :3 Export Date: 13 September 2021 Correspondence Address: Farkas, A.; Department of Organic Chemistry and Technology, Műegyetem rakpart 3, Hungary; email: farkas.attila@mail.bme.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; microcrystalline cellulose, 39394-43-9, 51395-75-6 Funding details: Hungarian Scientific Research Fund, OTKA Funding details: Magyar Tudományos Akadémia, MTA Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH Funding details: National Research, Development and Innovation Office, FK-132133, KH-112644, PD-121143 Funding text 1: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from OTKA grants by the National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644, FK-132133, PD-121143). H.P. is thankful for the J?nos Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.F. acknowledges the financial support received through the PREMIUM postdoctorate research program of the Hungarian Academy of Sciences. Funding text 2: Funding: This work was performed in the frame of FIEK_16-1-2016-0007 project, implemented with the support provided from the National Research, Development and Innovation Fund of Hungary, financed under the FIEK_16 funding scheme. This research was supported from OTKA grants by the National Research, Development and Innovation Office of Hungary (grant numbers: KH-112644, FK-132133, PD-121143). H.P. is thankful for the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. A.F. acknowledges the financial support received through the PREMIUM postdoctorate research program of the Hungarian Academy of Sciences. LA - English DB - MTMT ER -