@article{MTMT:33813141,
	title = {Residence Time Distribution-Based Smith Predictor: an Advanced Feedback Control for Dead Time–Dominated Continuous Powder Blending Process},
	url = {https://m2.mtmt.hu/api/publication/33813141},
	author = {Gyürkés, Martin and Tacsi, Kornélia and Pataki, Hajnalka and Farkas, Attila},
	doi = {10.1007/s12247-023-09728-3},
	journal-iso = {J PHARM INNOV},
	journal = {JOURNAL OF PHARMACEUTICAL INNOVATION},
	volume = {18},
	unique-id = {33813141},
	issn = {1872-5120},
	year = {2023},
	eissn = {1939-8042},
	pages = {1381-1394},
	orcid-numbers = {Farkas, Attila/0000-0002-8877-2587}
}

@article{MTMT:33126966,
	title = {Continuous integrated production of glucose granules with enhanced flowability and tabletability},
	url = {https://m2.mtmt.hu/api/publication/33126966},
	author = {Záhonyi, Petra and Szabó, Edina and Domokos, A. and Péter-Haraszti, Anna and Gyürkés, Martin and Moharos, E. and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ijpharm.2022.122197},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {626},
	unique-id = {33126966},
	issn = {0378-5173},
	abstract = {Glucose is widely used in both the food and pharmaceutical industry. However, the application of industrially crystallized glucose in solid dosage forms is challenged by its poor flowability and tabletability. To improve these characteristics continuous twin-screw granulation was tested, which has the potential to be integrated into the continuous production of solid glucose from corn starch. A completely continuous manufacturing line (including drying and milling) was developed and the different production steps were examined and synchronized. Our line was supplemented with an in-line applicable near-infrared spectroscopic probe to monitor the moisture content of the milled granules in real-time. The flowability and tabletability of the powder improved significantly, and tablets with acceptable breaking force (greater than 100 N) could be prepared from the granules. The developed continuous line can be easily installed into the industrial solid glucose production process resulting in pure glucose granules with adequate flow properties and tabletability in a simple, continuous and efficient way.},
	year = {2022},
	eissn = {1873-3476},
	orcid-numbers = {Szabó, Edina/0000-0001-9616-5122}
}

@article{MTMT:32918786,
	title = {Soft sensor for content prediction in an integrated continuous pharmaceutical formulation line based on the residence time distribution of unit operations},
	url = {https://m2.mtmt.hu/api/publication/32918786},
	author = {Gyürkés, Martin and Madarász, Lajos and Záhonyi, Petra and Köte, Ákos and Nagy, Brigitta and Pataki, Hajnalka and Nagy, Zsombor Kristóf and Domokos, András and Farkas, Attila},
	doi = {10.1016/j.ijpharm.2022.121950},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {624},
	unique-id = {32918786},
	issn = {0378-5173},
	abstract = {In this study, a concentration predicting soft sensor was achieved based on the Residence Time Distribution (RTD) of an integrated, three-step pharmaceutical formulation line. The RTD was investigated with color-based tracer experiments using image analysis. Twin-screw wet granulation (TSWG) was directly coupled with a horizontal fluid bed dryer and an oscillating mill. Based on integrated measurement, we proved that it is also possible to couple the unit operations in silico. Three surrogate tracers were produced with a coloring agent to investigate the separated unit operations and the solid and liquid inputs of the TSWG. The soft sensor’s prediction was compared to validating experiments of a 0.05 mg/g (15% of the nominal) concentration change with High-Performance Liquid Chromatography (HPLC) reference measurements of the active ingredient proving the adequacy of the soft sensor (RMSE < 4%).},
	year = {2022},
	eissn = {1873-3476},
	orcid-numbers = {Domokos, András/0000-0003-1968-4679; Farkas, Attila/0000-0002-8877-2587}
}

@article{MTMT:32633240,
	title = {Real‐time amino acid and glucose monitoring system for the automatic control of nutrient feeding in CHO cell culture using raman spectroscopy},
	url = {https://m2.mtmt.hu/api/publication/32633240},
	author = {Domján, Júlia and Pantea, Eszter and Gyürkés, Martin and Madarász, Lajos and Kozák, Dóra and Farkas, Attila and Horváth, Balázs and Benkő, Zsuzsa and Nagy, Zsombor Kristóf and Marosi, György and Hirsch, Edit},
	doi = {10.1002/biot.202100395},
	journal-iso = {BIOTECHNOL J},
	journal = {BIOTECHNOLOGY JOURNAL},
	volume = {17},
	unique-id = {32633240},
	issn = {1860-6768},
	abstract = {An innovative, Raman spectroscopy-based monitoring and control system is introduced in this paper for designing dynamic feeding strategies that allow the maintenance of key cellular nutrients at an ideal level in Chinese hamster ovary cell culture. The Partial Least Squares calibration models built for glucose, lactate and 16 (out of 20) individual amino acids had very good predictive power with low root mean square errors values and high square correlation coefficients. The developed models used for real-time measurement of nutrient and by-product concentrations allowed us to gain better insight into the metabolic behavior and nutritional consumption of cells. To establish a more beneficial nutritional environment for the cells, two types of dynamic feeding strategies were used to control the delivery of two-part multi-component feed media according to the prediction of Raman models (glucose or arginine). As a result, instead of high fluctuations, the nutrients (glucose together with amino acids) were maintained at the desired level providing a more balanced environment for the cells. Moreover, the use of amino acid-based feeding control enabled to prevent the excessive nutrient replenishment and was economically beneficial by significantly reducing the amount of supplied feed medium compared to the glucose-based dynamic fed culture.},
	year = {2022},
	eissn = {1860-7314},
	orcid-numbers = {Farkas, Attila/0000-0002-8877-2587; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:32244801,
	title = {Digital Twin of Low Dosage Continuous Powder Blending - Artificial Neural Networks and Residence Time Distribution Models},
	url = {https://m2.mtmt.hu/api/publication/32244801},
	author = {Beke, Áron Kristóf and Gyürkés, Martin and Nagy, Zsombor Kristóf and Marosi, György and Farkas, Attila},
	doi = {10.1016/j.ejpb.2021.09.006},
	journal-iso = {EUR J PHARM BIOPHARM},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS},
	volume = {169},
	unique-id = {32244801},
	issn = {0939-6411},
	year = {2021},
	eissn = {1873-3441},
	pages = {64-77},
	orcid-numbers = {Marosi, György/0000-0002-4774-2023; Farkas, Attila/0000-0002-8877-2587}
}

@article{MTMT:32063872,
	title = {Continuous downstream processing of milled electrospun fibers to tablets monitored by near-infrared and Raman spectroscopy},
	url = {https://m2.mtmt.hu/api/publication/32063872},
	author = {Szabó, Edina and Záhonyi, Petra and Gyürkés, Martin and Nagy, Brigitta and Galata, Dorián László and Madarász, Lajos and Hirsch, Edit and Farkas, Attila and Andersen, Sune K. and Vigh, Tamás and Verreck, Geert and Csontos, István and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ejps.2021.105907},
	journal-iso = {EUR J PHARM SCI},
	journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES},
	volume = {164},
	unique-id = {32063872},
	issn = {0928-0987},
	year = {2021},
	eissn = {1879-0720},
	orcid-numbers = {Szabó, Edina/0000-0001-9616-5122; Farkas, Attila/0000-0002-8877-2587; Andersen, Sune K./0000-0002-9721-2821; Csontos, István/0000-0002-6858-1388; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:31994941,
	title = {Combination of PAT and mechanistic modeling tools in a fully continuous powder to granule line: Rapid and deep process understanding},
	url = {https://m2.mtmt.hu/api/publication/31994941},
	author = {Domokos, András and Pusztai, Éva and Madarász, Lajos and Nagy, Brigitta and Gyürkés, Martin and Farkas, Attila and Fülöp, Gergő and Casian, Tibor and Szilágyi, Botond and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.powtec.2021.04.059},
	journal-iso = {POWDER TECHNOL},
	journal = {POWDER TECHNOLOGY},
	volume = {388},
	unique-id = {31994941},
	issn = {0032-5910},
	abstract = {Comprehensive understanding of an integrated continuous pharmaceutical technology was achieved in this study by a combining design of experiments and mechanistic modeling-based simulations. The powder to granule line consisted of twin-screw wet granulation, vibrational fluid-bed drying and milling. A Partial Least Squares (PLS) regression model was built using Near-infrared (NIR) spectroscopy for the real-time monitoring of the product moisture content after the milling step. A split-plot full factorial experimental design was set up and executed to help the understanding of the relationships between the moisture content and process parameters. Furthermore, a mechanistic model was built, involving heat transfer between the drying air and the solid material. The unknown kinetic model parameters were estimated using the results of the experimental study resulting in good calibration and validation performance. The simulations not only reinforced the experimental observations but also paves the way for model-based process monitoring and optimal control.},
	year = {2021},
	eissn = {1873-328X},
	pages = {70-81},
	orcid-numbers = {Domokos, András/0000-0003-1968-4679; Farkas, Attila/0000-0002-8877-2587; Szilágyi, Botond/0000-0001-7777-9612}
}

@article{MTMT:31916949,
	title = {Recycled PET foaming: supercritical carbon dioxide assisted extrusion with real-time quality monitoring},
	url = {https://m2.mtmt.hu/api/publication/31916949},
	author = {Bordácsné Bocz, Katalin and Ronkay, Ferenc György and Molnár, Béla and Vadas, Dániel and Gyürkés, Martin and Gere, Dániel and Marosi, György and Czigány, Tibor},
	doi = {10.1016/j.aiepr.2021.03.002},
	journal-iso = {ADV INDUST ENGIN POLYMER RES},
	journal = {ADVANCED INDUSTRIAL AND ENGINEERING POLYMER RESEARCH},
	volume = {4},
	unique-id = {31916949},
	issn = {2542-5048},
	year = {2021},
	pages = {178-186},
	orcid-numbers = {Ronkay, Ferenc György/0000-0003-0525-1493; Gere, Dániel/0000-0002-2808-2672; Marosi, György/0000-0002-4774-2023; Czigány, Tibor/0000-0002-5138-0141}
}

@article{MTMT:31831437,
	title = {Integrated twin-screw wet granulation, continuous vibrational fluid drying and milling: A fully continuous powder to granule line},
	url = {https://m2.mtmt.hu/api/publication/31831437},
	author = {Fülöp, Gergő and Domokos, András and Galata, Dorián László and Szabó, Edina and Gyürkés, Martin and Szabó, B. and Farkas, Attila and Madarász, Lajos and Démuth, Balázs and Lendér, T. and Nagy, T. and Kovács-Kiss, D. and Van der Gucht, F. and Marosi, György and Nagy, Zsombor Kristóf},
	doi = {10.1016/j.ijpharm.2020.120126},
	journal-iso = {INT J PHARM},
	journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS},
	volume = {594},
	unique-id = {31831437},
	issn = {0378-5173},
	year = {2021},
	eissn = {1873-3476},
	orcid-numbers = {Domokos, András/0000-0003-1968-4679; Szabó, Edina/0000-0001-9616-5122; Farkas, Attila/0000-0002-8877-2587; Marosi, György/0000-0002-4774-2023}
}

@article{MTMT:31678236,
	title = {Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models},
	url = {https://m2.mtmt.hu/api/publication/31678236},
	author = {Gyürkés, Martin and Madarász, Lajos and Köte, Ákos and Domokos, András and Mészáros, Dániel and Beke, Áron Kristóf and Nagy, Brigitta and Marosi, György and Pataki, Hajnalka and Nagy, Zsombor Kristóf and Farkas, Attila},
	doi = {10.3390/pharmaceutics12111119},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {12},
	unique-id = {31678236},
	issn = {1999-4923},
	year = {2020},
	eissn = {1999-4923},
	orcid-numbers = {Domokos, András/0000-0003-1968-4679; Marosi, György/0000-0002-4774-2023; Farkas, Attila/0000-0002-8877-2587}
}