TY - JOUR AU - Bitay, Enikő AU - Gergely, Attila Levente AU - Szabó, Zoltán-István TI - One-Step Preparation of Fiber-Based Chlorzoxazone Solid Dispersion by Centrifugal Spinning JF - POLYMERS J2 - POLYMERS-BASEL VL - 16 PY - 2023 IS - 1 SP - 123 PG - 12 SN - 2073-4360 DO - 10.3390/polym16010123 UR - https://m2.mtmt.hu/api/publication/34463679 ID - 34463679 AB - An amorphous fiber-based solid dispersion of chlorzoxazone was prepared for the first time by employing centrifugal spinning, using polyvinylpyrrolidone as the fiber-forming polymer. After optimization of the spinning parameters, the obtained fibers were characterized using a set of analytical techniques, both in a solid- and solution-state. Morphological characterization revealed a slightly aligned, defect-free fibrous structure with an average fiber diameter of d = 3.07 ± 1.32 μm μm. The differential scanning calorimetric results indicated a crystalline-to-amorphous transition of the active substance during the centrifugal spinning process, while gas chromatographic determinations revealed a residual ethanol content of 0.42 ± 0.04%. UV spectroscopy indicated the incorporation of chlorzoxazone in the fibrous structures, with an average active substance content of 15.91 ± 0.36 w/w%. During small-volume dissolution studies, the prepared fiber mats presented immediate disintegration upon contact with the dissolution media, followed by rapid dissolution of the active substance, with 84.8% dissolved at 1 min and 93.7% at 3 min, outperforming the micronized, pure chlorzoxazone. The obtained results indicate that centrifugal spinning is a low-cost, high-yield, viable alternative to the currently used methods to prepare fiber-based amorphous solid dispersions of poorly soluble drugs. The prepared chlorzoxazone-loaded microfibers could be used as a buccal dosage form for the systematic delivery of chlorzoxazone and could potentially lead to a rapid onset of action and longer efficacy of the muscle relaxant drug. LA - English DB - MTMT ER - TY - JOUR AU - Kántor, J. AU - Farmos, R.L. AU - Gergely, Attila Levente TI - Optimization of Oil Sorbent Thermoplastic Elastomer Microfiber Production by Centrifugal Spinning JF - POLYMERS J2 - POLYMERS-BASEL VL - 15 PY - 2023 IS - 16 SN - 2073-4360 DO - 10.3390/polym15163368 UR - https://m2.mtmt.hu/api/publication/34135821 ID - 34135821 LA - English DB - MTMT ER - TY - JOUR AU - Bitay, Enikő AU - Gergely, Attila Levente AU - Szabó, Zoltán-István TI - Optimization and Production of Aceclofenac-Loaded Microfiber Solid Dispersion by Centrifugal Spinning JF - PHARMACEUTICS J2 - PHARMACEUTICS VL - 15 PY - 2023 IS - 9 SP - 2256 SN - 1999-4923 DO - 10.3390/pharmaceutics15092256 UR - https://m2.mtmt.hu/api/publication/34123275 ID - 34123275 AB - Aceclofenac-loaded polyvinylpyrrolidone fiber-based amorphous solid dispersion was produced successfully by centrifugal spinning. The solution concentration and rotational speed were optimized to produce the fiber-based drug carrier system, with a determined production rate of 12.7 g/h dry solid fibers. The obtained fibers were bead-free and smooth-surfaced with an average diameter of 7.5 ± 2.5 μm. Gas chromatographic determinations revealed that ethanol, as a residual solvent, was well below the regulatory limit of 0.5%. Differential scanning calorimetric investigation and infrared spectroscopic measurements were used to track the physicochemical changes that intervene during fiber formation in the solid state. The results revealed that the rapid evaporation of the solvent was accompanied by a probable crystalline to amorphous transition of the active substance during centrifugal spinning. In vitro dissolution studies revealed an instantaneous disintegration of the fibrous structure and a rapid release of the active substance, with the microfibrous webs greatly outperforming the crystalline active substance, especially in the early time-points. This implies that centrifugal spinning offers a viable scale-up production process to prepare drug-loaded fiber-based solid dispersions. LA - English DB - MTMT ER - TY - BOOK AU - Gergely, Attila Levente TI - Polimer anyagok anyagtudományi és feldolgozástechnikai laboratóriuma T3 - Műszaki Tudományos Füzetek, ISSN 2668-3776 ; 18. PB - Erdélyi Múzeum Egyesület (EME) CY - Kolozsvár PY - 2022 SN - 9786067392296 DO - 10.36242/mtf-18 UR - https://m2.mtmt.hu/api/publication/33636356 ID - 33636356 LA - Hungarian DB - MTMT ER - TY - BOOK AU - Gergely, Attila Levente AU - Farmos, Rudolf Laszlo AU - Kantor, Jozsef AU - Kantor, Andrea Eva AU - Hodagyi, Norbert TI - Recycled PET nanofiber membranes for air filtration PY - 2022 DO - 10.1109/CINTI-MACRo57952.2022.10029511 UR - https://m2.mtmt.hu/api/publication/33636346 ID - 33636346 LA - English DB - MTMT ER - TY - BOOK AU - Kantor, Jozsef AU - Gergely, Attila Levente AU - Farmos, Rudolf Laszlo AU - Hodgyai, Norbert TI - Poly(styrene-b-isobutylene-b-styrene) Triblock Copolymer Fiber Generation with Centrifugal Spinning, and its Potential Application in Oil Collection PY - 2022 DO - 10.1109/CINTI-MACRo57952.2022.10029628 UR - https://m2.mtmt.hu/api/publication/33636333 ID - 33636333 LA - English DB - MTMT ER - TY - JOUR AU - Fábián, Hunor AU - Gergely, Attila Levente TI - Nagy teljesítményű szálképző berendezés tervezése JF - ACTA MATERIALIA TRANSYLVANICA (HU) J2 - ACTA MATER TRANSYLV (HU) VL - 5 PY - 2022 IS - 2 SP - 62 EP - 65 PG - 4 SN - 2601-1883 DO - 10.33923/amt-2022-02-03 UR - https://m2.mtmt.hu/api/publication/33573941 ID - 33573941 AB - A munka célja egy nagy termelékenységű, folyamatos működésű, centrifugális erőt kihasználó szálképző berendezés tervezése volt polimer nanoszálak előállítására. A berendezés működési elvében hasonló a szakirodalomban leírt berendezésekhez, viszont tejes mértékben saját fejlesztés eredménye. A tervezési követelmények között az automatikusan állítható kapilláris-kollektor távolság, 50–200 mm, a forgófej magas fordulatszáma, 0–25000 1/min, és folyamatos üzemű működés szerepel. A berendezés számos kutatási téma alapját képezi majd, mint például gyógyszeres, szilárd diszperziók megalkotása és tanulmányozása, nyomásmérő szenzorok fejlesztése, porózusos szűrő membránok létrehozása. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Fábián, Hunor AU - Gergely, Attila Levente TI - Design of a High Performance Fiber-producing Machine JF - ACTA MATERIALIA TRANSYLVANICA (EN) J2 - ACTA MATER TRANSYLV (EN) VL - 5 PY - 2022 IS - 2 SP - 62 EP - 65 PG - 4 SN - 2601-8799 DO - 10.33924/amt-2022-02-03 UR - https://m2.mtmt.hu/api/publication/33573931 ID - 33573931 AB - The aim of this work is to design a high-productivity, continuously operating fiber producing device utilizing the centrifugal force to yield polymeric nanofibers. The requirements for the design were 1) to provide a capillary-to-collector distance of 50–200 mm that could be adjusted automatically, 2) allow the rotational speed of the spinneret to be changed in the range of 0–25000 1/min and have continuous feeding. The equipment will form the basis of several research topics, such as the creation and study of solid dispersions of drugs, the development of pressure sensors, and the creation of porous filter membranes. LA - English DB - MTMT ER - TY - JOUR AU - Fábián, Hunor AU - Gergely, Attila Levente TI - Design of a High Performance Fiber-producing Machine JF - ACTA MATERIALIA TRANSYLVANICA (EN) J2 - ACTA MATER TRANSYLV (EN) VL - 5 PY - 2022 IS - 2 SP - 62 EP - 65 PG - 4 SN - 2601-8799 DO - 10.33924/amt-2022-02-03 UR - https://m2.mtmt.hu/api/publication/33573867 ID - 33573867 AB - The aim of this work is to design a high-productivity, continuously operating fiber producing device utilizing the centrifugal force to yield polymeric nanofibers. The requirements for the design were 1) to provide a capillary-to-collector distance of 50–200 mm that could be adjusted automatically, 2) allow the rotational speed of the spinneret to be changed in the range of 0–25000 1/min and have continuous feeding. The equipment will form the basis of several research topics, such as the creation and study of solid dispersions of drugs, the development of pressure sensors, and the creation of porous filter membranes. LA - English DB - MTMT ER - TY - JOUR AU - Bitay, Enikő AU - Gergely, Attila Levente AU - Kántor, József AU - Szabó, Zoltán-István TI - Evaluation of Lapatinib-Loaded Microfibers Prepared by Centrifugal Spinning JF - POLYMERS J2 - POLYMERS-BASEL VL - 14 PY - 2022 IS - 24 SP - 5557 SN - 2073-4360 DO - 10.3390/polym14245557 UR - https://m2.mtmt.hu/api/publication/33367782 ID - 33367782 N1 - Export Date: 18 January 2023 Correspondence Address: Gergely, A.L.; Department of Mechanical Engineering, Calea Sighișoarei nr. 2, Romania; email: agergely@ms.sapientia.ro AB - Lapatinib (Lap) is a lypophilic drug frequently used in cancer treatment; however, due to its limited solubility and permeability, achieving therapeutic dose through oral administration proves to be a challenge. There are various methods for enhancing the solubility of Lap and other similar drugs, one being the preparation of amorphous solid dispersions (ASD). In this study, a Lap-loaded polyvinylpyrrolidone (PVP) fiber mat was created with centrifugal spinning from a PVP/Lap solution in dimethyl formamide and ethanol. The production rate was 12.2 g/h dry fibers, and the fibers had an average thickness of 2.55 ± 0.92 μm. In the differential scanning calorimetry (DSC) thermogram of the fiber mat, the melting peak of the crystalline Lap was not visible, suggesting that Lap was in an amorphous state. A dissolution study was carried out in 0.2 M phosphate buffer saline solution at 37 °C. UV spectrophotometry data indicated that in the sample containing the fiber mat, the Lap concentration was 332 μg/mL (66%) in 10 min, decreasing to 227 μg/mL by 45 min. Meanwhile the crystalline Lap formed a 30–40 μg/mL (6–8%) solution in 5 min, maintaining that concentration. We conclude that centrifugal spinning can be an effective and easy method to produce ASDs. LA - English DB - MTMT ER -