@article{MTMT:34463679,
	title = {One-Step Preparation of Fiber-Based Chlorzoxazone Solid Dispersion by Centrifugal Spinning},
	url = {https://m2.mtmt.hu/api/publication/34463679},
	author = {Bitay, Enikő and Gergely, Attila Levente and Szabó, Zoltán-István},
	doi = {10.3390/polym16010123},
	journal-iso = {POLYMERS-BASEL},
	journal = {POLYMERS},
	volume = {16},
	unique-id = {34463679},
	abstract = {An amorphous fiber-based solid dispersion of chlorzoxazone was prepared for the first time by employing centrifugal spinning, using polyvinylpyrrolidone as the fiber-forming polymer. After optimization of the spinning parameters, the obtained fibers were characterized using a set of analytical techniques, both in a solid- and solution-state. Morphological characterization revealed a slightly aligned, defect-free fibrous structure with an average fiber diameter of d = 3.07 ± 1.32 μm μm. The differential scanning calorimetric results indicated a crystalline-to-amorphous transition of the active substance during the centrifugal spinning process, while gas chromatographic determinations revealed a residual ethanol content of 0.42 ± 0.04%. UV spectroscopy indicated the incorporation of chlorzoxazone in the fibrous structures, with an average active substance content of 15.91 ± 0.36 w/w%. During small-volume dissolution studies, the prepared fiber mats presented immediate disintegration upon contact with the dissolution media, followed by rapid dissolution of the active substance, with 84.8% dissolved at 1 min and 93.7% at 3 min, outperforming the micronized, pure chlorzoxazone. The obtained results indicate that centrifugal spinning is a low-cost, high-yield, viable alternative to the currently used methods to prepare fiber-based amorphous solid dispersions of poorly soluble drugs. The prepared chlorzoxazone-loaded microfibers could be used as a buccal dosage form for the systematic delivery of chlorzoxazone and could potentially lead to a rapid onset of action and longer efficacy of the muscle relaxant drug.},
	year = {2023},
	eissn = {2073-4360},
	pages = {123-135},
	orcid-numbers = {Bitay, Enikő/0000-0003-2991-7333; Gergely, Attila Levente/0000-0003-4536-7642; Szabó, Zoltán-István/0000-0002-8740-0212}
}

@article{MTMT:34135821,
	title = {Optimization of Oil Sorbent Thermoplastic Elastomer Microfiber Production by Centrifugal Spinning},
	url = {https://m2.mtmt.hu/api/publication/34135821},
	author = {Kántor, J. and Farmos, R.L. and Gergely, Attila Levente},
	doi = {10.3390/polym15163368},
	journal-iso = {POLYMERS-BASEL},
	journal = {POLYMERS},
	volume = {15},
	unique-id = {34135821},
	year = {2023},
	eissn = {2073-4360}
}

@article{MTMT:34123275,
	title = {Optimization and Production of Aceclofenac-Loaded Microfiber Solid Dispersion by Centrifugal Spinning},
	url = {https://m2.mtmt.hu/api/publication/34123275},
	author = {Bitay, Enikő and Gergely, Attila Levente and Szabó, Zoltán-István},
	doi = {10.3390/pharmaceutics15092256},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {15},
	unique-id = {34123275},
	issn = {1999-4923},
	abstract = {Aceclofenac-loaded polyvinylpyrrolidone fiber-based amorphous solid dispersion was produced successfully by centrifugal spinning. The solution concentration and rotational speed were optimized to produce the fiber-based drug carrier system, with a determined production rate of 12.7 g/h dry solid fibers. The obtained fibers were bead-free and smooth-surfaced with an average diameter of 7.5 ± 2.5 μm. Gas chromatographic determinations revealed that ethanol, as a residual solvent, was well below the regulatory limit of 0.5%. Differential scanning calorimetric investigation and infrared spectroscopic measurements were used to track the physicochemical changes that intervene during fiber formation in the solid state. The results revealed that the rapid evaporation of the solvent was accompanied by a probable crystalline to amorphous transition of the active substance during centrifugal spinning. In vitro dissolution studies revealed an instantaneous disintegration of the fibrous structure and a rapid release of the active substance, with the microfibrous webs greatly outperforming the crystalline active substance, especially in the early time-points. This implies that centrifugal spinning offers a viable scale-up production process to prepare drug-loaded fiber-based solid dispersions.},
	year = {2023},
	eissn = {1999-4923},
	pages = {2256},
	orcid-numbers = {Bitay, Enikő/0000-0003-2991-7333; Gergely, Attila Levente/0000-0003-4536-7642; Szabó, Zoltán-István/0000-0002-8740-0212}
}

@book{MTMT:33636356,
	title = {Polimer anyagok anyagtudományi és feldolgozástechnikai laboratóriuma},
	url = {https://m2.mtmt.hu/api/publication/33636356},
	isbn = {9786067392296},
	author = {Gergely, Attila Levente},
	doi = {10.36242/mtf-18},
	publisher = {Societatea Muzeului Ardelean; Transilvanian Museum Society},
	unique-id = {33636356},
	year = {2022}
}

@misc{MTMT:33636346,
	title = {Recycled PET nanofiber membranes for air filtration},
	url = {https://m2.mtmt.hu/api/publication/33636346},
	author = {Gergely, Attila Levente and Farmos, Rudolf Laszlo and Kantor, Jozsef and Kantor, Andrea Eva and Hodagyi, Norbert},
	doi = {10.1109/CINTI-MACRo57952.2022.10029511},
	unique-id = {33636346},
	year = {2022}
}

@misc{MTMT:33636333,
	title = {Poly(styrene-b-isobutylene-b-styrene) Triblock Copolymer Fiber Generation with Centrifugal Spinning, and its Potential Application in Oil Collection},
	url = {https://m2.mtmt.hu/api/publication/33636333},
	author = {Kantor, Jozsef and Gergely, Attila Levente and Farmos, Rudolf Laszlo and Hodgyai, Norbert},
	doi = {10.1109/CINTI-MACRo57952.2022.10029628},
	unique-id = {33636333},
	year = {2022}
}

@article{MTMT:33573941,
	title = {Nagy teljesítményű szálképző berendezés tervezése},
	url = {https://m2.mtmt.hu/api/publication/33573941},
	author = {Fábián, Hunor and Gergely, Attila Levente},
	doi = {10.33923/amt-2022-02-03},
	journal-iso = {ACTA MATER TRANSYLV (HU)},
	journal = {ACTA MATERIALIA TRANSYLVANICA (HU)},
	volume = {5},
	unique-id = {33573941},
	issn = {2601-1883},
	abstract = {A munka célja egy nagy termelékenységű, folyamatos működésű, centrifugális erőt kihasználó szálképző berendezés tervezése volt polimer nanoszálak előállítására. A berendezés működési elvében hasonló a szakirodalomban leírt berendezésekhez, viszont tejes mértékben saját fejlesztés eredménye. A tervezési követelmények között az automatikusan állítható kapilláris-kollektor távolság, 50–200 mm, a forgófej magas fordulatszáma, 0–25000 1/min, és folyamatos üzemű működés szerepel. A berendezés számos kutatási téma alapját képezi majd, mint például gyógyszeres, szilárd diszperziók megalkotása és tanulmányozása, nyomásmérő szenzorok fejlesztése, porózusos szűrő membránok létrehozása.},
	year = {2022},
	eissn = {2668-1366},
	pages = {62-65}
}

@article{MTMT:33573931,
	title = {Design of a High Performance Fiber-producing Machine},
	url = {https://m2.mtmt.hu/api/publication/33573931},
	author = {Fábián, Hunor and Gergely, Attila Levente},
	doi = {10.33924/amt-2022-02-03},
	journal-iso = {ACTA MATER TRANSYLV (EN)},
	journal = {ACTA MATERIALIA TRANSYLVANICA (EN)},
	volume = {5},
	unique-id = {33573931},
	abstract = {The aim of this work is to design a high-productivity, continuously operating fiber producing device utilizing the centrifugal force to yield polymeric nanofibers. The requirements for the design were 1) to provide a capillary-to-collector distance of 50–200 mm that could be adjusted automatically, 2) allow the rotational speed of the spinneret to be changed in the range of 0–25000 1/min and have continuous feeding. The equipment will form the basis of several research topics, such as the creation and study of solid dispersions of drugs, the development of pressure sensors, and the creation of porous filter membranes.},
	year = {2022},
	eissn = {2601-8799},
	pages = {62-65}
}

@article{MTMT:33573867,
	title = {Design of a High Performance Fiber-producing Machine},
	url = {https://m2.mtmt.hu/api/publication/33573867},
	author = {Fábián, Hunor and Gergely, Attila Levente},
	doi = {10.33924/amt-2022-02-03},
	journal-iso = {ACTA MATER TRANSYLV (EN)},
	journal = {ACTA MATERIALIA TRANSYLVANICA (EN)},
	volume = {5},
	unique-id = {33573867},
	abstract = {The aim of this work is to design a high-productivity, continuously operating fiber producing device utilizing the centrifugal force to yield polymeric nanofibers. The requirements for the design were 1) to provide a capillary-to-collector distance of 50–200 mm that could be adjusted automatically, 2) allow the rotational speed of the spinneret to be changed in the range of 0–25000 1/min and have continuous feeding. The equipment will form the basis of several research topics, such as the creation and study of solid dispersions of drugs, the development of pressure sensors, and the creation of porous filter membranes.},
	year = {2022},
	eissn = {2601-8799},
	pages = {62-65}
}

@article{MTMT:33367782,
	title = {Evaluation of Lapatinib-Loaded Microfibers Prepared by Centrifugal Spinning},
	url = {https://m2.mtmt.hu/api/publication/33367782},
	author = {Bitay, Enikő and Gergely, Attila Levente and Kántor, József and Szabó, Zoltán-István},
	doi = {10.3390/polym14245557},
	journal-iso = {POLYMERS-BASEL},
	journal = {POLYMERS},
	volume = {14},
	unique-id = {33367782},
	abstract = {Lapatinib (Lap) is a lypophilic drug frequently used in cancer treatment; however, due to its limited solubility and permeability, achieving therapeutic dose through oral administration proves to be a challenge. There are various methods for enhancing the solubility of Lap and other similar drugs, one being the preparation of amorphous solid dispersions (ASD). In this study, a Lap-loaded polyvinylpyrrolidone (PVP) fiber mat was created with centrifugal spinning from a PVP/Lap solution in dimethyl formamide and ethanol. The production rate was 12.2 g/h dry fibers, and the fibers had an average thickness of 2.55 ± 0.92 μm. In the differential scanning calorimetry (DSC) thermogram of the fiber mat, the melting peak of the crystalline Lap was not visible, suggesting that Lap was in an amorphous state. A dissolution study was carried out in 0.2 M phosphate buffer saline solution at 37 °C. UV spectrophotometry data indicated that in the sample containing the fiber mat, the Lap concentration was 332 μg/mL (66%) in 10 min, decreasing to 227 μg/mL by 45 min. Meanwhile the crystalline Lap formed a 30–40 μg/mL (6–8%) solution in 5 min, maintaining that concentration. We conclude that centrifugal spinning can be an effective and easy method to produce ASDs.},
	year = {2022},
	eissn = {2073-4360},
	pages = {5557},
	orcid-numbers = {Bitay, Enikő/0000-0003-2991-7333; Gergely, Attila Levente/0000-0003-4536-7642; Szabó, Zoltán-István/0000-0002-8740-0212}
}