TY - JOUR AU - Csoma, Balázs AU - Sydó, Nóra AU - Szűcs, Gergő AU - Seres, Éva AU - Erdélyi, Tamás AU - Horváth, Gábor AU - Csulak, Emese AU - Merkely, Béla Péter AU - Müller, Veronika TI - Exhaled and Systemic Biomarkers to Aid the Diagnosis of Bronchial Asthma in Elite Water Sports Athletes JF - MEDICINE AND SCIENCE IN SPORTS AND EXERCISE J2 - MED SCI SPORT EXER VL - 56 PY - 2024 IS - 7 SP - 1256 EP - 1264 PG - 9 SN - 0195-9131 DO - 10.1249/MSS.0000000000003419 UR - https://m2.mtmt.hu/api/publication/34815635 ID - 34815635 LA - English DB - MTMT ER - TY - JOUR AU - Szűcs, Gergő AU - Komáromi, Tamás AU - Matics, Zsombor Zoltán AU - Erdélyi, Tamás AU - Pápay, Judit AU - Kristóf, Katalin AU - Bohács, Anikó AU - Müller, Veronika TI - Pneumocystis diagnosztizálása nem ismert HIV fertőzött betegnél - Esetismertetés JF - MEDICINA THORACALIS (BUDAPEST) J2 - MED THORAC (BP) VL - 76 PY - 2023 IS - 6 SP - 323 EP - 326 PG - 4 SN - 0238-2571 UR - https://m2.mtmt.hu/api/publication/34441434 ID - 34441434 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Csósza, Györgyi AU - Szűcs, Gergő AU - Rozgonyi, Zsolt Dezső AU - Csoma, Balázs AU - Losonczy, György AU - Müller, Veronika AU - Karlócai, Kristóf AU - Lázár, Zsófia TI - Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension JF - PHYSIOLOGY INTERNATIONAL J2 - PHYSIOL INT VL - 110 PY - 2023 IS - 4 SP - 356 EP - 370 PG - 15 SN - 2498-602X DO - 10.1556/2060.2023.00264 UR - https://m2.mtmt.hu/api/publication/34441154 ID - 34441154 N1 - Department of Pulmonology, Semmelweis University, Budapest, Hungary Department of Anaesthesiology and Intensive Therapy, Semmelweis University, Budapest, Hungary Export Date: 22 July 2024 Correspondence Address: Lázár, Z.; Department of Pulmonology, Hungary; email: lazar.zsofia@med.semmelweis-univ.hu Chemicals/CAS: growth hormone, 36992-73-1, 37267-05-3, 66419-50-9, 9002-72-6; iloprost, 78919-13-8, 82889-99-4, 697225-02-8; interleukin 22, 457106-70-6, 478219-35-1, 554460-75-2; vasculotropin, 127464-60-2; vasculotropin A, 489395-96-2; Apelin; Biomarkers; Cytokines; IL22RA2 protein, human; Receptors, Interleukin; Vascular Endothelial Growth Factor A Manufacturers: Mindray, China; RayBiotech, United States Funding details: MPA/2019 Funding text 1: We thank Tímea Baranyi for assistance in collecting clinical data. This work was supported by the Hungarian Respiratory Foundation to Dr. Györgyi Csósza [grant number MPA/2019]. LA - English DB - MTMT ER - TY - BOOK AU - Horváth, Péter AU - Kiss, Judit AU - Jenei, Alex AU - Szűcs, Gergő AU - Lakatos, Gergely TI - Kétoldali, infiltratív tüdőbetegség esete COVID-19 infekció után PY - 2023 UR - https://m2.mtmt.hu/api/publication/33925821 ID - 33925821 LA - Hungarian DB - MTMT ER - TY - BOOK AU - Szűcs, Gergő AU - Szentkereszty, Márton AU - Tóvári, István AU - Ladányi, Andrea AU - Gálffy, Gabriella AU - Losonczy, György TI - A BMI és a túlélési idő közötti összefüggés korai stádiumú NSCLC-ben PY - 2023 UR - https://m2.mtmt.hu/api/publication/33925652 ID - 33925652 LA - Hungarian DB - MTMT ER - TY - CHAP AU - Tóth, Nóra Melinda AU - Szűcs, Gergő ED - Müller, Veronika ED - Bohács, Anikó ED - Eszes, Noémi ED - Horváth, Gábor ED - Lázár, Zsófia ED - Losonczy, György ED - Tamási, Lilla ED - Varga, János Tamás TI - Mikrobiológiai, laboratóriumi citológiai és szövettani vizsgálatok T2 - Tüdőgyógyászat PB - Semmelweis Kiadó CY - Budapest SN - 9789633315767 PY - 2022 SP - 89 EP - 96 PG - 8 UR - https://m2.mtmt.hu/api/publication/33620477 ID - 33620477 N1 - 3. fejezet: Tüdőbetegségek diagnosztikája LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szűcs, Gergő AU - Bohács, Anikó AU - Varga, János Tamás AU - Bogyó, Levente Zoltán AU - Müller, Veronika AU - Vincze, Krisztina TI - Helminthiasis diagnosztizálása tüdőrákos beteg esetén JF - MEDICINA THORACALIS (BUDAPEST) J2 - MED THORAC (BP) VL - 75 PY - 2022 IS - 5 SP - 312 EP - 315 PG - 4 SN - 0238-2571 UR - https://m2.mtmt.hu/api/publication/33168673 ID - 33168673 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Jáky-Kováts, Zsuzsanna Ágnes AU - Vámos, Melinda AU - Komlósi, Zsolt AU - Bikov, András AU - Madurka, Ildikó Eszter AU - Szűcs, Gergő AU - Müller, Veronika AU - Bohács, Anikó TI - Peripheral blood and bronchoalveolar leukocyte profile in lung transplant recipients and their changes according to immunosuppressive regimen: A single-center experience JF - IMMUNITY INFLAMMATION AND DISEASE J2 - IMMUN INFLAM DIS VL - 10 PY - 2022 IS - 8 PG - 8 SN - 2050-4527 DO - 10.1002/iid3.673 UR - https://m2.mtmt.hu/api/publication/33032862 ID - 33032862 N1 - Department of Pulmonology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Genetics, Cell- and Immunobiology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Division of Infection, Immunity & Respiratory Medicine, University of Manchester, Manchester, United Kingdom Department of Thoracic Surgery, Faculty of Medicine, Semmelweis University, Budapest, Hungary Department of Thoracic Surgery, National Institute of Oncology, Budapest, Hungary Export Date: 18 November 2022 Correspondence Address: Jáky-Kováts, Z.; Department of Pulmonology, Hungary; email: kovats.zsuzsanna@med.semmelweis-univ.hu AB - Background: After lung transplantation (LuTX), lower respiratory tract infections (LRTI) and acute cellular rejection (ACR) are associated with changes in peripheral blood and bronchoalveolar lavage fluid mononuclear cell profile (PBMC and BALIC). PBMC is also influenced by immunosuppressive regimen and its changes with postoperative time. First-year PBMC and BALIC changes were evaluated in this study with rabbit anti-thymocyte globulin (ATG) and alemtuzumab (AL) induction therapy. Methods: In total, 64 LuTX recipients were included, 53 of them received AL and 11 ATG as induction therapy. PBMC and BALIC were examined routinely and in cases suspicious of infection and/or rejection. A PBMC- and BALIC-based algorithm for infection and rejection prediction was also tested. Results: In the AL group, peripheral blood lymphocyte and basophil cell numbers were significantly reduced, while the neutrophil cell number elevation during LRTI was significantly higher compared to the control. Early postoperative measurements showed a lower BALIC lymphocyte count. The algorithm had 17% sensitivity and 94% specificity for ACR in all patients and 33% sensitivity and 95% specificity for ACR with coexisting LRTI. Conclusion: BALIC is not significantly influenced by the immunosuppressive regimen. PBMC- and BALIC-based algorithm may improve the differential diagnosis of ACR. LA - English DB - MTMT ER - TY - JOUR AU - Komlósi, Zsolt AU - van, de Veen W. AU - Kovács, N. AU - Szűcs, Gergő AU - Sokolowska, M. AU - O'Mahony, L. AU - Akdis, M. AU - Akdis, C.A. TI - Cellular and molecular mechanisms of allergic asthma JF - MOLECULAR ASPECTS OF MEDICINE J2 - MOL ASPECTS MED VL - 85 PY - 2022 PG - 30 SN - 0098-2997 DO - 10.1016/j.mam.2021.100995 UR - https://m2.mtmt.hu/api/publication/32151365 ID - 32151365 N1 - Department of Genetics, Cell- and Immunobiology, Semmelweis University, Nagyvárad Sqr. 4, Budapest, 1089, Hungary Swiss Institute of Allergy and Asthma Research (SIAF), Hermann-Burchard Strasse 9, Davos Wolfgand, CH7265, Switzerland Christine Kühne – Center for Allergy Research and Education, Davos, Switzerland Department of Pulmonology, Semmelweis University, Tömő Str. 25-29, Budapest, 1083, Hungary Department of Medicine and School of Microbiology, APC Microbiome Ireland, University College Cork, Ireland Lung Health Hospital, Munkácsy Mihály Str. 70, Törökbálint, 2045, Hungary Cited By :17 Export Date: 5 November 2022 CODEN: MAMED Correspondence Address: Komlósi, Z.I.; Department of Genetics, Nagyvárad Sqr. 4, Hungary; email: komlosi.zsolt@med.semmelweis-univ.hu AB - Asthma is a chronic disease of the airways, which affects more than 350 million people worldwide. It is the most common chronic disease in children, affecting at least 30 million children and young adults in Europe. Asthma is a complex, partially heritable disease with a marked heterogeneity. Its development is influenced both by genetic and environmental factors. The most common, as well as the most well characterized subtype of asthma is allergic eosinophilic asthma, which is characterized by a type 2 airway inflammation. The prevalence of asthma has substantially increased in industrialized countries during the last 60 years. The mechanisms underpinning this phenomenon are incompletely understood, however increased exposure to various environmental pollutants probably plays a role. Disease inception is thought to be enabled by a disadvantageous shift in the balance between protective and harmful lifestyle and environmental factors, including exposure to protective commensal microbes versus infection with pathogens, collectively leading to airway epithelial cell damage and disrupted barrier integrity. Epithelial cell-derived cytokines are one of the main drivers of the type 2 immune response against innocuous allergens, ultimately leading to infiltration of lung tissue with type 2 T helper (TH2) cells, type 2 innate lymphoid cells (ILC2s), M2 macrophages and eosinophils. This review outlines the mechanisms responsible for the orchestration of type 2 inflammation and summarizes the novel findings, including but not limited to dysregulated epithelial barrier integrity, alarmin release and innate lymphoid cell stimulation. © 2021 The Authors LA - English DB - MTMT ER - TY - JOUR AU - Csoma, Balázs AU - Beringer, Filippa AU - Szűcs, Gergő AU - Bikov, András AU - Müller, Veronika AU - Lázár, Zsófia TI - Measurements of upper and lower airway nitric oxide in healthy adults JF - JOURNAL OF BREATH RESEARCH J2 - J BREATH RES VL - 15 PY - 2021 IS - 4 PG - 7 SN - 1752-7155 DO - 10.1088/1752-7163/ac2567 UR - https://m2.mtmt.hu/api/publication/32245954 ID - 32245954 N1 - Ellenőrizve teljes szöveg alapján GT AB - Introduction. Nasal nitric oxide (NO) measurement can be a useful tool for monitoring upper airway diseases. However, there is a considerable lack of validation data. Aims. To evaluate the repeatability and intra-subject variations of nasal NO output (nV (NO)) in healthy adults and to study its correlation with lower airway NO parameters. Methods. nV (NO) was measured in healthy non-smokers at baseline (N = 31, age: 28 +/- 6 years), after 1 h (N = 15), 1 d (N = 15), 1 week (N = 17), and compared using the Bland-Altman method. At baseline, lower airway NO parameters (F (ENO), flux of NO in the conducting airways and alveolar NO concentration) were also measured and correlated to nV (NO) (Spearman correlation). Multivariate regression analysis was used to assess the factors influencing nV (NO). Results. Baseline median nV (NO) was 465 (interquartile range (IQR) = 404-536) nL min(-1). The mean differences between the baseline and repeated measurements were not significant (p > 0.05). The coefficient of repeatability (mean: 118, IQR = 88-181 nL min(-1)) and coefficient of variation (mean: 9.1%) were low. We found no correlation between nV (NO) and lower airway NO parameters (p > 0.05). Sex (beta = -0.52, p = 0.02) and body weight (beta = -0.65, p = 0.03) influenced nV (NO) (model: p = 0.04, R (2) = 0.31). Conclusion. nasal NO output has good repeatability in healthy adults. The NO productions of lower and upper airways are not related in health, but nasal NO output seems to be affected by sex and body weight. LA - English DB - MTMT ER -