TY - JOUR AU - He, Mingchen AU - Kis-Jakab, Gréta AU - Komáromy, Hedvig AU - Perlaki, Gábor AU - Orsi, Gergely AU - Bosnyák, Edit AU - Rozgonyi, Renáta AU - John, Flóra AU - Trauninger, Anita AU - Eklicsné Lepenye, Katalin AU - Pfund, Zoltán TI - Volumetric alteration of brainstem in female migraineurs with and without aura JF - CLINICAL NEUROLOGY AND NEUROSURGERY J2 - CLIN NEUROL NEUROSUR VL - 236 PY - 2024 PG - 6 SN - 0303-8467 DO - 10.1016/j.clineuro.2023.108089 UR - https://m2.mtmt.hu/api/publication/34477406 ID - 34477406 N1 - Pécs Diagnostic Center, Pécs, Hungary HUN-REN-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary Department of Neurology, Medical School, University of Pécs, Pécs, Hungary Department of Languages for Biomedical Purposes and Communication, University of Pécs, Pécs, Hungary Export Date: 29 January 2024 CODEN: CNNSB Correspondence Address: Pfund, Z.; Department of Neurology, Rét u. 2, Hungary; email: pfund.zoltan@pte.hu AB - Brainstem descending modulatory circuits have been postulated to be involved in migraine. Differences in brainstem volume between migraineurs and healthy controls have been demonstrated in previous research, nevertheless, the effect of migraine aura on brainstem volume is still uncertain. The aim of this study was to investigate the brainstem volume in migraineurs and examine the effect of migraine aura on brainstem volume.Our study included 90 female migraine patients without white matter lesions. (29 migraine patients with aura (MwA) and 61 migraine patients without aura (MwoA) and 32 age-matched female healthy controls (HC). Using the FreeSurfer image analysis suite, the volumes of the entire brainstem and its subfields (medulla, pons, and midbrain) were measured and compared between migraine subgroups (MwA vs. MwoA) and the healthy control group. The possible effects of migraine characteristics (i.e., disease duration and migraine attack frequency) on brainstem volume were also investigated.Migraineurs had greater medulla volume (MwoA 3552 ± 459 mm3, MwA 3424 ± 448 mm3) than healthy controls (3236 ± 411 mm3). Statistically, MwA vs. HC p = 0.040, MwoA vs. HC p = 0.002, MwA vs. MwoA p = 0.555. A significant positive correlation was found between disease duration and the volume of medulla in the whole migraine group (r = 0.334, p = 0.001). Neither the whole brainstem nor its subfields were significantly different in volume between migraine subgroups.Brainstem volume changes in migraine are mainly localized to the medulla and not specific to the presence of aura. LA - English DB - MTMT ER - TY - JOUR AU - He, Mingchen AU - Kis-Jakab, Gréta AU - Komáromy, Hedvig AU - Perlaki, Gábor AU - Orsi, Gergely AU - Bosnyák, Edit AU - Rozgonyi, Renáta AU - John, Flóra AU - Trauninger, Anita AU - Eklicsné Lepenye, Katalin AU - Pfund, Zoltán TI - The volume of the thalamus and hippocampus in a right-handed female episodic migraine group JF - FRONTIERS IN NEUROLOGY J2 - FRONT NEUR VL - 14 PY - 2023 PG - 10 SN - 1664-2295 DO - 10.3389/fneur.2023.1254628 UR - https://m2.mtmt.hu/api/publication/34207248 ID - 34207248 LA - English DB - MTMT ER - TY - CHAP AU - Nagy, Judit AU - Komáromy, Hedvig ED - Vekerdy-Nagy, Zsuzsanna ED - Cserháti, Péter ED - Polgár, Anna ED - Tenk Miklósné Zsebe, Andrea TI - Képalkotó diagnosztika alkalmazása a rehabilitációs ellátásban T2 - A rehabilitációs és fizikális medicina módszertana PB - Medicina Könyvkiadó CY - Budapest SN - 9789632268569 PY - 2023 SP - 209 EP - 230 PG - 22 UR - https://m2.mtmt.hu/api/publication/33126566 ID - 33126566 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tóth, Luca AU - Czigler, András AU - Hegedüs, Emőke AU - Komáromy, Hedvig AU - Amrein, Krisztina AU - Czeiter, Endre AU - Yabluchanskiy, Andriy AU - Koller, Ákos AU - Orsi, Gergely AU - Perlaki, Gábor AU - Schwarcz, Attila AU - Büki, András AU - Ungvári, Zoltán István AU - Tóth, Péter József TI - Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults. JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 44 PY - 2022 IS - 6 SP - 2771 EP - 2783 PG - 13 SN - 2509-2715 DO - 10.1007/s11357-022-00623-2 UR - https://m2.mtmt.hu/api/publication/33032134 ID - 33032134 AB - Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) contributes to the genesis of age-related cognitive impairment. Aging is associated with marked deficiency in the vasoprotective hormone insulin-like growth factor-1 (IGF-1). Preclinical studies on animal models of aging suggest that circulating IGF-1 deficiency is causally linked to impairment of NVC responses. The present study was designed to test the hypotheses that decreases in circulating IGF-1 levels in older adults also predict the magnitude of age-related decline of NVC responses. In a single-center cross-sectional study, we enrolled healthy young (n = 31, 11 female, 20 male, mean age: 28.4 + / - 4.2 years) and aged volunteers (n = 32, 18 female, 14 male, mean age: 67.9 + / - 4.1 years). Serum IGF-1 level, basal CBF (phase contrast magnetic resonance imaging (MRI)), and NVC responses during the trail making task (with transcranial Doppler sonography) were assessed. We found that circulating IGF-1 levels were significantly decreased with age and associated with decreased basal CBF. Age-related decline in IGF-1 levels predicted the magnitude of age-related decline in NVC responses. In conclusion, our study provides additional evidence in support of the concept that age-related circulating IGF-1 deficiency contributes to neurovascular aging, impairing CBF and functional hyperemia in older adults. LA - English DB - MTMT ER - TY - JOUR AU - Berta, Balázs AU - Komáromy, Hedvig AU - Schwarcz, Attila AU - Kajtár, Béla AU - Büki, András AU - Kuncz, Ádám TI - Krónikus dialízis kapcsán kialakult destruktív cervicalis spondylarthropathia esete JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 74 PY - 2021 IS - 5-6 SP - 211 EP - 215 PG - 5 SN - 0019-1442 DO - 10.18071/isz.74.0211 UR - https://m2.mtmt.hu/api/publication/32070948 ID - 32070948 AB - A case of a 61-year-old male patient suffered chronic renal failure and dialysed for 23 years with destructive cervical spondylarthropathy is presented. The patient presented with sudden onset of cervical pain radiating into his shoulders without neurological deficits. CT and MRI of the cervical and thoracic spine revealed severe destructive changes and compressive fractures of C6 and C7 vertebrae which caused the narrowing of the nerve root canals at these levels. A 360-degree fixation was performed to treat the unstable fracture and the patient's pain (C6 and C7 corpectomy, autolog bone graft replacement of the two vertebral bodies, anterior plate fixation and posterior instrumentation with screws and rods). Postoperatively the patient had no significant pain, no neurological deficit and he was able to manage independent life himself. During the immediate follow-up CT of the neck showed the satisfactory position of the bone graft and the metal implantations. The 6 months follow-up CT revealed the anterior migration of the two screws from the Th1 vertebral body and 2 mm ventral elevation of the caudal end of the plate from the anterior surface of the Th1 vertebral body. The 1-year follow-up could not be performed because the patient died due to cardio-pulmonary insufficiency. This is the second Hungarian report of a chronic dialysis related severe spondylarthropathy which may cause pathologic fractures of the vertebral bodies. The typical radiological and histological findings are discussed. This disease affect patients' quality of life and the conservative treatment alone seems to be ineffective in most cases. Based on the literature and personal experiences, the authors suggest 360-degree fixation of the spine to provide sufficient stability for the vertebrae of "bad bone quality", and early mobilisation of the patient can be achieved. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Ottóffy, Gábor AU - Komáromy, Hedvig TI - Extraskeletal, intradural, non-metastatic Ewing's sarcoma. Case report. JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 73 PY - 2020 IS - 7-8 SP - 286 EP - 288 PG - 3 SN - 0019-1442 DO - 10.18071/isz.73.0268 UR - https://m2.mtmt.hu/api/publication/31377480 ID - 31377480 AB - [Intracranialis lokalizációjú Ewing-sarcoma nagyon ritkán fordul elő. Egy négyéves fiúgyermek klinikai és képalkotó vizsgálatainak jellegzetességeit ismertetjük. Koraszülött volt, intraventricularis vérzés szövődményeként kialakult posthaemorrhagiás hydrocephalus miatt ventriculoperitonealis sönt beültetésen esett át újszülöttkorában. Rendszeres gondozás során nem észleltük söntvezetési zavar vagy emelkedett intracranialis nyomás tüneteit. Nyolc hónapos korában készült utolsó képalkotó vizsgálata. Négyéves korában ismétlődő hányás, fokális epilepsziás rohamok kezdődtek. Koponya-MR-vizsgálata bal oldali frontoparietalis, a sinus sagittalis superiorba betörő térfoglaló folyamatot mutatott. Cranio­tomia során a tumor teljes eltávolításra került. A tumor­szövet hisztológiai vizsgálata igazolta a kis, kék, kerek sejtes daganatot. A Ewing-sarcoma diagnózisát az EWSR1-gén­­transzlokáció kimutatása FISH-módszerrel megerősítette. A staging vizsgálatokkal metasztázis nem volt kimutatható. A beteg az EuroEwing99 protokoll szerint kapta meg kezelését. 10 év telt el a diagnózis és a műtét óta, jelenleg is tumor- és rohammentes, életminősége jó.] LA - English DB - MTMT ER - TY - JOUR AU - Deli, Gabriella AU - Komáromy, Hedvig AU - Pál, Endre AU - Pfund, Zoltán TI - Perifériás motoros tünettannal társuló kórképek JF - IDEGGYOGYASZATI SZEMLE / CLINICAL NEUROSCIENCE J2 - IDEGGYOGY SZEMLE VL - 73 PY - 2020 IS - 3-4 SP - 85 EP - 98 PG - 14 SN - 0019-1442 DO - 10.18071/isz.73.0085 UR - https://m2.mtmt.hu/api/publication/30556226 ID - 30556226 AB - A perifériás neuropathiák, radiculopathiák és neuronopathiák ritka, de fontos alcsoportját képezik azok a betegségek, melyekben szelektíven a motoros rostok károsodása uralja a klinikai képet. Rendszerint progrediáló, fájdalmatlan izomgyengeséggel és -sorvadással járó kórképek tartoznak ide, amelyek differenciáldiagnosztikája a gyakorlott klinikus számára is komoly kihívást jelent. A diagnózis alapját a gondos anamnézisfelvétel, a kórlefolyás és a fizikális vizsgálat képezik, míg az eszközös vizsgálatok közül az elektrofiziológiának van kiemelt szerepe. A jelen közlemény célja a perifériás motoros kórképek klinikai jellegzetességeinek áttekintése, a lehetséges diagnosztikus lépések átgondolása, elkülönítésük egyéb motoros kórképektől, és a terápiás lehetőségek összefoglalása. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Komáromy, Hedvig AU - Pfund, Zoltán TI - Migrénes betegek intracerebralis fehérállományi lézióinak vizsgálata JF - NEUROLÓGIAI PRAXIS J2 - NEUROL PRAX VL - 2 PY - 2019 IS - 4 SP - 20 EP - 21 PG - 2 SN - 2560-2667 UR - https://m2.mtmt.hu/api/publication/31295757 ID - 31295757 LA - Hungarian DB - MTMT ER - TY - THES AU - Komáromy, Hedvig TI - Investigation of Migraine-Related Intracerebral White Matter Lesions PY - 2019 UR - https://m2.mtmt.hu/api/publication/30820367 ID - 30820367 LA - English DB - MTMT ER - TY - JOUR AU - Komáromy, Hedvig AU - He, Mingchen AU - Perlaki, Gábor AU - Orsi, Gergely AU - Nagy, Szilvia Anett AU - Bosnyák, Edit AU - Kamson Olayinka, Dávid AU - John, Flóra AU - Trauninger, Anita AU - Pfund, Zoltán TI - Influence of hemispheric white matter lesions and migraine characteristics on cortical thickness and volume JF - JOURNAL OF HEADACHE AND PAIN J2 - J HEADACHE PAIN VL - 20 ET - 0 PY - 2019 IS - 1 PG - 8 SN - 1129-2369 DO - 10.1186/s10194-019-0959-2 UR - https://m2.mtmt.hu/api/publication/30390795 ID - 30390795 AB - Migraine-related intracerebral white matter lesions (WMLs) are likely to be microvascular in nature and can be found in all hemispheric lobes. The aim of this study was to investigate migraine patients with or without WMLs to see the effects of these tissue damages on cortical thickness and volume. The role of migraine characteristics (duration of headache, attack frequency, estimated lifetime attack number, aura) was also tested.As study participants, 161 female migraine patients (63 with aura; 52 with WMLs) and 40 age-matched healthy female subjects were enrolled in the study. None of the included migraine patients' headache or aura (where present) was unilaterally side-locked. Patients and controls were all right handed. Except for migraine, patients were free of any medical comorbidity. Cortical reconstruction and segmentation were performed on the 3D T1-weighted images using Freesurfer 5.3 image analysis suite. The automatic cortical parcellation was based on Freesurfer's Desikan-Killiany-Tourville atlas, which has 31 cortical regions per hemisphere. The segmented regions were divided into five lobes (frontal, parietal, temporal, occipital, insula). Since the left and right differences in lobar and insular volumes/thicknesses were not different among our groups, volume and cortical thickness were calculated for corresponding bilateral lobes.There was no significant difference in age between the whole migraine and the control groups. Migraineurs with WMLs (L+ patients) were significantly older than lesion-free (L-) patients (P = 0.0003) and controls (P = 0.018). Disease duration (P = 0.003), the total number of migraine attacks (P = 0.022) and the rate of aura (P = 0.0003) were significantly higher in L+ patients than in L- patients. Cortical thickness and volume measurements of lobes were not statistically different between the three groups (L+, L-, control). Age showed a significant negative association with both thickness and volume in each examined lobe (P < 0.001). Intracranial volume (ICV) showed a significant positive association with all regional volumes (P < 0.001). There were no significant group*age, group*ICV, or age*ICV interactions. None of the migraine characteristics were selected by stepwise linear regression as significant predictors of cortical thickness or volume. Only age (for both thickness and volume) and ICV (for volume) were identified as significant predictors (P < 0.001). When the L + group was divided into two subgroups by median split of total and lobar lesion number and volume, the cortical measures did not show any significant difference between the groups with low vs. high lesion number/volume by stepwise linear regression.In a female migraine group, we found that the WMLs and clinical migraine characteristics have no effect on cortical thickness and volume of bilateral lobes. Lobar cortical thicknesses were equivalent within the range of ±0.1 mm. Only age and ICV proved to be significant predictors; the former for both cortical thickness and volume, while the latter for cortical volume. LA - English DB - MTMT ER -