@mastersthesis{MTMT:32475805,
	title = {Innovative approach for the application of MTT, LDH and bis-ANS: ex vivo modelling of the extracellular beta-amyloid precipitation [Az MTT, az LDH és a bis-ANS újszerű alkalmazása: az extracelluláris béta-amiloid precipitációjának ex vivo modellezése]},
	url = {https://m2.mtmt.hu/api/publication/32475805},
	author = {Jánosi-Mózes, Emese},
	doi = {10.14232/phd.10783},
	publisher = {SZTE},
	unique-id = {32475805},
	year = {2021},
	orcid-numbers = {Jánosi-Mózes, Emese/0000-0003-1532-289X}
}

@article{MTMT:31341681,
	title = {Alzheimer risk factors age and female sex induce cortical Aβ aggregation by raising extracellular zinc [Alzheimer risk factors age and female sex induce cortical A beta aggregation by raising extracellular zinc]},
	url = {https://m2.mtmt.hu/api/publication/31341681},
	author = {Datki, Zsolt László and Oláh, Zita and Jánosi-Mózes, Emese and Szegedi, Viktor and Kálmán, János and Hunya, Ákos and Fülöp, Lívia and Tamano, Haruna and Takeda, Atsushi and Adlard, Paul A. and Bush, Ashley I.},
	doi = {10.1038/s41380-020-0800-y},
	journal-iso = {MOL PSYCHIATR},
	journal = {MOLECULAR PSYCHIATRY},
	volume = {25},
	unique-id = {31341681},
	issn = {1359-4184},
	abstract = {Aging and female sex are the major risk factors for Alzheimer's disease and its associated brain amyloid-beta (A beta) neuropathology, but the mechanisms mediating these risk factors remain uncertain. Evidence indicates that A beta aggregation by Zn(2+)released from glutamatergic neurons contributes to amyloid neuropathology, so we tested whether aging and sex adversely influences this neurophysiology. Using acute hippocampal slices, we found that extracellular Zn2+-elevation induced by high K(+)stimulation was significantly greater with older (65 weeks vs 10 weeks old) rats, and was exaggerated in females. This was driven by slower reuptake of extracellular Zn2+, which could be recapitulated by mitochondrial intoxication. Zn2+:A beta aggregates were toxic to the slices, but A beta alone was not. Accordingly, high K(+)caused synthetic human A beta added to the slices to form soluble oligomers as detected by bis-ANS, attaching to neurons and inducing toxicity, with older slices being more vulnerable. Age-dependent energy failure impairing Zn(2+)reuptake, and a higher maximal capacity for Zn(2+)release by females, could contribute to age and sex being major risk factors for Alzheimer's disease.},
	year = {2020},
	eissn = {1476-5578},
	pages = {2728-2741},
	orcid-numbers = {Datki, Zsolt László/0000-0002-2537-4741; Oláh, Zita/0000-0002-6372-532X; Jánosi-Mózes, Emese/0000-0003-1532-289X; Szegedi, Viktor/0000-0003-4191-379X; Kálmán, János/0000-0001-5319-5639; Hunya, Ákos/0000-0002-4547-9284; Fülöp, Lívia/0000-0002-8010-0129}
}

@article{MTMT:2246475,
	title = {Docosahexaenoic acid reduces amyloid β-induced toxicity in cells of the neurovascular unit},
	url = {https://m2.mtmt.hu/api/publication/2246475},
	author = {Veszelka, Szilvia and Tóth, Andrea and Walter, Fruzsina and Datki, Zsolt László and Jánosi-Mózes, Emese and Fülöp, Lívia and Bozsó, Zsolt and Virághné Hellinger, Éva and Vastag, M and Orsolits, Barbara and Környei, Zsuzsanna and Penke, Botond and Deli, Mária Anna},
	doi = {10.3233/JAD-120163},
	journal-iso = {J ALZHEIMERS DIS},
	journal = {JOURNAL OF ALZHEIMER'S DISEASE},
	volume = {36},
	unique-id = {2246475},
	issn = {1387-2877},
	year = {2013},
	eissn = {1875-8908},
	pages = {487-501},
	orcid-numbers = {Walter, Fruzsina/0000-0001-8145-2823; Datki, Zsolt László/0000-0002-2537-4741; Jánosi-Mózes, Emese/0000-0003-1532-289X; Fülöp, Lívia/0000-0002-8010-0129; Bozsó, Zsolt/0000-0002-5713-3096; Penke, Botond/0000-0003-0938-0567; Deli, Mária Anna/0000-0001-6084-6524}
}

@article{MTMT:2148799,
	title = {Proteome-wide study of endoplasmic reticulum stress induced by thapsigargin in N2a neuroblastoma cells},
	url = {https://m2.mtmt.hu/api/publication/2148799},
	author = {Földi, István and Tóth, Anikó M and Szabó, Zoltán and Jánosi-Mózes, Emese and Berkecz, Róbert and Datki, Zsolt László and Penke, Botond and Janáky, Tamás},
	doi = {10.1016/j.neuint.2012.11.003},
	journal-iso = {NEUROCHEM INT},
	journal = {NEUROCHEMISTRY INTERNATIONAL},
	volume = {62},
	unique-id = {2148799},
	issn = {0197-0186},
	keywords = {Humans; Image Processing, Computer-Assisted; Cells, Cultured; Cell Line, Tumor; Blotting, Western; Cell Survival/drug effects; Enzyme Inhibitors/*pharmacology; Spectrum Analysis; neurodegenerative disorder; thapsigargin; Electrophoresis, Gel, Two-Dimensional; proteomics; Energy Metabolism/drug effects; Endoplasmic reticulum stress; GRP78; Neurites/drug effects; Two-dimensional electrophoresis; Mitochondria/drug effects/metabolism; Neuroblastoma/*pathology; Molecular Chaperones/metabolism; Thapsigargin/*pharmacology; Proteome/*genetics; Heat-Shock Proteins/biosynthesis/genetics; Endoplasmic Reticulum Stress/*drug effects/*genetics},
	year = {2013},
	eissn = {1872-9754},
	pages = {58-69},
	orcid-numbers = {Szabó, Zoltán/0000-0001-8278-8038; Jánosi-Mózes, Emese/0000-0003-1532-289X; Berkecz, Róbert/0000-0002-9076-2177; Datki, Zsolt László/0000-0002-2537-4741; Penke, Botond/0000-0003-0938-0567; Janáky, Tamás/0000-0002-6466-8283}
}

@article{MTMT:2121113,
	title = {A novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays},
	url = {https://m2.mtmt.hu/api/publication/2121113},
	author = {Jánosi-Mózes, Emese and Hunya, Ákos and Pósa, Anikó and Penke, Botond and Datki, Zsolt László},
	doi = {10.1016/j.brainresbull.2012.02.005},
	journal-iso = {BRAIN RES BULL},
	journal = {BRAIN RESEARCH BULLETIN},
	volume = {87},
	unique-id = {2121113},
	issn = {0361-9230},
	abstract = {It is difficult task to measure precisely the toxic effect of beta-amyloid (Abeta 1-42) peptides and also the protective effect of novel drug candidates against Abeta-peptides. The widely used MTT-assay in cell lines or primary cell cultures could be insensitive against Abeta-peptides. We describe here an easy and relevant method for testing Abeta 1-42 toxicity on acute hippocampal slices derived from rat. Brain slice viability in different conditions was measured using MTT and LDH assays. The concomitant use of these two assays can give detailed and relevant results on the toxic effect of Abeta 1-42 in oxygen-glucose deprived (OGD) acute brain slice model. Both assays are capable of quantifying tissue viability by measuring optical density (OD). We found that simultaneous application of OGD and Abeta 1-42 treatment induced a more intensive decrease in hippocampal slice viability than their separate effects. The use of MTT and LDH assay for quantifying brain slice viability proved to be an easy ex vivo method for investigating Abeta toxicity. Testing brain slices is more relevant in Alzheimer's Disease research than using in vitro cell cultures, due to maintenance of the three dimensional cellular network, the cell variability and intact cell connections.},
	keywords = {Animals; Male; RATS; Analysis of Variance; Rats, Wistar; Animals, Newborn; Hydrogen Peroxide/pharmacology; Anoxia/pathology; Amyloid beta-Peptides/*toxicity; Thiazoles/*metabolism; Tetrazolium Salts/*metabolism; Peptide Fragments/*toxicity; L-Lactate Dehydrogenase/*metabolism; Hippocampus/*drug effects/*metabolism; Glucose/deficiency; Cyanates/pharmacology},
	year = {2012},
	eissn = {1873-2747},
	pages = {521-525},
	orcid-numbers = {Jánosi-Mózes, Emese/0000-0003-1532-289X; Hunya, Ákos/0000-0002-4547-9284; Pósa, Anikó/0000-0003-2167-2888; Penke, Botond/0000-0003-0938-0567; Datki, Zsolt László/0000-0002-2537-4741}
}

@article{MTMT:1842704,
	title = {A novel application of the fluorescent dye bis-ANS for labeling neurons in acute brain slices},
	url = {https://m2.mtmt.hu/api/publication/1842704},
	author = {Jánosi-Mózes, Emese and Hunya, Ákos and Toth, A and Ayaydin, Ferhan and Penke, Botond and Datki, Zsolt László},
	doi = {10.1016/j.brainresbull.2011.07.004},
	journal-iso = {BRAIN RES BULL},
	journal = {BRAIN RESEARCH BULLETIN},
	volume = {86},
	unique-id = {1842704},
	issn = {0361-9230},
	abstract = {The cell-impermeant oligomer-(e.g. beta-amyloid-, or tubulin-) specific fluorescent dye, bis-ANS (4,4'-bis-1-anilinonaphtalene-8-sulfonate), was successfully used for labeling mechanically damaged but still viable neuron bodies, neurites and neurite cross sections in acute brain slices. Acute hippocampal brain slices of rats were co-stained with bis-ANS and the cell-impermeant. DNA-specific dye propidium iodide (PI) and were then analyzed using fluorescence and confocal microscopes. Both the neuron bodies and the neurites were found to exhibit increased fluorescence intensities, suggesting that using this method they can be detected more easily. In addition, bis-ANS showed good region - but not cell specific co-localization with the neuron-specific fluorescent dye Dil (1,1'-Dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate). These two dyes label different neuronal structures: Dil binds specifically to intact cell membranes while bis-ANS can enter cells with compromised cell membranes and then stain the microtubules in the cytoplasm. For a quick (10 min) staining of acute brain slices with bis-ANS both HEPES and NaHCO(3) were needed in order to achieve high signal intensity. Labeling with bis-ANS fluorescent dye is an easy method for imaging the neuronal structures on the surface of acute brain slices. (C) 2011 Elsevier Inc. All rights reserved.},
	keywords = {Animals; Male; BINDING; hippocampus; RATS; FLUORESCENCE; Microtubules/ultrastructure; Cytoplasm/ultrastructure; Cell Membrane/ultrastructure; Microscopy, Fluorescence; Staining and Labeling; NEURON; Cell Line, Tumor; Rats, Wistar; MOLECULE; Brain/*cytology; Coloring Agents; Microscopy, Confocal; Neurons/physiology/*ultrastructure; SH-SY5Y; Propidium; Tubulin/metabolism; Carbocyanines; tubulin; Acute slice; Bis-ANS; *Fluorescent Dyes/metabolism; *Anilino Naphthalenesulfonates/metabolism},
	year = {2011},
	eissn = {1873-2747},
	pages = {217-221},
	orcid-numbers = {Jánosi-Mózes, Emese/0000-0003-1532-289X; Hunya, Ákos/0000-0002-4547-9284; Penke, Botond/0000-0003-0938-0567; Datki, Zsolt László/0000-0002-2537-4741}
}