@article{MTMT:33553138,
	title = {Functionally active TRPA1 ion channel is downregulated in peptidergic neurons of the Edinger-Westphal nucleus upon acute alcohol exposure},
	url = {https://m2.mtmt.hu/api/publication/33553138},
	author = {Al-omari, Ammar and Kecskés, Miklós and Gaszner, Balázs and Biró-Sütő, Tünde and Fazekas, Balázs and Berta, Gergely and Kuzma, Mónika and Pintér, Erika and Kormos, Viktória},
	doi = {10.3389/fcell.2022.1046559},
	journal-iso = {FRONT CELL DEV BIOL},
	journal = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY},
	volume = {10},
	unique-id = {33553138},
	issn = {2296-634X},
	abstract = {Introduction: The centrally projecting Edinger-Westphal nucleus (EWcp) contributes to the control of alcohol consumption by its urocortin 1 (UCN1) and cocaine- and amphetamine-regulated transcript (CART) co-expressing peptidergic neurons. Our group recently showed that the urocortinergic centrally projecting EWcp is the primary seat of central nervous system transient receptor potential ankyrin 1 (TRPA1) cation channel mRNA expression. Here, we hypothesized that alcohol and its metabolites, that pass through the blood-brain barrier, may influence the function of urocortinergic cells in centrally projecting EWcp by activating TRPA1 ion channels. We aimed to examine the functional activity of TRPA1 in centrally projecting EWcp and its possible role in a mouse model of acute alcohol exposure.},
	year = {2023},
	eissn = {2296-634X},
	orcid-numbers = {Gaszner, Balázs/0000-0003-2830-2732; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:33293967,
	title = {Transient receptor potential ankyrin 1 ion channel expressed by the Edinger-Westphal nucleus contributes to stress adaptation in murine model of posttraumatic stress disorder},
	url = {https://m2.mtmt.hu/api/publication/33293967},
	author = {Konkoly, János and Kormos, Viktória and Gaszner, Balázs and Correia, Pedro and Berta, Gergely and Biró-Sütő, Tünde and Zelena, Dóra and Pintér, Erika},
	doi = {10.3389/fcell.2022.1059073},
	journal-iso = {FRONT CELL DEV BIOL},
	journal = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY},
	volume = {10},
	unique-id = {33293967},
	issn = {2296-634X},
	abstract = {The centrally projecting Edinger-Westphal nucleus (EWcp) is involved in stress adaptation. Transient receptor potential ankyrin 1 (TRPA1) mRNA was previously shown to be expressed abundantly in mouse and human EWcp urocortin 1 (UCN1) positive neurons and reacted to chronic stress. Since UCN1 neurons are deeply implicated in stress-related disorders, we hypothesized that TRPA1/UCN1 neurons are also affected in posttraumatic stress disorder (PTSD). We examined male Trpa1 wild type (WT) and gene-deficient (KO) mice in the single prolonged stress (SPS) model of PTSD. Two weeks later the behavioral changes were monitored by forced swim test (FST) and restraint. The Trpa1 and Ucn1 mRNA expression and the UCN1 peptide content were assessed by RNAscope in situ hybridization technique combined with immunofluorescence labeling in the EWcp. SPS-induced immobility was lower in Trpa1 KO compared to WT animals, both in the FST and restraint, corresponding to diminished depression-like behavior. The copy number of Trpa1 mRNA decreased significantly in EWcp of WT animals in response to SPS. Higher basal Ucn1 mRNA expression was observed in the EWcp of KO animals, that was not affected by SPS exposure. EWcp neurons of WT animals responded to SPS with substantially increased amount of UCN1 peptide content compared to control animals, whereas such changes were not observable in KO mice. The decreased Trpa1 mRNA expression in the SPS model of PTSD associated with increased neuronal UCN1 peptide content suggests that this cation channel might be involved in the regulation of stress adaptation and may contribute to the pathomechanism of PTSD.},
	year = {2022},
	eissn = {2296-634X},
	orcid-numbers = {Gaszner, Balázs/0000-0003-2830-2732; Correia, Pedro/0000-0002-4410-9855; Pintér, Erika/0000-0001-9898-632X}
}

@article{MTMT:31848850,
	title = {Analgesic Effects of Lipid Raft Disruption by Sphingomyelinase and Myriocin via Transient Receptor Potential Vanilloid 1 and Transient Receptor Potential Ankyrin 1 Ion Channel Modulation},
	url = {https://m2.mtmt.hu/api/publication/31848850},
	author = {Horváth, Ádám and Payrits, Maja and Steib, Anita and Kántás, Boglárka and Biró-Sütő, Tünde and Erostyák, János and Makkai, Géza and Sághy, Éva and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3389/fphar.2020.593319},
	journal-iso = {FRONT PHARMACOL},
	journal = {FRONTIERS IN PHARMACOLOGY},
	volume = {11},
	unique-id = {31848850},
	year = {2021},
	eissn = {1663-9812},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461}
}

@{MTMT:31684068,
	title = {Resolvin D1 and D2 inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel activation on sensory neurons via lipid raft modification},
	url = {https://m2.mtmt.hu/api/publication/31684068},
	author = {Payrits, Maja and Ádám, Horváth and Biró-Sütő, Tünde and János, Erostyák and Géza, Makkai and Sághy, Éva and Pohóczky, Krisztina and Kecskés, Angéla and Kecskés, Miklós and Szolcsányi, János and Helyes, Zsuzsanna and Szőke, Éva},
	booktitle = {Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project},
	unique-id = {31684068},
	year = {2020},
	pages = {59-59},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Pohóczky, Krisztina/0000-0003-0385-5162}
}

@article{MTMT:31625361,
	title = {In vitro and in vivo evidence for the role of lipid rafts in Ca2+-gating of the Transient Receptor Potential channels in sensory neurons},
	url = {https://m2.mtmt.hu/api/publication/31625361},
	author = {Szőke, Éva and Horvath, Adam and Biró-Sütő, Tünde and Sághy, Éva and Payrits, Maja and Erostyák, János and Makkai, Géza and Szolcsányi, János and Helyes, Zsuzsanna},
	doi = {10.1096/fasebj.2020.34.s1.05167},
	journal-iso = {FASEB J},
	journal = {FASEB JOURNAL},
	volume = {34},
	unique-id = {31625361},
	issn = {0892-6638},
	keywords = {Biology; Biochemistry & Molecular Biology},
	year = {2020},
	eissn = {1530-6860},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461}
}

@article{MTMT:31608849,
	title = {Antinociceptive Effects of Lipid Raft Disruptors, a Novel Carboxamido-Steroid and Methyl β-Cyclodextrin, in Mice by Inhibiting Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Channel Activation},
	url = {https://m2.mtmt.hu/api/publication/31608849},
	author = {Horváth, Ádám and Biró-Sütő, Tünde and Kántás, Boglárka and Payrits, Maja and Skodáné Földes, Rita and Szánti-Pintér, Eszter and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3389/fphys.2020.559109},
	journal-iso = {FRONT PHYSIOL},
	journal = {FRONTIERS IN PHYSIOLOGY},
	volume = {11},
	unique-id = {31608849},
	year = {2020},
	eissn = {1664-042X},
	orcid-numbers = {Skodáné Földes, Rita/0000-0002-9810-1509; Szánti-Pintér, Eszter/0000-0001-8263-9884}
}

@article{MTMT:31387590,
	title = {Resolvin D1 and D2 inhibit transient receptor potential vanilloid 1 and ankyrin 1 ion channel activation on sensory neurons via lipid raft modification},
	url = {https://m2.mtmt.hu/api/publication/31387590},
	author = {Payrits, Maja and Horváth, Ádám and Biró-Sütő, Tünde and Erostyák, János and Makkai, Géza and Sághy, Éva and Pohóczky, Krisztina and Kecskés, Angéla and Kecskés, Miklós and Szolcsányi, János and Helyes, Zsuzsanna and Szőke, Éva},
	doi = {10.3390/ijms21145019},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {21},
	unique-id = {31387590},
	issn = {1661-6596},
	abstract = {Transient Receptor Potential Vanilloid 1 and Ankyrin 1 (TRPV1, TRPA1) cation channels are expressed in nociceptive primary sensory neurons and regulate nociceptor and inflammatory functions. Resolvins are endogenous lipid mediators. Resolvin D1 (RvD1) is described as a selective inhibitor of TRPA1-related postoperative and inflammatory pain in mice acting on the G protein-coupled receptor DRV1/GPR32. Resolvin D2 (RvD2) is a very potent TRPV1 and TRPA1 inhibitor in DRG neurons, and decreases inflammatory pain in mice acting on the GPR18 receptor, via TRPV1/TRPA1-independent mechanisms. We provided evidence that resolvins inhibited neuropeptide release from the stimulated sensory nerve terminals by TRPV1 and TRPA1 activators capsaicin (CAPS) and allyl-isothiocyanate (AITC), respectively. We showed that RvD1 and RvD2 in nanomolar concentrations significantly decreased TRPV1 and TRPA1 activation on sensory neurons by fluorescent calcium imaging and inhibited the CAPS-and AITC-evoked45Ca-uptake on TRPV1-and TRPA1-expressing CHO cells. Since CHO cells are unlikely to express resolvin receptors, resolvins are suggested to inhibit channel opening through surrounding lipid raft disruption. Here, we proved the ability of resolvins to alter the membrane polarity related to cholesterol composition by fluorescence spectroscopy. It is concluded that targeting lipid raft integrity can open novel peripheral analgesic opportunities by decreasing the activation of nociceptors. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.},
	keywords = {LIPID RAFTS; transient receptor potential channel; sensory neuron; resolvin D1; nerve terminal; Resolvin D2},
	year = {2020},
	eissn = {1422-0067},
	orcid-numbers = {Sághy, Éva/0000-0002-4031-3461; Pohóczky, Krisztina/0000-0003-0385-5162}
}