TY - JOUR AU - Cserni, Gábor AU - Kálmán, Endre AU - Udvarhelyi, Nóra AU - Papp, Eszter AU - Grote, Isabel AU - Bartels, Stephan AU - Christgen, Matthias AU - Kreipe, Hans AU - Kulka, Janina TI - Evaluation of the routine use of E-cadherin immunohistochemistry in the typing of breast carcinomas : results of a randomized diagnostic study JF - HISTOPATHOLOGY J2 - HISTOPATHOLOGY VL - 83 PY - 2023 IS - 5 SP - 810 EP - 821 PG - 12 SN - 0309-0167 DO - 10.1111/his.15026 UR - https://m2.mtmt.hu/api/publication/34113096 ID - 34113096 N1 - Department of Pathology, Bács-Kiskun County Teaching Hospital, Kecskemét, Hungary Department of Pathology, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary Institute of Pathology, University of Pécs, Pécs, Hungary Department of Surgical and Molecular Pathology, Centre of Tumour Pathology, National Institute of Oncology, Budapest, Hungary Institute of Pathology, Hannover Medical School, Hannover, Germany Department of Pathology, Forensic and Insurance Medicine, Semmelweis University, Budapest, Hungary Export Date: 20 March 2024 CODEN: HISTD Correspondence Address: Cserni, G.; Department of Pathology, Nyíri út 38, Hungary; email: cserni@freemail.hu Chemicals/CAS: uvomorulin, 112956-45-3 AB - Invasive lobular carcinoma (ILC) has distinct morphology and association with loss of E-cadherin function. It has special clinical and imaging features, and its proper recognition is important. Following a recent proposal, we tested the value of the routine use of E-cadherin immunohistochemistry (IHC) in recognizing ILC.Five pathologists with experience in breast pathology from four Hungarian institutions histotyped 1001 breast cancers from diagnostic core biopsies or excision specimens randomly assigned to haematoxylin and eosin (HE) diagnosis first, followed by E-cadherin IHC; or to immediate HE and E-cadherin-based diagnosis. Of 524 cases with HE diagnosis, 73(14%) were deemed uncertain. E-cadherin made the initial histological type change in 14/524 cases (2.7%), including three with confident HE-based type allocation. Use of E-cadherin immunostaining was considered useful in 88/477 cases (18%) with immediate dual assessment, and typing uncertainty went down to 5% (25/477 cases), but was not zero. Collective assessment of 171 uncertain, difficult, nonclassical cases resulted in consensus diagnosis in most cases, but 15 cases were still doubtful as concerns their proper histological type. CDH1 gene sequencing was attempted and successful in 13; pathogenic genetic alterations were identified in seven cases.The routine use of E-cadherin IHC decreases the uncertainty in typing and improves the typing accuracy at the cost of potentially redundant additional immunostains. Furthermore, this procedure does not exclude uncertainty due to E-cadherin-positive ILCs, which are occasionally difficult to confidently label as ILC, especially when the growth pattern is not classic. LA - English DB - MTMT ER - TY - GEN AU - Papp, Eszter AU - Udvarhelyi, Nóra TI - A VAB mintavételek feldolgozása. A szeletelt specimen mammográfia indikációi, kivitelezése és nehézségei a mindennapi patológiai gyakorlatban. PY - 2023 UR - https://m2.mtmt.hu/api/publication/33623554 ID - 33623554 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Cserni, Gábor AU - Francz, Monika AU - Járay, Balázs AU - Kálmán, Endre AU - Kovács, Ilona AU - Krenács, Tibor AU - Tóth, Erika AU - Udvarhelyi, Nóra AU - Vass, László AU - Vörös, András AU - Krivokuca, Ana AU - Kajo, Karol AU - Kajová Macháleková, Katarína AU - Kulka, Janina TI - Pathological Diagnosis, Work-Up and Reporting of Breast Cancer 1st Central-Eastern European Professional Consensus Statement on Breast Cancer JF - PATHOLOGY AND ONCOLOGY RESEARCH J2 - PATHOL ONCOL RES VL - 28 PY - 2022 PG - 26 SN - 1219-4956 DO - 10.3389/pore.2022.1610373 UR - https://m2.mtmt.hu/api/publication/33024107 ID - 33024107 N1 - Besorolása Jelentés az MTA V. Osztályának ajánlása alapján. (BA, SZTE admin5) AB - This text is based on the recommendations accepted by the 4th Hungarian Consensus Conference on Breast Cancer, modified on the basis of the international consultation and conference within the frames of the Central-Eastern European Academy of Oncology. The recommendations cover non-operative, intraoperative and postoperative diagnostics, determination of prognostic and predictive markers and the content of cytology and histology reports. Furthermore, they address some specific issues such as the current status of multigene molecular markers, the role of pathologists in clinical trials and prerequisites for their involvement, and some remarks about the future. LA - English DB - MTMT ER - TY - GEN AU - Papp, Eszter AU - Éles, Klára AU - Betenbuk, Judit AU - Udvarhelyi, Nóra TI - Emlődaganatok szövettani vizsgálatának eredménye a nemzetközi adatok tükrében az Országos Onkológiai Intézetben PY - 2022 UR - https://m2.mtmt.hu/api/publication/32742788 ID - 32742788 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Leiner, Maja AU - Tóth, Erika AU - Udvarhelyi, Nóra TI - Corynebacterium caused cystic neutrophilic granulomatous mastitis JF - VIRCHOWS ARCHIV J2 - VIRCHOWS ARCH VL - 479 PY - 2021 SP - S190 EP - S191 PG - 2 SN - 0945-6317 UR - https://m2.mtmt.hu/api/publication/33047856 ID - 33047856 LA - English DB - MTMT ER - TY - JOUR AU - Székely, Borbála AU - Papp, Eszter AU - Somorácz-Kiss, Dóra AU - Hegyi, Barbara AU - Udvarhelyi, Nóra AU - Szentkereszty, Márton AU - Tóth, Erika AU - Rubovszky, Gábor TI - Mellkasi SMARCA4-deficiens differenciálatlan tumor − esetbemutatás JF - MAGYAR ONKOLÓGIA J2 - MAGYAR ONKOLÓGIA VL - 65 PY - 2021 IS - 1 SP - 54 EP - 54 PG - 1 SN - 0025-0244 UR - https://m2.mtmt.hu/api/publication/32546673 ID - 32546673 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Újhelyi, Mihály AU - Szollar, Andras AU - Polgár, Csaba AU - Oláh, Edit AU - Pukancsik, Dávid AU - Rubovszky, Gábor AU - Udvarhelyi, Nóra AU - Kovacs, Tibor AU - Sávolt, Ákos AU - Kenessey, István AU - Mátrai, Zoltán Tamás TI - A Long-Term Retrospective Comparative Study of The Oncological Outcomes of 598 Very Young (≤35 Years) and Young (36-45 Years) Breast Cancer Patients JF - EUROPEAN JOURNAL OF SURGICAL ONCOLOGY J2 - EUR J SURG ONCOL (EJSO) VL - 46 PY - 2020 IS - 2 SP - e1 EP - e2 SN - 0748-7983 DO - 10.1016/j.ejso.2019.11.006 UR - https://m2.mtmt.hu/api/publication/31824193 ID - 31824193 LA - English DB - MTMT ER - TY - JOUR AU - Cserni, Gábor AU - Francz, Monika AU - Járay, Balázs AU - Kálmán, Endre AU - Kovács, Ilona AU - Krenács, Tibor AU - Tóth, Erika AU - Udvarhelyi, Nóra AU - Vass, László AU - Vörös, András AU - Kulka, Janina TI - Az emlőrák patológiai diagnosztikája, feldolgozása és kórszövettani leletezése. Szakmai útmutatás a IV. Emlőrák Konszenzus Konferencia alapján [Pathological diagnosis, work-up and reporting of breast cancer. Recommendations from the 4th Breast Cancer Consensus Conference] JF - MAGYAR ONKOLÓGIA J2 - MAGYAR ONKOLÓGIA VL - 64 PY - 2020 IS - 4 SP - 301 EP - 328 PG - 28 SN - 0025-0244 UR - https://m2.mtmt.hu/api/publication/31782993 ID - 31782993 N1 - Besorolása Jelentés az MTA V. Osztályának ajánlása alapján. (BCS, SZTE admin4) AB - There have been some relevant changes in the diagnosis and treatment of breast cancer to implement the updating of the 2016 recommendations made during the 3rd national consensus conference on the disease. Following a wide interdisciplinary consultation, the present recommendations have been finalized after their public discussion at the 4th Hungarian Breast Cancer Consensus Conference. The recommendations cover non-operative, intraoperative and postoperative diagnostics, the determination of prognostic and predictive markers and the content of the cytology and histology reports. Furthermore, it touches some special issues such as the current status of multigene molecular markers, the role of pathologists in clinical trials and prerequisites for their involvement, some relevant points about the future. The most important changes include the integration of the TNM 8th edition, the WHO classification of breast tumors 5th edition, the ASCO/CAP HER2 assessment guidelines from 2018, and the Yokohama terminology for cytology reporting; a more detailed text on tumor-infiltrating lymphocytes and size determination after neoadjuvant therapy and a broader discussion of molecular tests. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Újhelyi, Mihály AU - Szollár, András AU - Polgár, Csaba AU - Oláh, Edit AU - Pukancsik, Dávid AU - Rubovszky, Gábor AU - Udvarhelyi, Nóra AU - Kovács, Tibor AU - Sávolt, Ákos AU - Kenessey, István AU - Mátrai, Zoltán Tamás TI - 598 nagyon fiatal (≤35 év) és fiatal (36-45 év) emlőrákos beteg hosszú távú retrospektív klinikopatológiai összehasonlító vizsgálata JF - MAGYAR SEBÉSZET J2 - MAGYAR SEBÉSZET VL - 72 PY - 2019 IS - 3 SP - 129 SN - 0025-0295 UR - https://m2.mtmt.hu/api/publication/31409182 ID - 31409182 LA - Hungarian DB - MTMT ER - TY - CONF AU - Újhelyi, Mihály AU - Szollár, András AU - Polgár, Csaba AU - Oláh, Edit AU - Pukancsik, Dávid AU - Rubovszky, Gábor AU - Udvarhelyi, Nóra AU - Kovács, Tibor AU - Sávolt, Ákos AU - Kenessey, István AU - Mátrai, Zoltán Tamás TI - 598 nagyon fiatal (≤35 év) és fiatal (36-45 év) emlőrákos beteg hosszú távú retrospektív klinikopatológiai összehasonlító vizsgálata T2 - VIII. Szegedi Emlőrák Szimpózium PY - 2019 SP - 42 EP - 42 PG - 1 UR - https://m2.mtmt.hu/api/publication/31312114 ID - 31312114 LA - Hungarian DB - MTMT ER -