TY - THES AU - Ménesi, Rudolf TI - A ghrelin-indukálta oxitocin elválasztás vizsgálata in vivo állatmodellben [Examination of the ghrelin-induced oxytocin release in an in vivo animal model] PB - Szegedi Tudományegyetem (SZTE) PY - 2020 SP - 54 DO - 10.14232/phd.10412 UR - https://m2.mtmt.hu/api/publication/31390867 ID - 31390867 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szabó, Renáta AU - Ménesi, Rudolf AU - Molnár, Andor AU - Szalai, Zita AU - Daruka, Lejla AU - Tóth, Gábor AU - Gardi, János AU - Gálfi, Márta AU - Börzsei, Denise AU - Kupai, Krisztina AU - Juhász, Anna AU - Radács, Marianna AU - László, Ferenc AU - Varga, Csaba AU - Pósa, Anikó TI - New Metabolic Influencer on Oxytocin Release: The Ghrelin JF - MOLECULES J2 - MOLECULES VL - 24 PY - 2019 IS - 4 PG - 8 SN - 1420-3049 DO - 10.3390/molecules24040735 UR - https://m2.mtmt.hu/api/publication/30446615 ID - 30446615 N1 - The study was supported by GINOP-2.3.2-15-2016-00062 and the Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Furthermore, this work has been supported by the European Union, cofinanced by the European Social Fund EFOP-3.6.2-16-2017-00009. LA - English DB - MTMT ER - TY - GEN AU - Szabó, Renáta AU - Ménesi, Rudolf AU - Börzsei, Denise AU - Karácsonyi, Zoltán AU - Kupai, Krisztina AU - Veszelka, Médea AU - Török, Szilvia AU - Magyariné, Berkó Anikó AU - Varga, Csaba AU - Pósa, Anikó TI - A szabadidős testmozgás hatása az izoproterenol-indukálta miokardiális infarktus következményeire kísérletes menopauzában PY - 2018 UR - https://m2.mtmt.hu/api/publication/30445868 ID - 30445868 N1 - poszter LA - Hungarian DB - MTMT ER - TY - GEN AU - Szabó, Renáta AU - Csonka, Anett AU - Veszelka, Médea AU - Kupai, Krisztina AU - Magyariné, Berkó Anikó AU - Deim, Zoltán AU - Baráth, Zoltán Lajos AU - Ménesi, Rudolf AU - Pávó, Imre AU - Gyöngyösi, Mariann AU - László, Ferenc AU - Varga, Csaba AU - Pósa, Anikó TI - The effects of aging and experimental menopause on the cardiac and inflammatory parameters PY - 2016 UR - https://m2.mtmt.hu/api/publication/3080751 ID - 3080751 N1 - [előadás] LA - English DB - MTMT ER - TY - GEN AU - Szabó, Renáta AU - Kupai, Krisztina AU - Veszelka, Médea AU - Csonka, Anett AU - Török, Szilvia AU - Ménesi, Rudolf AU - Varga, Csaba AU - Pávó, Imre AU - Pósa, Anikó TI - Az ösztrogén-hiány következményeként kialakuló keringési és gyulladásos folyamatok vizsgálata patkány modellen PY - 2015 UR - https://m2.mtmt.hu/api/publication/3080854 ID - 3080854 N1 - előadás LA - Hungarian DB - MTMT ER - TY - JOUR AU - Pósa, Anikó AU - Szabó, Renáta AU - Csonka, Anett AU - Veszelka, Médea AU - Magyariné, Berkó Anikó AU - Baráth, Zoltán Lajos AU - Ménesi, Rudolf AU - Pavo, Imre AU - Gyongyosi, Mariann AU - Laszlo, Ferenc AU - Kupai, Krisztina AU - Varga, Csaba TI - Endogenous Estrogen-Mediated Heme Oxygenase Regulation in Experimental Menopause JF - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY J2 - OXID MED CELL LONGEV VL - 2015 PY - 2015 IS - Special Issue PG - 7 SN - 1942-0900 DO - 10.1155/2015/429713 UR - https://m2.mtmt.hu/api/publication/2934174 ID - 2934174 AB - Estrogen deficiency is one of the main causes of age-associated diseases in the cardiovascular system. Female Wistar rats were divided into four experimental groups: pharmacologically ovariectomized, surgically ovariectomized, and 24-month-old intact aging animals were compared with a control group. The activity and expression of heme oxygenases (HO) in the cardiac left ventricle, the concentrations of cardiac interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), the myeloperoxidase (MPO) activity in the cardiac left ventricle, and the effects of heme oxygenase blockade (by 24-hour and 1-hour pretreatment with tin-protoporphyrin IX, SnPP) on the epinephrine and phentolamine-induced electrocardiogram ST segment changes in vivo were investigated. The cardiac HO activity and the expression of HO-1 and HO-2 were significantly decreased in the aged rats and after ovariectomy. Estrogen depletion was accompanied by significant increases in the expression of IL-6 and TNF-alpha. The aged and ovariectomized animals exhibited a significantly elevated MPO activity and a significant ST segment depression. After pretreatment with SnPP augmented ST segment changes were determined. These findings demonstrate that the sensitivity to cardiac ischemia in estrogen depletion models is associated with suppression of the activity and expression of the HO system and increases in the secretion of proinflammatory cytokines and biomarkers. LA - English DB - MTMT ER - TY - JOUR AU - Pósa, Anikó AU - Szabó, Renáta AU - Kupai, Krisztina AU - Baráth, Zoltán Lajos AU - Szalai, Zita AU - Csonka, Anett AU - Veszelka, Médea AU - Gyöngyösi, Mariann AU - Radák, Zsolt AU - Ménesi, Rudolf AU - Pávó, Imre AU - Magyariné, Berkó Anikó AU - Varga, Csaba TI - Cardioprotective effects of voluntary exercise in a rat model: role of matrix metalloproteinase-2 JF - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY J2 - OXID MED CELL LONGEV VL - 2015 PY - 2015 IS - Special Issue PG - 9 SN - 1942-0900 DO - 10.1155/2015/876805 UR - https://m2.mtmt.hu/api/publication/2788926 ID - 2788926 N1 - Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Szeged, 6726, Hungary Faculty of Dentistry and Department of Orthodontics and Pediatric Dentistry, University of Szeged, Szeged, 6720, Hungary Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Alkotas Ucta 44, Budapest, 1123, Hungary Cited By :9 Export Date: 28 August 2019 Correspondence Address: Pósa, A.; Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Hungary; email: paniko@bio.u-szeged.hu Chemicals/CAS: gelatinase A, 146480-35-5; phentolamine, 50-60-2, 73-05-2; argipressin, 113-79-1; epinephrine, 51-43-4, 55-31-2, 6912-68-1; Arginine Vasopressin; Epinephrine; Matrix Metalloproteinase 2; Phentolamine Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Szeged, 6726, Hungary Faculty of Dentistry and Department of Orthodontics and Pediatric Dentistry, University of Szeged, Szeged, 6720, Hungary Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Alkotas Ucta 44, Budapest, 1123, Hungary Cited By :12 Export Date: 22 November 2020 Correspondence Address: Pósa, A.; Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Hungary; email: paniko@bio.u-szeged.hu Chemicals/CAS: gelatinase A, 146480-35-5; phentolamine, 50-60-2, 73-05-2; argipressin, 113-79-1; epinephrine, 51-43-4, 55-31-2, 6912-68-1; Arginine Vasopressin; Epinephrine; Matrix Metalloproteinase 2; Phentolamine Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Szeged, 6726, Hungary Faculty of Dentistry and Department of Orthodontics and Pediatric Dentistry, University of Szeged, Szeged, 6720, Hungary Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Alkotas Ucta 44, Budapest, 1123, Hungary Cited By :12 Export Date: 10 January 2021 Correspondence Address: Pósa, A.; Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Hungary; email: paniko@bio.u-szeged.hu Chemicals/CAS: gelatinase A, 146480-35-5; phentolamine, 50-60-2, 73-05-2; argipressin, 113-79-1; epinephrine, 51-43-4, 55-31-2, 6912-68-1; Arginine Vasopressin; Epinephrine; Matrix Metalloproteinase 2; Phentolamine Department of Physiology, Anatomy and Neuroscience, University of Szeged, Kozep Fasor 52, Szeged, 6726, Hungary Faculty of Dentistry and Department of Orthodontics and Pediatric Dentistry, University of Szeged, Szeged, 6720, Hungary Department of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, Vienna, 1090, Austria Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Alkotas Ucta 44, Budapest, 1123, Hungary Cited By :12 Export Date: 12 March 2021 Correspondence Address: Pósa, A.; Department of Physiology, Kozep Fasor 52, Hungary; email: paniko@bio.u-szeged.hu Chemicals/CAS: gelatinase A, 146480-35-5; phentolamine, 50-60-2, 73-05-2; argipressin, 113-79-1; epinephrine, 51-43-4, 55-31-2, 6912-68-1; Arginine Vasopressin; Epinephrine; Matrix Metalloproteinase 2; Phentolamine LA - English DB - MTMT ER - TY - JOUR AU - Pósa, Anikó AU - Kupai, Krisztina AU - Ménesi, Rudolf AU - Szalai, Zita AU - Szabó, Renáta AU - Pintér, Zoltán AU - Pálfi, György AU - Gyöngyösi, M AU - Magyariné, Berkó Anikó AU - Pávó, I AU - Varga, Csaba TI - Sexual dimorphism of cardiovascular ischemia susceptibility is mediated by heme oxygenase JF - OXIDATIVE MEDICINE AND CELLULAR LONGEVITY J2 - OXID MED CELL LONGEV VL - 2013 PY - 2013 IS - Special Issue PG - 11 SN - 1942-0900 DO - 10.1155/2013/521563 UR - https://m2.mtmt.hu/api/publication/2473505 ID - 2473505 AB - We investigated the gender differences in heme-oxygenase (HO) enzyme, which produces endogenous vascular protective carbon monoxide (CO). We studied (1) the activity and expression of HO enzymes in the left ventricle (LV) and aorta, (2) basal increase in basal blood pressure provoked by arginine vasopressine (AVP) in vivo, (3) the heart perfusion induced by AVP, (4) the ST segment depression provoked by adrenaline and 30 seconds later phentolamine, and (5) the aorta ring contraction induced by AVP in female and male Wistar rats. We found that HO activity and the expression of HO-1 and HO-2 were increased in female rat aorta and LV. We demonstrated that the basal blood pressure and administration of AVP provoked blood pressure response are increased in the males; the female myocardium was less sensitive towards angina. Both differences could be aggravated by the inhibition of HO. The aorta rings were more susceptible towards vasoconstriction by AVP in males; isolated heart perfusion decrease was higher in males. The HO inhibition aggravated the heart perfusion in both sexes. In conclusion, the increased HO activity and expression in females might play a role in the sexual dimorphism of cardiovascular ischemia susceptibility during the reproductive age. © 2013 Anikó Pósa et al. LA - English DB - MTMT ER - TY - CONF AU - Szabó, Renáta AU - Pósa, Anikó AU - Magyariné, Berkó Anikó AU - Szalai, Zita AU - Ménesi, Rudolf AU - Varga, Csaba ED - Csernoch, László TI - A rekreatív testmozgás hatása a hem-oxigenáz, nitrogénmonoxid-szintáz és matrix metalloproteázok aktivitására és expressziójára patkány kardiovaszkuláris rendszerben T2 - A Magyar Élettani Társaság, a Magyar Anatómusok Társasága, a Magyar Biofizikai Társaság és a Magyar Mikrocirkulációs és Vaszkuláris Biológiai Társaság Kongresszusa PB - Magyar Élettani Társaság PY - 2012 SP - 33 EP - 33 PG - 1 UR - https://m2.mtmt.hu/api/publication/2186611 ID - 2186611 N1 - [előadás] LA - Hungarian DB - MTMT ER - TY - CONF AU - Ménesi, Rudolf AU - Lelovics, Zsuzsanna AU - Kovács, Ildikó AU - László, Ferenc TI - Sodium sensitive hypertension, the effectiveness of salt restriction. T2 - Abstracts of Croatian–Hungarian Young Investigator Conference PY - 2010 SP - 101 EP - 101 PG - 1 UR - https://m2.mtmt.hu/api/publication/1526992 ID - 1526992 LA - English DB - MTMT ER -