@article{MTMT:35526600,
	title = {Formulation and characterization of nanofibrous scaffolds incorporating extracellular vesicles loaded with curcumin},
	url = {https://m2.mtmt.hu/api/publication/35526600},
	author = {Nochta-Kazsoki, Adrienn Katalin and Németh, Krisztina and Visnovitz, Tamás and Lenzinger, Dorina and Buzás, Edit Irén and Zelkó, Romána},
	doi = {10.1038/s41598-024-79277-3},
	journal-iso = {SCI REP},
	journal = {SCIENTIFIC REPORTS},
	volume = {14},
	unique-id = {35526600},
	year = {2024},
	eissn = {2045-2322},
	orcid-numbers = {Nochta-Kazsoki, Adrienn Katalin/0000-0002-0611-3124; Németh, Krisztina/0000-0002-3825-2137; Visnovitz, Tamás/0000-0002-7962-5083; Buzás, Edit Irén/0000-0002-3744-206X; Zelkó, Romána/0000-0002-5419-9137}
}

@article{MTMT:35467844,
	title = {Reduced circulating CD63+ extracellular vesicle levels associate with atherosclerosis in hypercholesterolaemic mice and humans},
	url = {https://m2.mtmt.hu/api/publication/35467844},
	author = {Kestecher, Brachyahu Meir and Németh, Krisztina and Ghosal, Sayam and Sayour, Viktor Nabil and Gergely, Tamás G and Bodnár, Bernadett Réka and Försönits, András and Sódar, Barbara and Oesterreicher, Johannes and Holnthoner, Wolfgang and Varga, Zoltán and Giricz, Zoltán and Ferdinandy, Péter and Buzás, Edit Irén and Osteikoetxea, Xabier},
	doi = {10.1186/s12933-024-02459-w},
	journal-iso = {CARDIOVASC DIABETOL},
	journal = {CARDIOVASCULAR DIABETOLOGY},
	volume = {23},
	unique-id = {35467844},
	issn = {1475-2840},
	year = {2024},
	eissn = {1475-2840},
	orcid-numbers = {Németh, Krisztina/0000-0002-3825-2137; Ghosal, Sayam/0000-0001-6618-930X; Bodnár, Bernadett Réka/0000-0003-3347-9225; Försönits, András/0000-0002-9298-8890; Sódar, Barbara/0000-0002-8803-7304; Varga, Zoltán/0000-0002-2758-0784; Giricz, Zoltán/0000-0003-2036-8665; Ferdinandy, Péter/0000-0002-6424-6806; Buzás, Edit Irén/0000-0002-3744-206X; Osteikoetxea, Xabier/0000-0003-3628-0174}
}

@article{MTMT:35401823,
	title = {Therapeutic and pharmacological applications of extracellular vesicles and lipoproteins},
	url = {https://m2.mtmt.hu/api/publication/35401823},
	author = {Németh, Krisztina and Kestecher, Brachyahu Meir and Ghosal, Sayam and Bodnár, Bernadett Réka and Kittel, Ágnes and Hambalkó, Szabolcs and Kovácsházi, Csenger and Giricz, Zoltán and Ferdinandy, Péter and Osteikoetxea, Xabier and Burkhardt, Ralph and Buzás, Edit Irén and Orsó, Evelin Katalin},
	doi = {10.1111/bph.17336},
	journal-iso = {BR J PHARMACOL},
	journal = {BRITISH JOURNAL OF PHARMACOLOGY},
	volume = {181},
	unique-id = {35401823},
	issn = {0007-1188},
	abstract = {In recent years, various approaches have been undertaken to eliminate lipoproteins co‐isolated with extracellular vesicles, as they were initially regarded as contaminating entities. However, novel discoveries are reshaping our perspective. In body fluids, these distinct particles not only co‐exist, but also interactions between them are likely to occur. Extracellular vesicles and lipoproteins can associate with each other, share cargo, influence each other's functions, and jointly have a role in the pathomechanisms of diseases. Additionally, their association carries important implications for therapeutic and pharmacological aspects of lipid‐lowering strategies. Extracellular vesicles and lipoprotein particles may have roles in the elimination of each other from the circulation. The objective of this minireview is to delve into these aspects. Here, we show that under certain physiological and pathological conditions, extracellular vesicles and lipoproteins are ‘partners’ rather than ‘strangers’ or ‘rivals’.},
	year = {2024},
	eissn = {1476-5381},
	pages = {4733-4749},
	orcid-numbers = {Németh, Krisztina/0000-0002-3825-2137; Ghosal, Sayam/0000-0001-6618-930X; Bodnár, Bernadett Réka/0000-0003-3347-9225; Kovácsházi, Csenger/0000-0003-0283-9486; Giricz, Zoltán/0000-0003-2036-8665; Ferdinandy, Péter/0000-0002-6424-6806; Osteikoetxea, Xabier/0000-0003-3628-0174; Buzás, Edit Irén/0000-0002-3744-206X}
}

@article{MTMT:34720930,
	title = {A “torn bag mechanism” of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)},
	url = {https://m2.mtmt.hu/api/publication/34720930},
	author = {Visnovitz, Tamás and Lenzinger, Dorina and Koncz, Anna and Vizi, Péter M and Bárkai, Tünde and Visnovitzné Dr Vukman, Krisztina and Galinsoga, Alicia and Németh, Krisztina and Fletcher, Kelsey and Komlósi, Zsolt and Lőrincz, Péter and Valcz, Gábor and Buzás, Edit Irén},
	doi = {10.7554/eLife.95828.1},
	journal-iso = {ELIFE},
	journal = {ELIFE},
	volume = {13},
	unique-id = {34720930},
	issn = {2050-084X},
	year = {2024},
	eissn = {2050-084X},
	orcid-numbers = {Visnovitz, Tamás/0000-0002-7962-5083; Koncz, Anna/0000-0003-2511-2394; Németh, Krisztina/0000-0002-3825-2137; Komlósi, Zsolt/0000-0002-4149-1497; Lőrincz, Péter/0000-0001-7374-667X; Valcz, Gábor/0000-0002-7109-3529; Buzás, Edit Irén/0000-0002-3744-206X}
}

@article{MTMT:34567532,
	title = {Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches},
	url = {https://m2.mtmt.hu/api/publication/34567532},
	author = {Welsh, Joshua A. and Goberdhan, Deborah C. I. and O'Driscoll, Lorraine and Buzás, Edit Irén and Blenkiron, Cherie and Bussolati, Benedetta and Cai, Houjian and Di Vizio, Dolores and Driedonks, Tom A. P. and Erdbrügger, Uta and Falcon‐Perez, Juan M. and Fu, Qing‐Ling and Hill, Andrew F. and Lenassi, Metka and Lim, Sai Kiang and Mahoney, Mỹ G. and Mohanty, Sujata and Möller, Andreas and Nieuwland, Rienk and Ochiya, Takahiro and Sahoo, Susmita and Torrecilhas, Ana C. and Zheng, Lei and Zijlstra, Andries and Abuelreich, Sarah and Bagabas, Reem and Bergese, Paolo and Bridges, Esther M. and Brucale, Marco and Burger, Dylan and Carney, Randy P. and Cocucci, Emanuele and Colombo, Federico and Crescitelli, Rossella and Hanser, Edveena and Harris, Adrian L. and Haughey, Norman J. and Hendrix, An and Ivanov, Alexander R. and Jovanovic‐Talisman, Tijana and Kruh‐Garcia, Nicole A. and Ku'ulei‐Lyn Faustino, Vroniqa and Kyburz, Diego and Lässer, Cecilia and Lennon, Kathleen M. and Lötvall, Jan and Maddox, Adam L. and Martens‐Uzunova, Elena S. and Mizenko, Rachel R. and Newman, Lauren A. and Ridolfi, Andrea and Rohde, Eva and Rojalin, Tatu and Rowland, Andrew and Saftics, Andras and Sandau, Ursula S. and Saugstad, Julie A. and Shekari, Faezeh and Swift, Simon and Ter‐Ovanesyan, Dmitry and Tosar, Juan P. and Useckaite, Zivile and Valle, Francesco and Varga, Zoltán and van der Pol, Edwin and van Herwijnen, Martijn J. C. and Wauben, Marca H. M. and Wehman, Ann M. and Williams, Sarah and Zendrini, Andrea and Zimmerman, Alan J. and Théry, Clotilde and Witwer, Kenneth W. and Beke-Somfai, Tamás and Szigyártó, Imola Csilla and Haseeb, Zubair},
	doi = {10.1002/jev2.12404},
	journal-iso = {J EXTRACELLULAR VESICL},
	journal = {JOURNAL OF EXTRACELLULAR VESICLES},
	volume = {13},
	unique-id = {34567532},
	abstract = {Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year‐on‐year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non‐vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.},
	year = {2024},
	eissn = {2001-3078},
	orcid-numbers = {Welsh, Joshua A./0000-0002-1097-9756; Goberdhan, Deborah C. I./0000-0003-0645-6714; Buzás, Edit Irén/0000-0002-3744-206X; Bussolati, Benedetta/0000-0002-3663-5134; Cai, Houjian/0000-0003-4887-2652; Falcon‐Perez, Juan M./0000-0003-3133-0670; Hill, Andrew F./0000-0001-5581-2354; Lenassi, Metka/0000-0002-9488-6855; Mohanty, Sujata/0000-0002-0047-4914; Nieuwland, Rienk/0000-0002-5671-3400; Ochiya, Takahiro/0000-0002-0776-9918; Sahoo, Susmita/0000-0002-7279-1564; Torrecilhas, Ana C./0000-0001-5724-2199; Zheng, Lei/0000-0003-2576-8780; Zijlstra, Andries/0000-0001-8460-8803; Brucale, Marco/0000-0001-7244-4389; Carney, Randy P./0000-0001-8193-1664; Crescitelli, Rossella/0000-0002-1714-3169; Haughey, Norman J./0000-0001-5194-4122; Martens‐Uzunova, Elena S./0000-0002-5363-2525; Newman, Lauren A./0000-0003-3303-1666; Rohde, Eva/0000-0001-8692-886X; Sandau, Ursula S./0000-0002-3646-7089; Saugstad, Julie A./0000-0002-2996-9611; Shekari, Faezeh/0000-0001-6026-5412; Tosar, Juan P./0000-0002-2021-2479; Varga, Zoltán/0000-0002-5741-2669; Wauben, Marca H. M./0000-0003-0360-0311; Wehman, Ann M./0000-0001-9826-4132; Zimmerman, Alan J./0000-0001-6280-4790; Théry, Clotilde/0000-0001-8294-6884; Witwer, Kenneth W./0000-0003-1664-4233; Bodnár, Bernadett Réka/0000-0003-3347-9225; Bukva, Mátyás/0000-0002-5225-0285; Buzás, Edit Irén/0000-0002-3744-206X; Buzás, Krisztina/0000-0001-8933-2033; Dobra, Gabriella/0000-0002-2814-7720; Försönits, András/0000-0002-9298-8890; Ghosal, Sayam/0000-0001-6618-930X; Gyukity-Sebestyén, Edina/0000-0003-1383-6301; Koncz, Anna/0000-0003-2511-2394; Lőrincz, Márton Ákos/0000-0002-2819-5116; Németh, Krisztina/0000-0002-3825-2137; Oláh, Attila/0000-0003-4122-5639; Osteikoetxea, Xabier/0000-0003-3628-0174; Pálóczi, Krisztina/0000-0001-7065-3582; Stepanova, Ganna/0000-0002-8285-2762; Visnovitz, Tamás/0000-0002-7962-5083; Wiener, Zoltán/0000-0001-7056-4926; Harmati, Mária/0000-0002-4875-5723; Hegyesi, Hargita/0000-0002-8800-5169}
}

@article{MTMT:34425078,
	title = {Nanoinjection of extracellular vesicles to single live cells by robotic fluidic force microscopy},
	url = {https://m2.mtmt.hu/api/publication/34425078},
	author = {Kovács, Kinga Dóra and Visnovitz, Tamás and Gerecsei, Tamás and Péter, Beatrix and Kurunczi, Sándor and Koncz, Anna and Németh, Krisztina and Lenzinger, Dorina and Visnovitzné Dr Vukman, Krisztina and Balogh, Anna and Rajmon, Imola and Lőrincz, Péter and Székács, Inna and Buzás, Edit Irén and Horváth, Róbert},
	doi = {10.1002/jev2.12388},
	journal-iso = {J EXTRACELLULAR VESICL},
	journal = {JOURNAL OF EXTRACELLULAR VESICLES},
	volume = {12},
	unique-id = {34425078},
	abstract = {In the past decade, extracellular vesicles (EVs) have attracted substantial interest in biomedicine. With progress in the field, we have an increasing understanding of cellular responses to EVs. In this Technical Report, we describe the direct nanoinjection of EVs into the cytoplasm of single cells of different cell lines. By using robotic fluidic force microscopy (robotic FluidFM), nanoinjection of GFP positive EVs and EV‐like particles into single live HeLa, H9c2, MDA‐MB‐231 and LCLC‐103H cells proved to be feasible. This injection platform offered the advantage of high cell selectivity and efficiency. The nanoinjected EVs were initially localized in concentrated spot‐like regions within the cytoplasm. Later, they were transported towards the periphery of the cells. Based on our proof‐of‐principle data, robotic FluidFM is suitable for targeting single living cells by EVs and may lead to information about intracellular EV cargo delivery at a single‐cell level.},
	year = {2023},
	eissn = {2001-3078},
	orcid-numbers = {Visnovitz, Tamás/0000-0002-7962-5083; Kurunczi, Sándor/0000-0002-6567-5231; Koncz, Anna/0000-0003-2511-2394; Németh, Krisztina/0000-0002-3825-2137; Lőrincz, Péter/0000-0001-7374-667X; Buzás, Edit Irén/0000-0002-3744-206X; Horváth, Róbert/0000-0001-8617-2302}
}

@article{MTMT:33785230,
	title = {Role of Extracellular Vesicles in Liver Diseases},
	url = {https://m2.mtmt.hu/api/publication/33785230},
	author = {Tamási, Viola and Németh, Krisztina and Csala, Miklós},
	doi = {10.3390/life13051117},
	journal-iso = {LIFE-BASEL},
	journal = {LIFE-BASEL},
	volume = {13},
	unique-id = {33785230},
	abstract = {Extracellular vesicles (EVs) are cell-derived membrane structures that are formed by budding from the plasma membrane or originate from the endosomal system. These microparticles (100 nm–100 µm) or nanoparticles (>100 nm) can transport complex cargos to other cells and, thus, provide communication and intercellular regulation. Various cells, such as hepatocytes, liver sinusoidal endothelial cells (LSECs) or hepatic stellate cells (HSCs), secrete and take up EVs in the healthy liver, and the amount, size and content of these vesicles are markedly altered under pathophysiological conditions. A comprehensive knowledge of the modified EV-related processes is very important, as they are of great value as biomarkers or therapeutic targets. In this review, we summarize the latest knowledge on hepatic EVs and the role they play in the homeostatic processes in the healthy liver. In addition, we discuss the characteristic changes of EVs and their potential exacerbating or ameliorating effects in certain liver diseases, such as non-alcoholic fatty liver disease (NAFLD), alcoholic fatty liver disease (AFLD), drug induced liver injury (DILI), autoimmune hepatitis (AIH), hepatocarcinoma (HCC) and viral hepatitis.},
	year = {2023},
	eissn = {2075-1729},
	orcid-numbers = {Tamási, Viola/0000-0001-7419-5603; Németh, Krisztina/0000-0002-3825-2137; Csala, Miklós/0000-0002-3829-4361}
}

@article{MTMT:33750753,
	title = {Endoplasmin Is a Hypoxia-Inducible Endoplasmic Reticulum-Derived Cargo of Extracellular Vesicles Released by Cardiac Cell Lines},
	url = {https://m2.mtmt.hu/api/publication/33750753},
	author = {Koncz, Anna and Turiák, Lilla and Németh, Krisztina and Lenzinger, Dorina and Bárkai, Tünde and Lőrincz, Péter and Zelenyánszki, Helga and Visnovitzné Dr Vukman, Krisztina and Buzás, Edit Irén and Visnovitz, Tamás},
	doi = {10.3390/membranes13040431},
	journal-iso = {MEMBRANES-BASEL},
	journal = {MEMBRANES (BASEL)},
	volume = {13},
	unique-id = {33750753},
	abstract = {Cardiomyopathies are leading causes of human mortality. Recent data indicate that the cardiomyocyte-derived extracellular vesicles (EVs) released upon cardiac injury are present in circulation. This paper aimed to analyze EVs released under normal and hypoxic conditions by H9c2 (rat), AC16 (human) and HL1 (mouse) cardiac cell lines. Small (sEVs), medium (mEVs) and large EVs (lEVs) were separated from a conditioned medium by a combination of gravity filtration, differential centrifugation and tangential flow filtration. The EVs were characterized by microBCA, SPV lipid assay, nanoparticle tracking analysis, transmission and immunogold electron microscopy, flow cytometry and Western blotting. Proteomic profiles of the EVs were determined. Surprisingly, an endoplasmic reticulum chaperone, endoplasmin (ENPL, grp94 or gp96), was identified in the EV samples, and its association with EVs was validated. The secretion and uptake of ENPL was followed by confocal microscopy using GFP-ENPL fusion protein expressing HL1 cells. We identified ENPL as an internal cargo of cardiomyocyte-derived mEVs and sEVs. Based on our proteomic analysis, its presence in EVs was linked to hypoxia in HL1 and H9c2 cells, and we hypothesize that EV-associated ENPL may have a cardioprotective role by reducing cardiomyocyte ER stress.},
	year = {2023},
	eissn = {2077-0375},
	orcid-numbers = {Koncz, Anna/0000-0003-2511-2394; Németh, Krisztina/0000-0002-3825-2137; Lőrincz, Péter/0000-0001-7374-667X; Zelenyánszki, Helga/0000-0001-6768-3748; Buzás, Edit Irén/0000-0002-3744-206X; Visnovitz, Tamás/0000-0002-7962-5083}
}

@article{MTMT:33726492,
	title = {High fat diet and PCSK9 knockout modulates lipid profile of the liver and changes the expression of lipid homeostasis related genes},
	url = {https://m2.mtmt.hu/api/publication/33726492},
	author = {Németh, Krisztina and Tóth, Blanka and Sarnyai, Farkas and Koncz, Anna and Lenzinger, Dorina and Kereszturi, Éva and Visnovitz, Tamás and Kestecher, Brachyahu Meir and Osteikoetxea, Xabier and Csala, Miklós and Buzás, Edit Irén and Tamási, Viola},
	doi = {10.1186/s12986-023-00738-z},
	journal-iso = {NUTR METAB},
	journal = {NUTRITION & METABOLISM},
	volume = {20},
	unique-id = {33726492},
	issn = {1743-7075},
	year = {2023},
	eissn = {1743-7075},
	orcid-numbers = {Németh, Krisztina/0000-0002-3825-2137; Sarnyai, Farkas/0000-0002-5525-5508; Koncz, Anna/0000-0003-2511-2394; Visnovitz, Tamás/0000-0002-7962-5083; Osteikoetxea, Xabier/0000-0003-3628-0174; Csala, Miklós/0000-0002-3829-4361; Buzás, Edit Irén/0000-0002-3744-206X; Tamási, Viola/0000-0001-7419-5603}
}

@article{MTMT:33254004,
	title = {Decreasing effects of protein kinase inhibitors on the expression of NOS2 and inflammatory cytokines and on phagocytosis in rat peritoneal macrophages is partly related to repolarization},
	url = {https://m2.mtmt.hu/api/publication/33254004},
	author = {Hrabák, András and Bőgel, Gábor and Murányi, József and Tamási, Viola and Németh, Krisztina and Szokol, Bálint and Kukor, Zoltán and Kardon Tamás, Zoltán and Őrfi, László},
	doi = {10.1016/j.molimm.2022.11.002},
	journal-iso = {MOL IMMUNOL},
	journal = {MOLECULAR IMMUNOLOGY},
	volume = {153},
	unique-id = {33254004},
	issn = {0161-5890},
	year = {2023},
	eissn = {1872-9142},
	pages = {10-24},
	orcid-numbers = {Hrabák, András/0000-0002-7818-6509; Bőgel, Gábor/0000-0002-7677-6855; Tamási, Viola/0000-0001-7419-5603; Németh, Krisztina/0000-0002-3825-2137; Kukor, Zoltán/0000-0002-7250-2160; Őrfi, László/0000-0001-6149-2385}
}