@article{MTMT:31610168, title = {Uninterrupted Dabigatran Administration Provides Greater Inhibition against Intracardiac Activation of Hemostasis as Compared to Vitamin K Antagonists during Cryoballoon Catheter Ablation of Atrial Fibrillation}, url = {https://m2.mtmt.hu/api/publication/31610168}, author = {Bagoly, Zsuzsa and Hajas, Orsolya and Urbancsek, Réka and Kiss, Alexandra and Fiak, Edit and Sarkady, Ferenc and Tóth, Noémi Klára and Orbán-Kálmándi, Rita Angéla and Kovács, Kitti Bernadett and Nagy, László Tibor and Nagy, Attila Csaba and Kappelmayer, János and Csiba, László and Csanádi, Zoltán}, doi = {10.3390/jcm9093050}, journal-iso = {J CLIN MED}, journal = {JOURNAL OF CLINICAL MEDICINE}, volume = {9}, unique-id = {31610168}, year = {2020}, eissn = {2077-0383}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Orbán-Kálmándi, Rita Angéla/0000-0002-2155-8279; Kovács, Kitti Bernadett/0000-0003-1781-2390; Nagy, Attila Csaba/0000-0002-0554-7350} } @article{MTMT:31143304, title = {Intracardiac Fibrinolysis and Endothelium Activation Related to Atrial Fibrillation Ablation with Different Techniques}, url = {https://m2.mtmt.hu/api/publication/31143304}, author = {Hajas, Orsolya and Bagoly, Zsuzsa and Tóth, Noémi Klára and Urbancsek, Réka and Kiss, Alexandra and Kovács, Kitti Bernadett and Sarkady, Ferenc and Nagy, Attila Csaba and Vargáné Oláh, Anna and Nagy, László Tibor and Clemens, Marcell and Csiba, László and Csanádi, Zoltán}, doi = {10.1155/2020/1570483}, journal-iso = {CARDIOL RES PRAC}, journal = {CARDIOLOGY RESEARCH AND PRACTICE}, volume = {2020}, unique-id = {31143304}, issn = {2090-0597}, year = {2020}, eissn = {2090-8016}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Kovács, Kitti Bernadett/0000-0003-1781-2390; Nagy, Attila Csaba/0000-0002-0554-7350} } @article{MTMT:31143253, title = {The factor XIII-A Val34Leu polymorphism decreases whole blood clot mass at high fibrinogen concentrations}, url = {https://m2.mtmt.hu/api/publication/31143253}, author = {Kattula, Sravya and Bagoly, Zsuzsa and Tóth, Noémi Klára and Muszbek, László and Wolberg, Alisa S.}, doi = {10.1111/jth.14744}, journal-iso = {J THROMB HAEMOST}, journal = {JOURNAL OF THROMBOSIS AND HAEMOSTASIS}, volume = {18}, unique-id = {31143253}, issn = {1538-7933}, year = {2020}, eissn = {1538-7836}, pages = {885-894}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Muszbek, László/0000-0002-3798-9962} } @article{MTMT:30766995, title = {Markers of Coagulation and Fibrinolysis Predicting the Outcome of Acute Ischemic Stroke Thrombolysis Treatment: A Review of the Literature}, url = {https://m2.mtmt.hu/api/publication/30766995}, author = {Bagoly, Zsuzsa and Szegedi, István and Orbán-Kálmándi, Rita Angéla and Tóth, Noémi Klára and Csiba, László}, doi = {10.3389/fneur.2019.00513}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {10}, unique-id = {30766995}, issn = {1664-2295}, abstract = {Intravenous administration of recombinant tissue plasminogen activator (rt-PA) has been proven to be safe and effective in the treatment of acute ischemic stroke. Little is known, however, why this treatment is less effective in some patients while in others life-threatening side-effects, e.g., symptomatic intracerebral hemorrhage might occur. Clinical failure of thrombolysis related to absent or partial recanalization or reocclusion as well as hemorrhagic complications of thrombolysis are possibly related to hemostatic events. Data on markers of coagulation and/or fibrinolysis in acute stroke patients are numerous and may provide indications regarding therapy outcomes. Better understanding of the hemostatic and fibrinolytic system during rt-PA therapy might be clinically useful and ultimately might lead to an improvement in the efficacy or safety of this treatment. Studies on thrombus composition retrieved from cerebral arteries may also advance our knowledge and provide a key to improve acute stroke therapy. Here we provide a comprehensive review on a wide range of factors and markers of coagulation and fibrinolysis that have been studied in the context of thrombolysis outcome in ischemic stroke patients. Moreover, a brief summary is given on the most recent research on thrombus composition having a potential influence on outcomes.}, keywords = {COAGULATION; FIBRINOLYSIS; thrombolysis; stroke; outcome}, year = {2019}, eissn = {1664-2295}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Szegedi, István/0000-0003-4181-4361; Orbán-Kálmándi, Rita Angéla/0000-0002-2155-8279} } @article{MTMT:3385993, title = {Low factor XIII levels after intravenous thrombolysis predict short-term mortality in ischemic stroke patients}, url = {https://m2.mtmt.hu/api/publication/3385993}, author = {Szekely, EG and Kovács, Katalin Réka and Bereczky, Zsuzsanna and Katona, Éva and Mezei, Zoltán András and Nagy, Attila Csaba and Tóth, Noémi Klára and Berényi, Ervin László and Muszbek, László and Csiba, László and Bagoly, Zsuzsa}, doi = {10.1038/s41598-018-26025-z}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {8}, unique-id = {3385993}, issn = {2045-2322}, abstract = {In this observational study we investigated whether levels of factor XIII (FXIII) and its major polymorphisms affect the outcome of thrombolysis by recombinant tissue plasminogen activator (rtPA) in acute ischemic stroke (AIS) patients. Study cohort included 132 consecutive AIS patients undergoing i.v. thrombolysis within 4.5 h of symptom onset. Blood samples taken on admission, immediately after and 24 h after therapy were analyzed for FXIII activity and antigen levels. FXIII-A p.Val34Leu, p.Tyr204Phe, FXIII-B p.His95Arg and intron K(IVS11 + 144) polymorphisms were genotyped. Neurological deficit was assessed using the National Institutes of Health Stroke Scale. Intracranial hemorrhage was classified according to ECASSII criteria. Long-term functional outcome was defined at 3 months post-event by the modified Rankin scale. FXIII levels showed a gradual decrease immediately after thrombolysis and 24 h later, which was not related to therapy-associated bleeding. In a multiple logistic regression model, a FXIII level in the lowest quartile 24 h post-lysis proved to be an independent predictor of mortality by 14 days post-event (OR:4.95, 95% CI:1.31-18.68, p < 0.05). No association was found between the investigated FXIII polymorphisms and therapeutic outcomes. In conclusion, our findings indicate that FXIII levels 24 h after thrombolysis might help to identify patients at increased risk for short-term mortality.}, keywords = {PLASMA; POLYMORPHISM; HEMORRHAGE; INFARCTION; A-SUBUNIT; COAGULATION-FACTOR-XIII; CHALLENGES; Definitions; HEMOSTATIC MARKERS; RT-PA}, year = {2018}, eissn = {2045-2322}, orcid-numbers = {Bereczky, Zsuzsanna/0000-0002-1483-3703; Katona, Éva/0000-0003-3476-794X; Mezei, Zoltán András/0000-0002-7886-8665; Nagy, Attila Csaba/0000-0002-0554-7350; Muszbek, László/0000-0002-3798-9962; Bagoly, Zsuzsa/0000-0001-5314-5607} } @article{MTMT:3328941, title = {Elevated factor VIII and von Willebrand factor levels predict unfavorable outcome in stroke patients treated with intravenous thrombolysis}, url = {https://m2.mtmt.hu/api/publication/3328941}, author = {Tóth, Noémi Klára and Székely , Edina Gabriella and Kovács, Katalin Réka and Sarkady, F and Nagy, Orsolya and Lánczi, LI and Berényi, E and Fekete, Klára and Fekete, István and Csiba, László and Bagoly, Zsuzsa}, doi = {10.3389/fneur.2017.00721}, journal-iso = {FRONT NEUR}, journal = {FRONTIERS IN NEUROLOGY}, volume = {8}, unique-id = {3328941}, issn = {1664-2295}, year = {2018}, eissn = {1664-2295}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607} } @article{MTMT:3227929, title = {Intracardiac hemostasis and fibrinolysis parameters in patients with atrial fibrillation}, url = {https://m2.mtmt.hu/api/publication/3227929}, author = {Tóth, Noémi Klára and Csanádi, Zoltán and Hajas, Orsolya and Kiss, Alexandra and Nagy-Baló, Edina and Kovács, Kitti Bernadett and Sarkady, Ferenc and Muszbek, László and Bereczky, Zsuzsanna and Csiba, László and Bagoly, Zsuzsa}, doi = {10.1155/2017/3678017}, journal-iso = {BIOMED RES INT}, journal = {BIOMED RESEARCH INTERNATIONAL}, volume = {2017}, unique-id = {3227929}, issn = {2314-6133}, year = {2017}, eissn = {2314-6141}, orcid-numbers = {Kovács, Kitti Bernadett/0000-0003-1781-2390; Muszbek, László/0000-0002-3798-9962; Bereczky, Zsuzsanna/0000-0002-1483-3703; Bagoly, Zsuzsa/0000-0001-5314-5607} } @article{MTMT:2977994, title = {Local parameters of hemostasis activation in the fibrillating atrium}, url = {https://m2.mtmt.hu/api/publication/2977994}, author = {Tóth, Noémi Klára and Bagoly, Zsuzsa and Csanádi, Zoltán and Kiss, Alexandra and Nagy-Baló, Edina and Kovacs, KB and Muszbek, László and Bereczky, Zsuzsanna and Csiba, L}, doi = {10.1111/jth.12993}, journal-iso = {J THROMB HAEMOST}, journal = {JOURNAL OF THROMBOSIS AND HAEMOSTASIS}, volume = {13}, unique-id = {2977994}, issn = {1538-7933}, year = {2015}, eissn = {1538-7836}, pages = {785-785}, orcid-numbers = {Bagoly, Zsuzsa/0000-0001-5314-5607; Muszbek, László/0000-0002-3798-9962; Bereczky, Zsuzsanna/0000-0002-1483-3703} }