@article{MTMT:34774854,
	title = {Colonic tubular adenoma with clear cell change – case report with whole exome sequencing and updated review of the literature},
	url = {https://m2.mtmt.hu/api/publication/34774854},
	author = {Ferenczi, Ádám and Kuthi, Levente and Sejben, István and Sejben, Anita},
	doi = {10.1159/000538705},
	journal-iso = {PATHOBIOLOGY},
	journal = {PATHOBIOLOGY},
	volume = {&},
	unique-id = {34774854},
	issn = {1015-2008},
	abstract = {Introduction: Colorectal tubular adenomas displaying clear cell change are rare entities, with unknown clinical relevance, prognosis, immunohistochemical, and molecular features. Case presentation: Hereby we report a case of a 43-year-old female patient with a rectosigmoid polyp. Histologically, conventional dysplasia was visible with scattered areas displaying clear cell change. Whole exome sequencing (WES) was carried out and revealed high tumour mutation burden, and 7 pathogenic mutations, including TP53, APC, FGFR4, EHBP1, IL4R, TYR, and ACTN3.Conclusion: Clear cell change may only be present in less than 0,1% of adenomas. Aetiology is not well understood, additionally, few authors suggest autolysis or fixation problems. Our WES resulted in newly found pathogenic mutations, and high mutation burden, proving the lesion’s neoplastic origin. Hitherto, neither special stainings, nor immunohistochemical markers proved to be useful in the diagnostic process. From a differential diagnostic perspective, enteroblastic differentiation, primary and secondary clear cell adenocarcinoma has to be excluded.},
	year = {2024},
	eissn = {1423-0291},
	pages = {&},
	orcid-numbers = {Kuthi, Levente/0000-0001-9247-6679; Sejben, Anita/0000-0002-9434-2989}
}

@article{MTMT:34486290,
	title = {POLE-Mutant Colon Adenocarcinoma-Case Presentation and Histopathological Evaluation},
	url = {https://m2.mtmt.hu/api/publication/34486290},
	author = {Pancsa, Tamás and Vasas, Béla and Melegh, Zsombor and Tóth, Erika and Torday, László and Sejben, Anita},
	doi = {10.1007/s12029-023-01004-4},
	journal-iso = {J GASTROINTEST CANCER},
	journal = {JOURNAL OF GASTROINTESTINAL CANCER},
	unique-id = {34486290},
	issn = {1941-6628},
	abstract = {POLE mutant phenotype in colon adenocarcinomas represents a rare molecular subtype. These tumours are generally responsive to immune-checkpoint inhibition therapy and, therefore, are currently considered as a subtype with good prognosis. We hereby present the first detailed case presentation of a POLE mutant colon adenocarcinoma with useful microscopic features.A 53-year-old male patient's colon adenocarcinoma histologically showed wide variety of growth patterns and massive intra- and peritumoural lymphocytic infiltrate. The majority of the tumour consisted of a high-grade component resembling medullary carcinoma of the colon, while approximately one-third of the tumour was composed of conventional areas exhibiting a tubular pattern. A minority of the tumour was constituted by poorly cohesive rhabdoid cells. Immunohistochemistry was performed, and colorectal origin was proven with CDX-2 and SATB2. Furthermore, proficiency in mismatch repair proteins and SMARCB1 deficiency was observed. The unusually high-grade colon adenocarcinoma, with areas mimicking medullary carcinoma, and generally aggressive morphology raised suspicion of microsatellite instability. The diverse morphology and the SMARCB1 deficiency also raised suspicion of ultramutation caused by POLE alteration. Next-generation sequencing panel confirmed a pathogenetic mutation in POLE exon 9: p.Pro286Arg, c.857C > G.The diverse, high-grade morphology and increased intratumoural lymphoid infiltration should raise suspicion for POLE-mutated adenocarcinoma during everyday histopathological practice. Mismatch repair proficiency results on immunohistochemistry should not determine the final diagnosis, as only a minor percentage of these tumours are MSI. In every case suspicious for POLE-mutated adenocarcinoma, a 500-cancer gene panel should be carried out.},
	keywords = {Next-generation sequencing; POLE mutation; Immune-checkpoint inhibition therapy; POLE-mutant colon adenocarcinoma},
	year = {2024},
	eissn = {1941-6636},
	orcid-numbers = {Melegh, Zsombor/0000-0001-7605-5719; Tóth, Erika/0000-0003-2054-8447; Torday, László/0000-0002-2911-5499; Sejben, Anita/0000-0002-9434-2989}
}

@article{MTMT:34395398,
	title = {Role of the kisspeptin-KISS1R axis in the pathogenesis of chronic kidney disease and uremic cardiomyopathy},
	url = {https://m2.mtmt.hu/api/publication/34395398},
	author = {Dinh, Hoa and Kovács, Zsuzsanna and Kis, Merse and Kupecz, Klaudia and Sejben, Anita and Szűcs, Gergő and Márványkövi, Fanni and Siska, Andrea and Freiwan, Marah and Pósa, Szonja Polett and Galla, Zsolt and Ibos, Katalin Eszter and Bodnár, Éva and Lauber, Gülsüm Yilmaz and Goncalves, Ana Isabel Antunes and Acar, Eylem and Kriston, András and Kovács, Ferenc and Horváth, Péter and Bozsó, Zsolt and Tóth, Gábor and Földesi, Imre and Monostori, Péter and Cserni, Gábor and Podesser, Bruno K. and Lehoczki, Andrea Marianna and Pokreisz, Peter and Kiss, Attila and Dux, László and Csabafi, Krisztina and Sárközy, Márta},
	doi = {10.1007/s11357-023-01017-8},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {46},
	unique-id = {34395398},
	issn = {2509-2715},
	abstract = {The prevalence of chronic kidney disease (CKD) is increasing globally, especially in elderly patients. Uremic cardiomyopathy is a common cardiovascular complication of CKD, characterized by left ventricular hypertrophy (LVH), diastolic dysfunction, and fibrosis. Kisspeptins and their receptor, KISS1R, exert a pivotal influence on kidney pathophysiology and modulate age-related pathologies across various organ systems. KISS1R agonists, including kisspeptin-13 (KP-13), hold promise as novel therapeutic agents within age-related biological processes and kidney-related disorders. Our investigation aimed to elucidate the impact of KP-13 on the trajectory of CKD and uremic cardiomyopathy. Male Wistar rats (300–350 g) were randomized into four groups: (I) sham-operated, (II) 5/6 nephrectomy-induced CKD, (III) CKD subjected to a low dose of KP-13 (intraperitoneal 13 µg/day), and (IV) CKD treated with a higher KP-13 dose (intraperitoneal 26 µg/day). Treatments were administered daily from week 3 for 10 days. After 13 weeks, KP-13 increased systemic blood pressure, accentuating diastolic dysfunction’s echocardiographic indicators and intensifying CKD-associated markers such as serum urea levels, glomerular hypertrophy, and tubular dilation. Notably, KP-13 did not exacerbate circulatory uremic toxin levels, renal inflammation, or fibrosis markers. In contrast, the higher KP-13 dose correlated with reduced posterior and anterior wall thickness, coupled with diminished cardiomyocyte cross-sectional areas and concurrent elevation of inflammatory ( Il6, Tnf ), fibrosis ( Col1 ), and apoptosis markers ( Bax/Bcl2 ) relative to the CKD group. In summary, KP-13’s influence on CKD and uremic cardiomyopathy encompassed heightened blood pressure and potentially activated inflammatory and apoptotic pathways in the left ventricle.},
	year = {2024},
	eissn = {2509-2723},
	pages = {2463-2488},
	orcid-numbers = {Kovács, Zsuzsanna/0000-0002-4197-4579; Sejben, Anita/0000-0002-9434-2989; Szűcs, Gergő/0000-0003-1874-2718; Márványkövi, Fanni/0000-0002-5114-1319; Pósa, Szonja Polett/0000-0002-7535-9689; Galla, Zsolt/0000-0002-9166-1212; Ibos, Katalin Eszter/0000-0001-5243-9945; Goncalves, Ana Isabel Antunes/0009-0009-3428-3321; Acar, Eylem/0000-0002-0599-6893; Kriston, András/0000-0001-8500-4315; Bozsó, Zsolt/0000-0002-5713-3096; Tóth, Gábor/0000-0002-3604-4385; Földesi, Imre/0000-0002-3329-8136; Monostori, Péter/0000-0003-3591-6054; Cserni, Gábor/0000-0003-1344-7744; Podesser, Bruno K./0000-0002-4641-7202; Lehoczki, Andrea Marianna/0000-0002-4285-7518; Pokreisz, Peter/0000-0003-2810-9000; Kiss, Attila/0000-0003-4652-1998; Dux, László/0000-0002-1270-1678; Csabafi, Krisztina/0000-0002-2008-7604; Sárközy, Márta/0000-0002-5929-2146}
}

@article{MTMT:34565527,
	title = {Cerebral manifestation and diagnostic dilemma of Rosai-Dorfman disease. [case report]},
	url = {https://m2.mtmt.hu/api/publication/34565527},
	author = {Almási, Szintia and Pancsa, Tamás and Tiszlavicz, László and Sejben, Anita},
	doi = {10.2217/cns-2023-0006},
	journal-iso = {CNS Oncol},
	journal = {CNS Oncology},
	volume = {12},
	unique-id = {34565527},
	issn = {2045-0907},
	abstract = {Rosai-Dorfman disease (RDD) is a rare, S100-positive histiocytic proliferation, that can cause both nodal and extranodal illness. We present a case of a 53-year-old male patient. Magnetic resonance imaging described a plaque-like meningeal lesion, and the preoperative diagnosis was meningioma. Histologically, dense infiltration of lymphocytes, plasma cells, and histiocytes was seen, furthermore, the presence of emperipolesis in the sample was pronounced. In the histiocytes nuclear and cytoplasmic positivity with S100 protein, and nuclear positivity with Cyclin D1 was observed. The case was concluded as RDD. Morphological appearance of intracranial RDD with imaging procedures can present a differential diagnostic challenge. The correct diagnosis is based on the presence of histiocytes with emperipolesis, and properly defined immunohistochemical characteristics.},
	year = {2023},
	eissn = {2045-0915},
	orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Sejben, Anita/0000-0002-9434-2989}
}

@article{MTMT:34565525,
	title = {Hypermucinosus és kehelysejtszegény, gyulladásos bélbetegséghez társult, non-conventionalis dysplasia colorectalis adenocarcinoma mellett [Hypermucinous and goblet cell-deficient, IBD-associated, non-conventional dysplasia besides colorectal adenocarcinoma]. [esetismertetés]},
	url = {https://m2.mtmt.hu/api/publication/34565525},
	author = {Almási, Szintia and Baráth, Bence and Szaszák, Panna and Kővári, Bence and Sejben, Anita},
	doi = {10.1556/650.2023.32946},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {164},
	unique-id = {34565525},
	issn = {0030-6002},
	abstract = {A gyulladásos bélbetegséggel (IBD) élő betegekben a colorectalis carcinoma kialakulásának esélye az átlagpopulációban észleltek kétszerese. Az invazív daganatokat megelőzően ezekben a betegekben nagyobb a rizikó dysplasia kialakulására is. Az utóbbi években számos, IBD-hez társult, ún. non-conventionalis dysplasia altípust azonosítottak, melyekről a jelenleg is zajló kutatásoknak köszönhetően egyre több információval rendelkezünk. Egy 62 éves, 14 éve relabáló colitis ulcerosával diagnosztizált és kezelt nőbeteg subtotalis colectomiás preparátumában colitis ulcerosa mellett a sigmabélben invazív adenocarcinomát azonosítottunk mucinosus területekkel. A daganat közvetlen környezetében kehelysejtszegény, valamint hypermucinosus IBD-hez társult, non-conventionalis dysplasiát észleltünk, az utóbbinak intestinalis és foveolaris altípusa is elkülöníthető volt. A felhalmozódó ismeretek tükrében az IBD-hez társult, non-conventionalis dysplasiák ismerete több szempontból is fontos lehet a diagnosztikában és a klinikai ellátásban, ugyanis ezek a laesiók makroszkóposan laposak vagy láthatatlanok lehetnek, megnehezítve a dysplasia endoszkópos szűrését. Ismeretük a patológus számára kiemelten fontos, hiszen a reaktív és reparatív folyamatoktól való elkülönítésük sokszor nagy kihívást jelent. Továbbá, a hagyományos típusoknál gyakrabban társultak ’high-grade’ dysplasiával, valamint colorectalis carcinomával. Molekuláris hátterüket tekintve, sokkal gyakrabban észlelhető bennük aneuploidia. Mindezen ismeretek a hagyományos neoplasiákhoz képest rosszabb prognózis rizikót vetítenek elő, és az esetlegesen nehezen azonosítható endoszkópos képüket is figyelembe véve felismerésük után az IBD-s betegek szorosabb utánkövetése és esetleges véletlenszerű biopsziás mintavétel mérlegelendő. Orv Hetil. 2023; 164(51): 2039–2044.},
	year = {2023},
	eissn = {1788-6120},
	pages = {2039-2044},
	orcid-numbers = {Baráth, Bence/0000-0001-5713-8471; Kővári, Bence/0000-0002-4498-8781; Sejben, Anita/0000-0002-9434-2989}
}

@article{MTMT:34211651,
	title = {Az alsó végtag myxoinflammatoricus fibroblastos sarcomája [Myxoinflammatory fibroblastic sarcoma of the lower limb]. [esetismertetés]},
	url = {https://m2.mtmt.hu/api/publication/34211651},
	author = {Almakrami, Mohammed and Pancsa, Tamás and Kuthi, Levente and Sejben, Anita},
	doi = {10.1556/650.2023.32891},
	journal-iso = {ORV HETIL},
	journal = {ORVOSI HETILAP},
	volume = {164},
	unique-id = {34211651},
	issn = {0030-6002},
	abstract = {A myxoinflammatoricus fibroblastos sarcoma (MIFS) ritka, ’low-grade’, fájdalommentes, mesenchymalis eredetű daganat. A lágyrész- és csonttumoroknak az Egészségügyi Világszervezet (WHO) által kiadott jelenlegi, 5. kiadású osztályozásában a MIFS esetében nincs meghatározva pontos diagnosztikus genetikai eltérés. Egy 71 éves nőbeteg esetét mutatjuk be, akinek a kórtörténetében benignus essentialis hypertensio szerepelt. A jobb sípcsontja fölötti elváltozás miatt került kivizsgálásra. Az elváltozást 1,5 évvel az orvosi megjelenés előtt észlelte, és csak a bőrfelületen jelentkező fájdalom, erózió és papulaképződés miatt kereste fel az egészségügyi intézményt. Mikroszkóposan az elváltozás cellularis és pleiomorph megjelenésű, nodularis szerkezetű volt, a subcutan zsírszövet ún. lépesmézszerű infiltrációjával. A dermis kollagénrostjai között szintén tumorszövet volt látható. A daganatsejtek nagyrészt multinuclearis morfológiát mutattak prominens, vírusos inclusioszerű nucleolusszal, nagy mennyiségű fibrillaris, gyakran vakuolizált és ún. tejüvegszerű citoplazmával. Az immunhisztokémiai vizsgálat során a tumorsejtek multifokális pozitivitást mutattak CD34-, CD31-, podoplanin- (D2–40), ciklin-D1- és epithelialis membránantigén (EMA-) reakciókkal. A tumorsejtek továbbá diffúz pozitívnak bizonyultak a simaizomaktinnal (SMA). Mivel az általunk vizsgált elváltozás a jelenlegi WHO-osztályozás minden lényeges kritériumának megfelelt, az esetet ’high-grade’ vonásokat mutató MIFS-nek kórisméztük. Tapasztalataink alapján a podoplanin, ciklin-D1, CD10, EMA, CD34 és CD31 immunhisztokémiai reakciókból álló panel segíti a helyes diagnózis felállítását. Esetünk rávilágít e ritka, fokálisan ’high-grade’ vonásokat mutató, a hétköznapokban kihívást jelentő betegség szövettani jellemzőire. A diffúz SMA-pozitivitás ismert, de ritka jellemzője a daganatnak. Orv Hetil. 2023; 164(41): 1637–1641.},
	year = {2023},
	eissn = {1788-6120},
	pages = {1637-1641},
	orcid-numbers = {Kuthi, Levente/0000-0001-9247-6679; Sejben, Anita/0000-0002-9434-2989}
}

@misc{MTMT:34172152,
	title = {Low-grade oncocytic tumour of the kidney – clinical, pathological, and genetic features},
	url = {https://m2.mtmt.hu/api/publication/34172152},
	author = {Sánta, Fanni Viktória and Borbála, Dénes and Somorácz, Áron and Jenei, Alex and Forika, Gertrud and Fintha, Attila and Noémi, Kránicz and Zsófia, Mészáros and Salamon, Ferenc and Kornélia, Eizler and Nándor, Giba and Semjén, Dávid and Pósfai, Boglárka and Sejben, Anita and Kuthi, Levente},
	doi = {10.1007/s00428-023-03602-w},
	unique-id = {34172152},
	year = {2023},
	orcid-numbers = {Somorácz, Áron/0000-0003-4015-2263; Forika, Gertrud/0000-0001-9622-1040; Fintha, Attila/0000-0002-0519-8170; Sejben, Anita/0000-0002-9434-2989; Kuthi, Levente/0000-0001-9247-6679}
}

@misc{MTMT:34172107,
	title = {Analysis of renal cell carcinoma in end-stage renal disease of Hungarian patients},
	url = {https://m2.mtmt.hu/api/publication/34172107},
	author = {Kuthi, Levente and Sánta, Fanni Viktória and Pósfai, Boglárka and Semjén, Dávid and Borbála, Dénes and Somorácz, Áron and Fintha, Attila and Forika, Gertrud and Jenei, Alex and Micsik, Tamás and Dobi, Deján and Kornélia, Eizler and Nándor, Giba and Iványi, Béla and Sejben, Anita},
	unique-id = {34172107},
	year = {2023},
	orcid-numbers = {Kuthi, Levente/0000-0001-9247-6679; Somorácz, Áron/0000-0003-4015-2263; Fintha, Attila/0000-0002-0519-8170; Forika, Gertrud/0000-0001-9622-1040; Sejben, Anita/0000-0002-9434-2989}
}

@article{MTMT:34172032,
	title = {TRPS1 expression in cytokeratin 5 expressing triple negative breast cancers, its value as a marker of breast origin},
	url = {https://m2.mtmt.hu/api/publication/34172032},
	author = {Almási, Szintia and Kuthi, Levente and Sejben, Anita and Vörös, András and Nagy, Ákos and Zombori, Tamás and Cserni, Gábor},
	journal-iso = {VIRCHOWS ARCH},
	journal = {VIRCHOWS ARCHIV},
	volume = {483},
	unique-id = {34172032},
	issn = {0945-6317},
	year = {2023},
	eissn = {1432-2307},
	pages = {S57-S57},
	orcid-numbers = {Kuthi, Levente/0000-0001-9247-6679; Sejben, Anita/0000-0002-9434-2989; Vörös, András/0000-0001-6837-0567; Zombori, Tamás/0000-0002-0654-563X; Cserni, Gábor/0000-0003-1344-7744}
}

@article{MTMT:34106758,
	title = {Proposal of a grading system for squamous cell carcinoma of the lung — the prognostic importance of tumour budding, single cell invasion, and nuclear diameter},
	url = {https://m2.mtmt.hu/api/publication/34106758},
	author = {Zombori-Tóth, Noémi and Hegedűs, Fanni and Almási, Szintia and Sejben, Anita and Tiszlavicz, László and Furák, József and Cserni, Gábor and Zombori, Tamás},
	doi = {10.1007/s00428-023-03612-8},
	journal-iso = {VIRCHOWS ARCH},
	journal = {VIRCHOWS ARCHIV},
	volume = {483},
	unique-id = {34106758},
	issn = {0945-6317},
	abstract = {The prognostic markers of lung squamous cell carcinoma (LSCC) are less investigated. The aim of our study was to evaluate tumour budding (TB), minimal cell nest size, nuclear diameter (ND), and spread through air spaces (STAS) among patients with resected LSCC, semi-quantitatively. Furthermore, we aimed to identify a grading system for the best prognostic stratification of LSCC. Patients who underwent surgical resection at the Department of Surgery, University of Szeged between 2010 and 2016 were included. Follow-up data were collected from medical charts. Morphological characteristics were recorded from histologic revision of slides. Kaplan-Meier analysis, log rank test and Cox proportional-hazards model, ROC curve analysis, and intraclass correlation were utilised. Altogether 220 patients were included. In univariate analysis, higher degree of TB, infiltrative tumour border, larger ND, the presence of single cell invasion (SCI) and STAS were associated with adverse prognosis. Based on our results, we proposed an easily applicable grading scheme focusing on TB, ND, and SCI. In multivariate analysis, the proposed grading system (p OS< 0.001, p RFS< 0.001) and STAS (p OS= 0.008, p RFS< 0.001) were independent prognosticators. Compared to the previously introduced grading systems, ROC curve analysis revealed that the proposed grade had the highest AUC values (AUCOS: 0.83, AUCRFS: 0.78). Each category of the proposed grading system has good (ICC: 0.79–0.88) reproducibility. We validated the prognostic impact of TB, SCI, ND, and STAS in LSCC. We recommend a reproducible grading system combining TB, SCI, and ND for proper prognostic stratification of LSCC patients. Further research is required for validation of this grading scheme. © 2023, The Author(s).},
	keywords = {GRADE; lung squamous cell carcinoma; tumour budding; Spread through air spaces; Nuclear diameter; Single-cell invasion},
	year = {2023},
	eissn = {1432-2307},
	pages = {393-404},
	orcid-numbers = {Sejben, Anita/0000-0002-9434-2989; Tiszlavicz, László/0000-0003-1134-6587; Furák, József/0000-0002-7224-1642; Cserni, Gábor/0000-0003-1344-7744; Zombori, Tamás/0000-0002-0654-563X}
}