@article{MTMT:34677129, title = {Role of CFTR in diabetes‐induced pancreatic ductal fluid and HCO 3 − secretion}, url = {https://m2.mtmt.hu/api/publication/34677129}, author = {Ébert, Attila and Gál, Eleonóra and Tóth, Emese and Szögi, Titanilla and Hegyi, Péter and Venglovecz, Viktória}, doi = {10.1113/JP285702}, journal-iso = {J PHYSIOL-LONDON}, journal = {JOURNAL OF PHYSIOLOGY-LONDON}, volume = {602}, unique-id = {34677129}, issn = {0022-3751}, year = {2024}, eissn = {1469-7793}, pages = {1065-1083}, orcid-numbers = {Szögi, Titanilla/0000-0002-9854-7340; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:34053481, title = {The role of CFTR in the diabetes-induced pancreatic ductal fluid and HCO3-secretion}, url = {https://m2.mtmt.hu/api/publication/34053481}, author = {Ébert, Attila and Gál, Eleonóra and Tóth, Emese and Hegyi, Péter and Venglovecz, Viktória}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {9}, unique-id = {34053481}, year = {2023}, eissn = {2415-9107}, pages = {74-75}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:32867137, title = {Calcium imaging in intact mouse acinar cells in acute pancreas tissue slices}, url = {https://m2.mtmt.hu/api/publication/32867137}, author = {Marolt, Urška and Paradiž Leitgeb, Eva and Pohorec, Viljem and Lipovšek, Saška and Venglovecz, Viktória and Gál, Eleonóra and Ébert, Attila and Menyhárt, István and Potrč, Stojan and Gosak, Marko and Dolenšek, Jurij and Stožer, Andraž}, doi = {10.1371/journal.pone.0268644}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {32867137}, issn = {1932-6203}, abstract = {The physiology and pathophysiology of the exocrine pancreas are in close connection to changes in intra-cellular Ca2+ concentration. Most of our knowledge is based on in vitro experiments on acinar cells or acini enzymatically isolated from their surroundings, which can alter their structure, physiology, and limit our understanding. Due to these limitations, the acute pancreas tissue slice technique was introduced almost two decades ago as a complementary approach to assess the morphology and physiology of both the endocrine and exocrine pancreas in a more conserved in situ setting. In this study, we extend previous work to functional multicellular calcium imaging on acinar cells in tissue slices. The viability and morphological characteristics of acinar cells within the tissue slice were assessed using the LIVE/DEAD assay, transmission electron microscopy, and immunofluorescence imaging. The main aim of our study was to characterize the responses of acinar cells to stimulation with acetylcholine and compare them with responses to cerulein in pancreatic tissue slices, with special emphasis on inter-cellular and inter-acinar heterogeneity and coupling. To this end, calcium imaging was performed employing confocal microscopy during stimulation with a wide range of acetylcholine concentrations and selected concentrations of cerulein. We show that various calcium oscillation parameters depend monotonically on the stimulus concentration and that the activity is rather well synchronized within acini, but not between acini. The acute pancreas tissue slice represents a viable and reliable experimental approach for the evaluation of both intra- and inter-cellular signaling characteristics of acinar cell calcium dynamics. It can be utilized to assess many cells simultaneously with a high spatiotemporal resolution, thus providing an efficient and high-yield platform for future studies of normal acinar cell biology, pathophysiology, and screening pharmacological substances.}, keywords = {SECRETION; PANCREAS; Mitochondria; VESICLES; cell signaling; calcium imaging; cell staining; Endocrine physiology}, year = {2022}, eissn = {1932-6203}, orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:32843432, title = {Islet damage and regeneration in a mouse model of chronic pancreatititis}, url = {https://m2.mtmt.hu/api/publication/32843432}, author = {Ébert, Attila and Gajdos, T and Erdélyi, M and Molnár, Réka and Kelemen, D and Hegyi, P and Venglovecz, Viktória}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {32843432}, year = {2022}, eissn = {2415-9107}, pages = {73}, orcid-numbers = {Molnár, Réka/0000-0002-3128-825X; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:32246015, title = {Mechanisms of Post-Pancreatitis Diabetes Mellitus and Cystic Fibrosis-Related Diabetes. A Review of Preclinical Studies}, url = {https://m2.mtmt.hu/api/publication/32246015}, author = {Gál, Eleonóra and Dolenšek, Jurij and Stožer, Andraž and Czakó, László and Ébert, Attila and Venglovecz, Viktória}, doi = {10.3389/fendo.2021.715043}, journal-iso = {FRONT ENDOCRINOL}, journal = {FRONTIERS IN ENDOCRINOLOGY}, volume = {12}, unique-id = {32246015}, issn = {1664-2392}, abstract = {Anatomical proximity and functional correlations between the exocrine and endocrine pancreas warrant reciprocal effects between the two parts. Inflammatory diseases of the exocrine pancreas, such as acute or chronic pancreatitis, or the presence of cystic fibrosis disrupt endocrine function, resulting in diabetes of the exocrine pancreas. Although novel mechanisms are being increasingly identified, the intra- and intercellular pathways regulating exocrine-endocrine interactions are still not fully understood, making the development of new and more effective therapies difficult. Therefore, this review sought to accumulate current knowledge regarding the pathogenesis of diabetes in acute and chronic pancreatitis, as well as cystic fibrosis.}, keywords = {Interaction; cystic fibrosis (CF); acute pancreatitis (AP); Chronic pancreatitis (CP); diabetes of the exocrine pancreas (DEP)}, year = {2021}, eissn = {1664-2392}, pages = {715043-715055}, orcid-numbers = {Czakó, László/0000-0002-6331-0802; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:31815619, title = {Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis: a cross-sectional multicentre international study with experimental animal model}, url = {https://m2.mtmt.hu/api/publication/31815619}, author = {Hegyi, Péter Jenő and Soós, Alexandra and Tóth, Emese and Ébert, Attila and Venglovecz, Viktória and Márta, Katalin and Mátrai, Péter and Mikó, Alexandra and Bajor, Judit and Sarlós, Patrícia and Vincze, Áron and Szabó-Halász, Adrienn and Izbéki, Ferenc and Szepes, Zoltán and Czakó, László and Kovács, György and Papp, Mária and Dubravcsik, Zsolt and Varga, Márta and Hamvas, József and Németh, Balázs and Macarie, Melania and Ince, Ali Tüzün and Bordin, Dmitry S and Dubtsova, Elena A and Kiryukova, Mariya A and Khatkov, Igor E and Bideeva, Tanya and Mickevicius, Artautas and Ramírez-Maldonado, Elena and Sallinen, Ville and Erőss, Bálint Mihály and Pécsi, Dániel and Szentesi, Andrea Ildikó and Párniczky, Andrea and Tiszlavicz, László and Hegyi, Péter}, doi = {10.1038/s41598-020-80532-6}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {11}, unique-id = {31815619}, issn = {2045-2322}, abstract = {Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.}, year = {2021}, eissn = {2045-2322}, orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247; Márta, Katalin/0000-0002-2213-4865; Sarlós, Patrícia/0000-0002-5086-9455; Vincze, Áron/0000-0003-2217-7686; Izbéki, Ferenc/0000-0001-7767-4319; Szepes, Zoltán/0000-0002-9466-8719; Czakó, László/0000-0002-6331-0802; Papp, Mária/0000-0003-3662-4010; Dubravcsik, Zsolt/0000-0002-7231-3300; Németh, Balázs/0000-0001-5338-7577; Erőss, Bálint Mihály/0000-0003-3658-8427; Pécsi, Dániel/0000-0003-0499-6004; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Tiszlavicz, László/0000-0003-1134-6587; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:31822043, title = {Diabetes increases secretory activity of pancreatic ductal epithelial cells}, url = {https://m2.mtmt.hu/api/publication/31822043}, author = {Ébert, Attila and Tóth, Emese and Gajdos, T and Hegyi, Péter and Venglovecz, Viktória}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {6}, unique-id = {31822043}, year = {2020}, eissn = {2415-9107}, pages = {91}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:31822032, title = {The new definition of early chronic pancreatitis}, url = {https://m2.mtmt.hu/api/publication/31822032}, author = {Hegyi, P and Soós, A and Tóth, Emese and Ébert, Attila and Venglovecz, Viktória and Márta, K and Mátrai, P and Mikó, A and Bajor, Judit and Sarlós, P and Szabó-Halász, Adrienn and Izbéki, F and Szepes, Zoltán and Czakó, László and Kovács, G and Papp, M and Dubravcsik, Zsolt and Varga, M and Hamvas, J and Németh, Balázs and Macarie, Mq and Tüzün, A and Bordin, D and Kiryukova, M and Khatkov, I and Bideeva, T and Mickevicius, A and Ramírez-Maldonado, E and Sallinen, V and ErÖss, B and Pécsi, Dániel and Szentesi, Andrea Ildikó and Párniczky, A and Hegyi, Péter}, doi = {10.1016/j.pan.2020.07.071}, journal-iso = {PANCREATOLOGY}, journal = {PANCREATOLOGY}, volume = {20}, unique-id = {31822032}, issn = {1424-3903}, year = {2020}, eissn = {1424-3911}, pages = {S56-S58}, orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247; Szepes, Zoltán/0000-0002-9466-8719; Czakó, László/0000-0002-6331-0802; Dubravcsik, Zsolt/0000-0002-7231-3300; Németh, Balázs/0000-0001-5338-7577; Pécsi, Dániel/0000-0003-0499-6004; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:31784556, title = {The new definition of early chronic pancreatitis}, url = {https://m2.mtmt.hu/api/publication/31784556}, author = {Hegyi, P and Soós, A and Tóth, Emese and Ébert, Attila and Venglovecz, Viktória and Márta, K and Mikó, A and Bajor, J and Sarlós, P and Vincze, Á and Szabó-Halász, Adrienn and Izbéki, F and Szepes, Zoltán and Czakó, László and Kovács, L. Gábor and Papp, Mária and Dubravcsik, Zsolt and Varga, M and Hamvas, J and Németh, Balázs and Erőss, B and Pécsi, D and Szentesi, Andrea Ildikó and Párniczky, A and Hegyi, Péter}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {6}, unique-id = {31784556}, year = {2020}, eissn = {2415-9107}, pages = {54-54}, orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247; Szepes, Zoltán/0000-0002-9466-8719; Czakó, László/0000-0002-6331-0802; Kovács, L. Gábor/0000-0001-5298-5401; Papp, Mária/0000-0003-3662-4010; Dubravcsik, Zsolt/0000-0002-7231-3300; Németh, Balázs/0000-0001-5338-7577; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Hegyi, Péter/0000-0003-0399-7259} } @{MTMT:31641281, title = {Development of a new method for the examination of pancreatic ducts}, url = {https://m2.mtmt.hu/api/publication/31641281}, author = {Gál, Eleonóra and Dolenšek, J and Stožer, A and Pohorec, V and Ébert, Attila and Venglovecz, Viktória}, booktitle = {Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project}, unique-id = {31641281}, year = {2020}, pages = {16}, orcid-numbers = {Venglovecz, Viktória/0000-0002-2316-7247} }