@article{MTMT:34523817, title = {Tumour regression predicts better response to interferon therapy in melanoma patients. a retrospective single centre study.}, url = {https://m2.mtmt.hu/api/publication/34523817}, author = {Mezőlaki, Noémi and Baltás, Eszter and Ócsai, Henriette and Varga, Anita and Korom, Irma and Varga, Erika and Németh, István Balázs and Kis, Erika and Varga, János and Kocsis, Ádám László and Gyulai, Rolland Péter and Bukva, Mátyás and Kemény, Lajos and Oláh, Judit Magdolna}, doi = {10.1097/CMR.0000000000000935}, journal-iso = {MELANOMA RES}, journal = {MELANOMA RESEARCH}, volume = {34}, unique-id = {34523817}, issn = {0960-8931}, abstract = {We hypothesise that regression may have an impact on the effectiveness of adjuvant IFN therapy, based on its role in the host immune response. Our purpose is to investigate regression and ulceration as prognostic factors in case of interferon-alpha (IFN)-treated melanoma patients. We followed 357 IFN-treated melanoma patients retrospectively, investigating progression-free survival (PFS) and overall survival (OS) depending on the presence of ulceration and regression. A Kaplan-Meier analysis was performed, and we used a Cox regression analysis to relate risk factors. The survival function of the Cox regression was used to measure the effect of regression and ulceration on PFS and OS depending on the Breslow thickness (T1-T4) of the primary tumour. Regression was significantly positively related to PFS ( P = 0.0018, HR = 0.352) and OS ( P = 0.0112, HR = 0.380), while ulceration showed a negative effect (PFS: P = 0.0001, HR = 2.629; OS: P = 0.0003, HR = 2.388). They influence survival independently. The most favourable outcome was measured in the regressed/non-ulcerated group, whereas the worse was in the non-regressed/ulcerated one. Of risk factors, Breslow thickness is the most significant predictor. The efficacy of regression is regardless of Breslow thickness, though the more favourable the impact of regression was in the thicker primary lesions. Our results indicate that regression is associated with a more favourable outcome for IFN-treated melanoma patients, whereas ulceration shows an inverse relation. Further studies are needed to analyse the survival benefit of regression in relation to innovative immune checkpoint inhibitors.}, year = {2024}, eissn = {1473-5636}, pages = {54-62}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Gyulai, Rolland Péter/0000-0002-3286-8846; Bukva, Mátyás/0000-0002-5225-0285; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:33928935, title = {Az SZTE Bőrgyógyászati és Allergológiai Klinikán a melanoma malignum sebészi kezelésében történt változások az elmúlt évtizedben [Changes in the surgical treatment of melanoma malignum at the Department of Dermatology and Allergology University of Szeged over the last decade]}, url = {https://m2.mtmt.hu/api/publication/33928935}, author = {Varga, Ákos and Bende, Balázs and Baltás, Eszter and Németh, István Balázs and Varga, Erika and Vass, Gábor and Kis, Erika and Oláh, Judit Magdolna and Varga, János and Kocsis, Ádám László}, doi = {10.7188/bvsz.2023.99.2.6}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {99}, unique-id = {33928935}, issn = {0006-7768}, year = {2023}, eissn = {2064-261X}, pages = {122-124}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Vass, Gábor/0000-0003-0787-8679} } @article{MTMT:33190247, title = {SVF cell therapy for the treatment of non-healing limb ulcers}, url = {https://m2.mtmt.hu/api/publication/33190247}, author = {Bende, Balázs and Degovics, Döníz and Varga, János and Varga, Ákos and Kocsis, Ádám László and Kis, Erika and Guba, Melinda and Szűcs, Diána and Monostori, Tamás and Kemény, Lajos and Veréb, Zoltán}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {98}, unique-id = {33190247}, issn = {0006-7768}, year = {2022}, eissn = {2064-261X}, pages = {179-180}, orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501; Veréb, Zoltán/0000-0002-9518-2155} } @mastersthesis{MTMT:31956396, title = {New aspects of surgery for cutaneous malignancies [Új szempontok a bőrdaganatok sebészi kezelésében]}, url = {https://m2.mtmt.hu/api/publication/31956396}, author = {Kocsis, Ádám László}, doi = {10.14232/phd.10621}, publisher = {SZTE}, unique-id = {31956396}, year = {2020} } @article{MTMT:31640438, title = {Az őrszemnyirokcsomó-áttét kimutatása 4 mm-nél vastagabb melanomában esélyt ad ígéretes adjuváns kezelésre [Detection of sentinel lymph node metastasis in thick melanoma provides promising adjuvant treatment]}, url = {https://m2.mtmt.hu/api/publication/31640438}, author = {Kocsis, Ádám László and Mezőlaki, Noémi and Porkoláb, Dorottya and Mohos, Gábor and Kis, Erika and Varga, János and Baltás, Eszter and Ócsai, Henriette and Korom, Irma and Varga, Erika and Németh, István Balázs and Kemény, Lajos and Oláh, Judit Magdolna}, doi = {10.1556/650.2020.31835}, journal-iso = {ORV HETIL}, journal = {ORVOSI HETILAP}, volume = {161}, unique-id = {31640438}, issn = {0030-6002}, year = {2020}, eissn = {1788-6120}, pages = {1675-1680}, orcid-numbers = {Baltás, Eszter/0000-0003-0357-7393; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:31067970, title = {Is it Necessary to Perform Sentinel Lymph Node Biopsy in Thin Melanoma?. A Retrospective Single Center Analysis}, url = {https://m2.mtmt.hu/api/publication/31067970}, author = {Kocsis, Ádám László and Karsko, L and Kurgyis, Zsuzsanna and Besenyi, Zsuzsanna and Pávics, László and Viharosné Dósa-Rácz, Éva and Kis, Erika and Baltás, Eszter and Ócsai, Henriette and Varga, Erika and Bende, Balázs and Varga, Ákos and Mohos, Gábor and Korom, Irma and Varga, János and Kemény, Lajos and Németh, István Balázs and Oláh, Judit Magdolna}, doi = {10.1007/s12253-019-00769-z}, journal-iso = {PATHOL ONCOL RES}, journal = {PATHOLOGY AND ONCOLOGY RESEARCH}, volume = {26}, unique-id = {31067970}, issn = {1219-4956}, abstract = {Sentinel lymph node biopsy (SLNB) is a standard procedure for regional lymph node staging and still has the most important prognostic value for the outcome of patients with thin melanoma. In addition to ulceration, SLNB had to be considered even for a single mitotic figure in thin (<1 mm) melanoma according to AJCC7th guideline, therefore, a retrospective review was conducted involving 403 pT1 melanoma patients. Among them, 152 patients suffered from pT1b ulcerated or mitotic rate ≥ 1/ mm2 melanomas according to the AJCC7th staging system. SLNB was performed in 78 cases, of which nine (11.5%) showed SLN positivity. From them, interestingly, we found a relatively high positive sentinel rate (6/78-8%) in the case of thin primary melanomas ˂0.8 mm. Moreover, the presence of regression increased the probability of sentinel positivity by 5.796 fold. After reassessing pT stage based on the new AJCC8th, 37 pT1b cases were reordered into pT1a category. There was no significant relation between other characteristics examined (age, gender, Breslow, Clark level, and mitosis index) and sentinel node positivity. Based on our data, we suggest that mitotic rate alone is not a sufficiently powerful predictor of SLN status in thin melanomas. If strict histopathological definition criteria are applied, regression might be an additional adverse feature that aids in identifying T1 patients most likely to be SLN-positive. After reassessing of pT1b cases according to AJCC8th regression proved to be independent prognostic factor on sentinel lymph node positivity. Our results propose that sentinel lymph node biopsy might also be considered at patients with regressive thin (˂0.8 mm) melanomas.}, keywords = {STAGE; Regression; Melanoma; Sentinel Lymph Node Biopsy; Mitotic rate}, year = {2020}, eissn = {1532-2807}, pages = {1861-1868}, orcid-numbers = {Besenyi, Zsuzsanna/0000-0001-9115-9620; Pávics, László/0000-0002-7319-1667; Baltás, Eszter/0000-0003-0357-7393; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:30634855, title = {Reconstruction of Alar-Perialar Defects with a Combined Subcutaneous and Cutaneous Pedicled Rotation-Advancement Nasolabial Flap}, url = {https://m2.mtmt.hu/api/publication/30634855}, author = {Mohos, Gábor and Kocsis, Ádám László and Erős, Gábor and Korponyai, Csilla and Varga, Ákos and Bende, Balázs and Varga, János}, doi = {10.1080/08941939.2018.1538397}, journal-iso = {J INVEST SURG}, journal = {JOURNAL OF INVESTIGATIVE SURGERY}, volume = {33}, unique-id = {30634855}, issn = {0894-1939}, abstract = {During the reconstruction of alar defects involving the upper lip, reconstructive surgeons face the need for various thicknesses of tissues crucial to preserving the facial sulcus which is important for a cosmetically acceptable result. Our aim was to reconstruct the deep perialar and thinner lateral nasal alar defect in a single step procedure with a suitable flap which is reliable, has appropriate blood supply and provides an esthetically good result.Extended alar defect was reconstructed with a combined flap in 10 cases. During the procedure, a subcutaneous pedicle was created and the proximal part of the flap was rotated into the defect as a rotational flap. The procedure and the follow-up have been photo-documented in all cases. Furthermore, the perfusion of the flaps was monitored by means of laser Doppler flowmetry. Postoperative complications were evaluated with a semi-quantitative score and the patients completed a patient satisfaction questionnaire, too.An optimal esthetic result was obtained in all cases after the operation. The lateral nasal alar part of the defect was reconstructed with the thinner proximal part of the flap while the deeper perialar region involving the upper lip was covered with the thicker distal part. The flaps have shown sufficient blood flow after the operation. There was no significant pin cushioning or "trap-door" effect in any case. Mild erythema and edema was found in few cases. The patients were satisfied with the cosmetic result of the intervention.The flap is suitable for the reconstruction of alar defects involving the perialar region. It has the advantage of covering the deeper perialar and the thinner alar defects, whilst eliminating the pin cushioning effect of the conventional subcutaneous island pedicle flaps.}, keywords = {skin defect; combined flap; cutaneous pedicle flap; perialar reconstruction; subcutaneous pedicle flap}, year = {2020}, eissn = {1521-0553}, pages = {666-672} } @article{MTMT:30729353, title = {Új terápiás lehetőségek a plasztikai sebészet és a dermatológia határterületén}, url = {https://m2.mtmt.hu/api/publication/30729353}, author = {Varga, János and Bende, Balázs and Altmayer, Anita and Gaál, Magdolna and Kis, Erika and Kocsis, Ádám László and Mohos, Gábor and Varga, Ákos and Vas, Krisztina and Veréb, Zoltán and Kemény, Lajos}, doi = {10.7188/bvsz.2019.95.2.7}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {95}, unique-id = {30729353}, issn = {0006-7768}, year = {2019}, eissn = {2064-261X}, pages = {69-73}, orcid-numbers = {Veréb, Zoltán/0000-0002-9518-2155; Kemény, Lajos/0000-0002-2119-9501} } @article{MTMT:3347287, title = {A Possible Technique for the Complex Reconstruction of Exposed Breast Implant: Applicability and Microcirculation of the Capsule Flap}, url = {https://m2.mtmt.hu/api/publication/3347287}, author = {Varga, János and Mohos, Gábor and Varga, Ákos and Erős, Gábor and Bende, Balázs and Németh, István Balázs and Kocsis, Ádám László}, doi = {10.1080/08941939.2018.1442532}, journal-iso = {J INVEST SURG}, journal = {JOURNAL OF INVESTIGATIVE SURGERY}, volume = {32}, unique-id = {3347287}, issn = {0894-1939}, abstract = {AIM OF THE STUDY: Immediate breast reconstruction is often applied after mastectomy. However, inappropriate surgical technique, postoperative radiotherapy and infection may lead to tissue necrosis and implant protrusion. Traditional therapies frequently fail. However, previous data suggested that capsule flaps may be appropriate for the salvage of implants. Our goal was to investigate the usefulness of capsuloplasty in patients with exposed breast implant and to monitor the blood supply of capsule flaps during the operation. MATERIALS AND METHODS: Capsuloplasty was performed in 19 patients with exposed implant. After removal of necrotic tissue, capsulotomy was performed, the planned flap was dissected free, the implant was covered with the flap and the wound was then closed. During operation, the blood flow of the flap was determined by means of laser Doppler flowmetry. Moreover, tissue samples were taken for histology and immunostaining for CD34. RESULTS: The postoperative follow-up showed that capsule flaps survived in each case: no complications were found. The blood flow of the flaps did not change significantly during the intervention as compared with the baseline values. The histology and the immunohistochemistry revealed considerable vascularization and angiogenesis in the flap. CONCLUSIONS: Capsule flaps seem to be appropriate for the salvage of exposed implants and for enhancement of implant cover in the case of thin and injured tissue.}, year = {2019}, eissn = {1521-0553}, pages = {530-535} } @article{MTMT:3014802, title = {Hidradenitis Suppurativa sebészi kezelése}, url = {https://m2.mtmt.hu/api/publication/3014802}, author = {Varga, János and Kis, Erika and Mohos, Gábor and Kocsis, Ádám László and Bende, Balázs and Varga, Ákos and Kemény, Lajos}, journal-iso = {BVSZ}, journal = {BŐRGYÓGYÁSZATI ÉS VENEROLÓGIAI SZEMLE}, volume = {91}, unique-id = {3014802}, issn = {0006-7768}, year = {2015}, eissn = {2064-261X}, pages = {211-212}, orcid-numbers = {Kemény, Lajos/0000-0002-2119-9501} }