@article{MTMT:34738061,
	title = {Stable knockdown of Drp1 improves retinoic acid-BDNF-induced neuronal differentiation through global transcriptomic changes and results in reduced phosphorylation of ERK1/2 independently of DUSP1 and 6},
	url = {https://m2.mtmt.hu/api/publication/34738061},
	author = {Ghani, Marvi and Zohar, Peleg and Ujlaki, Gyula and Tóth, Melinda and Amsalu, Hailemariam and Póliska, Szilárd and Tar, Krisztina},
	doi = {10.3389/fcell.2024.1342741},
	journal-iso = {FRONT CELL DEV BIOL},
	journal = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY},
	volume = {12},
	unique-id = {34738061},
	issn = {2296-634X},
	abstract = {Background: Dynamin-related protein Drp1 —a major mitochondrial fission protein— is widely distributed in the central nervous system and plays a crucial role in regulating mitochondrial dynamics, specifically mitochondrial fission and the organelle's shaping. Upregulated Drp1 function may contribute to the pathological progression of neurodegenerative diseases by dysregulating mitochondrial fission/ fusion. The study aims to investigate the effects of Drp1 on retinoic acid-BDNF-induced (RA-BDNF) neuronal differentiation and mitochondrial network reorganization in SH-SY5Y neuroblastoma cells.},
	year = {2024},
	eissn = {2296-634X},
	pages = {1-25}
}

@article{MTMT:34089348,
	title = {Identification of Bacterial Metabolites Modulating Breast Cancer Cell Proliferation and Epithelial-Mesenchymal Transition},
	url = {https://m2.mtmt.hu/api/publication/34089348},
	author = {Ujlaki, Gyula and Kovács, Tünde and Vida, András and Kókai, Endre and Rauch, Boglárka and Schwarcz, Szandra and Mikó, Edit and Janka, Eszter and Sipos, Adrienn and Hegedűs, Csaba and Uray (Davis), Karen L. and Nagy, Péter and Bay, Péter},
	doi = {10.3390/molecules28155898},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {28},
	unique-id = {34089348},
	issn = {1420-3049},
	abstract = {Breast cancer patients are characterized by the oncobiotic transformation of multiple microbiome communities, including the gut microbiome. Oncobiotic transformation of the gut microbiome impairs the production of antineoplastic bacterial metabolites. The goal of this study was to identify bacterial metabolites with antineoplastic properties. We constructed a 30-member bacterial metabolite library and screened the library compounds for effects on cell proliferation and epithelial-mesenchymal transition. The metabolites were applied to 4T1 murine breast cancer cells in concentrations corresponding to the reference serum concentrations. However, yric acid, glycolic acid, d-mannitol, 2,3-butanediol, and trans-ferulic acid exerted cytostatic effects, and 3-hydroxyphenylacetic acid, 4-hydroxybenzoic acid, and vanillic acid exerted hyperproliferative effects. Furthermore, 3-hydroxyphenylacetic acid, 4-hydroxybenzoic acid, 2,3-butanediol, and hydrocinnamic acid inhibited epithelial-to-mesenchymal (EMT) transition. We identified redox sets among the metabolites (d-mannitol—d-mannose, 1-butanol—butyric acid, ethylene glycol—glycolic acid—oxalic acid), wherein only one partner within the set (d-mannitol, butyric acid, glycolic acid) possessed bioactivity in our system, suggesting that changes to the local redox potential may affect the bacterial secretome. Of the nine bioactive metabolites, 2,3-butanediol was the only compound with both cytostatic and anti-EMT properties.},
	year = {2023},
	eissn = {1420-3049},
	orcid-numbers = {Janka, Eszter/0000-0003-0724-5281; Nagy, Péter/0000-0002-7466-805X}
}

@article{MTMT:34034279,
	title = {PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes},
	url = {https://m2.mtmt.hu/api/publication/34034279},
	author = {Antal, Dóra and Pór, Ágnes and Kovács, Ilona and Dull, Katalin and Póliska, Szilárd and Ujlaki, Gyula and Demény, Máté Ágoston and Szöllősi, Attila and Kiss, Borbála and Szegedi, Andrea and Bay, Péter and Szántó, Magdolna},
	doi = {10.1007/s00109-023-02338-z},
	journal-iso = {J MOL MED-JMM},
	journal = {JOURNAL OF MOLECULAR MEDICINE-JMM},
	volume = {101},
	unique-id = {34034279},
	issn = {0946-2716},
	year = {2023},
	eissn = {1432-1440},
	pages = {987-999},
	orcid-numbers = {Pór, Ágnes/0000-0002-2945-0684; Kovács, Ilona/0000-0003-0629-5615; Dull, Katalin/0000-0001-5594-0364; Póliska, Szilárd/0000-0002-9722-251X; Szöllősi, Attila/0000-0001-6046-8236; Kiss, Borbála/0000-0002-6076-9984; Szegedi, Andrea/0000-0003-2109-9014}
}

@article{MTMT:34020857,
	title = {Adenosine A2A Receptor Activation Regulates Niemann–Pick C1 Expression and Localization in Macrophages},
	url = {https://m2.mtmt.hu/api/publication/34020857},
	author = {Skopál, Adrienn and Ujlaki, Gyula and Gerencsér, Attila Tibor and Bankó, Csaba and Bacsó, Zsolt and Ciruela, Francisco and Virág, László and Haskó, György and Kókai, Endre},
	doi = {10.3390/cimb45060315},
	journal-iso = {CURR ISSUES MOL BIOL},
	journal = {CURRENT ISSUES IN MOLECULAR BIOLOGY},
	volume = {45},
	unique-id = {34020857},
	issn = {1467-3037},
	abstract = {Adenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A2A receptors (A2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A2AR interactome and provided evidence for the interaction between the receptor and the Niemann–Pick type C intracellular cholesterol transporter 1 (NPC1) protein. The NPC1 protein was identified to interact with the C-terminal tail of A2AR in RAW 264.7 and IPMФ cells by two independent and parallel proteomic approaches. The interaction between the NPC1 protein and the full-length A2AR was further validated in HEK-293 cells that permanently express the receptor and RAW264.7 cells that endogenously express A2AR. A2AR activation reduces the expression of NPC1 mRNA and protein density in LPS-activated mouse IPMФ cells. Additionally, stimulation of A2AR negatively regulates the cell surface expression of NPC1 in LPS-stimulated macrophages. Furthermore, stimulation of A2AR also altered the density of lysosome-associated membrane protein 2 (LAMP2) and early endosome antigen 1 (EEA1), two endosomal markers associated with the NPC1 protein. Collectively, these results suggested a putative A2AR-mediated regulation of NPC1 protein function in macrophages, potentially relevant for the Niemann–Pick type C disease when mutations in NPC1 protein result in the accumulation of cholesterol and other lipids in lysosomes.},
	year = {2023},
	eissn = {1467-3045},
	pages = {4948-4969},
	orcid-numbers = {Bacsó, Zsolt/0000-0001-6885-3796; Ciruela, Francisco/0000-0003-0832-3739}
}

@article{MTMT:34003596,
	title = {Transglutaminase 2 deficiency leads to lipid accumulation and reduced autophagy in SZ95 sebocytes},
	url = {https://m2.mtmt.hu/api/publication/34003596},
	author = {Lénárt, Kinga and Kovács, Dóra and Demény, Máté Ágoston and Ujlaki, Gyula and Christos, Zouboulis and Szegedi, Andrea and Törőcsik, Dániel},
	journal-iso = {J INVEST DERMATOL},
	journal = {JOURNAL OF INVESTIGATIVE DERMATOLOGY},
	volume = {143},
	unique-id = {34003596},
	issn = {0022-202X},
	year = {2023},
	eissn = {1523-1747},
	pages = {S228-S228}
}

@{MTMT:33998388,
	title = {PARP2 promotes inflammation in psoriasis by modulating estradiol biosynthesis in keratinocytes .},
	url = {https://m2.mtmt.hu/api/publication/33998388},
	author = {Antal, Dóra and Pór, Ágnes and Kovács, Ilona and Dull, Katalin and Póliska, Szilárd and Ujlaki, Gyula and Demény, Máté Ágoston and Szöllősi, A. G. and Kiss, B. and Szegedi, Andrea and Bay, Péter and Szántó, Magdolna},
	booktitle = {FEBS Advanced Lecture Course: PARP 2023: Research on the family of poly(ADP-ribose) polymerases; Book of Abstracts},
	unique-id = {33998388},
	year = {2023},
	pages = {60}
}

@article{MTMT:33764771,
	title = {The pro- and antineoplastic effects of deoxycholic acid in pancreatic adenocarcinoma cell models},
	url = {https://m2.mtmt.hu/api/publication/33764771},
	author = {Schwarcz, Szandra and Kovács, Patrik Bence and Kovács, Tünde and Ujlaki, Gyula and Nyerges, P. and Uray (Davis), Karen L. and Bay, Péter and Mikó, Edit},
	doi = {10.1007/s11033-023-08453-x},
	journal-iso = {MOL BIOL REP},
	journal = {MOLECULAR BIOLOGY REPORTS},
	volume = {50},
	unique-id = {33764771},
	issn = {0301-4851},
	year = {2023},
	eissn = {1573-4978},
	pages = {5273-5282}
}

@article{MTMT:32820433,
	title = {Tissue Transglutaminase Knock-Out Preadipocytes and Beige Cells of Epididymal Fat Origin Possess Decreased Mitochondrial Functions Required for Thermogenesis},
	url = {https://m2.mtmt.hu/api/publication/32820433},
	author = {Lénárt, Kinga and Bankó, Csaba and Ujlaki, Gyula and Póliska, Szilárd and Kis, Nikoletta Gréta and Csősz, Éva and Antal, Miklós and Bacsó, Zsolt and Bay, Péter and Fésüs, László and Mádi, András},
	doi = {10.3390/ijms23095175},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {23},
	unique-id = {32820433},
	issn = {1661-6596},
	year = {2022},
	eissn = {1422-0067}
}

@article{MTMT:32540511,
	title = {The involvement of oncobiosis and bacterial metabolite signaling in metastasis formation in breast cancer},
	url = {https://m2.mtmt.hu/api/publication/32540511},
	author = {Kovács, Tünde and Mikó, Edit and Ujlaki, Gyula and Yousef, H and Csontos, V and Uray (Davis), Karen L. and Bay, Péter},
	doi = {10.1007/s10555-021-10013-3},
	journal-iso = {CANCER METAST REV},
	journal = {CANCER AND METASTASIS REVIEWS},
	volume = {40},
	unique-id = {32540511},
	issn = {0167-7659},
	year = {2021},
	eissn = {1573-7233},
	pages = {1223-1249}
}

@article{MTMT:32287783,
	title = {Ruthenium half-sandwich type complexes with bidentate monosaccharide ligands show antineoplastic activity in ovarian cancer cell models through reactive oxygen species production},
	url = {https://m2.mtmt.hu/api/publication/32287783},
	author = {Kacsir, I and Sipos, Adrienn and Ujlaki, Gyula and Buglyó, Péter and Somsák, László and Bay, Péter and Bokor, Éva},
	doi = {10.3390/ijms221910454},
	journal-iso = {INT J MOL SCI},
	journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES},
	volume = {22},
	unique-id = {32287783},
	issn = {1661-6596},
	abstract = {Ruthenium complexes are developed as substitutes for platinum complexes to be used in the chemotherapy of hematological and gynecological malignancies, such as ovarian cancer. We synthesized and screened 14 ruthenium half-sandwich complexes with bidentate monosaccharide ligands in ovarian cancer cell models. Four complexes were cytostatic, but not cytotoxic on A2780 and ID8 cells. The IC50 values were in the low micromolar range (the best being 0.87 µM) and were similar to or lower than those of the clinically available platinum complexes. The active complexes were cytostatic in cell models of glioblastoma, breast cancer, and pancreatic adenocarcinoma, while they were not cytostatic on non-transformed human skin fibroblasts. The bioactive ruthenium complexes showed cooperative binding to yet unidentified cellular target(s), and their activity was dependent on reactive oxygen species production. Large hydrophobic protective groups on the hydroxyl groups of the sugar moiety were needed for biological activity. The cytostatic activity of the ruthenium complexes was dependent on reactive species production. Rucaparib, a PARP inhibitor, potentiated the effects of ruthenium complexes.},
	keywords = {Ovarian cancer; Half-sandwich; ruthenium complex; COOPERATIVE BINDING; triazole; rucaparib; reactive oxygen species production; oxadiazole; Glycosyl heterocycle},
	year = {2021},
	eissn = {1422-0067},
	orcid-numbers = {Buglyó, Péter/0000-0002-6714-7598; Somsák, László/0000-0002-9103-9845}
}