TY - JOUR AU - Senobar Tahaei, Seyyed Ashkan AU - Kulmány, Ágnes Erika AU - Minorics, Renáta AU - Kiss, Anita AU - Szabó, Zoltán AU - Germán, Péter AU - Szebeni, Gábor AU - Gémes, Nikolett AU - Mernyák, Erzsébet AU - Zupkó, István TI - Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 18 PG - 16 SN - 1661-6596 DO - 10.3390/ijms241813749 UR - https://m2.mtmt.hu/api/publication/34131836 ID - 34131836 N1 - Funding Agency and Grant Number: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. Funding text: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. AB - Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies. LA - English DB - MTMT ER - TY - JOUR AU - Bamou Zahra, Fatima AU - Le Minh, Tam AU - Tayeb, Bizhar Ahmed AU - Senobar Tahaei, Seyyed Ashkan AU - Minorics, Renáta AU - Zupkó, István AU - Szakonyi, Zsolt TI - Antiproliferative Activity of (-)-Isopulegol-based 1,3-Oxazine, 1,3-Thiazine and 2,4-Diaminopyrimidine Derivative JF - CHEMISTRYOPEN J2 - CHEMISTRYOPEN VL - 11 PY - 2022 IS - 10 PG - 11 SN - 2191-1363 DO - 10.1002/open.202200169 UR - https://m2.mtmt.hu/api/publication/33128234 ID - 33128234 AB - A series of novel heterocyclic structures, namely 1,3-oxazines, 1,3-thiazines and 2,4-diaminopyrimidines, were designed and synthesised. The bioassay tests demonstrated that, among these analogues, 2,4-diaminopyridine derivatives showed significant antiproliferative activity against different human cancer cell lines (A2780, SiHa, HeLa, MCF-7 and MDA-MB-231). Pyrimidines substituted with N-2-(p-trifluoromethyl)aniline, in particular, displayed a potent inhibitory effect on the growth of cancer cells. Structure-activity relationships were also studied from the aspects of stereochemistry on the aminodiol moiety as well as exploring the effects of substituents on the pyrimidine scaffold. LA - English DB - MTMT ER - TY - CHAP AU - Senaobar Tahaei, Seyed Arad AU - Senobar Tahaei, Seyyed Ashkan AU - Mencser, Zoltán AU - Barzó, Pál ED - Li, Jie ED - Huang, Lixing ED - Neri, Vincenzo TI - Infections in Neurosurgery and Their Management T2 - Infections and Sepsis Development PB - IntechOpen SN - 9781839694578 PY - 2021 SP - 219 EP - 244 PG - 26 DO - 10.5772/intechopen.99115 UR - https://m2.mtmt.hu/api/publication/32544386 ID - 32544386 LA - English DB - MTMT ER - TY - CONF AU - Gajdács, Márió AU - Senobar Tahaei, Seyyed Ashkan AU - Stájer, Anette AU - Barrak, Ibrahim Ádám AU - Ostorházi, Eszter AU - Szabó, Dóra TI - Correlation between biofilm-formation and antibiotic resistance in Staphylococcus aureus. an in vitro study using phenotypic methods TS - an in vitro study using phenotypic methods T2 - Proceedings of the 1st International Electronic Conference on Antibiotics T3 - International Electronic Conference on Antibiotics PY - 2021 PG - 2 DO - 10.3390/ECA2021-09746 UR - https://m2.mtmt.hu/api/publication/32118833 ID - 32118833 LA - English DB - MTMT ER - TY - JOUR AU - Senobar Tahaei, Seyyed Ashkan AU - Stájer, Anette AU - Barrak, Ibrahim Ádám AU - Ostorházi, Eszter AU - Szabó, Dóra AU - Gajdács, Márió TI - Correlation Between Biofilm-Formation and the Antibiotic Resistant Phenotype in Staphylococcus aureus Isolates: A Laboratory-Based Study in Hungary and a Review of the Literature JF - INFECTION AND DRUG RESISTANCE J2 - INFEC DRUG RESIST VL - 14 PY - 2021 SP - 1155 EP - 1168 PG - 14 SN - 1178-6973 DO - 10.2147/IDR.S303992 UR - https://m2.mtmt.hu/api/publication/31922466 ID - 31922466 N1 - Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, 6720, Hungary Department of Periodontology, Faculty of Dentistry, University of Szeged, Szeged, 6720, Hungary Institute of Medical Microbiology, Faculty of Medicine, Semmelweis University, Budapest, 1089, Hungary Cited By :53 Export Date: 17 March 2024 Correspondence Address: Gajdács, M.; Department of Pharmacodynamics and Biopharmacy, Hungary; email: gajdacs.mario@szte.hu Chemicals/CAS: ceftaroline, 189345-04-8; ciprofloxacin, 85721-33-1, 86393-32-0; clindamycin, 18323-44-9; cotrimoxazole, 8064-90-2; dalfopristin plus quinupristin, 126602-89-9; erythromycin, 114-07-8, 70536-18-4; fusidic acid, 6990-06-3; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; linezolid, 165800-03-3; rifampicin, 13292-46-1; tigecycline, 220620-09-7; vancomycin, 1404-90-6, 1404-93-9 Tradenames: Microflex MALDI Biotyper, Bruker Daltonics, Germany Manufacturers: Bruker Daltonics, Germany Funding details: 5175, BO/00144/20/5 Funding details: European Society of Clinical Microbiology and Infectious Diseases, ESCMID Funding details: Magyar Tudományos Akadémia, MTA, ÚNKP-20-5-SZTE-330 Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRA T Funding text 1: The article processing charge (APC) was funded by the University of Szeged Open Access fund (ID: 5175). M. G. was supported by the János Bolyai Research Scholarship (BO/00144/20/5) of the Hungarian Academy of Sciences and the New National Excellence Programme (ÚNKP-20-5-SZTE-330) of the Ministry of Human Resources. Support from Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRA T is acknowledged. M.G. would also like to acknowledge the support of ESCMID’ s “30 under 30” A ward. LA - English DB - MTMT ER - TY - JOUR AU - Jójárt, Rebeka AU - Senobar Tahaei, Seyyed Ashkan AU - Trungel-Nagy, Péter AU - Kele, Zoltán AU - Minorics, Renáta AU - Paragi, Gábor AU - Zupkó, István AU - Mernyák, Erzsébet TI - Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives JF - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY J2 - J ENZYM INHIB MED CH VL - 36 PY - 2021 IS - 1 SP - 58 EP - 67 PG - 10 SN - 1475-6366 DO - 10.1080/14756366.2020.1838500 UR - https://m2.mtmt.hu/api/publication/31645359 ID - 31645359 LA - English DB - MTMT ER - TY - JOUR AU - Csupor, Dezső AU - Kurtán, Tibor AU - Vollár, Martin AU - Kúsz, Norbert AU - E Kövér, Katalin AU - Mándi, Attila AU - Szűcs, Péter AU - Marschall, Marianna AU - Senobar Tahaei, Seyyed Ashkan AU - Zupkó, István AU - Hohmann, Judit TI - Correction to Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8′-Linked 9,10-Phenanthrenequinone Dimers JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 83 PY - 2020 IS - 4 SP - 1355 EP - 1355 PG - 1 SN - 0163-3864 DO - 10.1021/acs.jnatprod.0c00243 UR - https://m2.mtmt.hu/api/publication/31391195 ID - 31391195 LA - English DB - MTMT ER - TY - JOUR AU - Csupor, Dezső AU - Kurtán, Tibor AU - Vollár, Martin AU - Kúsz, Norbert AU - E Kövér, Katalin AU - Mándi, Attila AU - Szűcs, Péter AU - Marschall, Marianna AU - Senobar Tahaei, Seyyed Ashkan AU - Zupkó, István AU - Hohmann, Judit TI - Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8′-Linked 9,10-Phenanthrenequinone Dimers JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 83 PY - 2020 IS - 2 SP - 268 EP - 276 PG - 9 SN - 0163-3864 DO - 10.1021/acs.jnatprod.9b00655 UR - https://m2.mtmt.hu/api/publication/31196414 ID - 31196414 AB - In a search for new secondary metabolites from mosses, leucobryns A-E, axially chiral 9,10-phenanthrenequinone dimers, were isolated from Paraleucobryum longifolium (1-5), together with diosmetin triglycoside. Leucobryns B (2) and C (3) were proved to be homodimeric atropodiastereomers containing both axial and central chirality elements, while leucobryns D (4) and E (5) were found to be heterodimeric atropodiastereomers containing central chirality in only one of the two monomeric units. Axial chirality of the compounds was determined by ECD measurements and sTDA ECD calculations, while the central chirality elements were assigned by TDDFT-SOR calculations. Leucobryns represent the first 9,10-phenanthrenequinone dimers, the monomers of which are linked through their C-8 atoms. Leucobryns B E contain an uncommon C-10 monoterpenoid side chain, in which isoprenoid units are joined by 3,4 linkages. Leucobryns A and B exhibited weak antiproliferative activity against several human cancer cell lines. LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Anita AU - Wölfling, János AU - Mernyák, Erzsébet AU - Nagyné Frank, Éva AU - Benke, Zsanett Amália AU - Senobar Tahaei, Seyyed Ashkan AU - Zupkó, István AU - Mahó, Sándor AU - Schneider, Gyula TI - Stereocontrolled synthesis of the four possible 3-methoxy and 3-benzyloxy-16-triazolyl-methyl-estra-17-ol hybrids and their antiproliferative activities JF - STEROIDS J2 - STEROIDS VL - 152 PY - 2019 PG - 14 SN - 0039-128X DO - 10.1016/j.steroids.2019.108500 UR - https://m2.mtmt.hu/api/publication/30838971 ID - 30838971 N1 - Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, H-6720, Eötvös u. 6, H-6720 Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Chemical Works of Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary Export Date: 11 February 2020 CODEN: STEDA Correspondence Address: Schneider, G.; Department of Organic Chemistry, University of Szeged, Dóm tér 8, Hungary; email: schneider@chem.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2 Funding details: Emberi Eroforrások Minisztériuma, 20391-3/2018/FEKUSTRAT Funding details: Hungarian Scientific Research Fund, OTKA Funding details: GINOP-2.3.2-15-2016-00038, EFOP-3.6.2 Funding details: Richter Gedeon Talentum Alapítvány Funding details: K113150 Funding text 1: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150 ). Ministry of Human Capacities , Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Appendix A Funding Agency and Grant Number: Talentum Fund of Richter Gedeon Plc. (Budapest); Economic Development and Innovation Operative Programme of Hungary [GINOP-2.3.2-15-2016-00038]; Ultrafast physical processes in atoms, molecules, nanostructures and biological systems [EFOP-3.6.2.-2017-00005]; Hungarian Scientific Research Fund, Ministry of Human Capacities, Hungary [OTKA K113150, 20391-3/2018/FEKUSTRAT] Funding text: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150). Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, H-6720, Eötvös u. 6, H-6720 Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Chemical Works of Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary Cited By :1 Export Date: 29 August 2020 CODEN: STEDA Correspondence Address: Schneider, G.; Department of Organic Chemistry, University of Szeged, Dóm tér 8, Hungary; email: schneider@chem.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; Antineoplastic Agents; Triazoles Funding details: Emberi Eroforrások Minisztériuma, 20391-3/2018/FEKUSTRAT Funding details: Hungarian Scientific Research Fund, OTKA Funding details: GINOP-2.3.2-15-2016-00038, EFOP-3.6.2 Funding details: Richter Gedeon Talentum Alapítvány Funding details: K113150 Funding text 1: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150 ). Ministry of Human Capacities , Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Appendix A Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, H-6720, Eötvös u. 6, H-6720 Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Chemical Works of Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary Cited By :1 Export Date: 10 January 2021 CODEN: STEDA Correspondence Address: Schneider, G.; Department of Organic Chemistry, University of Szeged, Dóm tér 8, Hungary; email: schneider@chem.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; Antineoplastic Agents; Triazoles Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K113150 Funding details: Richter Gedeon Talentum Alapítvány Funding details: -2017-00005, GINOP-2.3.2-15-2016-00038, EFOP-3.6.2 Funding text 1: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150 ). Ministry of Human Capacities , Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. LA - English DB - MTMT ER - TY - JOUR AU - Bús, Csaba AU - Kúsz, Norbert AU - Jakab, Gusztáv AU - Senobar Tahaei, Seyyed Ashkan AU - Zupkó, István AU - Endrész, Valéria AU - Bogdanov, Anita AU - Burián, Katalin AU - Csupor-Löffler, Boglárka AU - Hohmann, Judit AU - Vasas, Andrea TI - Phenanthrenes from Juncus Compressus Jacq. with Promising Antiproliferative and Anti-HSV-2 Activities JF - MOLECULES J2 - MOLECULES VL - 23 PY - 2018 IS - 8 PG - 13 SN - 1420-3049 DO - 10.3390/molecules23082085 UR - https://m2.mtmt.hu/api/publication/3405566 ID - 3405566 N1 - Department of Pharmacognosy, University of Szeged, Szeged, 6720, Hungary Institute of Environmental Sciences, Faculty of Water and Environmental Management, Szent István University Szarvas, Szarvas, H-5540, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, 6720, Hungary Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, 6720, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, 6720, Hungary Cited By :1 Export Date: 3 December 2019 CODEN: MOLEF Correspondence Address: Vasas, A.; Department of Pharmacognosy, University of SzegedHungary; email: vasasa@pharm.u-szeged.hu Department of Pharmacognosy, University of Szeged, Szeged, 6720, Hungary Institute of Environmental Sciences, Faculty of Water and Environmental Management, Szent István University Szarvas, Szarvas, H-5540, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, 6720, Hungary Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, 6720, Hungary Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, 6720, Hungary Cited By :3 Export Date: 24 June 2020 CODEN: MOLEF Correspondence Address: Vasas, A.; Department of Pharmacognosy, University of SzegedHungary; email: vasasa@pharm.u-szeged.hu Chemicals/CAS: Antineoplastic Agents, Phytogenic; Antiviral Agents; Flavonoids; Phenanthrenes; Plant Extracts Funding details: Secretaría de Estado de Investigación, Desarrollo e Innovación, SEIDI, K128963 Funding text 1: This work was funded by the National Research, Development and Innovation Office, Hungary (NKFIH; K128963). The Authors acknowledge support from the GINOP research program (project no. 2.3.2-15-2016-00012) funded by the European Regional Development Fund and TÁMOP 4.2.4.A/2-11/1-2012-0001. The authors are grateful to Attila Csorba for the HRMS measurements. LA - English DB - MTMT ER -