@article{MTMT:34131836, title = {Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs}, url = {https://m2.mtmt.hu/api/publication/34131836}, author = {Senobar Tahaei, Seyyed Ashkan and Kulmány, Ágnes Erika and Minorics, Renáta and Kiss, Anita and Szabó, Zoltán and Germán, Péter and Szebeni, Gábor and Gémes, Nikolett and Mernyák, Erzsébet and Zupkó, István}, doi = {10.3390/ijms241813749}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {24}, unique-id = {34131836}, issn = {1661-6596}, abstract = {Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies.}, year = {2023}, eissn = {1422-0067}, orcid-numbers = {Minorics, Renáta/0000-0001-9685-813X; Kiss, Anita/0000-0003-3352-0996; Szabó, Zoltán/0000-0001-8278-8038; Szebeni, Gábor/0000-0002-6998-5632; Mernyák, Erzsébet/0000-0003-4494-1817; Zupkó, István/0000-0003-3243-5300} } @article{MTMT:33128234, title = {Antiproliferative Activity of (-)-Isopulegol-based 1,3-Oxazine, 1,3-Thiazine and 2,4-Diaminopyrimidine Derivative}, url = {https://m2.mtmt.hu/api/publication/33128234}, author = {Bamou Zahra, Fatima and Le Minh, Tam and Tayeb, Bizhar Ahmed and Senobar Tahaei, Seyyed Ashkan and Minorics, Renáta and Zupkó, István and Szakonyi, Zsolt}, doi = {10.1002/open.202200169}, journal-iso = {CHEMISTRYOPEN}, journal = {CHEMISTRYOPEN}, volume = {11}, unique-id = {33128234}, issn = {2191-1363}, abstract = {A series of novel heterocyclic structures, namely 1,3-oxazines, 1,3-thiazines and 2,4-diaminopyrimidines, were designed and synthesised. The bioassay tests demonstrated that, among these analogues, 2,4-diaminopyridine derivatives showed significant antiproliferative activity against different human cancer cell lines (A2780, SiHa, HeLa, MCF-7 and MDA-MB-231). Pyrimidines substituted with N-2-(p-trifluoromethyl)aniline, in particular, displayed a potent inhibitory effect on the growth of cancer cells. Structure-activity relationships were also studied from the aspects of stereochemistry on the aminodiol moiety as well as exploring the effects of substituents on the pyrimidine scaffold.}, keywords = {2; 1; 3-oxazines; (-)-isopulegol; (+)-neoisopulegol; 3-thiazines; 4-diaminopyrimidines}, year = {2022}, eissn = {2191-1363}, orcid-numbers = {Le Minh, Tam/0000-0002-8296-887X; Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300; Szakonyi, Zsolt/0000-0003-2432-8409} } @{MTMT:32544386, title = {Infections in Neurosurgery and Their Management}, url = {https://m2.mtmt.hu/api/publication/32544386}, author = {Senaobar Tahaei, Seyed Arad and Senobar Tahaei, Seyyed Ashkan and Mencser, Zoltán and Barzó, Pál}, booktitle = {Infections and Sepsis Development}, doi = {10.5772/intechopen.99115}, unique-id = {32544386}, year = {2021}, pages = {219-244}, orcid-numbers = {Barzó, Pál/0000-0001-8717-748X} } @CONFERENCE{MTMT:32118833, title = {Correlation between biofilm-formation and antibiotic resistance in Staphylococcus aureus. an in vitro study using phenotypic methods}, url = {https://m2.mtmt.hu/api/publication/32118833}, author = {Gajdács, Márió and Senobar Tahaei, Seyyed Ashkan and Stájer, Anette and Barrak, Ibrahim Ádám and Ostorházi, Eszter and Szabó, Dóra}, booktitle = {Proceedings of the 1st International Electronic Conference on Antibiotics}, doi = {10.3390/ECA2021-09746}, unique-id = {32118833}, year = {2021}, orcid-numbers = {Gajdács, Márió/0000-0003-1270-0365; Stájer, Anette/0000-0003-4158-173X; Barrak, Ibrahim Ádám/0000-0001-8808-1762; Ostorházi, Eszter/0000-0002-9459-7316; Szabó, Dóra/0000-0002-8601-3923} } @article{MTMT:31922466, title = {Correlation Between Biofilm-Formation and the Antibiotic Resistant Phenotype in Staphylococcus aureus Isolates: A Laboratory-Based Study in Hungary and a Review of the Literature}, url = {https://m2.mtmt.hu/api/publication/31922466}, author = {Senobar Tahaei, Seyyed Ashkan and Stájer, Anette and Barrak, Ibrahim Ádám and Ostorházi, Eszter and Szabó, Dóra and Gajdács, Márió}, doi = {10.2147/IDR.S303992}, journal-iso = {INFEC DRUG RESIST}, journal = {INFECTION AND DRUG RESISTANCE}, volume = {14}, unique-id = {31922466}, issn = {1178-6973}, year = {2021}, eissn = {1178-6973}, pages = {1155-1168}, orcid-numbers = {Stájer, Anette/0000-0003-4158-173X; Barrak, Ibrahim Ádám/0000-0001-8808-1762; Ostorházi, Eszter/0000-0002-9459-7316; Szabó, Dóra/0000-0002-8601-3923; Gajdács, Márió/0000-0003-1270-0365} } @article{MTMT:31645359, title = {Synthesis and evaluation of anticancer activities of 2- or 4-substituted 3-(N-benzyltriazolylmethyl)-13α-oestrone derivatives}, url = {https://m2.mtmt.hu/api/publication/31645359}, author = {Jójárt, Rebeka and Senobar Tahaei, Seyyed Ashkan and Trungel-Nagy, Péter and Kele, Zoltán and Minorics, Renáta and Paragi, Gábor and Zupkó, István and Mernyák, Erzsébet}, doi = {10.1080/14756366.2020.1838500}, journal-iso = {J ENZYM INHIB MED CH}, journal = {JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY}, volume = {36}, unique-id = {31645359}, issn = {1475-6366}, year = {2021}, eissn = {1475-6374}, pages = {58-67}, orcid-numbers = {Kele, Zoltán/0000-0002-4401-0302; Minorics, Renáta/0000-0001-9685-813X; Paragi, Gábor/0000-0001-5408-1748; Zupkó, István/0000-0003-3243-5300; Mernyák, Erzsébet/0000-0003-4494-1817} } @article{MTMT:31391195, title = {Correction to Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8′-Linked 9,10-Phenanthrenequinone Dimers}, url = {https://m2.mtmt.hu/api/publication/31391195}, author = {Csupor, Dezső and Kurtán, Tibor and Vollár, Martin and Kúsz, Norbert and E Kövér, Katalin and Mándi, Attila and Szűcs, Péter and Marschall, Marianna and Senobar Tahaei, Seyyed Ashkan and Zupkó, István and Hohmann, Judit}, doi = {10.1021/acs.jnatprod.0c00243}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {83}, unique-id = {31391195}, issn = {0163-3864}, keywords = {Chemistry, Medicinal; Plant Sciences}, year = {2020}, eissn = {1520-6025}, pages = {1355-1355}, orcid-numbers = {Csupor, Dezső/0000-0002-4088-3333; Kúsz, Norbert/0000-0002-9973-6442; Marschall, Marianna/0009-0009-8060-9767; Zupkó, István/0000-0003-3243-5300; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:31196414, title = {Pigments of the Moss Paraleucobryum longifolium: Isolation and Structure Elucidation of Prenyl-Substituted 8,8′-Linked 9,10-Phenanthrenequinone Dimers}, url = {https://m2.mtmt.hu/api/publication/31196414}, author = {Csupor, Dezső and Kurtán, Tibor and Vollár, Martin and Kúsz, Norbert and E Kövér, Katalin and Mándi, Attila and Szűcs, Péter and Marschall, Marianna and Senobar Tahaei, Seyyed Ashkan and Zupkó, István and Hohmann, Judit}, doi = {10.1021/acs.jnatprod.9b00655}, journal-iso = {J NAT PROD}, journal = {JOURNAL OF NATURAL PRODUCTS}, volume = {83}, unique-id = {31196414}, issn = {0163-3864}, abstract = {In a search for new secondary metabolites from mosses, leucobryns A-E, axially chiral 9,10-phenanthrenequinone dimers, were isolated from Paraleucobryum longifolium (1-5), together with diosmetin triglycoside. Leucobryns B (2) and C (3) were proved to be homodimeric atropodiastereomers containing both axial and central chirality elements, while leucobryns D (4) and E (5) were found to be heterodimeric atropodiastereomers containing central chirality in only one of the two monomeric units. Axial chirality of the compounds was determined by ECD measurements and sTDA ECD calculations, while the central chirality elements were assigned by TDDFT-SOR calculations. Leucobryns represent the first 9,10-phenanthrenequinone dimers, the monomers of which are linked through their C-8 atoms. Leucobryns B E contain an uncommon C-10 monoterpenoid side chain, in which isoprenoid units are joined by 3,4 linkages. Leucobryns A and B exhibited weak antiproliferative activity against several human cancer cell lines.}, year = {2020}, eissn = {1520-6025}, pages = {268-276}, orcid-numbers = {Csupor, Dezső/0000-0002-4088-3333; Kúsz, Norbert/0000-0002-9973-6442; Marschall, Marianna/0009-0009-8060-9767; Zupkó, István/0000-0003-3243-5300; Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:30838971, title = {Stereocontrolled synthesis of the four possible 3-methoxy and 3-benzyloxy-16-triazolyl-methyl-estra-17-ol hybrids and their antiproliferative activities}, url = {https://m2.mtmt.hu/api/publication/30838971}, author = {Kiss, Anita and Wölfling, János and Mernyák, Erzsébet and Nagyné Frank, Éva and Benke, Zsanett Amália and Senobar Tahaei, Seyyed Ashkan and Zupkó, István and Mahó, Sándor and Schneider, Gyula}, doi = {10.1016/j.steroids.2019.108500}, journal-iso = {STEROIDS}, journal = {STEROIDS}, volume = {152}, unique-id = {30838971}, issn = {0039-128X}, year = {2019}, eissn = {1878-5867}, orcid-numbers = {Kiss, Anita/0000-0003-3352-0996; Wölfling, János/0000-0002-3037-309X; Mernyák, Erzsébet/0000-0003-4494-1817; Nagyné Frank, Éva/0000-0002-1332-0551; Zupkó, István/0000-0003-3243-5300} } @article{MTMT:3405566, title = {Phenanthrenes from Juncus Compressus Jacq. with Promising Antiproliferative and Anti-HSV-2 Activities}, url = {https://m2.mtmt.hu/api/publication/3405566}, author = {Bús, Csaba and Kúsz, Norbert and Jakab, Gusztáv and Senobar Tahaei, Seyyed Ashkan and Zupkó, István and Endrész, Valéria and Bogdanov, Anita and Burián, Katalin and Csupor-Löffler, Boglárka and Hohmann, Judit and Vasas, Andrea}, doi = {10.3390/molecules23082085}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {23}, unique-id = {3405566}, issn = {1420-3049}, year = {2018}, eissn = {1420-3049}, orcid-numbers = {Bús, Csaba/0000-0002-4515-8317; Kúsz, Norbert/0000-0002-9973-6442; Jakab, Gusztáv/0000-0002-2569-5967; Zupkó, István/0000-0003-3243-5300; Endrész, Valéria/0000-0002-9402-3857; Bogdanov, Anita/0000-0003-3067-8835; Burián, Katalin/0000-0003-1300-2374; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702} }