TY - JOUR AU - Fabrikov, Dmitri AU - Varga, Ágnes Timea AU - García, María Carmen Vargas AU - Bélteky, Péter AU - Kozma, Gábor AU - Kónya, Zoltán AU - López Martínez, Josefa L. AU - Barroso, Fernando AU - Sánchez-Muros, María José TI - Antimicrobial and antioxidant activity of encapsulated tea polyphenols in chitosan/alginate-coated zein nanoparticles: a possible supplement against fish pathogens in aquaculture JF - ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH J2 - ENVIRON SCI POLLUT R VL - 31 PY - 2024 SP - 13673 EP - 13687 PG - 15 SN - 0944-1344 DO - 10.1007/s11356-024-32058-x UR - https://m2.mtmt.hu/api/publication/34535462 ID - 34535462 AB - Regulation of antibiotic use in aquaculture calls for the emergence of more sustainable alternative treatments. Tea polyphenols (GTE), particularly epigallocatechin gallate (EGCG), have various biological activities. However, tea polyphenols are susceptible to degradation. In this work, EGCG and GTE were encapsulated in zein nanoparticles (ZNP) stabilized with alginate (ALG) and chitosan (CS) to reduce the degradation effect. ALG-coated ZNP and ALG/CS-coated ZNP encapsulating EGCG or GTE were obtained with a hydrodynamic size of less than 300 nm, an absolute ζ -potential value >30 mV, and an encapsulation efficiency greater than 75%. The antioxidant capacity of the encapsulated substances, although lower than that of the free ones, maintained high levels. On the other hand, the evaluation of antimicrobial activity showed greater efficiency in terms of growth inhibition for ALG/CS-ZNP formulations, with average overall values of around 60%, reaching an inhibition of more than 90% for Photobacterium damselae . These results support encapsulation as a good strategy for tea polyphenols, as it allows maintaining significant levels of antioxidant activity and increasing the potential for antimicrobial activity, in addition to increasing protection against sources of degradation. LA - English DB - MTMT ER - TY - JOUR AU - Papp, Ibolya Zita AU - Szerlauth, Adél AU - Szűcs, Tímea AU - Bélteky, Péter AU - Perez, Juan Fernando Gomez AU - Kónya, Zoltán AU - Kukovecz, Ákos TI - Fabrication and characterization of a bifunctional zinc oxide/multiwalled carbon nanotube/ poly(3,4-ethylenedioxythiophene): polystyrene sulfonate composite thin film JF - THIN SOLID FILMS J2 - THIN SOLID FILMS VL - 778 PY - 2023 PG - 10 SN - 0040-6090 DO - 10.1016/j.tsf.2023.139908 UR - https://m2.mtmt.hu/api/publication/33917149 ID - 33917149 LA - English DB - MTMT ER - TY - JOUR AU - Igaz, Nóra AU - Bélteky, Péter AU - Kovács, Dávid AU - Papp, Csaba Gergő AU - Rónavári, Andrea AU - Szabó, Diána AU - Gácser, Attila AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Functionalized Mesoporous Silica Nanoparticles for Drug-Delivery to Multidrug-Resistant Cancer Cells JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 17 PY - 2022 SP - 3079 EP - 3096 PG - 18 SN - 1176-9114 DO - 10.2147/IJN.S363952 UR - https://m2.mtmt.hu/api/publication/33003489 ID - 33003489 N1 - Department of Biochemistry and Molecular Biology, University of Szeged, Szeged, Hungary Department of Applied and Environmental Chemistry, University of Szeged, Szeged, Hungary Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d’Azur, Inserm, CNRS, Valbonne, France HCEMM-USZ Fungal Pathogens Research Group, Department of Microbiology, University of Szeged, Szeged, Hungary Department of Oto-Rhino-Laryngology and Head & Neck Surgery, Szeged, Hungary Eötvös Loránd Research Network, Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary Cited By :8 Export Date: 27 February 2024 Correspondence Address: Kónya, Z.; Department of Applied and Environmental Chemistry, Rerrich square 1, Hungary; email: konya@chem.u-szeged.hu Correspondence Address: Kiricsi, M.; Department of Biochemistry and Molecular Biology, Közép fasor 52, Hungary; email: kiricsim@bio.u-szeged.hu AB - Background: Multidrug resistance is a common reason behind the failure of chemotherapy. Even if the therapy is effective, serious adverse effects might develop due to the low specificity and selectivity of antineoplastic agents. Mesoporous silica nanoparticles (MSNs) are promising materials for tumor-targeting and drug-delivery due to their small size, relatively inert nature, and extremely large specific surfaces that can be functionalized by therapeutic and targeting entities. We aimed to create a fluorescently labeled MSN-based drug-delivery system and investigate their internalization and drug-releasing capability in drug-sensitive MCF-7 and P-glycoprotein-overexpressing multidrug-resistant MCF-7 KCR cancer cells.Methods and Results: To track the uptake and subcellular distribution of MSNs, particles with covalently coupled red fluorescent Rhodamine B (RhoB) were produced (RhoB@MSNs). Both MCF-7 and MCF-7 KCR cells accumulated a significant amount of RhoB@MSNs. The intracellular RhoB@MSN concentrations did not differ between sensitive and multidrug-resistant cells and were kept at the same level even after cessation of RhoB@MSN exposure. Although most RhoB@MSNs resided in the cytoplasm, significantly more RhoB@MSNs co-localized with lysosomes in multidrug-resistant cells compared to sensitive counterparts. To examine the drug-delivery capability of these particles, RhoB@Rho123@MSNs were established, where RhoB-functionalized nanoparticles carried green fluorescent Rhodamine 123 (Rho123) -a P-glycoprotein substrate - as cargo within mesopores. Significantly higher Rho123 fluorescence intensity was detected in RhoB@Rho123@MSN-treated multidrug-resistant cells than in free Rho123-exposed counterparts. The exceptional drug-delivery potential of MSNs was further verified using Mitomycin C (MMC)-loaded RhoB@MSNs (RhoB@MMC@MSNs). Exposures to RhoB@MMC@MSNs significantly decreased the viability not only of drug-sensitive but of multidrug-resistant cells and the elimination of MDR cells was significantly more robust than upon free MMC treatments.Conclusion: The efficient delivery of Rho123 and MMC to multidrug-resistant cells via MSNs, the amplified and presumably prolonged intracellular drug concentration, and the consequently enhanced cytotoxic effects envision the enormous potential of MSNs to defeat multidrug-resistant cancer. LA - English DB - MTMT ER - TY - JOUR AU - Crisci, Matteo AU - Dolcet, Paolo AU - Yang, Jijin AU - Salerno, Marco AU - Bélteky, Péter AU - Kukovecz, Ákos AU - Lamberti, Francesco AU - Agnoli, Stefano AU - Osella, Silvio AU - Gross, Silvia AU - Gatti, Teresa TI - Design Principles and Insights into the Liquid-Phase Exfoliation of Alpha-MoO3 for the Production of Colloidal 2D Nano-inks in Green Solvents JF - JOURNAL OF PHYSICAL CHEMISTRY C J2 - J PHYS CHEM C VL - 126 PY - 2022 IS - 1 SP - 404 EP - 415 PG - 12 SN - 1932-7447 DO - 10.1021/acs.jpcc.1c09221 UR - https://m2.mtmt.hu/api/publication/32724347 ID - 32724347 N1 - Center for Materials Research, Justus Liebig University, Heinrich-Buff-Ring 17, Giessen, 35392, Germany Institute for Chemical Technology and Polymer Chemistry, Karlsruhe Institute of Technology (KIT), Karlsruhe, D-76131, Germany Department of Chemical Sciences, University of Padua, Via Marzolo 1, Padova, 35131, Italy Materials Characterization Facility, Italian Institute of Technology, Via Morego 30, Genova, 16163, Italy Interdisciplinary Excellence Centre, Department of Applied and Environmental Chemistry, University of Szeged, Rerrich Béla tér 1, Szeged, H-6720, Hungary Chemical and Biological Systems Simulation Lab, Center of New Technologies, University of Warsaw, Banacha 2C, Warsaw, 02-097, Poland Export Date: 14 March 2022 Correspondence Address: Osella, S.; Chemical and Biological Systems Simulation Lab, Banacha 2C, Poland; email: s.osella@cent.uw.edu.pl Correspondence Address: Gross, S.; Institute for Chemical Technology and Polymer Chemistry, Germany; email: silvia.gross@unipd.it Correspondence Address: Gatti, T.; Center for Materials Research, Heinrich-Buff-Ring 17, Germany; email: teresa.gatti@phys.chemie.uni-giessen.de LA - English DB - MTMT ER - TY - THES AU - Bélteky, Péter TI - Különböző méretű és felületi borítottságú ezüst nanorészecskék aggregációjának és toxicitásának kapcsolata bioreleváns körülmények között [Aggregation behavior of silver nanoparticles in varying sizes and surface capping under biorelevant conditions and its effect on nanoparticle toxicity] PB - Szegedi Tudományegyetem (SZTE) PY - 2021 SP - 120 DO - 10.14232/phd.10974 UR - https://m2.mtmt.hu/api/publication/32861860 ID - 32861860 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Schmitz, Fabian AU - Horn, Jonas AU - Dengo, Nicola AU - Sedykh, Alexander E. AU - Becker, Jonathan AU - Maiworm, Elena AU - Bélteky, Péter AU - Kukovecz, Ákos AU - Gross, Silvia AU - Lamberti, Francesco AU - Müller-Buschbaum, Klaus AU - Schlettwein, Derck AU - Meggiolaro, Daniele AU - Righetto, Marcello AU - Gatti, Teresa TI - Large Cation Engineering in Two-Dimensional Silver–Bismuth Bromide Double Perovskites JF - CHEMISTRY OF MATERIALS J2 - CHEM MATER VL - 33 PY - 2021 IS - 12 SP - 4688 EP - 4700 PG - 13 SN - 0897-4756 DO - 10.1021/acs.chemmater.1c01182 UR - https://m2.mtmt.hu/api/publication/32724422 ID - 32724422 N1 - Center for Materials Research, Justus Liebig University, Heinrich Buff Ring 16, Giessen, 35392, Germany Institute of Physical Chemistry, Justus Liebig University, Heinrich Buff Ring 17, Giessen, 35392, Germany Institute of Applied Physics, Justus Liebig University, Heinrich Buff Ring 16, Giessen, 35392, Germany Department of Chemical Sciences, University of Padova, via Marzolo 1, Padova, 35131, Italy Institute of Inorganic and Analytical Chemistry, Justus Liebig University, Heinrich-Buff-Ring 17, Giessen, 35392, Germany Interdisciplinary Excellence Centre, Department of Applied and Environmental Chemistry, University of Szeged, Rerrich Béla tér 1, Szeged, H-6720, Hungary Interdepartmental Centre Giorgio Levi Cases for Energy Economics and Technology, University of Padova, via Marzolo 9, Padova, 35131, Italy Computational Laboratory for Hybrid/Organic Photovoltaics (CLHYO), Istituto CNR di Scienze e Tecnologie Chimiche Giulio Natta (CNR-SCITEC), Via Elce di Sotto 8, Perugia, 06123, Italy Department of Physics and Astronomy, University College London, London, WC1E 6BT, United Kingdom Cited By :2 Export Date: 14 March 2022 CODEN: CMATE Correspondence Address: Gatti, T.; Center for Materials Research, Heinrich Buff Ring 16, Germany; email: teresa.gatti@phys.chemie.uni-giessen.de LA - English DB - MTMT ER - TY - JOUR AU - Rónavári, Andrea AU - Bélteky, Péter AU - Boka, Eszter AU - Zakupszky, Dalma AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Pfeiffer, Ilona AU - Kónya, Zoltán AU - Csontné Kiricsi, Mónika TI - Polyvinyl-Pyrrolidone-Coated Silver Nanoparticles—The Colloidal, Chemical, and Biological Consequences of Steric Stabilization under Biorelevant Conditions JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 16 PG - 21 SN - 1661-6596 DO - 10.3390/ijms22168673 UR - https://m2.mtmt.hu/api/publication/32131688 ID - 32131688 N1 - Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, H-6720, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, H-6720, Hungary Cited By :2 Export Date: 11 March 2022 Correspondence Address: Kónya, Z.; Department of Applied and Environmental Chemistry, Hungary; email: konya@chem.u-szeged.hu Chemicals/CAS: povidone, 9003-39-8; silver, 7440-22-4; Anti-Infective Agents; Antineoplastic Agents; Povidone; Silver LA - English DB - MTMT ER - TY - JOUR AU - Bélteky, Péter AU - Rónavári, Andrea AU - Zakupszky, Dalma AU - Boka, Eszter AU - Igaz, Nóra AU - Szerencsés, Bettina AU - Pfeiffer, Ilona AU - Vágvölgyi, Csaba AU - Csontné Kiricsi, Mónika AU - Kónya, Zoltán TI - Are Smaller Nanoparticles Always Better? Understanding the Biological Effect of Size-Dependent Silver Nanoparticle Aggregation Under Biorelevant Conditions JF - INTERNATIONAL JOURNAL OF NANOMEDICINE J2 - INT J NANOMED VL - 16 PY - 2021 SP - 3021 EP - 3040 PG - 20 SN - 1176-9114 DO - 10.2147/IJN.S304138 UR - https://m2.mtmt.hu/api/publication/31982606 ID - 31982606 N1 - Department of Applied and Environmental Chemistry, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary Department of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary MTA-SZTE Reaction Kinetics and Surface Chemistry Research Group, Szeged, Hungary Export Date: 31 May 2021 Correspondence Address: Kónya, Z.; Department of Applied and Environmental Chemistry, Rerrich Square 1, Hungary; email: konya@chem.u-szeged.hu LA - English DB - MTMT ER - TY - JOUR AU - Siposné Musza, Katalin AU - Szabados, Márton AU - Ádám, Anna Adél AU - Bélteky, Péter AU - Kónya, Zoltán AU - Kukovecz, Ákos AU - Sipos, Pál Miklós AU - Pálinkó, István TI - Mechanochemical synthesis of the NiSn, CuSn bimetallic and NiCuSn trimetallic nanocomposites using various types of additives JF - JOURNAL OF SOLID STATE CHEMISTRY J2 - J SOLID STATE CHEM VL - 293 PY - 2021 PG - 10 SN - 0022-4596 DO - 10.1016/j.jssc.2020.121756 UR - https://m2.mtmt.hu/api/publication/31611326 ID - 31611326 LA - English DB - MTMT ER - TY - CHAP AU - Bélteky, Péter AU - Zakupszky, Dalma AU - Boka, Eszter AU - Rónavári, Andrea AU - Kónya, Zoltán ED - Böszörményi, Éva ED - Kocsis, Marianna TI - A felületi stabilizáció mechanizmusának szerepe az ezüst nanorészecskék aggregációs viselkedésére bioreleváns körülmények között T2 - XLIII. Kémiai Előadói Napok - Előadás összefoglalók PB - Szegedi Tudományegyetem (SZTE) CY - Szeged SN - 9786156018045 PY - 2020 SP - . UR - https://m2.mtmt.hu/api/publication/31821559 ID - 31821559 LA - Hungarian DB - MTMT ER -