TY - JOUR AU - Tari, Edina AU - Gagyi , Endre AU - Rancz, Anett AU - Veres, Dániel AU - Váncsa, Szilárd AU - Hegyi, Péter Jenő AU - Hagymási, Krisztina AU - Hegyi, Péter AU - Erőss, Bálint Mihály TI - Morphology of the papilla can predict procedural safety and efficacy of ERCP-a systematic review and meta-analysis. JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 14 PY - 2024 IS - 1 PG - 12 SN - 2045-2322 DO - 10.1038/s41598-024-57758-9 UR - https://m2.mtmt.hu/api/publication/34763940 ID - 34763940 N1 - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary Selye János Doctoral College for Advanced Studies, Semmelweis University, Budapest, Hungary Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pecs, Hungary Department of Surgery, Transplantation, and Gastroenterology, Semmelweis University, Budapest, Hungary Export Date: 12 April 2024 Correspondence Address: Erőss, B.; Centre for Translational Medicine, Hungary; email: dr.eross.balint@gmail.com AB - Endoscopic Retrograde Cholangiopancreatography (ERCP) is the primary therapeutic procedure for pancreaticobiliary disorders, and studies highlighted the impact of papilla anatomy on its efficacy and safety. Our objective was to quantify the influence of papilla morphology on ERCP outcomes. We systematically searched three medical databases in September 2022, focusing on studies detailing the cannulation process or the rate of adverse events in the context of papilla morphology. The Haraldsson classification served as the primary system for papilla morphology, and a pooled event rate with a 95% confidence interval was calculated as the effect size measure. Out of 17 eligible studies, 14 were included in the quantitative synthesis. In studies using the Haraldsson classification, the rate of difficult cannulation was the lowest in type I papilla (26%), while the highest one was observed in the case of type IV papilla (41%). For post-ERCP pancreatitis, the event rate was the highest in type II papilla (11%) and the lowest in type I and III papilla (6-6%). No significant difference was observed in the cannulation failure and post-ERCP bleeding event rates between the papilla types. In conclusion, certain papilla morphologies are associated with a higher rate of difficult cannulation and post-ERCP pancreatitis. LA - English DB - MTMT ER - TY - JOUR AU - Borbély, Ruben Zsolt AU - Szalai, Eszter AU - Philip, Bryan Mangalath AU - Dobszai, Dalma AU - Teutsch, Brigitta AU - Zolcsák, Ádám AU - Veres, Dániel AU - Erőss, Bálint Mihály AU - Gellért, Bálint AU - Hegyi, Péter Jenő AU - Hegyi, Péter AU - Faluhelyi, Nándor TI - The risk of developing splanchnic vein thrombosis in acute pancreatitis increases 3 days after symptom onset: A systematic review and meta-analysis JF - UNITED EUROPEAN GASTROENTEROLOGY JOURNAL J2 - UEG JOURNAL PY - 2024 SN - 2050-6406 DO - 10.1002/ueg2.12550 UR - https://m2.mtmt.hu/api/publication/34682498 ID - 34682498 N1 - Export Date: 25 April 2024 Correspondence Address: Hegyi, P.; MAE Institute of Pancreatic Diseases, Tömő utca 25-29, Hungary; email: hegyi2009@gmail.com AB - Abstract Background Splanchnic vein thrombosis is a complication of acute pancreatitis (AP) and is likely often underdiagnosed. Objectives We aimed to understand the time course and risk factors of splanchnic vein thrombosis in the early phase of AP. Methods A systematic search was conducted using the PRISMA guidelines (PROSPERO registration CRD42022367578). Inclusion criteria were appropriate imaging techniques in adult AP patients, studies that reported splanchnic vein thrombosis data from the early phase, and reliable information on the timing of imaging in relation to the onset of pancreatitis symptoms or hospital admission. The proportion of patients with thrombosis with 95% confidence intervals (CI) was calculated using random-effects meta-analyses, and multiple subgroup analyses were performed. Results Data from 1951 patients from 14 studies were analyzed. The proportion of patients with splanchnic vein thrombosis within 12 days after symptom onset was 0.13 (CI 0.07?0.23). The occurrence was lowest at 0.06 (CI 0.03?0.1) between 0 and 3 days after symptom onset, and increased fourfold to 0.23 (CI 0.16?0.31) between 3 and 11 days. On hospital admission, the proportion of patients affected was 0.12 (CI 0.02?0.49); it was 0.17 (CI 0.03?0.58) 1?5 days after admission. The prevalence in mild, moderate, and severe AP was 0.15 (CI 0.05?0.36), 0.26 (CI 0.15?0.43), and 0.27 (CI 0.17?0.4), respectively. Alcoholic etiology (0.31, CI 0.13?0.58) and pancreatic necrosis (0.55, CI 0.29?0.78, necrosis above 30%) correlated with increased SVT prevalence. Conclusion The risk of developing splanchnic vein thrombosis is significant in the early stages of AP and may affect up to a quarter of patients. Alcoholic etiology, pancreatic necrosis, and severity may increase the prevalence of splanchnic vein thrombosis. LA - English DB - MTMT ER - TY - JOUR AU - Ünal, Pelin AU - Lu, Ye AU - Bueno-de-Mesquita, Bas AU - van Eijck, Casper H J AU - Talar-Wojnarowska, Renata AU - Szentesi, Andrea Ildikó AU - Gazouli, Maria AU - Kreivenaite, Edita AU - Tavano, Francesca AU - Małecka-Wojciesko, Ewa AU - Erőss, Bálint Mihály AU - Oliverius, Martin AU - Bunduc, Stefania AU - Nóbrega Aoki, Mateus AU - Vodickova, Ludmila AU - Boggi, Ugo AU - Giaccherini, Matteo AU - Kondrackiene, Jurate AU - Chammas, Roger AU - Palmieri, Orazio AU - Theodoropoulos, George E AU - Bijlsma, Maarten F AU - Basso, Daniela AU - Mohelnikova-Duchonova, Beatrice AU - Soucek, Pavel AU - Izbicki, Jakob R AU - Kiudelis, Vytautas AU - Vanella, Giuseppe AU - Arcidiacono, Paolo Giorgio AU - Włodarczyk, Barbara AU - Hackert, Thilo AU - Schöttker, Ben AU - Uzunoglu, Faik G AU - Bambi, Franco AU - Goetz, Mara AU - Hlavac, Viktor AU - Brenner, Hermann AU - Perri, Francesco AU - Carrara, Silvia AU - Landi, Stefano AU - Hegyi, Péter AU - Dijk, Frederike AU - Maiello, Evaristo AU - Capretti, Giovanni AU - Testoni, Sabrina Gloria Giulia AU - Petrone, Maria Chiara AU - Stocker, Hannah AU - Ermini, Stefano AU - Archibugi, Livia AU - Gentiluomo, Manuel AU - Cavestro, Giulia Martina AU - Pezzilli, Raffaele AU - Di Franco, Gregorio AU - Milanetto, Anna Caterina AU - Sperti, Cosimo AU - Neoptolemos, John P AU - Morelli, Luca AU - Vokacova, Klara AU - Pasquali, Claudio AU - Lawlor, Rita T AU - Bazzocchi, Francesca AU - Kupcinskas, Juozas AU - Capurso, Gabriele AU - Campa, Daniele AU - Canzian, Federico TI - Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk JF - HUMAN GENOMICS J2 - HUM GENOMICS VL - 18 PY - 2024 IS - 1 PG - 12 SN - 1473-9542 DO - 10.1186/s40246-024-00576-x UR - https://m2.mtmt.hu/api/publication/34561485 ID - 34561485 AB - Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci. We aimed to investigate single-nucleotide polymorphisms (SNP) in regulatory regions [transcription factor binding sites (TFBSs) and enhancers] that could change the expression profile of multiple genes they act upon and thereby modify PDAC risk. We analyzed a total of 12,636 PDAC cases and 43,443 controls from PanScan/PanC4 and the East Asian GWAS (discovery populations), and the PANDoRA consortium (replication population). We identified four associations that reached study-wide statistical significance in the overall meta-analysis: rs2472632(A) (enhancer variant, OR 1.10, 95%CI 1.06,1.13, p = 5.5 × 10-8), rs17358295(G) (enhancer variant, OR 1.16, 95%CI 1.10,1.22, p = 6.1 × 10-7), rs2232079(T) (TFBS variant, OR 0.88, 95%CI 0.83,0.93, p = 6.4 × 10-6) and rs10025845(A) (TFBS variant, OR 1.88, 95%CI 1.50,1.12, p = 1.32 × 10-5). The SNP with the most significant association, rs2472632, is located in an enhancer predicted to target the coiled-coil domain containing 34 oncogene. Our results provide new insights into genetic risk factors for PDAC by a focused analysis of polymorphisms in regulatory regions and demonstrating the usefulness of functional prioritization to identify loci associated with PDAC risk. LA - English DB - MTMT ER - TY - JOUR AU - Tarján, Dorottya AU - Szalai, Eszter AU - Lipp, Mónika Bernadett AU - Verbói, Máté AU - Kói, Tamás AU - Erőss, Bálint Mihály AU - Teutsch, Brigitta AU - Faluhelyi, Nándor AU - Hegyi, Péter AU - Mikó, Alexandra TI - Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-Analysis JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 2 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25021273 UR - https://m2.mtmt.hu/api/publication/34530314 ID - 34530314 N1 - * Megosztott szerzőség AB - Infected necrotizing pancreatitis (INP) is associated with an increased risk of organ failure and mortality. Its early recognition and timely initiation of antibiotic therapy can save patients’ lives. We systematically searched three databases on 27 October 2022. In the eligible studies, the presence of infection in necrotizing pancreatitis was confirmed via a reference test, which involved either the identification of gas within the necrotic collection through computed tomography imaging or the examination of collected samples, which yielded positive results in Gram staining or culture. Laboratory biomarkers compared between sterile necrotizing pancreatitis and INP were used as the index test, and our outcome measures included sensitivity, specificity, the receiver operating characteristic (ROC) curve and area under the ROC curve (AUC). Within the first 72 hours (h) after admission, the AUC of C-reactive protein (CRP) was 0.69 (confidence interval (CI): 0.62–0.76), for procalcitonin (PCT), it was 0.69 (CI: 0.60–0.78), and for white blood cell count, it was 0.61 (CI: 0.47–0.75). After the first 72 h, the pooled AUC of CRP showed an elevated level of 0.88 (CI: 0.75–1.00), and for PCT, it was 0.86 (CI: 0.60–1.11). The predictive value of CRP and PCT for infection is poor within 72 h after hospital admission but seems good after the first 72 h. Based on these results, infection is likely in case of persistently high CRP and PCT, and antibiotic initiation may be recommended. LA - English DB - MTMT ER - TY - JOUR AU - Eitmann, Szimonetta AU - Mátrai, Péter AU - Hegyi, Péter AU - Balaskó, Márta AU - Erőss, Bálint Mihály AU - Dorogi, Kira AU - Pétervári, Erika TI - Obesity paradox in older sarcopenic adults - a delay in aging : A systematic review and meta-analysis JF - AGEING RESEARCH REVIEWS J2 - AGEING RES REV VL - 93 PY - 2024 PG - 20 SN - 1568-1637 DO - 10.1016/j.arr.2023.102164 UR - https://m2.mtmt.hu/api/publication/34453597 ID - 34453597 AB - The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO. LA - English DB - MTMT ER - TY - JOUR AU - Kovács, Adrienn Nikolett AU - Bunduc, Stefania AU - Veres, Dániel AU - Pálinkás, Dániel AU - Gagyi , Endre AU - Hegyi, Péter Jenő AU - Erőss, Bálint Mihály AU - Mihály, Emese AU - Hegyi, Péter AU - Hosszúfalusi, Nóra TI - One third of cases of new-onset diabetic ketosis in adults are associated with ketosis-prone type 2 diabetes-A systematic review and meta-analysis JF - DIABETES-METABOLISM RESEARCH AND REVIEWS J2 - DIABETES-METAB RES VL - 40 PY - 2024 IS - 3 PG - 10 SN - 1520-7552 DO - 10.1002/dmrr.3743 UR - https://m2.mtmt.hu/api/publication/34227657 ID - 34227657 AB - Ketosis-prone type 2 diabetes was defined by the World Health Organization in 2019. According to the literature, the diagnosis is based on the presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta-analysis assessed the prevalence and clinical characteristics of ketosis-prone type 2 diabetes among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis.The systematic search was performed in five main databases as of 15 October 2021 without restrictions. We calculated the pooled prevalence of ketosis-prone type 2 diabetes (exposed group) within the diabetic population under examination, patients with ketoacidosis or ketosis, to identify the clinical characteristics, and we compared it to type 1 diabetes (the comparator group). The random effects model provided pooled estimates as prevalence, odds ratio and mean difference (MD) with 95% confidence intervals.Eleven articles were eligible for meta-analysis, thus incorporating 2010 patients of various ethnic backgrounds. Among patients presenting with DKA or ketosis at the onset of diabetes, 35% (95% CI: 24%-49%) had ketosis-prone type 2 diabetes. These patients were older (MD = 11.55 years; 95% CI: 5.5-17.6) and had a significantly higher body mass index (BMI) (MD = 5.48 kg/m2 ; 95% CI: 3.25-7.72) than those with type 1 diabetes.Ketosis-prone type 2 diabetes accounts for one third of DKA or ketosis at the onset of diabetes in adults. These patients are characterised by islet autoantibody negativity and preserved insulin secretion. They are older and have a higher BMI compared with type 1 diabetes. C-peptide and diabetes-related autoantibody measurement is essential to identify this subgroup among patients with ketosis at the onset of diabetes. LA - English DB - MTMT ER - TY - JOUR AU - Rancz, Anett AU - Teutsch, Brigitta AU - Obeidat, Mahmoud Mohammadnour Suleiman AU - Veres, Dániel AU - Weidinger, G AU - Erőss, Bálint Mihály AU - Hegyi, Péter AU - Mihály, Emese TI - A MIKROSZKÓPOS COLITIS RIZIKÓ FAKTORAI: AZ IRODALOM ÖSSZEFOGLALÁSA ÉS METAANALÍZIS JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 329 EP - 330 PG - 2 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34566520 ID - 34566520 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Zahariev, Julia Olga AU - Bunduc, Stefania AU - Kovács, Adrienn Nikolett AU - Demeter, Dóra AU - Havelda, Luca AU - Budai, Bettina Csilla AU - Veres, Dániel AU - Hosszúfalusi, Nóra AU - Erőss, Bálint Mihály AU - Teutsch, Brigitta AU - Juhász, Márk Félix AU - Hegyi, Péter TI - Risk factors for diabetes mellitus after acute pancreatitis : a systematic review and meta-analysis JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 10 PY - 2023 PG - 18 SN - 2296-858X DO - 10.3389/fmed.2023.1257222 UR - https://m2.mtmt.hu/api/publication/34536097 ID - 34536097 N1 - * Megosztott szerzőség AB - Within 5 years of having acute pancreatitis (AP), approximately 20% of patients develop diabetes mellitus (DM), which later increases to approximately 40%. Some studies suggest that the prevalence of prediabetes (PD) and/or DM can grow as high as 59% over time. However, information on risk factors is limited. We aimed to identify risk factors for developing PD or DM following AP.We systematically searched three databases up to 4 September 2023 extracting direct, within-study comparisons of risk factors on the rate of new-onset PD and DM in AP patients. When PD and DM event rates could not be separated, we reported results for this composite outcome as PD/DM. Meta-analysis was performed using the random-effects model to calculate pooled odds ratios (OR) with 95% confidence intervals (CI).Of the 61 studies identified, 50 were included in the meta-analysis, covering 76,797 participants. The studies reported on 79 risk factors, and meta-analysis was feasible for 34 risk factor and outcome pairs. The odds of developing PD/DM was significantly higher after severe and moderately severe AP (OR: 4.32; CI: 1.76-10.60) than mild AP. Hypertriglyceridemic AP etiology (OR: 3.27; CI: 0.17-63.91) and pancreatic necrosis (OR: 5.53; CI: 1.59-19.21) were associated with a higher risk of developing PD/DM. Alcoholic AP etiology (OR: 1.82; CI: 1.09-3.04), organ failure (OR: 3.19; CI: 0.55-18.64), recurrent AP (OR: 1.89; CI: 0.95-3.77), obesity (OR: 1.85; CI: 1.43-2.38), chronic kidney disease (OR: 2.10; CI: 1.85-2.38), liver cirrhosis (OR: 2.48; CI: 0.18-34.25), and dyslipidemia (OR: 1.82; CI: 0.68-4.84) were associated with a higher risk of developing DM.Severe and moderately severe AP, alcoholic and hypertriglyceridemic etiologies, pancreatic necrosis, organ failure, recurrent acute pancreatitis and comorbidities of obesity, chronic kidney disease liver disease, and dyslipidemia are associated with a higher risk of developing PD or DM.https://www.crd.york.ac.uk/prospero/, identifier CRD42021281983. LA - English DB - MTMT ER - TY - JOUR AU - Nagy, Rita AU - Ocskay, Klementina AU - Sipos, Zoltán AU - Szentesi, Andrea Ildikó AU - Vincze, Áron AU - Czakó, László AU - Izbéki, Ferenc AU - Shirinskaya, Natalia V AU - Poluektov, Vladimir L AU - Zolotov, Alexandr N AU - Zhu, Yin AU - Xia, Liang AU - He, Wenhua AU - Sutton, Robert AU - Szatmary, Peter AU - Mukherjee, Rajarshi AU - Burridge, Isobel Saffron AU - Wauchope, Emma AU - Francisco, Elsa AU - Aparicio, David AU - Pinto, Bruno AU - Gomes, António AU - Nunes, Vitor AU - Tantau, Vasile Marcel AU - Sagau, Emanuela Denisa AU - Tantau, Alina Ioana AU - Suceveanu, Andra Iulia AU - Tocia, Cristina AU - Dumitru, Andrei AU - Pando, Elizabeth AU - Alberti, Piero AU - Cirera, Arturo AU - Molero, Xavier AU - Lee, Hong Sik AU - Jung, Min Kyu AU - Kim, Eui Joo AU - Lee, Sanghyub AU - Rebollo, María Lourdes Ruiz AU - Nistal, Reyes Busta AU - Santervas, Sandra Izquierdo AU - Lesko, Dusan AU - Soltes, Marek AU - Radonak, Jozef AU - Zatorski, Hubert AU - Małecka-Panas, Ewa AU - Fabisiak, Adam AU - Yaroslav, M Susak AU - Mykhailo, V Maksymenko AU - Olekcandr, A Tkachenko AU - Barauskas, Giedrius AU - Simanaitis, Vytautas AU - Ignatavicius, Povilas AU - Jinga, Mariana AU - Balaban, Vasile-Daniel AU - Patoni, Cristina AU - Gong, Liang AU - Song, Kai AU - Li, Yunlong AU - Gonçalves, T Cúrdia AU - Freitas, Marta AU - Macedo, Vítor AU - Vornhuelz, Marlies AU - Klauss, Sarah AU - Beyer, Georg AU - Koksal, Aydin Seref AU - Tozlu, Mukaddes AU - Eminler, Ahmet Tarik AU - Monclús, Nuria Torres AU - Comas, Eva Pijoan AU - Oballe, Juan Armando Rodriguez AU - Nawacki, Łukasz AU - Głuszek, Stanisław AU - Rama-Fernández, Alberto AU - Galego, Marco AU - de la Iglesia, Daniel AU - Aykut, Umut Emre AU - Duman, Deniz Güney AU - Aslan, Rahmi AU - Gherbon, Adriana AU - Deng, Lihui AU - Huang, Wei AU - Xia, Qing AU - Poropat, Goran AU - Radovan, Anja AU - Vranić, Luka AU - Ricci, Claudio AU - Ingaldi, Carlo AU - Casadei, Riccardo AU - Negoi, Ionut AU - Ciubotaru, Cezar AU - Iordache, Florin Mihail AU - Constantinescu, Gabriel AU - Sandru, Vasile AU - Altintas, Engin AU - Balci, Hatice Rizaoglu AU - Constantino, Júlio AU - Aveiro, Débora AU - Pereira, Jorge AU - Gunay, Suleyman AU - Misirlioglu Sucan, Seda AU - Dronov, Oleksiy AU - Kovalska, Inna AU - Bush, Nikhil AU - Rana, Surinder Singh AU - Chooklin, Serge AU - Chuklin, Serhii AU - Saizu, Ionut Adrian AU - Gheorghe, Cristian AU - Göltl, Philipp AU - Hirth, Michael AU - Mateescu, Radu Bogdan AU - Papuc, Geanina AU - Minkov, Georgi Angelov AU - Enchev, Emil Tihomirov AU - Mastrangelo, Laura AU - Jovine, Elio AU - Chen, Weiwei AU - Zhu, Quping AU - Gąsiorowska, Anita AU - Fabisiak, Natalia AU - Bezmarevic, Mihailo AU - Litvin, Andrey AU - Mottes, Martina Cattani AU - Choi, Eun Kwang AU - Bánovčin, Peter AU - Nosáková, Lenka AU - Kovacheva-Slavova, Mila Dimitrova AU - Kchaou, Ali AU - Tlili, Ahmed AU - Marino, Marco V AU - Kusnierz, Katarzyna AU - Mickevicius, Artautas AU - Hollenbach, Marcus AU - Molcan, Pavol AU - Ioannidis, Orestis AU - Tokarev, Mark Valerievich AU - Ince, Ali Tüzün AU - Semenenko, Ivan Albertovich AU - Galeev, Shamil AU - Ramírez-Maldonado, Elena AU - Sallinen, Ville AU - Pencik, Petr AU - Bajor, Judit AU - Sarlós, Patrícia AU - Hágendorn, Roland AU - Gódi, Szilárd AU - Szabó, Imre AU - Czimmer, József AU - Pár, Gabriella AU - Illés, Anita AU - Faluhelyi, Nándor AU - Kanizsai, Péter László AU - Nagy, Tamás AU - Mikó, Alexandra AU - Németh, Balázs AU - Hamvas, József AU - Bod, Barnabás AU - Varga, Márta AU - Török, Imola AU - Novák, János AU - Patai, Árpád AU - Sümegi, János AU - Góg, Csaba AU - Papp, Mária AU - Erőss, Bálint Mihály AU - Váncsa, Szilárd AU - Teutsch, Brigitta AU - Márta, Katalin AU - Hegyi, Péter Jenő AU - Tornai, Tamás AU - Lázár, Balázs AU - Hussein, Tamás AU - Tarján, Dorottya AU - Lipp, Mónika Bernadett AU - Kovács, Beáta AU - Urbán, Orsolya AU - Fürst, Emese Rita AU - Tari, Edina AU - Kocsis, Ibolya AU - Maurovich-Horvat, Pál AU - Tihanyi, Balázs AU - Eperjesi, Orsolya AU - Kormos, Zita AU - Deák, Pál Ákos AU - Párniczky, Andrea AU - Hegyi, Péter TI - Discharge protocol in acute pancreatitis: an international survey and cohort analysis JF - SCIENTIFIC REPORTS J2 - SCI REP VL - 13 PY - 2023 IS - 1 PG - 10 SN - 2045-2322 DO - 10.1038/s41598-023-48480-z UR - https://m2.mtmt.hu/api/publication/34434496 ID - 34434496 AB - There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients' care. LA - English DB - MTMT ER - TY - JOUR AU - Patoni, Cristina AU - Bunduc, Stefania AU - Frim, Levente AU - Veres, Dániel AU - Dembrovszky, Fanni AU - Éliás, Anna Júlia AU - Pálinkás, Dániel AU - Hegyi, Péter AU - Erőss, Bálint Mihály AU - Hegyi, Péter Jenő TI - Low molecular weight heparin decreases mortality and major complication rates in moderately severe and severe acute pancreatitis–a systematic review and meta-analysis JF - FRONTIERS IN MEDICINE J2 - FRONT MED VL - 10 PY - 2023 PG - 10 SN - 2296-858X DO - 10.3389/fmed.2023.1241301 UR - https://m2.mtmt.hu/api/publication/34376533 ID - 34376533 N1 - * Megosztott szerzőség LA - English DB - MTMT ER -