@article{MTMT:34763940, title = {Morphology of the papilla can predict procedural safety and efficacy of ERCP-a systematic review and meta-analysis.}, url = {https://m2.mtmt.hu/api/publication/34763940}, author = {Tari, Edina and Gagyi , Endre and Rancz, Anett and Veres, Dániel and Váncsa, Szilárd and Hegyi, Péter Jenő and Hagymási, Krisztina and Hegyi, Péter and Erőss, Bálint Mihály}, doi = {10.1038/s41598-024-57758-9}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {14}, unique-id = {34763940}, issn = {2045-2322}, abstract = {Endoscopic Retrograde Cholangiopancreatography (ERCP) is the primary therapeutic procedure for pancreaticobiliary disorders, and studies highlighted the impact of papilla anatomy on its efficacy and safety. Our objective was to quantify the influence of papilla morphology on ERCP outcomes. We systematically searched three medical databases in September 2022, focusing on studies detailing the cannulation process or the rate of adverse events in the context of papilla morphology. The Haraldsson classification served as the primary system for papilla morphology, and a pooled event rate with a 95% confidence interval was calculated as the effect size measure. Out of 17 eligible studies, 14 were included in the quantitative synthesis. In studies using the Haraldsson classification, the rate of difficult cannulation was the lowest in type I papilla (26%), while the highest one was observed in the case of type IV papilla (41%). For post-ERCP pancreatitis, the event rate was the highest in type II papilla (11%) and the lowest in type I and III papilla (6-6%). No significant difference was observed in the cannulation failure and post-ERCP bleeding event rates between the papilla types. In conclusion, certain papilla morphologies are associated with a higher rate of difficult cannulation and post-ERCP pancreatitis.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2045-2322}, orcid-numbers = {Tari, Edina/0000-0002-8540-0614; Veres, Dániel/0000-0002-9687-3556; Váncsa, Szilárd/0000-0002-9347-8163; Hagymási, Krisztina/0000-0002-5859-1320; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @article{MTMT:34682498, title = {The risk of developing splanchnic vein thrombosis in acute pancreatitis increases 3 days after symptom onset: A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34682498}, author = {Borbély, Ruben Zsolt and Szalai, Eszter and Philip, Bryan Mangalath and Dobszai, Dalma and Teutsch, Brigitta and Zolcsák, Ádám and Veres, Dániel and Erőss, Bálint Mihály and Gellért, Bálint and Hegyi, Péter Jenő and Hegyi, Péter and Faluhelyi, Nándor}, doi = {10.1002/ueg2.12550}, journal-iso = {UEG JOURNAL}, journal = {UNITED EUROPEAN GASTROENTEROLOGY JOURNAL}, unique-id = {34682498}, issn = {2050-6406}, abstract = {Abstract Background Splanchnic vein thrombosis is a complication of acute pancreatitis (AP) and is likely often underdiagnosed. Objectives We aimed to understand the time course and risk factors of splanchnic vein thrombosis in the early phase of AP. Methods A systematic search was conducted using the PRISMA guidelines (PROSPERO registration CRD42022367578). Inclusion criteria were appropriate imaging techniques in adult AP patients, studies that reported splanchnic vein thrombosis data from the early phase, and reliable information on the timing of imaging in relation to the onset of pancreatitis symptoms or hospital admission. The proportion of patients with thrombosis with 95% confidence intervals (CI) was calculated using random-effects meta-analyses, and multiple subgroup analyses were performed. Results Data from 1951 patients from 14 studies were analyzed. The proportion of patients with splanchnic vein thrombosis within 12 days after symptom onset was 0.13 (CI 0.07?0.23). The occurrence was lowest at 0.06 (CI 0.03?0.1) between 0 and 3 days after symptom onset, and increased fourfold to 0.23 (CI 0.16?0.31) between 3 and 11 days. On hospital admission, the proportion of patients affected was 0.12 (CI 0.02?0.49); it was 0.17 (CI 0.03?0.58) 1?5 days after admission. The prevalence in mild, moderate, and severe AP was 0.15 (CI 0.05?0.36), 0.26 (CI 0.15?0.43), and 0.27 (CI 0.17?0.4), respectively. Alcoholic etiology (0.31, CI 0.13?0.58) and pancreatic necrosis (0.55, CI 0.29?0.78, necrosis above 30%) correlated with increased SVT prevalence. Conclusion The risk of developing splanchnic vein thrombosis is significant in the early stages of AP and may affect up to a quarter of patients. Alcoholic etiology, pancreatic necrosis, and severity may increase the prevalence of splanchnic vein thrombosis.}, keywords = {portal vein thrombosis; splenic vein thrombosis; Superior mesenteric vein thrombosis; portosplenomesenteric venous thrombosis; [Meta-analysis]}, year = {2024}, eissn = {2050-6414}, orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Zolcsák, Ádám/0000-0002-9128-4867; Veres, Dániel/0000-0002-9687-3556; Erőss, Bálint Mihály/0000-0003-3658-8427; Gellért, Bálint/0000-0003-2356-6464; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:34561485, title = {Polymorphisms in transcription factor binding sites and enhancer regions and pancreatic ductal adenocarcinoma risk}, url = {https://m2.mtmt.hu/api/publication/34561485}, author = {Ünal, Pelin and Lu, Ye and Bueno-de-Mesquita, Bas and van Eijck, Casper H J and Talar-Wojnarowska, Renata and Szentesi, Andrea Ildikó and Gazouli, Maria and Kreivenaite, Edita and Tavano, Francesca and Małecka-Wojciesko, Ewa and Erőss, Bálint Mihály and Oliverius, Martin and Bunduc, Stefania and Nóbrega Aoki, Mateus and Vodickova, Ludmila and Boggi, Ugo and Giaccherini, Matteo and Kondrackiene, Jurate and Chammas, Roger and Palmieri, Orazio and Theodoropoulos, George E and Bijlsma, Maarten F and Basso, Daniela and Mohelnikova-Duchonova, Beatrice and Soucek, Pavel and Izbicki, Jakob R and Kiudelis, Vytautas and Vanella, Giuseppe and Arcidiacono, Paolo Giorgio and Włodarczyk, Barbara and Hackert, Thilo and Schöttker, Ben and Uzunoglu, Faik G and Bambi, Franco and Goetz, Mara and Hlavac, Viktor and Brenner, Hermann and Perri, Francesco and Carrara, Silvia and Landi, Stefano and Hegyi, Péter and Dijk, Frederike and Maiello, Evaristo and Capretti, Giovanni and Testoni, Sabrina Gloria Giulia and Petrone, Maria Chiara and Stocker, Hannah and Ermini, Stefano and Archibugi, Livia and Gentiluomo, Manuel and Cavestro, Giulia Martina and Pezzilli, Raffaele and Di Franco, Gregorio and Milanetto, Anna Caterina and Sperti, Cosimo and Neoptolemos, John P and Morelli, Luca and Vokacova, Klara and Pasquali, Claudio and Lawlor, Rita T and Bazzocchi, Francesca and Kupcinskas, Juozas and Capurso, Gabriele and Campa, Daniele and Canzian, Federico}, doi = {10.1186/s40246-024-00576-x}, journal-iso = {HUM GENOMICS}, journal = {HUMAN GENOMICS}, volume = {18}, unique-id = {34561485}, issn = {1473-9542}, abstract = {Genome-wide association studies (GWAS) are a powerful tool for detecting variants associated with complex traits and can help risk stratification and prevention strategies against pancreatic ductal adenocarcinoma (PDAC). However, the strict significance threshold commonly used makes it likely that many true risk loci are missed. Functional annotation of GWAS polymorphisms is a proven strategy to identify additional risk loci. We aimed to investigate single-nucleotide polymorphisms (SNP) in regulatory regions [transcription factor binding sites (TFBSs) and enhancers] that could change the expression profile of multiple genes they act upon and thereby modify PDAC risk. We analyzed a total of 12,636 PDAC cases and 43,443 controls from PanScan/PanC4 and the East Asian GWAS (discovery populations), and the PANDoRA consortium (replication population). We identified four associations that reached study-wide statistical significance in the overall meta-analysis: rs2472632(A) (enhancer variant, OR 1.10, 95%CI 1.06,1.13, p = 5.5 × 10-8), rs17358295(G) (enhancer variant, OR 1.16, 95%CI 1.10,1.22, p = 6.1 × 10-7), rs2232079(T) (TFBS variant, OR 0.88, 95%CI 0.83,0.93, p = 6.4 × 10-6) and rs10025845(A) (TFBS variant, OR 1.88, 95%CI 1.50,1.12, p = 1.32 × 10-5). The SNP with the most significant association, rs2472632, is located in an enhancer predicted to target the coiled-coil domain containing 34 oncogene. Our results provide new insights into genetic risk factors for PDAC by a focused analysis of polymorphisms in regulatory regions and demonstrating the usefulness of functional prioritization to identify loci associated with PDAC risk.}, keywords = {single nucleotide polymorphism; ENHANCER; Pancreatic cancer; Association study; Transcription factor binding site}, year = {2024}, eissn = {1479-7364}, orcid-numbers = {Szentesi, Andrea Ildikó/0000-0003-2097-6927; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:34530314, title = {Persistently High Procalcitonin and C-Reactive Protein Are Good Predictors of Infection in Acute Necrotizing Pancreatitis: A Systematic Review and Meta-Analysis}, url = {https://m2.mtmt.hu/api/publication/34530314}, author = {Tarján, Dorottya and Szalai, Eszter and Lipp, Mónika Bernadett and Verbói, Máté and Kói, Tamás and Erőss, Bálint Mihály and Teutsch, Brigitta and Faluhelyi, Nándor and Hegyi, Péter and Mikó, Alexandra}, doi = {10.3390/ijms25021273}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34530314}, issn = {1661-6596}, abstract = {Infected necrotizing pancreatitis (INP) is associated with an increased risk of organ failure and mortality. Its early recognition and timely initiation of antibiotic therapy can save patients’ lives. We systematically searched three databases on 27 October 2022. In the eligible studies, the presence of infection in necrotizing pancreatitis was confirmed via a reference test, which involved either the identification of gas within the necrotic collection through computed tomography imaging or the examination of collected samples, which yielded positive results in Gram staining or culture. Laboratory biomarkers compared between sterile necrotizing pancreatitis and INP were used as the index test, and our outcome measures included sensitivity, specificity, the receiver operating characteristic (ROC) curve and area under the ROC curve (AUC). Within the first 72 hours (h) after admission, the AUC of C-reactive protein (CRP) was 0.69 (confidence interval (CI): 0.62–0.76), for procalcitonin (PCT), it was 0.69 (CI: 0.60–0.78), and for white blood cell count, it was 0.61 (CI: 0.47–0.75). After the first 72 h, the pooled AUC of CRP showed an elevated level of 0.88 (CI: 0.75–1.00), and for PCT, it was 0.86 (CI: 0.60–1.11). The predictive value of CRP and PCT for infection is poor within 72 h after hospital admission but seems good after the first 72 h. Based on these results, infection is likely in case of persistently high CRP and PCT, and antibiotic initiation may be recommended.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Erőss, Bálint Mihály/0000-0003-3658-8427; Teutsch, Brigitta/0000-0002-9530-7886; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:34453597, title = {Obesity paradox in older sarcopenic adults - a delay in aging : A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34453597}, author = {Eitmann, Szimonetta and Mátrai, Péter and Hegyi, Péter and Balaskó, Márta and Erőss, Bálint Mihály and Dorogi, Kira and Pétervári, Erika}, doi = {10.1016/j.arr.2023.102164}, journal-iso = {AGEING RES REV}, journal = {AGEING RESEARCH REVIEWS}, volume = {93}, unique-id = {34453597}, issn = {1568-1637}, abstract = {The prognostic significance of obesity in sarcopenic adults is controversial. This systematic review and meta-analysis aimed to investigate the effect of additional obesity on health outcomes in sarcopenia. MEDLINE, EMBASE, Scopus and CENTRAL were systematically searched for studies to compare health outcomes of adults with sarcopenic obesity (SO) to those of sarcopenic non-obese (SNO) adults. We also considered the methods of assessing obesity. Of 15060 records screened, 65 papers were included (100612 participants). Older community-dwelling SO adults had 15% lower mortality risk than the SNO group (hazard ratio, HR: 0.85, 95% confidence interval 0.76, 0.94) even when obesity was assessed by measurement of body composition. Additionally, meta-regression analysis revealed a significant negative linear correlation between the age and the HR of all-cause mortality in SO vs. SNO community-dwelling adults, but not in severely ill patients. Compared with SNO, SO patients presented lower physical performance, higher risk for metabolic syndrome, but similar cognitive function, risk of falls and cardiovascular diseases. Age-related obesity, SO and later fat loss leading to SNO represent consecutive phases of biological aging. Additional obesity could worsen the health state in sarcopenia, but above 65 years SO represents a biologically earlier phase with longer life expectancy than SNO.}, keywords = {Body Mass Index; Sarcopenia; fat mass; Sarcopenic obesity; Biological aging; [Meta-analysis]}, year = {2024}, eissn = {1872-9649}, orcid-numbers = {Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427; Pétervári, Erika/0000-0002-3673-8491} } @article{MTMT:34227657, title = {One third of cases of new-onset diabetic ketosis in adults are associated with ketosis-prone type 2 diabetes-A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34227657}, author = {Kovács, Adrienn Nikolett and Bunduc, Stefania and Veres, Dániel and Pálinkás, Dániel and Gagyi , Endre and Hegyi, Péter Jenő and Erőss, Bálint Mihály and Mihály, Emese and Hegyi, Péter and Hosszúfalusi, Nóra}, doi = {10.1002/dmrr.3743}, journal-iso = {DIABETES-METAB RES}, journal = {DIABETES-METABOLISM RESEARCH AND REVIEWS}, volume = {40}, unique-id = {34227657}, issn = {1520-7552}, abstract = {Ketosis-prone type 2 diabetes was defined by the World Health Organization in 2019. According to the literature, the diagnosis is based on the presence of ketosis, islet autoantibody negativity and preserved insulin secretion. Our meta-analysis assessed the prevalence and clinical characteristics of ketosis-prone type 2 diabetes among patients hospitalised with diabetic ketoacidosis (DKA) or ketosis.The systematic search was performed in five main databases as of 15 October 2021 without restrictions. We calculated the pooled prevalence of ketosis-prone type 2 diabetes (exposed group) within the diabetic population under examination, patients with ketoacidosis or ketosis, to identify the clinical characteristics, and we compared it to type 1 diabetes (the comparator group). The random effects model provided pooled estimates as prevalence, odds ratio and mean difference (MD) with 95% confidence intervals.Eleven articles were eligible for meta-analysis, thus incorporating 2010 patients of various ethnic backgrounds. Among patients presenting with DKA or ketosis at the onset of diabetes, 35% (95% CI: 24%-49%) had ketosis-prone type 2 diabetes. These patients were older (MD = 11.55 years; 95% CI: 5.5-17.6) and had a significantly higher body mass index (BMI) (MD = 5.48 kg/m2 ; 95% CI: 3.25-7.72) than those with type 1 diabetes.Ketosis-prone type 2 diabetes accounts for one third of DKA or ketosis at the onset of diabetes in adults. These patients are characterised by islet autoantibody negativity and preserved insulin secretion. They are older and have a higher BMI compared with type 1 diabetes. C-peptide and diabetes-related autoantibody measurement is essential to identify this subgroup among patients with ketosis at the onset of diabetes.}, keywords = {Meta-analysis; diabetic ketoacidosis; diabetes classification; ketosis-prone type 2; [Meta-analysis]}, year = {2024}, eissn = {1520-7560}, orcid-numbers = {Veres, Dániel/0000-0002-9687-3556; Erőss, Bálint Mihály/0000-0003-3658-8427; Mihály, Emese/0000-0003-3046-7341; Hegyi, Péter/0000-0003-0399-7259; Hosszúfalusi, Nóra/0000-0002-9469-372X} } @article{MTMT:34566520, title = {A MIKROSZKÓPOS COLITIS RIZIKÓ FAKTORAI: AZ IRODALOM ÖSSZEFOGLALÁSA ÉS METAANALÍZIS}, url = {https://m2.mtmt.hu/api/publication/34566520}, author = {Rancz, Anett and Teutsch, Brigitta and Obeidat, Mahmoud Mohammadnour Suleiman and Veres, Dániel and Weidinger, G and Erőss, Bálint Mihály and Hegyi, Péter and Mihály, Emese}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {76}, unique-id = {34566520}, issn = {0133-5464}, year = {2023}, pages = {329-330}, orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Erőss, Bálint Mihály/0000-0003-3658-8427; Hegyi, Péter/0000-0003-0399-7259; Mihály, Emese/0000-0003-3046-7341} } @article{MTMT:34536097, title = {Risk factors for diabetes mellitus after acute pancreatitis : a systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34536097}, author = {Zahariev, Julia Olga and Bunduc, Stefania and Kovács, Adrienn Nikolett and Demeter, Dóra and Havelda, Luca and Budai, Bettina Csilla and Veres, Dániel and Hosszúfalusi, Nóra and Erőss, Bálint Mihály and Teutsch, Brigitta and Juhász, Márk Félix and Hegyi, Péter}, doi = {10.3389/fmed.2023.1257222}, journal-iso = {FRONT MED}, journal = {FRONTIERS IN MEDICINE}, volume = {10}, unique-id = {34536097}, abstract = {Within 5 years of having acute pancreatitis (AP), approximately 20% of patients develop diabetes mellitus (DM), which later increases to approximately 40%. Some studies suggest that the prevalence of prediabetes (PD) and/or DM can grow as high as 59% over time. However, information on risk factors is limited. We aimed to identify risk factors for developing PD or DM following AP.We systematically searched three databases up to 4 September 2023 extracting direct, within-study comparisons of risk factors on the rate of new-onset PD and DM in AP patients. When PD and DM event rates could not be separated, we reported results for this composite outcome as PD/DM. Meta-analysis was performed using the random-effects model to calculate pooled odds ratios (OR) with 95% confidence intervals (CI).Of the 61 studies identified, 50 were included in the meta-analysis, covering 76,797 participants. The studies reported on 79 risk factors, and meta-analysis was feasible for 34 risk factor and outcome pairs. The odds of developing PD/DM was significantly higher after severe and moderately severe AP (OR: 4.32; CI: 1.76-10.60) than mild AP. Hypertriglyceridemic AP etiology (OR: 3.27; CI: 0.17-63.91) and pancreatic necrosis (OR: 5.53; CI: 1.59-19.21) were associated with a higher risk of developing PD/DM. Alcoholic AP etiology (OR: 1.82; CI: 1.09-3.04), organ failure (OR: 3.19; CI: 0.55-18.64), recurrent AP (OR: 1.89; CI: 0.95-3.77), obesity (OR: 1.85; CI: 1.43-2.38), chronic kidney disease (OR: 2.10; CI: 1.85-2.38), liver cirrhosis (OR: 2.48; CI: 0.18-34.25), and dyslipidemia (OR: 1.82; CI: 0.68-4.84) were associated with a higher risk of developing DM.Severe and moderately severe AP, alcoholic and hypertriglyceridemic etiologies, pancreatic necrosis, organ failure, recurrent acute pancreatitis and comorbidities of obesity, chronic kidney disease liver disease, and dyslipidemia are associated with a higher risk of developing PD or DM.https://www.crd.york.ac.uk/prospero/, identifier CRD42021281983.}, keywords = {diabetes mellitus; prediabetes; gastrointestinal disorders; acute pancreatitis (AP); risk factor (RF); pancreatitis—complications; [Meta-analysis]}, year = {2023}, eissn = {2296-858X}, orcid-numbers = {Veres, Dániel/0000-0002-9687-3556; Hosszúfalusi, Nóra/0000-0002-9469-372X; Erőss, Bálint Mihály/0000-0003-3658-8427; Teutsch, Brigitta/0000-0002-9530-7886; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:34434496, title = {Discharge protocol in acute pancreatitis: an international survey and cohort analysis}, url = {https://m2.mtmt.hu/api/publication/34434496}, author = {Nagy, Rita and Ocskay, Klementina and Sipos, Zoltán and Szentesi, Andrea Ildikó and Vincze, Áron and Czakó, László and Izbéki, Ferenc and Shirinskaya, Natalia V and Poluektov, Vladimir L and Zolotov, Alexandr N and Zhu, Yin and Xia, Liang and He, Wenhua and Sutton, Robert and Szatmary, Peter and Mukherjee, Rajarshi and Burridge, Isobel Saffron and Wauchope, Emma and Francisco, Elsa and Aparicio, David and Pinto, Bruno and Gomes, António and Nunes, Vitor and Tantau, Vasile Marcel and Sagau, Emanuela Denisa and Tantau, Alina Ioana and Suceveanu, Andra Iulia and Tocia, Cristina and Dumitru, Andrei and Pando, Elizabeth and Alberti, Piero and Cirera, Arturo and Molero, Xavier and Lee, Hong Sik and Jung, Min Kyu and Kim, Eui Joo and Lee, Sanghyub and Rebollo, María Lourdes Ruiz and Nistal, Reyes Busta and Santervas, Sandra Izquierdo and Lesko, Dusan and Soltes, Marek and Radonak, Jozef and Zatorski, Hubert and Małecka-Panas, Ewa and Fabisiak, Adam and Yaroslav, M Susak and Mykhailo, V Maksymenko and Olekcandr, A Tkachenko and Barauskas, Giedrius and Simanaitis, Vytautas and Ignatavicius, Povilas and Jinga, Mariana and Balaban, Vasile-Daniel and Patoni, Cristina and Gong, Liang and Song, Kai and Li, Yunlong and Gonçalves, T Cúrdia and Freitas, Marta and Macedo, Vítor and Vornhuelz, Marlies and Klauss, Sarah and Beyer, Georg and Koksal, Aydin Seref and Tozlu, Mukaddes and Eminler, Ahmet Tarik and Monclús, Nuria Torres and Comas, Eva Pijoan and Oballe, Juan Armando Rodriguez and Nawacki, Łukasz and Głuszek, Stanisław and Rama-Fernández, Alberto and Galego, Marco and de la Iglesia, Daniel and Aykut, Umut Emre and Duman, Deniz Güney and Aslan, Rahmi and Gherbon, Adriana and Deng, Lihui and Huang, Wei and Xia, Qing and Poropat, Goran and Radovan, Anja and Vranić, Luka and Ricci, Claudio and Ingaldi, Carlo and Casadei, Riccardo and Negoi, Ionut and Ciubotaru, Cezar and Iordache, Florin Mihail and Constantinescu, Gabriel and Sandru, Vasile and Altintas, Engin and Balci, Hatice Rizaoglu and Constantino, Júlio and Aveiro, Débora and Pereira, Jorge and Gunay, Suleyman and Misirlioglu Sucan, Seda and Dronov, Oleksiy and Kovalska, Inna and Bush, Nikhil and Rana, Surinder Singh and Chooklin, Serge and Chuklin, Serhii and Saizu, Ionut Adrian and Gheorghe, Cristian and Göltl, Philipp and Hirth, Michael and Mateescu, Radu Bogdan and Papuc, Geanina and Minkov, Georgi Angelov and Enchev, Emil Tihomirov and Mastrangelo, Laura and Jovine, Elio and Chen, Weiwei and Zhu, Quping and Gąsiorowska, Anita and Fabisiak, Natalia and Bezmarevic, Mihailo and Litvin, Andrey and Mottes, Martina Cattani and Choi, Eun Kwang and Bánovčin, Peter and Nosáková, Lenka and Kovacheva-Slavova, Mila Dimitrova and Kchaou, Ali and Tlili, Ahmed and Marino, Marco V and Kusnierz, Katarzyna and Mickevicius, Artautas and Hollenbach, Marcus and Molcan, Pavol and Ioannidis, Orestis and Tokarev, Mark Valerievich and Ince, Ali Tüzün and Semenenko, Ivan Albertovich and Galeev, Shamil and Ramírez-Maldonado, Elena and Sallinen, Ville and Pencik, Petr and Bajor, Judit and Sarlós, Patrícia and Hágendorn, Roland and Gódi, Szilárd and Szabó, Imre and Czimmer, József and Pár, Gabriella and Illés, Anita and Faluhelyi, Nándor and Kanizsai, Péter László and Nagy, Tamás and Mikó, Alexandra and Németh, Balázs and Hamvas, József and Bod, Barnabás and Varga, Márta and Török, Imola and Novák, János and Patai, Árpád and Sümegi, János and Góg, Csaba and Papp, Mária and Erőss, Bálint Mihály and Váncsa, Szilárd and Teutsch, Brigitta and Márta, Katalin and Hegyi, Péter Jenő and Tornai, Tamás and Lázár, Balázs and Hussein, Tamás and Tarján, Dorottya and Lipp, Mónika Bernadett and Kovács, Beáta and Urbán, Orsolya and Fürst, Emese Rita and Tari, Edina and Kocsis, Ibolya and Maurovich-Horvat, Pál and Tihanyi, Balázs and Eperjesi, Orsolya and Kormos, Zita and Deák, Pál Ákos and Párniczky, Andrea and Hegyi, Péter}, doi = {10.1038/s41598-023-48480-z}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {13}, unique-id = {34434496}, issn = {2045-2322}, abstract = {There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p = 0.005). There was no difference in median discharge CRP level among the international cohorts (p = 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confirmed by the low rate of readmittance (n = 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the first clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients' care.}, year = {2023}, eissn = {2045-2322}, orcid-numbers = {Nagy, Rita/0000-0002-2663-4912; Ocskay, Klementina/0000-0001-5848-2506; Sipos, Zoltán/0000-0001-7845-8116; Szentesi, Andrea Ildikó/0000-0003-2097-6927; Vincze, Áron/0000-0003-2217-7686; Czakó, László/0000-0002-6331-0802; Izbéki, Ferenc/0000-0001-7767-4319; Sarlós, Patrícia/0000-0002-5086-9455; Czimmer, József/0000-0001-7831-3523; Kanizsai, Péter László/0000-0001-7896-2857; Nagy, Tamás/0000-0001-5437-1411; Németh, Balázs/0000-0001-5338-7577; Papp, Mária/0000-0003-3662-4010; Erőss, Bálint Mihály/0000-0003-3658-8427; Váncsa, Szilárd/0000-0002-9347-8163; Teutsch, Brigitta/0000-0002-9530-7886; Márta, Katalin/0000-0002-2213-4865; Tari, Edina/0000-0002-8540-0614; Kocsis, Ibolya/0000-0003-3128-2832; Maurovich-Horvat, Pál/0000-0003-0885-736X; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:34376533, title = {Low molecular weight heparin decreases mortality and major complication rates in moderately severe and severe acute pancreatitis–a systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/34376533}, author = {Patoni, Cristina and Bunduc, Stefania and Frim, Levente and Veres, Dániel and Dembrovszky, Fanni and Éliás, Anna Júlia and Pálinkás, Dániel and Hegyi, Péter and Erőss, Bálint Mihály and Hegyi, Péter Jenő}, doi = {10.3389/fmed.2023.1241301}, journal-iso = {FRONT MED}, journal = {FRONTIERS IN MEDICINE}, volume = {10}, unique-id = {34376533}, keywords = {[Meta-analysis]}, year = {2023}, eissn = {2296-858X}, orcid-numbers = {Veres, Dániel/0000-0002-9687-3556; Dembrovszky, Fanni/0000-0001-6953-3591; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} }