TY - JOUR AU - Senobar Tahaei, Seyyed Ashkan AU - Kulmány, Ágnes Erika AU - Minorics, Renáta AU - Kiss, Anita AU - Szabó, Zoltán AU - Germán, Péter AU - Szebeni, Gábor AU - Gémes, Nikolett AU - Mernyák, Erzsébet AU - Zupkó, István TI - Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 24 PY - 2023 IS - 18 PG - 16 SN - 1661-6596 DO - 10.3390/ijms241813749 UR - https://m2.mtmt.hu/api/publication/34131836 ID - 34131836 N1 - Funding Agency and Grant Number: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. Funding text: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. AB - Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies. LA - English DB - MTMT ER - TY - JOUR AU - Peřina, Miroslav AU - Kiss, Anita AU - Mernyák, Erzsébet AU - Mada, Lukáš AU - Schneider, Gyula AU - Jorda, Radek TI - Synthesis of hydrocortisone esters targeting androgen and glucocorticoid receptors in prostate cancer in vitro JF - JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY J2 - J STEROID BIOCHEM MOL BIOL VL - 229 PY - 2023 PG - 12 SN - 0960-0760 DO - 10.1016/j.jsbmb.2023.106269 UR - https://m2.mtmt.hu/api/publication/33663109 ID - 33663109 LA - English DB - MTMT ER - TY - JOUR AU - Tyagi, Mohit AU - Adolfsson, Dan E. AU - Singh, Pardeep AU - Ådén, Jörgen AU - Jayaweera, Sanduni Wasana AU - Gharibyan, Anna AU - Bharate, Jaideep B. AU - Kiss, Anita AU - Sarkar, Souvik AU - Olofsson, Anders AU - Almqvist, Fredrik TI - Tandem Ring Opening/Intramolecular [2 + 2] Cycloaddition Reaction for the Synthesis of Cyclobutane Fused Thiazolino-2-Pyridones JF - JOURNAL OF ORGANIC CHEMISTRY J2 - J ORG CHEM VL - 86 PY - 2021 SN - 0022-3263 DO - 10.1021/acs.joc.1c01875 UR - https://m2.mtmt.hu/api/publication/32493860 ID - 32493860 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Anita AU - Jójárt, Rebeka AU - Mernyák, Erzsébet AU - Bartha, Sándor AU - Minorics, Renáta AU - Zupkó, István AU - Schneider, Gyula TI - Novel preparation of substituted oxazolines condensed to d-ring of estrane skeleton and characterization of their antiproliferative properties JF - STEROIDS J2 - STEROIDS VL - 176 PY - 2021 PG - 6 SN - 0039-128X DO - 10.1016/j.steroids.2021.108911 UR - https://m2.mtmt.hu/api/publication/32241841 ID - 32241841 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Anita AU - Wölfling, János AU - Mernyák, Erzsébet AU - Nagyné Frank, Éva AU - Benke, Zsanett Amália AU - Senobar Tahaei, Seyyed Ashkan AU - Zupkó, István AU - Mahó, Sándor AU - Schneider, Gyula TI - Stereocontrolled synthesis of the four possible 3-methoxy and 3-benzyloxy-16-triazolyl-methyl-estra-17-ol hybrids and their antiproliferative activities JF - STEROIDS J2 - STEROIDS VL - 152 PY - 2019 PG - 14 SN - 0039-128X DO - 10.1016/j.steroids.2019.108500 UR - https://m2.mtmt.hu/api/publication/30838971 ID - 30838971 N1 - Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, H-6720, Eötvös u. 6, H-6720 Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Chemical Works of Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary Export Date: 11 February 2020 CODEN: STEDA Correspondence Address: Schneider, G.; Department of Organic Chemistry, University of Szeged, Dóm tér 8, Hungary; email: schneider@chem.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2 Funding details: Emberi Eroforrások Minisztériuma, 20391-3/2018/FEKUSTRAT Funding details: Hungarian Scientific Research Fund, OTKA Funding details: GINOP-2.3.2-15-2016-00038, EFOP-3.6.2 Funding details: Richter Gedeon Talentum Alapítvány Funding details: K113150 Funding text 1: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150 ). Ministry of Human Capacities , Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Appendix A Funding Agency and Grant Number: Talentum Fund of Richter Gedeon Plc. (Budapest); Economic Development and Innovation Operative Programme of Hungary [GINOP-2.3.2-15-2016-00038]; Ultrafast physical processes in atoms, molecules, nanostructures and biological systems [EFOP-3.6.2.-2017-00005]; Hungarian Scientific Research Fund, Ministry of Human Capacities, Hungary [OTKA K113150, 20391-3/2018/FEKUSTRAT] Funding text: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150). Ministry of Human Capacities, Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, H-6720, Eötvös u. 6, H-6720 Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Chemical Works of Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary Cited By :1 Export Date: 29 August 2020 CODEN: STEDA Correspondence Address: Schneider, G.; Department of Organic Chemistry, University of Szeged, Dóm tér 8, Hungary; email: schneider@chem.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; Antineoplastic Agents; Triazoles Funding details: Emberi Eroforrások Minisztériuma, 20391-3/2018/FEKUSTRAT Funding details: Hungarian Scientific Research Fund, OTKA Funding details: GINOP-2.3.2-15-2016-00038, EFOP-3.6.2 Funding details: Richter Gedeon Talentum Alapítvány Funding details: K113150 Funding text 1: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150 ). Ministry of Human Capacities , Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. Appendix A Department of Organic Chemistry, University of Szeged, Dóm tér 8, H-6720 Szeged, Hungary Institute of Pharmaceutical Chemistry, University of Szeged, H-6720, Eötvös u. 6, H-6720 Szeged, Hungary Department of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Interdisciplinary Centre for Natural Products, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary Chemical Works of Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary Cited By :1 Export Date: 10 January 2021 CODEN: STEDA Correspondence Address: Schneider, G.; Department of Organic Chemistry, University of Szeged, Dóm tér 8, Hungary; email: schneider@chem.u-szeged.hu Chemicals/CAS: cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; Antineoplastic Agents; Triazoles Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018/FEKUSTRAT Funding details: Hungarian Scientific Research Fund, OTKA, OTKA K113150 Funding details: Richter Gedeon Talentum Alapítvány Funding details: -2017-00005, GINOP-2.3.2-15-2016-00038, EFOP-3.6.2 Funding text 1: The work of Anita Kiss was supported by a PhD Fellowship of the Talentum Fund of Richter Gedeon Plc. (Budapest). Financial support from the Economic Development and Innovation Operative Programme of Hungary (GINOP-2.3.2-15-2016-00038) and Ultrafast physical processes in atoms, molecules, nanostructures and biological systems (No: EFOP-3.6.2.-2017-00005) is gratefully acknowledged. This research was supported by the Hungarian Scientific Research Fund (OTKA K113150 ). Ministry of Human Capacities , Hungary grant 20391-3/2018/FEKUSTRAT is acknowledged. LA - English DB - MTMT ER - TY - JOUR AU - Herman, Bianka Edina AU - Kiss, Anita AU - Wölfling, János AU - Mernyák, Erzsébet AU - Szécsi, Mihály AU - Schneider, Gyula TI - Synthesis of substituted 15β-alkoxy estrone derivatives and their cofactor-dependent inhibitory effect on 17β-HSD1 JF - JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY J2 - J ENZYM INHIB MED CH VL - 34 PY - 2019 IS - 1 SP - 1271 EP - 1286 PG - 16 SN - 1475-6366 DO - 10.1080/14756366.2019.1634064 UR - https://m2.mtmt.hu/api/publication/30747981 ID - 30747981 N1 - Export Date: 6 August 2019 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Anita AU - Wölfling, János AU - Mernyák, Erzsébet AU - Nagyné Frank, Éva AU - Gyovai, András AU - Kulmány, Ágnes Erika AU - Zupkó, István AU - Schneider, Gyula TI - Stereoselective Synthesis of New Type of Estradiol Hybrid Molecules and their Antiproliferative Activities JF - STEROIDS J2 - STEROIDS VL - 148 PY - 2019 SP - 63 EP - 72 PG - 10 SN - 0039-128X DO - 10.1016/j.steroids.2019.02.016 UR - https://m2.mtmt.hu/api/publication/30672538 ID - 30672538 LA - English DB - MTMT ER - TY - THES AU - Kiss, Anita TI - Szteroid Hibridek sztereoszelektív szintézise PB - Szegedi Tudományegyetem (SZTE) PY - 2018 SP - 87 DO - 10.14232/phd.9929 UR - https://m2.mtmt.hu/api/publication/30617247 ID - 30617247 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Froehlich, Tony AU - Kiss, Anita AU - Wölfling, János AU - Mernyák, Erzsébet AU - Kulmány, Ágnes Erika AU - Minorics, Renáta AU - Zupkó, István AU - Leidenberger, Maria AU - Friedrich, Oliver AU - Kappes, Barbara AU - Hahn, Friedrich AU - Marschall, Manfred AU - Schneider, Gyula AU - Tsogoeva, Svetlana B. TI - Synthesis of Artemisinin-Estrogen Hybrids Highly Active against HCMV, P. falciparum, and Cervical and Breast Cancer JF - ACS MEDICINAL CHEMISTRY LETTERS J2 - ACS MED CHEM LETT VL - 9 PY - 2018 IS - 11 SP - 1128 EP - 1133 PG - 6 SN - 1948-5875 DO - 10.1021/acsmedchemlett.8b00381 UR - https://m2.mtmt.hu/api/publication/30387211 ID - 30387211 LA - English DB - MTMT ER - TY - JOUR AU - Kiss, Anita AU - Mernyák, Erzsébet AU - Wölfling, János AU - Szőllősi, György AU - Schneider, Gyula TI - Improved stereoselective synthesis of 3-methoxy- and 3-benzyloxy-16-hydroxymethyl-13α-estra-1,3,5(10)-trien-17-ol isomers by transfer hydrogenation using chiral Ru catalysts JF - REACTION KINETICS MECHANISMS AND CATALYSIS J2 - REACT KINET MECH CATAL VL - 125 PY - 2018 IS - 1 SP - 47 EP - 53 PG - 7 SN - 1878-5190 DO - 10.1007/s11144-018-1453-6 UR - https://m2.mtmt.hu/api/publication/3414282 ID - 3414282 LA - English DB - MTMT ER -