TY - JOUR AU - Dohos, Dóra AU - Váradi, Alex AU - Borbásné Farkas, Kornélia AU - Erős, Adrienn AU - Müller, Katalin Eszter AU - Karoliny, Anna AU - Gombos, Eszter AU - Nemes, Éva AU - Vass, Noémi AU - Tárnok, András AU - Hegyi, Péter AU - Sarlós, Patrícia TI - Hungarian Linguistic, Cross-Cultural and Age Adaptation of Transition Specific Questionnaires in Patients with Inflammatory Bowel Disease JF - CHILDREN (BASEL) J2 - CHILDREN-BASEL VL - 10 PY - 2023 IS - 4 PG - 14 SN - 2227-9067 DO - 10.3390/children10040711 UR - https://m2.mtmt.hu/api/publication/33754180 ID - 33754180 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [FK 132834]; National Research, Development and Innovation Fund [UNKP-22-5-PTE-1737]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00317/21] Funding text: This work was supported by the National Research, Development and Innovation Office (FK 132834 to PS), by the UNKP-22-5 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (UNKP-22-5-PTE-1737 to PS) and by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00317/21 to PS). AB - Objective: In the TRANS–IBD clinical trial, the outcomes are measured with selected validated questionnaires. Cross-cultural and age adaptations of the Self-Efficacy Scale for adolescents and young adults (IBD–SES), the Transition Readiness Assessment Questionnaire (TRAQ), and the Self-Management and Transition Readiness Questionnaire (STARx) were performed. Methods: Linguistic and cultural adaptation was carried out with the usage of reliability coefficients (Cronbach’s α coefficients, Spearman’s rank correlation), and with confirmatory factor analysis (CFA; root Mean Square Error of Approximation [RMSEA], Comparative Fit Index [CFI], and Tucker-Lewis Index [TLI]). Results: 112 adolescents participated in the study (45.5% male, mean age 17 ± 1.98 years). CFA was acceptable in the IBD–SES and the TRAQ. Internal consistency was acceptable in IBD–SES and good in TRAQ (0.729; 0.865, respectively). Test–retest reliability was good in IBD–SES, but below the acceptable threshold in TRAQ (ρ = 0.819; ρ = 0.034). In STARx tools, RMSEA showed poor fit values, CFI and TLI were below acceptable fit values, and internal consistency was not satisfied (0.415; 0.693, respectively), while test–retest reliabilities were acceptable (ρ = 0.787; ρ = 0.788, respectively). Conclusions: Cross-cultural, age-specific adaptation was successfully completed with IBD–SES and TRAQ. Those are comparable to the original validated versions. The adaption of the STARx tools was not successful. LA - English DB - MTMT ER - TY - JOUR AU - Dohos, Dóra AU - Váradi, Alex AU - Borbásné Farkas, Kornélia AU - Erős, Adrienn AU - Párniczky, Andrea AU - Schäfer, Eszter AU - Kosaras, Éva AU - Czelecz, Judit AU - Hegyi, Péter AU - Sarlós, Patrícia TI - Hungarian Linguistic, Cross-Cultural, and Age Adaptation of the Patient Satisfaction with Health Care in Inflammatory Bowel Disease Questionnaire (CACHE) and the Medication Adherence Report Scale (MARS). JF - CHILDREN (BASEL) J2 - CHILDREN-BASEL VL - 9 PY - 2022 IS - 8 PG - 14 SN - 2227-9067 DO - 10.3390/children9081143 UR - https://m2.mtmt.hu/api/publication/33068977 ID - 33068977 N1 - Funding Agency and Grant Number: National Research, Development and Innovation Office [FK 132834]; New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund [UNKP21-5-PTE-1341, UNKP-21-5]; Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00317/21] Funding text: This work was supported by the National Research, Development and Innovation Office (FK 132834 to PS), by the UNKP-21-5 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund (UNKP21-5-PTE-1341 to PS) and by the Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00317/21 to PS). AB - The TRANS-IBD study examines the superiority of joint transition visits, with drug adherence and patient satisfaction among the outcome measures. Our aim was a cross-cultural, age- and disease-specific adaptation of the 'Medication Adherence Rating Scale' (MARS) and 'Patient satisfaction with health care in inflammatory bowel disease questionnaire' (CACHE) questionnaires in patients with inflammatory bowel disease (IBD).Linguistic and cultural adaptation using test and re-test procedures were performed. Internal consistency with Cronbach's α coefficients, confirmatory factor analyses with root Mean Square Error of Approximation (RMSEA), Comparative Fit Index (CFI), and Tucker-Lewis Index (TLI) were determined.A total of 122 adolescents and 164 adults completed the questionnaires (47.5% male, mean age 17 ± 1; and 29.3% male, mean age 38 ± 11, respectively). In the MARS questionnaire, Cronbach's α scores were found good in adolescents (0.864) and acceptable in adults (0.790), while in the CACHE questionnaire, scores were rated as excellent in both populations (0.906 and 0.945, respectively). The test-retest reliabilities were satisfactory in both groups (MARS questionnaire: r = 0.814 and r = 0.780, CACHE questionnaire: r = 0.892 and r = 0.898, respectively). RMSEA showed poor fit values in the MARS questionnaire and reasonable fit values in the CAHCE questionnaire, CFI and TLI had statistically acceptable results.Age-and disease-specific Hungarian versions of the questionnaires were developed, which are appropriate tools for TRANS-IBD RCT and daily IBD care. LA - English DB - MTMT ER - TY - JOUR AU - Dohos, Dóra AU - Erős, Adrienn AU - Szemes, Kata AU - Sarlós, Patrícia TI - Közös felelősség a gyulladásos bélbetegség diagnosztikájában és kezelésében. Mikor utaljuk a gyulladásos bélbetegséggel kezelt beteget biológiai terápiás centrumba? = Shared responsibility in the diagnosis and treatment of inflammatory bowel disease : When to refer a patient with inflammatory bowel disease to a biological therapy center? JF - ORVOSI HETILAP J2 - ORV HETIL VL - 162 PY - 2021 IS - 33 SP - 1311 EP - 1317 PG - 7 SN - 0030-6002 DO - 10.1556/650.2021.32182 UR - https://m2.mtmt.hu/api/publication/32150100 ID - 32150100 N1 - Cited By :1 Export Date: 29 January 2024 CODEN: ORHEA Correspondence Address: Sarlós, P.; Pécsi Tudományegyetem, Hungary; email: sarlos.patricia@pte.hu AB - Összefoglaló. Az idült betegségek, köztük a gyulladásos bélbetegség kezelése összetett feladat, amely a megfelelő technikai feltételek mellett naprakész szaktudással és tapasztalattal rendelkező egészségügyi személyzet együttműködését igényli. Célunk a gyulladásos bélbetegség ellátásának célirányos összegzése volt. Kiemelten foglalkoztunk a korai diagnosztika és szakorvoshoz utalás kérdésével, a korszerű ellátáshoz szükséges, személyre szabott terápia és a célértékre történő kezelés, valamint a biológiai terápiás centrumba utalás szükségességével. Részleteztük továbbá a kompetens és felelősségteljes gondozás ellátószintjeit, és bemutattuk az ellátásban együttműködő multidiszciplináris csoport felépítését is. Az összefoglaló közleményhez a nemzetközi irodalmat és a hazai terápiás protokollokat tekintettük át. A krónikus betegségek gondozásában elengedhetetlen a társszakmák együttműködése. A betegség kezelésében fontos a folyamatosan változó ajánlások, protokollok ismerete és a kompetenciaszintek elfogadása a beteg megfelelő életminőségének elérése és a szövődmények csökkentése céljából. Orv Hetil. 2021; 162(33): 1311-1317. Summary. The treatment of chronic diseases, including inflammatory bowel disease, is a complex task that requires the collaboration of health professionals with up-to-date expertise and experience under the appropriate technical conditions. Our aim was to systematically review the management of inflammatory bowel disease. We focused on the issue of early diagnosis and referral to a specialist, the need for personalized therapy and "treat-to-target" concept, and the appropriate timing of referral to a biological therapy center. The levels of competent and responsible care and the structure of a multidisciplinary team were also discussed. For the article, international and Hungarian therapeutic protocols and literature were reviewed. The collaboration of disciplines is essential in the management of chronic diseases. For disease management, it is critical to be up-to-date with changing recommendations, protocols, and to adopt competency levels to achieve a patient's adequate quality of life and reduce disease complications. Orv Hetil. 2021; 162(33): 1311-1317. LA - Hungarian DB - MTMT ER - TY - JOUR AU - Szakács, Zsolt AU - Hegyi, Péter Jenő AU - Borbásné Farkas, Kornélia AU - Hegyi, Péter AU - Balaskó, Márta AU - Erős, Adrienn AU - Szujó, Szabina AU - Pammer, Judit AU - Mosdósi, Bernadett AU - Simon, Mária AU - Nagy, Arnold AU - Fűr, Gabriella AU - Alizadeh, Hussain TI - Pregnancy outcomes of women whom spouse fathered children after tyrosine kinase inhibitor therapy for chronic myeloid leukemia : A systematic review JF - PLOS ONE J2 - PLOS ONE VL - 15 PY - 2020 IS - 12 PG - 17 SN - 1932-6203 DO - 10.1371/journal.pone.0243045 UR - https://m2.mtmt.hu/api/publication/31709065 ID - 31709065 N1 - * Megosztott szerzőség AB - The introduction of tyrosine kinase inhibitors (TKIs) has revolutionized the therapy of chronic myeloid leukemia (CML). Although the efficacy of TKIs is beyond dispute, conception-related safety issues are still waiting to be explored, particularly in males. This systematic review aimed to summarize all available evidence on pregnancy outcomes of female spouses of male CML patients who fathered children after TKI treatment for CML.We performed a systematic search in seven electronic databases for studies that reported on male CML patients who did or did not discontinue TKI treatment before conceiving, and the pregnancy outcomes of their female spouse are available. The search centered on the TKI era (from 2001 onward) without any other language or study design restrictions.Out of a total of 38 potentially eligible papers, 27 non-overlapping study cohorts were analyzed. All were descriptive studies (case or case series studies). Altogether, 428 pregnancies from 374 fathers conceived without treatment discontinuation, 400 of which (93.5%) ended up in a live birth. A total of ten offspring with a malformation (2.5%) were reported: six with imatinib (of 313 live births, 1.9%), two with nilotinib (of 26 live births, 7.7%), one with dasatinib (of 43 live births, 2.3%), and none with bosutinib (of 12 live births). Data on CML status were scarcely reported. Only nine pregnancies (from nine males) and no malformation were reported in males who discontinued TKI treatment before conception.Malformations affected, on average 2.5% of live births from fathers who did not discontinue TKI treatment before conception, which is comparable with the rate of malformations in the general population. Large-scale studies with representative samples are awaited to confirm our results. LA - English DB - MTMT ER - TY - THES AU - Erős, Adrienn TI - A gyulladásos bélbetegségben szenvedő serdülők tranzíciós ellátásának hazai és nemzetközi vonatkozásai PY - 2020 UR - https://m2.mtmt.hu/api/publication/31662183 ID - 31662183 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Erős, Adrienn AU - Dohos, Dóra AU - Veres, Gábor AU - Tárnok, András AU - Vincze, Áron AU - Tészás, Alexandra AU - Zádori, Noémi AU - Gede, Noémi AU - Hegyi, Péter AU - Sarlós, Patrícia TI - Effect of joint transition visits on quality of life in adolescents with inflammatory bowel diseases: a protocol for a prospective, randomised, multicentre, controlled trial (TRANS-IBD) JF - BMJ OPEN J2 - BMJ OPEN VL - 10 PY - 2020 IS - 10 PG - 9 SN - 2044-6055 DO - 10.1136/bmjopen-2020-038410 UR - https://m2.mtmt.hu/api/publication/31622967 ID - 31622967 N1 - Protocol LA - English DB - MTMT ER - TY - JOUR AU - Szakács, Zsolt AU - Csiszár, Beáta AU - Nagy, Mátyás AU - Borbásné Farkas, Kornélia AU - Kenyeres, Péter AU - Erős, Adrienn AU - Alizadeh, Hussain AU - Márta, Katalin AU - Szentesi, Andrea Ildikó AU - Tőkés-Füzesi, Margit AU - Berki, Tímea AU - Vincze, Áron AU - Tóth, Kálmán AU - Hegyi, Péter AU - Bajor, Judit TI - Diet-dependent and diet-independent hemorheological alterations in celiac disease: A case-control study JF - CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY J2 - CLIN TRANSLAT GASTROENT VL - 11 PY - 2020 IS - 11 PG - 11 SN - 2155-384X DO - 10.14309/ctg.0000000000000256 UR - https://m2.mtmt.hu/api/publication/31619587 ID - 31619587 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary János Szentágothai Research Center, University of Pécs, Pécs, Hungary Division of Cardiology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Institute of Bioanalysis, Medical School, University of Pécs, Pécs, Hungary Heim Pál National Insititute of Pediatrics, Budapest, Hungary Division of Hematology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Laboratory Medicine, Medical School, University of Pécs, Pécs, Hungary Department of Immunology and Biotechnology, Medical School, University of Pécs, Pécs, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Cited By :2 Export Date: 26 October 2023 Correspondence Address: Bajor, J.; Division of Gastroenterology, Hungary; email: bajor.judit@pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Váncsa, Szilárd AU - Németh, Dávid AU - Hegyi, Péter AU - Szakács, Zsolt AU - Hegyi, Péter Jenő AU - Pécsi, Dániel AU - Mikó, Alexandra AU - Erőss, Bálint Mihály AU - Erős, Adrienn AU - Pár, Gabriella TI - Fatty Liver Disease and Non-Alcoholic Fatty Liver Disease Worsen the Outcome in Acute Pancreatitis : A Systematic Review and Meta-Analysis JF - JOURNAL OF CLINICAL MEDICINE J2 - J CLIN MED VL - 9 PY - 2020 IS - 9 PG - 15 SN - 2077-0383 DO - 10.3390/jcm9092698 UR - https://m2.mtmt.hu/api/publication/31410857 ID - 31410857 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Pécs, 7624, Hungary János Szentágothai Research Centre, University of Pécs, Pécs, 7624, Hungary Centre for Translational Medicine, Department of Medicine, University of Szeged, Szeged, 6725, Hungary Division of Gastroenterology, First Department of Medicine, Medical School, University of Pécs, Pécs, 7624, Hungary Heim Pál Children’s Hospital, Budapest, 1089, Hungary Cited By :16 Export Date: 11 September 2023 Correspondence Address: Pár, G.; Division of Gastroenterology, Hungary; email: par.gabriella@pte.hu AB - The prevalence of fatty liver disease (FLD) and that of non-alcoholic fatty liver disease (NAFLD) share some risk factors known to exacerbate the course of acute pancreatitis (AP). This meta-analysis aimed to investigate whether FLD or NAFLD carry a higher risk of untoward outcomes in AP. In accordance with PRISMA guidelines, we performed a systematic search in seven medical databases for cohort studies that compared the outcomes of AP for the presence of FLD or NAFLD, and we calculated pooled odds ratio (OR) or weighted mean difference (WMD) with 95% confidence interval (CI). We included 13 articles in our meta-analysis. AP patients with FLD were more likely to die (5.09% vs 1.89%, OR = 3.56, CI = 1.75-7.22), develop severe AP (16.33% vs 7.87%, OR = 2.67, CI = 2.01-3.56), necrotizing pancreatitis (34.83% vs 15.75%, OR = 3.08, CI = 2.44-3.90) and had longer in-hospital stay (10.8 vs 9.2 days, WMD = 1.46, OR = 0.54-2.39). Patients with NAFLD were more likely to have severe AP and longer hospital stay. Both FLD and NAFLD proved to be independent risk factors of a more severe disease course (OR = 3.68, CI = 2.16-6.29 and OR = 3.39, CI = 1.52-7.56 for moderate/ severe vs. mild AP, respectively). FLD and NAFLD worsen the outcomes of AP, which suggests that incorporating FLD or NAFLD into prognostic scoring systems of AP outcomes might improve the prediction of severity and contribute to a more individualized patient care. LA - English DB - MTMT ER - TY - JOUR AU - Erős, Adrienn AU - Veres, Gábor AU - Tárnok, András AU - Dohos, Dóra AU - Otto, Caroline AU - Szakács, Zsolt AU - Hegyi, Péter AU - Vincze, Áron AU - Sarlós, Patrícia TI - A cross-sectional survey on the transitional care of adolescents with inflammatory bowel disease in Hungary JF - JOURNAL OF PEDIATRIC NURSING: NURSING CARE OF CHILDREN AND FAMILIES J2 - J PEDIATR NURS VL - 55 PY - 2020 SP - e279 EP - e285 PG - 7 SN - 0882-5963 DO - 10.1016/j.pedn.2020.06.002 UR - https://m2.mtmt.hu/api/publication/31376050 ID - 31376050 N1 - Institute for Translational Medicine, Medical School, University of Pécs, Hungary Szentágothai Research Centre, Medical School, University of Pécs, Hungary Heim Pál Children's Hospital, Hungary Department of Paediatrics, Medical School, University of Debrecen, Hungary Department of Paediatrics, Medical School, University of Pécs, Hungary First Department of Medicine, Medical School, University of Pécs, Hungary Cited By :1 Export Date: 29 January 2024 CODEN: JLPNE Correspondence Address: Sarlós, P.; First Department of Medicine, 13 Ifjúság Street, Hungary; email: sarlos.patricia@pte.hu AB - Since little is known about transitional care practices of adolescents with inflammatory bowel diseases (IBD) in Central-Eastern Europe, we aimed to investigate the currently applied transition practices in Hungary.A nationwide, multicentre survey was conducted with the invitation of 41 pediatric and adult IBD centres in February 2019.We developed a 34-item questionnaire, which included single- and multiple-choice questions related to the current clinical practice of IBD transition.The overall response rate was 31.7% (13/41); answers came predominantly from tertiary centres. Only 15.4% of the respondent centres followed international IBD guidelines. The majority of the IBD centres provided transition support; however, responses revealed a marked heterogeneity of these services. Joint visits were held only in 54% of the clinics. Gastroenterologists and next of kin are not provided education regarding transition across most centres (85 and 92%). Although adolescents received age-specific education, transition readiness was not measured. More IBD nurses and dietitians were employed in adult centres than in pediatric ones.The current survey revealed critical gaps in the Hungarian IBD transition practices. As the beneficial effects of structured IBD transition programmes are recognized in Hungary, there is a growing need for the introduction of new, more effective transition practices.Our results can serve as a basis for planning more effective transition strategies. LA - English DB - MTMT ER - TY - JOUR AU - Tinusz, Benedek AU - Soós, Alexandra AU - Hegyi, Péter AU - Sarlós, Patrícia AU - Szapáry, László Botond AU - Erős, Adrienn AU - Feczák, Donáta AU - Szakács, Zsolt AU - Márta, Katalin AU - Venglovecz, Viktória AU - Erőss, Bálint Mihály TI - Efficacy and safety of stenting and additional oncological treatment versus stenting alone in unresectable esophageal cancer: a meta-analysis and systematic review JF - RADIOTHERAPY AND ONCOLOGY J2 - RADIOTHER ONCOL VL - 147 PY - 2020 SP - 169 EP - 177 PG - 9 SN - 0167-8140 DO - 10.1016/j.radonc.2020.05.015 UR - https://m2.mtmt.hu/api/publication/31315923 ID - 31315923 LA - English DB - MTMT ER -