TY - THES AU - Gombos, Zoltán TI - Az alternatív hipertrófia módszerek molekuláris hatásai PY - 2024 UR - https://m2.mtmt.hu/api/publication/34753785 ID - 34753785 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Jókai, Mátyás AU - Torma, Ferenc Gergely AU - McGreevy, Kristen M. AU - Koltai, Erika AU - Bori, Zoltán AU - Bábszky, Gergely AU - Bakonyi, Péter AU - Gombos, Zoltán AU - György, Bernadett AU - Aczél, Dóra Tímea AU - Tóth, László AU - Osváth, Péter AU - Fridvalszki, Marcell Norbert AU - Téglás, Tímea AU - Pósa, Anikó AU - Kujach, Sylwester AU - Olek, Robert AU - Kawamura, Takuji AU - Seki, Yasuhiro AU - Suzuki, Katsuhiko AU - Tanisawa, Kumpei AU - Goto, Sataro AU - Kerepesi, Csaba AU - Boldogh, Istvan AU - Ba, Xueqing AU - Davies, Kelvin J. A. AU - Horvath, Steve AU - Radák, Zsolt TI - DNA methylation clock DNAmFitAge shows regular exercise is associated with slower aging and systemic adaptation JF - GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE) J2 - GEROSCIENCE VL - 45 PY - 2023 IS - 5 SP - 2805 EP - 2817 PG - 13 SN - 2509-2715 DO - 10.1007/s11357-023-00826-1 UR - https://m2.mtmt.hu/api/publication/33866054 ID - 33866054 AB - DNAmPhenoAge, DNAmGrimAge, and the newly developed DNAmFitAge are DNA methylation (DNAm)-based biomarkers that reflect the individual aging process. Here, we examine the relationship between physical fitness and DNAm-based biomarkers in adults aged 33–88 with a wide range of physical fitness (including athletes with long-term training history). Higher levels of VO 2 max ( ρ = 0.2, p = 6.4E − 4, r = 0.19, p = 1.2E − 3), Jumpmax ( p = 0.11, p = 5.5E − 2, r = 0.13, p = 2.8E − 2), Gripmax ( ρ = 0.17, p = 3.5E − 3, r = 0.16, p = 5.6E − 3), and HDL levels ( ρ = 0.18, p = 1.95E − 3, r = 0.19, p = 1.1E − 3) are associated with better verbal short-term memory. In addition, verbal short-term memory is associated with decelerated aging assessed with the new DNAm biomarker FitAgeAcceleration ( ρ : − 0.18, p = 0.0017). DNAmFitAge can distinguish high-fitness individuals from low/medium-fitness individuals better than existing DNAm biomarkers and estimates a younger biological age in the high-fit males and females (1.5 and 2.0 years younger, respectively). Our research shows that regular physical exercise contributes to observable physiological and methylation differences which are beneficial to the aging process. DNAmFitAge has now emerged as a new biological marker of quality of life. LA - English DB - MTMT ER - TY - CONF AU - Bábszky, Gergely AU - Torma, Ferenc Gergely AU - Aczél, Dóra Tímea AU - Bakonyi, Péter AU - Gombos, Zoltán AU - Radák, Zsolt TI - Testedzés hatása a humán mikrobiomra: élsportolók vizsgálata a koronavírus függvényében T2 - VII. SPORTTUDOMÁNYI PHD SZIMPÓZIUM - PROGRAM- ÉS ABSZTRAKTFÜZET PY - 2022 SP - 15 EP - 15 PG - 1 UR - https://m2.mtmt.hu/api/publication/33022291 ID - 33022291 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Katrics, Petra AU - Laczkó, Attila AU - Gombos, Zoltán AU - Béres, Sándor AU - Tóth, László AU - Bogár, Lilla AU - Márton, Laura AU - Benczenleitner, Ottó TI - A premenstruációs tünetegyüttes hatása a maximális és robbanékony erőre női felnőtt jégkorongozók esetében JF - ACTA UNIVERSITATIS DE CAROLO ESZTERHÁZY NOMINATAE: SECTIO SPORT J2 - ACTA Universitatis: Sectio Sport VL - 51 PY - 2021 IS - 2021 SP - 7 EP - 18 PG - 12 SN - 2677-0105 UR - https://m2.mtmt.hu/api/publication/33807683 ID - 33807683 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Gombos, Zoltán AU - Torma, Ferenc Gergely AU - Kolonics, Attila AU - Radák, Zsolt TI - A több évtizeden át tartó testedzés hatása az irizin hormon szintjére. the effect of decades long training on the irisin hormone TS - the effect of decades long training on the irisin hormone JF - MAGYAR SPORTTUDOMÁNYI SZEMLE J2 - M SPORTTUD SZLE VL - 22 PY - 2021 IS - 5-6 (93-94) SP - 10 EP - 16 PG - 7 SN - 1586-5428 UR - https://m2.mtmt.hu/api/publication/32547313 ID - 32547313 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Bábszky, Gergely AU - Torma, Ferenc Gergely AU - Aczél, Dóra Tímea AU - Bakonyi, Péter AU - Gombos, Zoltán AU - Feher, Janos AU - Szabó, Dóra AU - Ligeti, Balázs AU - Pongor, Sándor AU - Balogh, László AU - Pósa, Anikó AU - Radák, Zsolt TI - COVID-19 Infection Alters the Microbiome: Elite Athletes and Sedentary Patients Have Similar Bacterial Flora JF - GENES J2 - GENES-BASEL VL - 12 PY - 2021 IS - 10 PG - 11 SN - 2073-4425 DO - 10.3390/genes12101577 UR - https://m2.mtmt.hu/api/publication/32318905 ID - 32318905 LA - English DB - MTMT ER - TY - JOUR AU - Gombos, Zoltán AU - Koltai, Erika AU - Torma, Ferenc Gergely AU - Bakonyi, Péter AU - Kolonics, Attila AU - Aczél, Dóra Tímea AU - Ditrói, Tamás AU - Nagy, Péter AU - Kawamura, Takuji AU - Radák, Zsolt TI - Hypertrophy of Rat Skeletal Muscle Is Associated with Increased SIRT1/Akt/mTOR/S6 and Suppressed Sestrin2/SIRT3/FOXO1 Levels. JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 22 PY - 2021 IS - 14 PG - 11 SN - 1661-6596 DO - 10.3390/ijms22147588 UR - https://m2.mtmt.hu/api/publication/32113803 ID - 32113803 N1 - Funding Agency and Grant Number: National Excellence Program at the University of Physical Education, Innovation and Technology Ministry, Hungary [126823]; Scientific Excellence Program at the University of Physical Education, Innovation and Technology Ministry, Hungary [TUDFO/51757/2019-ITM]; Hungarian Thematic Excellence Program from the Hungarian National Research, Development and Innovation Office [TKP2020-NKA-26] Funding text: This study was supported by National Excellence Program (126823), and Scientific Excellence Program TUDFO/51757/2019-ITM, at the University of Physical Education, Innovation and Technology Ministry, Hungary. Grants awarded to Z.R., P.N. acknowledges financial support from the Hungarian Thematic Excellence Program TKP2020-NKA-26 from the Hungarian National Research, Development and Innovation Office. AB - Despite the intensive investigation of the molecular mechanism of skeletal muscle hypertrophy, the underlying signaling processes are not completely understood. Therefore, we used an overload model, in which the main synergist muscles (gastrocnemius, soleus) of the plantaris muscle were surgically removed, to cause a significant overload in the remaining plantaris muscle of 8-month-old Wistar male rats. SIRT1-associated pro-anabolic, pro-catabolic molecular signaling pathways, NAD and H2S levels of this overload-induced hypertrophy were studied. Fourteen days of overload resulted in a significant 43% (p < 0.01) increase in the mass of plantaris muscle compared to sham operated animals. Cystathionine-β-synthase (CBS) activities and bioavailable H2S levels were not modified by overload. On the other hand, overload-induced hypertrophy of skeletal muscle was associated with increased SIRT1 (p < 0.01), Akt (p < 0.01), mTOR, S6 (p < 0.01) and suppressed sestrin 2 levels (p < 0.01), which are mostly responsible for anabolic signaling. Decreased FOXO1 and SIRT3 signaling (p < 0.01) suggest downregulation of protein breakdown and mitophagy. Decreased levels of NAD+, sestrin2, OGG1 (p < 0.01) indicate that the redox milieu of skeletal muscle after 14 days of overloading is reduced. The present investigation revealed novel cellular interactions that regulate anabolic and catabolic processes in the hypertrophy of skeletal muscle. LA - English DB - MTMT ER - TY - CONF AU - Gombos, Zoltán AU - Koltai, Erika AU - Torma, Ferenc Gergely AU - Radák, Zsolt TI - A kompenzatórikus hipertrófia molekuláris hatásai T2 - VI. SPORTTUDOMÁNYI PHD SZIMPÓZIUM PROGRAM- ÉS ABSZTRAKTFÜZET PB - Testnevelési Egyetem C1 - Budapest PY - 2021 SP - 27 EP - 27 PG - 1 UR - https://m2.mtmt.hu/api/publication/32092019 ID - 32092019 LA - Hungarian DB - MTMT ER - TY - CONF AU - Bábszky, Gergely AU - Torma, Ferenc Gergely AU - Aczél, Dóra Tímea AU - Bakonyi, Péter AU - Gombos, Zoltán AU - Radák, Zsolt TI - Testedzés hatása a humán mikrobiomra: élsportolók vizsgálata a koronavírus függvényében T2 - VI. SPORTTUDOMÁNYI PHD SZIMPÓZIUM PROGRAM- ÉS ABSZTRAKTFÜZET PB - Testnevelési Egyetem C1 - Budapest PY - 2021 SP - 18 EP - 18 PG - 1 UR - https://m2.mtmt.hu/api/publication/32091974 ID - 32091974 LA - Hungarian DB - MTMT ER - TY - CONF AU - Gombos, Zoltán AU - Koltai, Erika AU - Torma, Ferenc Gergely AU - Radák, Zsolt TI - Az élethosszon át tartó edzés hatása a vér irizin szintjére T2 - VI. SPORTTUDOMÁNYI PHD SZIMPÓZIUM PROGRAM- ÉS ABSZTRAKTFÜZET PB - Testnevelési Egyetem C1 - Budapest PY - 2021 SP - 12 EP - 12 PG - 1 UR - https://m2.mtmt.hu/api/publication/32091922 ID - 32091922 LA - Hungarian DB - MTMT ER -