@article{MTMT:33556530,
	title = {Lipid Changes in the Peri-Implantation Period with Mass Spectrometry Imaging: A Systematic Review},
	url = {https://m2.mtmt.hu/api/publication/33556530},
	author = {Gitta, Stefánia and Márk, László and Szentpéteri, József László (Joe Petersburger) and Szabó, Éva},
	doi = {10.3390/life13010169},
	journal-iso = {LIFE-BASEL},
	journal = {LIFE-BASEL},
	volume = {13},
	unique-id = {33556530},
	abstract = {Mass spectrometry imaging is a sensitive method for detecting molecules in tissues in their native form. Lipids mainly act as energy stores and membrane constituents, but they also play a role in lipid signaling. Previous studies have suggested an important role of lipids in implantation; therefore, our aim was to investigate the lipid changes during this period based on the available literature. The systematic literature search was performed on Ovid MEDLINE, Cochrane Library, Embase, and LILACS. We included studies about lipid changes in the early embryonal stage of healthy mammalian development published as mass spectrometry imaging. The search retrieved 917 articles without duplicates, and five articles were included in the narrative synthesis of the results. Two articles found a different spatial distribution of lipids in the early bovine embryo and receptive uterus. Three articles investigated lipids in mice in the peri-implantation period and found a different spatial distribution of several glycerophospholipids in both embryonic and maternal tissues. Although only five studies from three different research groups were included in this systematic review, it is clear that the spatial distribution of lipids is diverse in different tissues and their distribution varies from day to day. This may be a key factor in successful implantation, but further studies are needed to elucidate the exact mechanism.},
	year = {2023},
	eissn = {2075-1729},
	orcid-numbers = {Márk, László/0000-0002-9301-8159; Szabó, Éva/0000-0002-3563-2492}
}

@article{MTMT:32760041,
	title = {Application of Mass Spectrometry Imaging in Uro-Oncology : Discovering Potential Biomarkers},
	url = {https://m2.mtmt.hu/api/publication/32760041},
	author = {Czétány, Péter and Gitta, Stefánia and Balló, András and Sulc, Alexandra and Máté, Gábor and Szántó, Árpád László and Márk, László},
	doi = {10.3390/life12030366},
	journal-iso = {LIFE-BASEL},
	journal = {LIFE-BASEL},
	volume = {12},
	unique-id = {32760041},
	abstract = {A growing need is emerging worldwide for new molecular markers which could enhance the accuracy of diagnostic and therapeutic methods for detecting urogenital cancers. Mass spectrometry imaging (MSI) is a very promising tool in this regard. In this review, we attempt to provide a subjective summary of the latest publications on potential biomarkers of renal, bladder, prostate, and testicular malignancies detected with MSI through the eyes of a clinical urologist.},
	keywords = {Mass spectrometry; Oncology; biomarker; Urology; bladder cancer; Prostate cancer; Renal cancer; testicular cancer},
	year = {2022},
	eissn = {2075-1729},
	orcid-numbers = {Márk, László/0000-0002-9301-8159}
}

@{MTMT:31177272,
	title = {Spatiotemporal Lipid Change in Embryo Transfer During Early Stage Embryogenesis},
	url = {https://m2.mtmt.hu/api/publication/31177272},
	author = {Szabó, Éva and Gitta, Stefánia and Schmidt, János and Márk, László},
	booktitle = {12th Balaton Symposium on High-Performance Separation Methods},
	unique-id = {31177272},
	abstract = {Introduction: The receptive phase of uterus is marked by structural and functional maturation of endometrium. This is a limited time span when the blastocyst competency is superimposed on the receptive endometrium. It is a well known fact, that the lipid metabolism and signaling of early stage pregnancy are of a vital importance in successful embryogenesis. However, the embryo-maternal molecular communication is not well understood, nor is it understood whether the low take home baby outcome of IVF is the result of some abnormal lipid networking.
		Methods: In this multidisciplinary study, multimodal imaging techniques, such as matrix-assisted laser desorption ionization time-of-flight imaging mass spectrometry, micro computer tomography, Raman spectroscopy and histology were used for in-vitro molecular analyses of the cryosections of CD-1 mice uteri. The lipids were identified by liquid and gas chromatography coupled ultra high-resolution tandem mass spectrometry. 
		Results: On day 6 of normal pregnancy we found an increase for phosphatidylcholine (PC) 32:0 (16:0/16:0) in uterine stromal cells at implantation sites except for primary decidual zone. The 34-carbonic PCs [PC 34:0 (16:0/18:0), PC 34:1 (16:0/18:1) and PC 34:2(16:0/18:2)] showed higher expressions in uterine stromal cells at implantation sites, while PC 36:1 (18:0/18:1) and PC 36:2 (18:0/18:2) in the PDZ. In contrast, in transferred animals the PCs showed an increase in glandular epithel at interimplantation sites. On day 8 of normal pregnancy PC 32:0 (16:0/16:0), PC 34:0 (16:0/18:0) and PC 34:1 (16:0/18:1) showed higher levels in the mesometrial pole (M-pole), while PCs containing polyunsaturated fatty acids [PC 34:2 (16:0/18:2), PC 36:2 (18:0/18:2), PC 36:4 (16:0/20:4), PC 38:4 (18:0/20:4) and PC 40:6 (18:0/22:6)] showed higher levels in the antimesometrial pole (AM-pole). In contrast, in transferred uterus samples PC 32:0 (16:0/16:0), PC 34:0 (16:0/18:0), PC 34:1 (16:0/18:1) and PC 34:2 (16:0/18:2) were increased in the M-pole, PC 36:4 (16:0/20:4), PC 38:4 (18:0/20:4) in the AM-pole, while PC 36:2 (18:0/18:2) and PC 40:6 (18:0/22:6) showed higher expression in both M-pole and AM-pole. On day 10 of normal pregnancy PC 32:0 (16:0/16:0) showed higher intensity in the placenta, PC 34:1 (16:0/18:1), PC 34:2 (16:0/18:2), PC 36:2 (18:0/18:2), PC 40:6 (18:0/22:6) in the mesometrial decidua, while PC 34:0 (16:0/18:0) and PC 36:4 (16:0/20:4) in both placenta and mesometrial decidua. In the embryonal tissues PC 32:0 (16:0/16:0) and PC 34:0 (16:0/18:0) were increased, while in the AM decidua the two 20:4 containing PCs: PC 36:4 (16:0/20:4) and PC 38:4 (18:0/20:4). In transferred uterus samples higher expression of PC 34:0 (16:0/18:0), PC 34:1 (16:0/18:1), PC 34:2 (16:0/18:2), PC 36:1 (18:0/18:1) and PC 36:2 (18:0/18:2) in mesometrial decidua was seen, whereas the two 20:4 containing PC: the PC 36:4 (16:0/20:4) and PC 38:4 (18:0/20:4) showed increased expression in the AM and lateral decidua. 
		Conclusion: This paper shows a significant spatiotemporal change in lipid metabolism during IVF procedure at the first time.},
	year = {2019},
	pages = {128},
	orcid-numbers = {Márk, László/0000-0002-9301-8159}
}

@misc{MTMT:30886707,
	title = {Investigation of embryo-maternal molecular network in mouse models with MALDI Imaging},
	url = {https://m2.mtmt.hu/api/publication/30886707},
	author = {Gitta, Stefánia and Szabó, Éva and Schmidt, János and Márk, László},
	unique-id = {30886707},
	abstract = {Introduction/Rationale: It is a well-known fact that the lipid metabolism and signaling of early stage of pregnancy are of a vital importance in successful embryogenesis. However, the embryo-maternal
		molecular communication is not well understood, nor it is understood whether the low take home baby outcome of in vitro fertilization is the result of some abnormal lipid networking. Although previous imaging mass spectrometry studies have provided outstanding profiles of phospholipid and protein changes during the implantation, the discovery of the in situ molecular alterations during the early stage of embryogenesis needs further investigations. The objective of this study was to characterize the spatiotemporal alterations of lipids during the early stage development of natural and transferred mouse embryos. 
		Methods: In this multidisciplinary study, multimodal imaging techniques, such as matrixassisted
		laser desorption ionization time-of-flight imaging mass spectrometry, fluorescent confocal
		microscopy and histochemistry were used for in vitro molecular analyses of cryosections of CD-1 mice uteri. The MALDI measurements were performed in positive linear mode in a detection range of m/z 200-3,000. The lateral resolution for MALDI imaging was set to 60 μm or 30 μm. The evaluation was carried out using FlexImaging 3.0 and FlexControl 3.4 softwares. Finally, the lipids were identified by liquid chromatography coupled ultra-high-resolution tandem mass spectrometry. The uterus samples were collected from pregnant animals (natural and transferred embryos) at embryonic day of 4.5, 6.5, 8.5, 10.5, 12.5, respectively. Results: Since phosphatidylcholine (PC) and sphingomyelins (SM) are well ionized in positive mode during MALDI measurements, we were able to identify these subclasses of phospholipids. Our findings showed significant changes of phospholipid spatiotemporal distribution between the sample cohorts, the phosphatidylcholines as well as the sphingomyelins altered by type and age of pregnancy. Surprisingly, remarkable molecular differences in phospholipids were detected between the identical stage transferred and natural (non-transferred) embryos. On day 6 of normal pregnancy we found an increase for PC 32:0 (16:0/16:0) in uterine stromal cells at implantation sites except for primary decidual zone. In contrast, in transferred animals the PCs showed an increase in glandular epithel at interimplantation sites. On day 8 of normal pregnancy PC 34:2 (16:0/18:2) showed higher level in the antimesometrial pole (AM-pole). In contrast, in transferred uterus samples PC 34:2 (16:0/18:2) were increased in the M-pole. On day 10 of normal pregnancy in the embryonal tissues PC 32:0 (16:0/16:0) and PC 34:0 (16:0/18:0) were increased, while in the AM decidua the two 20:4 containing PCs: PC 36:4 (16:0/20:4) and PC 38:4 (18:0/20:4). In transferred uterus samples higher expression of PC 36:2 (18:0/18:2) in mesometrial decidua was seen, whereas PC 36:4 (16:0/20:4) and PC 38:4 (18:0/20:4) showed increased expression in the AM and lateral decidua. On day 12 of normal pregnancy the SM (16:0/d18:1) was more abundant in the placenta than in case of IVF pregnancy. These molecular differences between the normal and IVF pregnancies can be of a vital importance in
		successful embryogenesis. 
		Conclusions/Novelty: Our results suggest that the embryo transfer induces abnormal phospholipid distribution during the embryogenesis that can be one of the causes of the high rate of failed IVF pregnancies. Further studies are required to discover the embryonic lipid changes during up- and down-regulation of key enzymes of phospholipid pathways.},
	year = {2019},
	orcid-numbers = {Márk, László/0000-0002-9301-8159}
}

@misc{MTMT:30885914,
	title = {Effect of COX-inhibition on the lipid change in early pregnancy in mice},
	url = {https://m2.mtmt.hu/api/publication/30885914},
	author = {Szabó, Éva and Gitta, Stefánia and Schmidt, János and Márk, László},
	unique-id = {30885914},
	abstract = {Introduction: Prostaglandins (PGs) are produced from arachidonic acid (C20:4n-6) by cyclooxygenase (COX), that exist in two isoforms: COX-1 and COX-2. As Cox-1 and Cox-2 gene expression has a spatiotemporal change, it suggests that PGs generated by the two isoforms of COX have a key role in the early embryo development as well as the decidualization and the establishment of the placenta. Our aim was to investigate the effect of the nonselective COX-inhibitor Aspirin in the early pregnancy in mice.
		Methods: CD-1 female mice were treated with oral Aspirin from the 10th day before pregnancy until uterus sample collection on the 4.5th, 6.5th and 8.5th day of pregnancy. In this multidisciplinary study, matrix-assisted laser desorption ionization time-of-flight imaging mass spectrometry and histology were used for in-vitro molecular analyses of the cryosections of CD-1 mice uteri. The lipids were identified by liquid and gas chromatography coupled ultra high-resolution tandem mass spectrometry. 
		Results: On day 4.5 the phosphatidylcholine (PC) 32:0 (16:0/16:0), PC 34:0 (16:0/18:0), PC 36:2 (18:0/18:2) cumulated in the endometrium, around the implanting embryo. On day 6.5 the PC 32:0 (16:0/16:0) and PC 34:1 (16:0/18:1) showed higher expression in the ante-mesometrial (AM)-pole, while PC36:1 (18:0/18:1) in the primary decidual zone (PDZ). The PC 36:4 (16:0/20:4) and PC 38:4 (18:0/20:4) in the interimplantation zones as well as in the PDZ showed a weak, but higher expression. On day 8.5 of pregnancy PC 34:0 (16:0/18:0), PC 34:1 (16:0/18:1) showed higher intensity in the mesometrial decidua while PC32:0 (16:0/16:0), PC 34:2 (16:0/18:2), PC 36:1 (18:0/18:1) PC 36:2 (18:0/18:1) in both mesometrial and ante-mesometrial decidua. In contrast, the arachidonic acid (C20:4n-6) containing PCs, the PC 36:4 (16:0/20:4), PC 36:5 (16:1/20:4) as well as PC 38:4 (18:0/20:4) showed increased expression in the ante-mesometrial decidua.
		Conclusions: This paper shows a significant spatiotemporal change in lipid metabolism during early embryo development under Aspirin treatment. The arachidonic acid containing PCs on day 6.5 seem to play an important role in the placentation and on day 8.5 in the involution of anti-mesometrial decidua.},
	year = {2019},
	orcid-numbers = {Márk, László/0000-0002-9301-8159}
}

@article{MTMT:30755181,
	title = {Validation and translation of the Hungarian version of the Female Sexual Function Index (FSFI-H)},
	url = {https://m2.mtmt.hu/api/publication/30755181},
	author = {Hock, Márta and Borbásné Farkas, Kornélia and Tiringer, István and Gitta, Stefánia and Németh, Zoltán and Farkas, Bálint},
	doi = {10.1007/s00192-019-04049-x},
	journal-iso = {INT UROGYNECOL J},
	journal = {INTERNATIONAL UROGYNECOLOGY JOURNAL},
	volume = {30},
	unique-id = {30755181},
	issn = {0937-3462},
	abstract = {The Female Sexual Function Index (FSFI) has been used for clinical and research purposes in many countries. The aim of this study was to translate, adapt and perform a psychometric validation of a Hungarian version of the FSFI.The FSFI was translated into Hungarian, and its precision was ascertained through reverse translation by an expert team. As a first step, 40 volunteers participated in an evaluation of the test-retest reliability of the Hungarian version over a 2-week period. After that, 418 (331 control and 87 with pelvic organ prolapse) women who had been in a stable sexual relationship in the previous 4 weeks participated in the study. The data were summarized using descriptive statistics. The structure validity was examined by confirmatory factor analysis, with which we tested the hypothesized original factor structure, using maximum likelihood model estimation. We calculated the Comparative Fit Index (CFI), root mean square error of approximation (RMSEA), standardized root mean residual and Akaike information criterion (AIC). To test the internal consistency, Cronbach's alpha coefficients of the full scale were determined. Spearman's rank correlation was used for testing divergent validity and Mann-Whitney U-test for examining discriminant validity.The FSFI was easily understandable and acceptable as well as capable of adequately evaluating and measuring various aspects of female sexual functioning. A high degree of internal consistency was demonstrated by the Cronbach's alpha value (0.963).The FSFI Hungarian version is a valid tool that measures the same functioning as the original English questionnaire.},
	keywords = {VALIDATION; FSFI; sexual functioning; FSFI-H; Hungarian language adaptation},
	year = {2019},
	eissn = {1433-3023},
	pages = {2109-2120},
	orcid-numbers = {Borbásné Farkas, Kornélia/0000-0002-5349-6527; Farkas, Bálint/0000-0003-0638-2057}
}

@article{MTMT:33337021,
	title = {What do we know about diastasis recti abdominis in Hungary?},
	url = {https://m2.mtmt.hu/api/publication/33337021},
	author = {Gitta, Stefánia and Tardi, Péter and Hock, Márta},
	journal-iso = {INT UROGYNECOL J},
	journal = {INTERNATIONAL UROGYNECOLOGY JOURNAL},
	volume = {29},
	unique-id = {33337021},
	issn = {0937-3462},
	keywords = {Obstetrics & Gynecology},
	year = {2018},
	eissn = {1433-3023},
	pages = {S255-S255},
	orcid-numbers = {Tardi, Péter/0000-0002-5091-7373}
}

@article{MTMT:30669719,
	title = {PELVIC FLOOR MUSCLE EXERCISES FOR THE IMPROVEMENT OF MALE SEXUAL FUNCTIONS},
	url = {https://m2.mtmt.hu/api/publication/30669719},
	author = {Palancsa, M and Damásdi, M and Tardi, Péter and Gitta, Stefánia and Járomi, Melinda and Ács, Pongrác and Simon-Ugron, Á and Hock, Márta},
	journal-iso = {STUD UNIV BABES-BOLYAI EDUCATIO ARTIS GYMNASTICAE},
	journal = {STUDIA UNIVERSITATIS BABES-BOLYAI EDUCATIO ARTIS GYMNASTICAE},
	volume = {63},
	unique-id = {30669719},
	issn = {1453-4223},
	year = {2018},
	eissn = {2065-9547},
	pages = {5-9},
	orcid-numbers = {Tardi, Péter/0000-0002-5091-7373; Ács, Pongrác/0000-0002-4999-7345}
}

@{MTMT:3361966,
	title = {EFFECTIVENESS OF TRADITIONAL OPENED – AND FUNCTIONAL CLOSED KINETIC CHAIN EXERCISES IN OSTEOARTHRITIS},
	url = {https://m2.mtmt.hu/api/publication/3361966},
	author = {Tardi, Péter and Gitta, Stefánia and Betlehem, József and Ács, Pongrác and Hock, Márta},
	booktitle = {REKREAČNÝ ŠPORT, ZDRAVIE, KVALITA ŽIVOTA IV.},
	unique-id = {3361966},
	year = {2018},
	pages = {55-56},
	orcid-numbers = {Tardi, Péter/0000-0002-5091-7373; Ács, Pongrác/0000-0002-4999-7345}
}

@article{MTMT:3353832,
	title = {Régi probléma új köntösben. Osteosarcopenia és fizioterápiás kezelési lehetőségei},
	url = {https://m2.mtmt.hu/api/publication/3353832},
	author = {Tardi, Péter and Gitta, Stefánia and Hock, Márta},
	journal-iso = {FIZIOTERÁPIA},
	journal = {FIZIOTERÁPIA},
	volume = {27},
	unique-id = {3353832},
	issn = {1789-4492},
	year = {2018},
	pages = {16-20},
	orcid-numbers = {Tardi, Péter/0000-0002-5091-7373}
}