@article{MTMT:34502046,
	title = {Artificial intelligence-based screening for amblyopia and its risk factors: comparison with four classic stereovision tests},
	url = {https://m2.mtmt.hu/api/publication/34502046},
	author = {Csizek, Zsófia and Mikó-Baráth, Eszter and Budai, Anna and Frigyik, Bela Andras and Pusztai, Á. and Nemes, Vanda Ágnes and Závori, L. and Fülöp, Diána and Czigler, András and Guth, Kitti and Buzás, Péter and Piñero, D.P. and Jandó, Gábor},
	doi = {10.3389/fmed.2023.1294559},
	journal-iso = {FRONT MED},
	journal = {FRONTIERS IN MEDICINE},
	volume = {10},
	unique-id = {34502046},
	year = {2023},
	eissn = {2296-858X},
	orcid-numbers = {Frigyik, Bela Andras/0000-0002-4220-4680; Buzás, Péter/0000-0002-4390-3360}
}

@mastersthesis{MTMT:33118201,
	title = {Regulation of cerebral blood flow in humans: ex vivo and in vivo studies},
	url = {https://m2.mtmt.hu/api/publication/33118201},
	author = {Czigler, András},
	unique-id = {33118201},
	year = {2022}
}

@article{MTMT:33032134,
	title = {Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults.},
	url = {https://m2.mtmt.hu/api/publication/33032134},
	author = {Tóth, Luca and Czigler, András and Hegedüs, Emőke and Komáromy, Hedvig and Amrein, Krisztina and Czeiter, Endre and Yabluchanskiy, Andriy and Koller, Ákos and Orsi, Gergely and Perlaki, Gábor and Schwarcz, Attila and Büki, András and Ungvári, Zoltán István and Tóth, Péter József},
	doi = {10.1007/s11357-022-00623-2},
	journal-iso = {GEROSCIENCE},
	journal = {GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)},
	volume = {44},
	unique-id = {33032134},
	issn = {2509-2715},
	abstract = {Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) contributes to the genesis of age-related cognitive impairment. Aging is associated with marked deficiency in the vasoprotective hormone insulin-like growth factor-1 (IGF-1). Preclinical studies on animal models of aging suggest that circulating IGF-1 deficiency is causally linked to impairment of NVC responses. The present study was designed to test the hypotheses that decreases in circulating IGF-1 levels in older adults also predict the magnitude of age-related decline of NVC responses. In a single-center cross-sectional study, we enrolled healthy young (n = 31, 11 female, 20 male, mean age: 28.4 + / - 4.2 years) and aged volunteers (n = 32, 18 female, 14 male, mean age: 67.9 + / - 4.1 years). Serum IGF-1 level, basal CBF (phase contrast magnetic resonance imaging (MRI)), and NVC responses during the trail making task (with transcranial Doppler sonography) were assessed. We found that circulating IGF-1 levels were significantly decreased with age and associated with decreased basal CBF. Age-related decline in IGF-1 levels predicted the magnitude of age-related decline in NVC responses. In conclusion, our study provides additional evidence in support of the concept that age-related circulating IGF-1 deficiency contributes to neurovascular aging, impairing CBF and functional hyperemia in older adults.},
	keywords = {Aging; cognitive decline; VCI; VCID; Vascular cognitive impairment; neurovascular uncoupling},
	year = {2022},
	eissn = {2509-2723},
	pages = {2771-2783},
	orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944; Koller, Ákos/0000-0003-3256-8701; Ungvári, Zoltán István/0000-0002-6035-6039}
}

@article{MTMT:32172268,
	title = {The effect of mild traumatic brain injury on cerebral microbleeds in aging},
	url = {https://m2.mtmt.hu/api/publication/32172268},
	author = {Tóth, Luca and Czigler, András and Horváth, Péter and Szarka, Nikolett and Környei, Bálint Soma and Tóth, Arnold and Schwarcz, Attila and Ungvári, Zoltán István and Büki, András and Tóth, Péter József},
	doi = {10.3389/fnagi.2021.717391},
	journal-iso = {FRONT AGING NEUROSCI},
	journal = {FRONTIERS IN AGING NEUROSCIENCE},
	volume = {13},
	unique-id = {32172268},
	issn = {1663-4365},
	abstract = {A traumatic brain injury (TBI) induces the formation of cerebral microbleeds (CMBs), which are associated with cognitive impairments, psychiatric disorders, and gait dysfunctions in patients. Elderly people frequently suffer TBIs, especially mild brain trauma (mTBI). Interestingly, aging is also an independent risk factor for the development of CMBs. However, how TBI and aging may interact to promote the development of CMBs is not well established. In order to test the hypothesis that an mTBI exacerbates the development of CMBs in the elderly, we compared the number and cerebral distribution of CMBs and assessed them by analysing susceptibility weighted (SW) MRI in young (25 ± 10 years old, n = 18) and elder (72 ± 7 years old, n = 17) patients after an mTBI and in age-matched healthy subjects (young: 25 ± 6 years old, n = 20; aged: 68 ± 5 years old, n = 23). We found significantly more CMBs in elder patients after an mTBI compared with young patients; however, we did not observe a significant difference in the number of cerebral microhemorrhages between aged and aged patients with mTBI. The majority of CMBs were found supratentorially (lobar and basal ganglion). The lobar distribution of supratentorial CMBs showed that aging enhances the formation of parietal and occipital CMBs after mTBIs. This suggests that aging and mTBIs do not synergize in the induction of the development of CMBs, and that the different distribution of mTBI-induced CMBs in aged patients may lead to specific age-related clinical characteristics of mTBIs.},
	year = {2021},
	eissn = {1663-4365},
	orcid-numbers = {Ungvári, Zoltán István/0000-0002-6035-6039}
}

@{MTMT:32131009,
	title = {Evaluation of neurovascular coupling by transcranial doppler ultrasound system},
	url = {https://m2.mtmt.hu/api/publication/32131009},
	author = {Tóth, Luca and Czigler, András and Viktoria, Kovacs and Szarka, Nikolett and Tóth, Péter József},
	booktitle = {Medical Conference for PhD Students and Experts of Clinical Sciences 2021},
	unique-id = {32131009},
	year = {2021},
	pages = {92-92}
}

@{MTMT:32130294,
	title = {Cardiovascular effects of neonatal hyperglycemia-experimental study},
	url = {https://m2.mtmt.hu/api/publication/32130294},
	author = {Márton, F. Schandl and Vass, Réka Anna and Czigler, András and Kvárik, Tímea and Dorottya, Balika and Eszter, Horányi and Reglődi, Dóra and Ertl, Tibor},
	booktitle = {Medical Conference for PhD Students and Experts of Clinical Sciences 2021},
	unique-id = {32130294},
	year = {2021},
	pages = {66-66}
}

@inbook{MTMT:31961972,
	title = {Errors and Consequences of Inaccurate Estimation of Mean Blood Flow Velocity in Cerebral Arteries},
	url = {https://m2.mtmt.hu/api/publication/31961972},
	author = {Czigler, András and Fedriga, Marta and Beqiri, Erta and Lalou, Afroditi D and Calviello, Leanne A and Cabeleira, Manuel and Tóth, Péter József and Smielewski, Peter and Czosnyka, Marek},
	booktitle = {Intracranial Pressure and Neuromonitoring XVII},
	doi = {10.1007/978-3-030-59436-7_5},
	unique-id = {31961972},
	abstract = {Many transcranial Doppler ultrasonography devices estimate the mean flow velocity (FVm) by using the traditional formula (FVsystolic + 2 × FVdiastolic)/3 instead of a more accurate formula calculating it as the time integral of the current flow velocities divided by the integration period. We retrospectively analyzed flow velocity and intracranial pressure signals containing plateau waves (transient intracranial hypertension), which were collected from 14 patients with a traumatic brain injury. The differences in FVm and its derivative pulsatility index (PI) calculated with the two different methods were determined. We found that during plateau waves, when the intracranial pressure (ICP) rose, the error in FVm and PI increased significantly from the baseline to the plateau (from 4.6 ± 2.4 to 9.8 ± 4.9 cm/s, P < 0.05). Similarly, the error in PI also increased during plateau waves (from 0.11 ± 0.07 to 0.44 ± 0.24, P < 0.005). These effects were most likely due to changes in the pulse waveform during increased ICP, which alter the relationship between systolic, diastolic, and mean flow velocities. If a change in the mean ICP is expected, then calculation of FVm with the traditional formula is not recommended.},
	keywords = {TRANSCRANIAL DOPPLER; Intracranial Hypertension; flow velocity; Pulse amplitude index},
	year = {2021},
	pages = {23-25}
}

@inbook{MTMT:31961971,
	title = {Cerebrovascular Consequences of Elevated Intracranial Pressure After Traumatic Brain Injury},
	url = {https://m2.mtmt.hu/api/publication/31961971},
	author = {Calviello, Leanne Alexis and Zeiler, Frederick A and Donnelly, Joseph and Czigler, András and Lavinio, Andrea and Hutchinson, Peter J and Czosnyka, Marek and Smielewski, Peter},
	booktitle = {Intracranial Pressure and Neuromonitoring XVII},
	doi = {10.1007/978-3-030-59436-7_10},
	unique-id = {31961971},
	abstract = {We compared various descriptors of cerebral hemodynamics in 517 patients with traumatic brain injury (TBI) who had, on average, elevated (>23 mmHg) or normal (<15 mmHg) intracranial pressure (ICP). In a subsample of 193 of those patients, transcranial Doppler ultrasound (TCD) recordings were made. Arterial blood pressure (ABP), cerebral blood flow velocity (CBFV), cerebral autoregulation indices based on TCD (the mean flow index (Mx; the coefficient of correlation between the the cerebral perfusion pressure CPP and flow velocity) and the autoregulation index (ARI)), and the pressure reactivity index (PRx) were compared between groups. We also analyzed the TCD-based cerebral blood flow (CBF) index (diastolic CBFV/mean CBFV), the spectral pulsatility index (sPI), and the critical closing pressure (CrCP). Finally, we also looked at brain tissue oxygenation (cerebral oxygen partial tension (PbtO2)) in 109 patients. The mean cerebral perfusion pressure (CPP) was lower in the group with elevated ICP (p < 0.01), despite a higher mean arterial pressure (MAP) (p < 0.005) and worse autoregulation (as assessed with the Mx, ARI, and PRx indices), greater CrCP, a lower CBF index, and a higher sPI (all with p values of <0.001). Neither the mean CBFV nor PbtO2 reached significant differences between groups. Mortality in the group with elevated ICP was almost three times greater than that in the group with normal ICP (45% versus 17%). Elevated ICP affects cerebral autoregulation. When autoregulation is not working properly, the brain is exposed to ischemic insults whenever CPP falls.},
	keywords = {Intracranial Hypertension; TBI; Cerebral autoregulation; ICP; Mx; PRx; CrCP; Critical closing pressure},
	year = {2021},
	pages = {43-48}
}

@inbook{MTMT:31961970,
	title = {Usability of Noninvasive Counterparts of Traditional Autoregulation Indices in Traumatic Brain Injury.},
	url = {https://m2.mtmt.hu/api/publication/31961970},
	author = {Czigler, András and Calviello, Leanne A and Zeiler, Frederick A and Tóth, Péter József and Smielewski, Peter and Czosnyka, Marek},
	booktitle = {Intracranial Pressure and Neuromonitoring XVII},
	doi = {10.1007/978-3-030-59436-7_33},
	unique-id = {31961970},
	abstract = {The pressure reactivity index (PRx) and the pulse amplitude index (PAx) are invasively determined parameters that are commonly used to describe autoregulation following traumatic brain injury (TBI). Using a transcranial Doppler ultrasound (TCD) technique, it is possible to approximate cerebral arterial blood volume (CaBV) solely from cerebral blood flow velocities, and further, to calculate non-invasive markers of autoregulation. In this brief study, we aimed to investigate whether the estimation of relative CaBV with different models could describe the cerebrovascular reactivity of TBI patients. PRx, PAx and their non-invasive counterparts (nPRx and nPAx) were calculated retrospectively from data collected during the monitoring of TBI patients. CaBV, an essential parameter for the calculation of nPRx and nPAx, was determined with both a continuous flow forward (CFF) model-considering a non-pulsatile blood outflow from the brain-and a pulsatile flow forward (PFF) model, presuming a pulsatile outflow. We found that the estimated CaBV demonstrates good coherence with ICP and that nPRx and nPAx can describe cerebrovascular reactivity similarly to PRx and PAx. Continuous monitoring with TCD is difficult, so the usability of PRx and PAx is limited. However, they might become useful for clinicians in the near future owing to rapid advances in these technologies.},
	keywords = {TRANSCRANIAL DOPPLER; Cerebral autoregulation; Cerebral blood volume; Pressure reactivity index; Pulse amplitude index},
	year = {2021},
	pages = {163-166}
}

@inbook{MTMT:31961969,
	title = {Optimal Cerebral Perfusion Pressure Assessed with a Multi-Window Weighted Approach Adapted for Prospective Use : A Validation Study},
	url = {https://m2.mtmt.hu/api/publication/31961969},
	author = {Beqiri, Erta and Ercole, Ari and Aries, Marcel J and Cabeleira, Manuel and Czigler, András and Liberti, Annalisa and Tas, Jeanette and Donnelly, Joseph and Liu, Xiuyun and Fedriga, Marta and Chu, Ka Hing and Zeiler, Frederick A and Czosnyka, Marek and Smielewski, Peter},
	booktitle = {Intracranial Pressure and Neuromonitoring XVII},
	doi = {10.1007/978-3-030-59436-7_36},
	unique-id = {31961969},
	abstract = {Pressure reactivity index (PRx)-cerebral perfusion pressure (CPP) relationships over a given time period can be used to detect a value of CPP at which PRx shows the best autoregulation (optimal CPP, or CPPopt). Algorithms for continuous assessment of CPPopt in traumatic brain injury (TBI) patients reached the desired high yield with a multi-window approach (CPPopt_MA). However, the calculations were tested on retrospective manually cleaned datasets. Moreover, CPPopt false-positive values can be generated from non-physiological variations of intracranial pressure (ICP) and arterial blood pressure (ABP). Therefore, the algorithm robustness was improved, making it suitable for prospective bedside application (COGiTATE trial).To validate the CPPopt revised algorithm in a large single-centre retrospective cohort of TBI patients.840 TBI patients were included. CPPopt yield, stability and ability to discriminate outcome groups were compared to CPPopt_MA and the Brain Trauma Foundation (BTF) guideline reference.CPPopt yield was lower than CPPopt_MA yield (85% and 90%, p < 0.001), but, importantly, with increased stability (p < 0.0001). The ∆(CPP-CPPopt) could distinguish the mortality and survival outcome (t = -6.7, p < 0.0001) with a statistical significance higher than the ∆CPP calculated with the guideline reference (CPP-60) (t = -4.5, p < 0.0001).This study validates, on a large cohort of patients, the new algorithm proposed for prospective use of CPPopt as a CPP target at bedside.},
	keywords = {AUTOREGULATION; Precision Medicine; neuromonitoring; Traumatic brain injury (TBI); CPPopt},
	year = {2021},
	pages = {181-185}
}