TY - JOUR AU - Révész, Péter AU - Kopjár, E. AU - Szakács, Zsolt AU - Warta, Vilmos AU - Szántóné Csongor, Alexandra AU - Gerlinger, Imre AU - Szanyi, István TI - Comparing the Quality of Life and Hearing Thresholds Following Stapedectomy Versus Laser Stapedotomy with NiTiBOND Piston JF - JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY J2 - J INT ADV OTOL VL - 20 PY - 2024 IS - 2 SP - 142 EP - 146 PG - 5 SN - 1308-7649 DO - 10.5152/iao.2024.231337 UR - https://m2.mtmt.hu/api/publication/34803973 ID - 34803973 LA - English DB - MTMT ER - TY - JOUR AU - Szakács, Zsolt AU - Nagy, Á AU - Kosztolányi, Szabolcs AU - Szomor, Árpád AU - Kohl, Zoltán AU - Pammer, Judit AU - Alizadeh, Hussain TI - A VENETOCLAX KLINIKAI ALKALMAZÁSA – TAPASZTALATAINK A PÉCSI TUDOMÁNYEGYETEMEN JF - MAGYAR BELORVOSI ARCHIVUM J2 - MBA VL - 76 PY - 2023 IS - 5-6 SP - 332 EP - 332 PG - 1 SN - 0133-5464 UR - https://m2.mtmt.hu/api/publication/34567540 ID - 34567540 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Balikó, Anett AU - Szakács, Zsolt AU - Kajtár, Béla AU - Ritter, Zsombor AU - Gyenesei, Attila AU - Borbásné Farkas, Kornélia AU - Kereskai, László AU - Vályi-Nagy, István AU - Alizadeh, Hussain AU - Pajor, László TI - Clinicopathological analysis of diffuse large B-cell lymphoma using molecular biomarkers: a retrospective analysis from 7 Hungarian centers JF - FRONTIERS IN ONCOLOGY J2 - FRONT ONCOL VL - 13 PY - 2023 PG - 13 SN - 2234-943X DO - 10.3389/fonc.2023.1224733 UR - https://m2.mtmt.hu/api/publication/34167253 ID - 34167253 N1 - Funding Agency and Grant Number: The research was supported by the NVKP_16-1-2016-0005 project of National Research and Development Office, Hungary as well as the EFOP-3.6.1-16-2016-0004 and the MTA PAB Clinicopathology WG. [NVKP_16-1-2016-0005]; project of National Research and Development Office, Hungary Funding text: The authors thank the patients, all primary treating physicians, nursing and laboratory staff members who participated in this multicenter trial for their excellent cooperation.r The research was supported by the NVKP_16-1-2016-0005 project of National Research and Development Office, Hungary as well as the EFOP-3.6.1-16-2016-0004 and the MTA PAB Clinicopathology WG. LA - English DB - MTMT ER - TY - JOUR AU - Vereczkei, Zsófia AU - Imrei, Marcell AU - Szakács, Zsolt AU - Kővári, Bálint AU - Papp, Veronika AU - Lénárt, Zsuzsanna AU - Berki, Tímea AU - Szirmay, Balázs AU - Borbásné Farkas, Kornélia AU - Balaskó, Márta AU - Habon, Tamás AU - Hegyi, Péter AU - Bajor, Judit TI - Cardiovascular risk factors in coeliac disease (ARCTIC): a protocol of multicentre series of studies JF - BMJ OPEN J2 - BMJ OPEN VL - 13 PY - 2023 IS - 9 PG - 8 SN - 2044-6055 DO - 10.1136/bmjopen-2022-068989 UR - https://m2.mtmt.hu/api/publication/34140873 ID - 34140873 N1 - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Heim Pal National Pediatric Institute, Budapest, Hungary First Department of Medicine, Medical School, University of Pecs, Pecs, Hungary Department of Surgery, Transplantation and Gastroenterology, Semmelweis University, Budapest, Hungary First Department of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary Department of Immunology and Biotechnology, Medical School, University of Pecs, Pecs, Hungary Department of Laboratory Medicine, Medical School, University of Pecs, Pecs, Hungary Institute of Bioanalysis, Medical School, University of Pecs, Pecs, Hungary Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary Export Date: 18 February 2024 Correspondence Address: Bajor, J.; First Department of Medicine, Hungary; email: bajor.judit@pte.hu LA - English DB - MTMT ER - TY - JOUR AU - Németh, Márton Ferenc AU - Mühl, Diána AU - Csontos, Csaba AU - Nagy, Ágnes AU - Alizadeh, Hussain AU - Szakács, Zsolt TI - Acquired hemophilia A after SARS-CoV-2 infection: A case report and an updated systematic review JF - BIOMEDICINES J2 - BIOMEDICINES VL - 11 PY - 2023 IS - 9 PG - 13 SN - 2227-9059 DO - 10.3390/biomedicines11092400 UR - https://m2.mtmt.hu/api/publication/34113217 ID - 34113217 N1 - ISSN:2227-9059 LA - English DB - MTMT ER - TY - JOUR AU - Vereczkei, Zsófia AU - Dergez, Tímea AU - Fodor, Zsuzsanna AU - Szakács, Zsolt AU - Bajor, Judit TI - Body Mass Index during Gluten-Free Diet in Patients with Celiac Disease JF - NUTRIENTS J2 - NUTRIENTS VL - 15 PY - 2023 IS - 16 PG - 13 SN - 2072-6643 DO - 10.3390/nu15163517 UR - https://m2.mtmt.hu/api/publication/34095089 ID - 34095089 N1 - Funding Agency and Grant Number: Authors would like to thank Jon Eugene Marquette for language proofreading. Funding text: Authors would like to thank Jon Eugene Marquette for language proofreading. AB - The association of clinical variables with body mass index (BMI) and changes experienced during a gluten-free diet (GFD) in celiac disease (CD) is not well established. In this retrospective cohort study, we aimed to investigate factors aligned with baseline and a follow-up regarding BMI in CD cases diagnosed at the University of Pécs (Hungary). Data were collected regarding gender, age, clinical presentation, histology, serology, extraintestinal manifestations, and BMI upon diagnosis and during follow-up. To compare variables with baseline BMI and BMI changes in short-, intermediate-, and long-term periods, we applied univariate analyses. A total of 192 CD patients were included. Males had significantly higher mean BMI when compared with females at diagnosis (22.9 ± 4.1 vs. 21.4 ± 4.3 kg/m2, p = 0.041) and during follow-up (p = 0.031, p = 0.029, and p = 0.033 for short-, intermediate-, and long-term follow-ups, respectively). Non-classical CD patients experienced higher mean BMI at diagnosis (22.9 ± 4.0 vs. 20.7 ± 4.4 kg/m2, p < 0.001) and following long-term follow-up (24.5 ± 3.2 vs. 22.6 ± 3.4 kg/m2, p = 0.039) than classical patients. In conclusion, although the mean BMI remained in the normal range, it increased significantly during follow-up, even at the short-term follow-up. This change was characteristic for non-classical cases and males on the long-term follow-ups. LA - English DB - MTMT ER - TY - JOUR AU - Szakács, Zsolt AU - Borbásné Farkas, Kornélia AU - Nagy, Enikő AU - Bencs, Réka AU - Vereczkei, Zsófia AU - Bajor, Judit TI - Clinical Presentation Is Dependent on Age and Calendar Year of Diagnosis in Celiac Disease : A Hungarian Cross-Sectional Study JF - JOURNAL OF PERSONALIZED MEDICINE J2 - J PERS MED VL - 13 PY - 2023 IS - 3 PG - 10 SN - 2075-4426 DO - 10.3390/jpm13030487 UR - https://m2.mtmt.hu/api/publication/33728537 ID - 33728537 N1 - Cited By :1 Export Date: 11 September 2023 Correspondence Address: Bajor, J.; First Department of Medicine, Ifjúság Str 13, Hungary; email: bajor.judit@pte.hu AB - International trends indicate that celiac disease (CeD) is becoming more common, while the clinical presentation of CeD tends to change. We aimed to investigate factors associated with the clinical presentation of CeD. We reviewed all CeD cases diagnosed at our tertiary center, University of Pécs (Hungary), between 1992 and 2019. We collected data of verified CeD patients on clinical presentations (classified by the Oslo Classification), the age at and calendar year of diagnosis, and sex, serology and histology at diagnosis. To assess the associations of baseline variables with clinical presentations, we applied univariate and multivariate (binary logistic regression) statistics. A total of 738 CeD patients were eligible for inclusion. In the univariate analysis, patients with classical CeD were more common in the latest calendar period (p < 0.001) and tended to be older (p = 0.056), but we failed to observe a significant association between the clinical presentation and sex, serology or histology at diagnosis. In the multivariate analysis, only age at diagnosis and calendar year were independently associated with clinical presentations (OR = 1.02, CI: 1.01-1.04 and OR = 0.93, CI: 0.89-0.98, respectively). Our findings confirmed that classical CeD is independently associated with age at diagnosis and calendar year of diagnosis of CeD, whereas other parameters were not significantly associated with clinical presentations. LA - English DB - MTMT ER - TY - JOUR AU - Pap, István AU - Kovács, Márton AU - Bölcsföldi, Barbara AU - Szakács, Zsolt AU - Gerlinger, Imre AU - Imreh, Bence AU - Szántóné Csongor, Alexandra AU - Warta, Vilmos AU - Szanyi, István TI - Quality-of-life outcomes with endoscopic and microscopic type I tympanoplasty-a prospective cohort study JF - EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY J2 - EUR ARCH OTO-RHINO-L VL - 280 PY - 2023 IS - 10 SP - 4401 EP - 4408 PG - 8 SN - 0937-4477 DO - 10.1007/s00405-023-07938-6 UR - https://m2.mtmt.hu/api/publication/33728524 ID - 33728524 N1 - Department of Otorhinolaryngology, Head and Neck Surgery (ENT), Medical School, University of Pécs, Munkácsy M. Street, No. 2, Pécs, 7621, Hungary Department of Languages for Biomedical Purposes and Communication, Medical School, University of Pécs, Pécs, Hungary First Department of Medicine, Medical School, University of Pécs, Pécs, Hungary Kanizsai Dorottya County Hospital, Nagykanizsa, Hungary Export Date: 29 January 2024 CODEN: EAOTE Correspondence Address: Pap, I.; Department of Otorhinolaryngology, Munkácsy M. Street, No. 2, Hungary; email: pap.istvan@pte.hu AB - Endoscopic type I tympanoplasty was originally introduced in the 1990s and the extensive spread of this practice can be easily observed. The conventional technique performed involves the repair of a tympanic membrane perforation and is defined as microscopic type I tympanoplasty. The aim of this study is the comparison of quality-of-life (QoL) outcomes with endoscopic to that with microscopic type I tympanoplasty.All patients, or in the case of children with the aid of a parent, were asked to complete a novel QoL questionnaire drafted by our study group. The analysis was performed with descriptive statistics-mean, SD and relative frequency-and with a mixed model (generalized least squares fit). A two-sided p value of < 0.05 was regarded as statistically significant.A total of 83 patients completed the questionnaire, 38 in the endoscopic group and 45 in the microscopic group. Every question represented a different. A statistically significant result was found in favor of the endoscopic approach regarding average hospitalization rate (p = 0.003) and cosmetic outcomes (p = 0.015). No statistically significant difference was otherwise observed between the groups.Based on our prospective cohort study, the QoL outcomes of endoscopic type I tympanoplasty in terms of postoperative pain, headache, nausea, vomiting, dizziness, taste disorder and hearing were comparable to the microscopic type I tympanoplasty. In regard to cosmetics, an increase in desirable results was achieved in the endoscopic group, particularly the average hospitalization rate proved to be statistically significantly lower than in the microscopic group. LA - English DB - MTMT ER - TY - JOUR AU - Teutsch, Brigitta AU - Váncsa, Szilárd AU - Borbásné Farkas, Kornélia AU - Szakács, Zsolt AU - Vörhendi, Nóra AU - Boros, Eszter AU - Szabó, Imre AU - Hágendorn, Roland AU - Alizadeh, Hussain AU - Hegyi, Péter AU - Erőss, Bálint Mihály TI - Intravenous ferric carboxymaltose versus oral ferrous sulfate replacement in elderly patients after acute non-variceal gastrointestinal bleeding (FIERCE) : protocol of a multicentre, open-label, randomised controlled trial JF - BMJ OPEN J2 - BMJ OPEN VL - 13 PY - 2023 IS - 3 PG - 8 SN - 2044-6055 DO - 10.1136/bmjopen-2022-063554 UR - https://m2.mtmt.hu/api/publication/33706189 ID - 33706189 N1 - Protocol AB - Acute gastrointestinal bleeding (GIB) is a life-threatening emergency with a critical economic burden. As a result of bleeding, anaemia often requires intravenous or oral iron supplementation. Elderly patients are even more prone to untoward outcomes after hospital discharge if iron supplementation is inefficient. There is a gap in current guidelines on which supplementation route clinicians should choose. We aim to investigate the effect of one dose of intravenous iron therapy versus 3-month oral iron administration on anaemia in an elderly population.The FIERCE study is an open-label, randomised controlled, two-armed trial. At least 48 hours after the acute non-variceal GIB treatment, patients will be recruited in participating centres. A random sequence generator will allocate the participants to group A (intravenous ferric carboxymaltose, 1000 mg) or group B (oral ferrous sulfate (FS), ca. 200 mg every day) with an allocation ratio of 1:1 on the day of the planned discharge from the hospital. Randomisation will be stratified for participating centres and the need for transfusion within the same hospitalisation before recruitment to the trial. Quality of life assessment, functional measurement and laboratory tests will be performed at baseline, 1 and 3 months±7 days after enrolment to the trial. The primary endpoint is a composite endpoint, including all-cause mortality, anaemia-associated unplanned emergency visit and anaemia-associated unplanned hospital admission within 3 months of enrolment in the trial.The study has been approved by the relevant organisation, the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (46395-5/2021/EÜIG). We will disseminate our results to the medical community and will publish our results in peer-reviewed journals.The trial has been registered at ClinicalTrials.gov (NCT05060731). LA - English DB - MTMT ER - TY - JOUR AU - Bálint, Alexandra AU - Hanák, Lilla AU - Hegyi, Péter AU - Szakács, Zsolt AU - Eitmann, Szimonetta AU - Garami, András AU - Varjú-Solymár, Margit AU - Márta, Katalin AU - Rumbus, Zoltán AU - Komócsi, András TI - Increased risk of adverse events in patients with low-on clopidogrel platelet reactivity after percutaneous coronary intervention : A systematic review and meta-analysis JF - CARDIOLOGY JOURNAL J2 - CARDIOL J VL - 30 PY - 2023 IS - 3 SP - 391 EP - 400 PG - 10 SN - 1897-5593 DO - 10.5603/CJ.a2021.0084 UR - https://m2.mtmt.hu/api/publication/32127261 ID - 32127261 N1 - Heart Institute, Medical School, University of Pécs, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Hungary Szentágothai Research Center, University of Pécs, Hungary Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pecs, Hungary Export Date: 12 October 2023 Correspondence Address: Bálint, A.; Heart Institute, Ifjúság útja 13, Hungary; email: balint.alexandra@pte.hu Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; clopidogrel, 113665-84-2, 120202-66-6, 90055-48-4, 94188-84-8, 120202-65-5, 120202-67-7, 894353-16-3, 744256-69-7; ticagrelor, 274693-27-5; Clopidogrel; Platelet Aggregation Inhibitors Manufacturers: R Foundation AB - Clinical evidence has been controversial regarding the influence of low platelet reactivity (LPR), ischemic and bleeding outcomes among patients receiving coronary stent implantation. Hence, the present study performed a meta-analysis to systematically evaluate the significance of LPR on adverse cardiovascular events.MEDLINE, EMBASE and CENTRAL databases were searched up to November 2020 for relevant studies including patients with acute coronary syndrome undergoing percutaneous coronary intervention. LPR was the exposed arm while the non-LPR group represented the control. The primary outcome of interest was bleeding risk including major and minor bleeding events. Secondary outcomes included all-cause mortality, repeated revascularization, nonfatal myocardial infarction, and stent thrombosis. Study-level outcomes were evaluated in random-effect models.A total of 20 studies with 19,064 patients were included. Pooled analysis showed that LPR was associated with an increased bleeding risk (relative risk [RR] 2.80, 95% confidence interval [CI] 1.95-4.02, p < 0.01). Patients with LPR had a lower risk of non-fatal myocardial infarction (RR 0.59, 95% CI 0.38-0.91, p < 0.05) and of serious vascular events (RR 0.50, 95% CI 0.30-0.84, p < 0.01).LPR is associated with an increased bleeding risk of patients who underwent coronary stent implantation. The results suggest possible benefits of this marker in risk stratification, with potential improvement in risk prediction. There are potential advantages using combinations with other factors in prediction models, however, they require further study. PROSPERO registration number: CRD42019136393). LA - English DB - MTMT ER -