@article{MTMT:34803973, title = {Comparing the Quality of Life and Hearing Thresholds Following Stapedectomy Versus Laser Stapedotomy with NiTiBOND Piston}, url = {https://m2.mtmt.hu/api/publication/34803973}, author = {Révész, Péter and Kopjár, E. and Szakács, Zsolt and Warta, Vilmos and Szántóné Csongor, Alexandra and Gerlinger, Imre and Szanyi, István}, doi = {10.5152/iao.2024.231337}, journal-iso = {J INT ADV OTOL}, journal = {JOURNAL OF INTERNATIONAL ADVANCED OTOLOGY}, volume = {20}, unique-id = {34803973}, issn = {1308-7649}, year = {2024}, eissn = {2148-3817}, pages = {142-146}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X} } @article{MTMT:34567540, title = {A VENETOCLAX KLINIKAI ALKALMAZÁSA – TAPASZTALATAINK A PÉCSI TUDOMÁNYEGYETEMEN}, url = {https://m2.mtmt.hu/api/publication/34567540}, author = {Szakács, Zsolt and Nagy, Á and Kosztolányi, Szabolcs and Szomor, Árpád and Kohl, Zoltán and Pammer, Judit and Alizadeh, Hussain}, journal-iso = {MBA}, journal = {MAGYAR BELORVOSI ARCHIVUM}, volume = {76}, unique-id = {34567540}, issn = {0133-5464}, year = {2023}, pages = {332-332}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X} } @article{MTMT:34167253, title = {Clinicopathological analysis of diffuse large B-cell lymphoma using molecular biomarkers: a retrospective analysis from 7 Hungarian centers}, url = {https://m2.mtmt.hu/api/publication/34167253}, author = {Balikó, Anett and Szakács, Zsolt and Kajtár, Béla and Ritter, Zsombor and Gyenesei, Attila and Borbásné Farkas, Kornélia and Kereskai, László and Vályi-Nagy, István and Alizadeh, Hussain and Pajor, László}, doi = {10.3389/fonc.2023.1224733}, journal-iso = {FRONT ONCOL}, journal = {FRONTIERS IN ONCOLOGY}, volume = {13}, unique-id = {34167253}, issn = {2234-943X}, year = {2023}, eissn = {2234-943X}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Kajtár, Béla/0000-0001-5551-3709; Borbásné Farkas, Kornélia/0000-0002-5349-6527} } @article{MTMT:34140873, title = {Cardiovascular risk factors in coeliac disease (ARCTIC): a protocol of multicentre series of studies}, url = {https://m2.mtmt.hu/api/publication/34140873}, author = {Vereczkei, Zsófia and Imrei, Marcell and Szakács, Zsolt and Kővári, Bálint and Papp, Veronika and Lénárt, Zsuzsanna and Berki, Tímea and Szirmay, Balázs and Borbásné Farkas, Kornélia and Balaskó, Márta and Habon, Tamás and Hegyi, Péter and Bajor, Judit}, doi = {10.1136/bmjopen-2022-068989}, journal-iso = {BMJ OPEN}, journal = {BMJ OPEN}, volume = {13}, unique-id = {34140873}, issn = {2044-6055}, year = {2023}, eissn = {2044-6055}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628; Imrei, Marcell/0000-0003-0175-7462; Szakács, Zsolt/0000-0002-7035-941X; Berki, Tímea/0000-0002-0134-8127; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Habon, Tamás/0000-0002-4816-857X; Hegyi, Péter/0000-0003-0399-7259} } @article{MTMT:34113217, title = {Acquired hemophilia A after SARS-CoV-2 infection: A case report and an updated systematic review}, url = {https://m2.mtmt.hu/api/publication/34113217}, author = {Németh, Márton Ferenc and Mühl, Diána and Csontos, Csaba and Nagy, Ágnes and Alizadeh, Hussain and Szakács, Zsolt}, doi = {10.3390/biomedicines11092400}, journal-iso = {BIOMEDICINES}, journal = {BIOMEDICINES}, volume = {11}, unique-id = {34113217}, year = {2023}, eissn = {2227-9059}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X} } @article{MTMT:34095089, title = {Body Mass Index during Gluten-Free Diet in Patients with Celiac Disease}, url = {https://m2.mtmt.hu/api/publication/34095089}, author = {Vereczkei, Zsófia and Dergez, Tímea and Fodor, Zsuzsanna and Szakács, Zsolt and Bajor, Judit}, doi = {10.3390/nu15163517}, journal-iso = {NUTRIENTS}, journal = {NUTRIENTS}, volume = {15}, unique-id = {34095089}, abstract = {The association of clinical variables with body mass index (BMI) and changes experienced during a gluten-free diet (GFD) in celiac disease (CD) is not well established. In this retrospective cohort study, we aimed to investigate factors aligned with baseline and a follow-up regarding BMI in CD cases diagnosed at the University of Pécs (Hungary). Data were collected regarding gender, age, clinical presentation, histology, serology, extraintestinal manifestations, and BMI upon diagnosis and during follow-up. To compare variables with baseline BMI and BMI changes in short-, intermediate-, and long-term periods, we applied univariate analyses. A total of 192 CD patients were included. Males had significantly higher mean BMI when compared with females at diagnosis (22.9 ± 4.1 vs. 21.4 ± 4.3 kg/m2, p = 0.041) and during follow-up (p = 0.031, p = 0.029, and p = 0.033 for short-, intermediate-, and long-term follow-ups, respectively). Non-classical CD patients experienced higher mean BMI at diagnosis (22.9 ± 4.0 vs. 20.7 ± 4.4 kg/m2, p < 0.001) and following long-term follow-up (24.5 ± 3.2 vs. 22.6 ± 3.4 kg/m2, p = 0.039) than classical patients. In conclusion, although the mean BMI remained in the normal range, it increased significantly during follow-up, even at the short-term follow-up. This change was characteristic for non-classical cases and males on the long-term follow-ups.}, year = {2023}, eissn = {2072-6643}, orcid-numbers = {Vereczkei, Zsófia/0000-0002-8144-4628; Szakács, Zsolt/0000-0002-7035-941X} } @article{MTMT:33728537, title = {Clinical Presentation Is Dependent on Age and Calendar Year of Diagnosis in Celiac Disease : A Hungarian Cross-Sectional Study}, url = {https://m2.mtmt.hu/api/publication/33728537}, author = {Szakács, Zsolt and Borbásné Farkas, Kornélia and Nagy, Enikő and Bencs, Réka and Vereczkei, Zsófia and Bajor, Judit}, doi = {10.3390/jpm13030487}, journal-iso = {J PERS MED}, journal = {JOURNAL OF PERSONALIZED MEDICINE}, volume = {13}, unique-id = {33728537}, abstract = {International trends indicate that celiac disease (CeD) is becoming more common, while the clinical presentation of CeD tends to change. We aimed to investigate factors associated with the clinical presentation of CeD. We reviewed all CeD cases diagnosed at our tertiary center, University of Pécs (Hungary), between 1992 and 2019. We collected data of verified CeD patients on clinical presentations (classified by the Oslo Classification), the age at and calendar year of diagnosis, and sex, serology and histology at diagnosis. To assess the associations of baseline variables with clinical presentations, we applied univariate and multivariate (binary logistic regression) statistics. A total of 738 CeD patients were eligible for inclusion. In the univariate analysis, patients with classical CeD were more common in the latest calendar period (p < 0.001) and tended to be older (p = 0.056), but we failed to observe a significant association between the clinical presentation and sex, serology or histology at diagnosis. In the multivariate analysis, only age at diagnosis and calendar year were independently associated with clinical presentations (OR = 1.02, CI: 1.01-1.04 and OR = 0.93, CI: 0.89-0.98, respectively). Our findings confirmed that classical CeD is independently associated with age at diagnosis and calendar year of diagnosis of CeD, whereas other parameters were not significantly associated with clinical presentations.}, keywords = {celiac disease; clinical presentation; clinical phenotype; calendar year; children and adults}, year = {2023}, eissn = {2075-4426}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Vereczkei, Zsófia/0000-0002-8144-4628} } @article{MTMT:33728524, title = {Quality-of-life outcomes with endoscopic and microscopic type I tympanoplasty-a prospective cohort study}, url = {https://m2.mtmt.hu/api/publication/33728524}, author = {Pap, István and Kovács, Márton and Bölcsföldi, Barbara and Szakács, Zsolt and Gerlinger, Imre and Imreh, Bence and Szántóné Csongor, Alexandra and Warta, Vilmos and Szanyi, István}, doi = {10.1007/s00405-023-07938-6}, journal-iso = {EUR ARCH OTO-RHINO-L}, journal = {EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY}, volume = {280}, unique-id = {33728524}, issn = {0937-4477}, abstract = {Endoscopic type I tympanoplasty was originally introduced in the 1990s and the extensive spread of this practice can be easily observed. The conventional technique performed involves the repair of a tympanic membrane perforation and is defined as microscopic type I tympanoplasty. The aim of this study is the comparison of quality-of-life (QoL) outcomes with endoscopic to that with microscopic type I tympanoplasty.All patients, or in the case of children with the aid of a parent, were asked to complete a novel QoL questionnaire drafted by our study group. The analysis was performed with descriptive statistics-mean, SD and relative frequency-and with a mixed model (generalized least squares fit). A two-sided p value of < 0.05 was regarded as statistically significant.A total of 83 patients completed the questionnaire, 38 in the endoscopic group and 45 in the microscopic group. Every question represented a different. A statistically significant result was found in favor of the endoscopic approach regarding average hospitalization rate (p = 0.003) and cosmetic outcomes (p = 0.015). No statistically significant difference was otherwise observed between the groups.Based on our prospective cohort study, the QoL outcomes of endoscopic type I tympanoplasty in terms of postoperative pain, headache, nausea, vomiting, dizziness, taste disorder and hearing were comparable to the microscopic type I tympanoplasty. In regard to cosmetics, an increase in desirable results was achieved in the endoscopic group, particularly the average hospitalization rate proved to be statistically significantly lower than in the microscopic group.}, keywords = {Quality of Life; Treatment Outcome; endoscopy; Cosmetics; tympanoplasty; myringoplasty}, year = {2023}, eissn = {1434-4726}, pages = {4401-4408}, orcid-numbers = {Szakács, Zsolt/0000-0002-7035-941X} } @article{MTMT:33706189, title = {Intravenous ferric carboxymaltose versus oral ferrous sulfate replacement in elderly patients after acute non-variceal gastrointestinal bleeding (FIERCE) : protocol of a multicentre, open-label, randomised controlled trial}, url = {https://m2.mtmt.hu/api/publication/33706189}, author = {Teutsch, Brigitta and Váncsa, Szilárd and Borbásné Farkas, Kornélia and Szakács, Zsolt and Vörhendi, Nóra and Boros, Eszter and Szabó, Imre and Hágendorn, Roland and Alizadeh, Hussain and Hegyi, Péter and Erőss, Bálint Mihály}, doi = {10.1136/bmjopen-2022-063554}, journal-iso = {BMJ OPEN}, journal = {BMJ OPEN}, volume = {13}, unique-id = {33706189}, issn = {2044-6055}, abstract = {Acute gastrointestinal bleeding (GIB) is a life-threatening emergency with a critical economic burden. As a result of bleeding, anaemia often requires intravenous or oral iron supplementation. Elderly patients are even more prone to untoward outcomes after hospital discharge if iron supplementation is inefficient. There is a gap in current guidelines on which supplementation route clinicians should choose. We aim to investigate the effect of one dose of intravenous iron therapy versus 3-month oral iron administration on anaemia in an elderly population.The FIERCE study is an open-label, randomised controlled, two-armed trial. At least 48 hours after the acute non-variceal GIB treatment, patients will be recruited in participating centres. A random sequence generator will allocate the participants to group A (intravenous ferric carboxymaltose, 1000 mg) or group B (oral ferrous sulfate (FS), ca. 200 mg every day) with an allocation ratio of 1:1 on the day of the planned discharge from the hospital. Randomisation will be stratified for participating centres and the need for transfusion within the same hospitalisation before recruitment to the trial. Quality of life assessment, functional measurement and laboratory tests will be performed at baseline, 1 and 3 months±7 days after enrolment to the trial. The primary endpoint is a composite endpoint, including all-cause mortality, anaemia-associated unplanned emergency visit and anaemia-associated unplanned hospital admission within 3 months of enrolment in the trial.The study has been approved by the relevant organisation, the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (46395-5/2021/EÜIG). We will disseminate our results to the medical community and will publish our results in peer-reviewed journals.The trial has been registered at ClinicalTrials.gov (NCT05060731).}, keywords = {Anaemia; GASTROENTEROLOGY; adult gastroenterology}, year = {2023}, eissn = {2044-6055}, orcid-numbers = {Teutsch, Brigitta/0000-0002-9530-7886; Váncsa, Szilárd/0000-0002-9347-8163; Borbásné Farkas, Kornélia/0000-0002-5349-6527; Szakács, Zsolt/0000-0002-7035-941X; Hegyi, Péter/0000-0003-0399-7259; Erőss, Bálint Mihály/0000-0003-3658-8427} } @article{MTMT:32127261, title = {Increased risk of adverse events in patients with low-on clopidogrel platelet reactivity after percutaneous coronary intervention : A systematic review and meta-analysis}, url = {https://m2.mtmt.hu/api/publication/32127261}, author = {Bálint, Alexandra and Hanák, Lilla and Hegyi, Péter and Szakács, Zsolt and Eitmann, Szimonetta and Garami, András and Varjú-Solymár, Margit and Márta, Katalin and Rumbus, Zoltán and Komócsi, András}, doi = {10.5603/CJ.a2021.0084}, journal-iso = {CARDIOL J}, journal = {CARDIOLOGY JOURNAL}, volume = {30}, unique-id = {32127261}, issn = {1897-5593}, abstract = {Clinical evidence has been controversial regarding the influence of low platelet reactivity (LPR), ischemic and bleeding outcomes among patients receiving coronary stent implantation. Hence, the present study performed a meta-analysis to systematically evaluate the significance of LPR on adverse cardiovascular events.MEDLINE, EMBASE and CENTRAL databases were searched up to November 2020 for relevant studies including patients with acute coronary syndrome undergoing percutaneous coronary intervention. LPR was the exposed arm while the non-LPR group represented the control. The primary outcome of interest was bleeding risk including major and minor bleeding events. Secondary outcomes included all-cause mortality, repeated revascularization, nonfatal myocardial infarction, and stent thrombosis. Study-level outcomes were evaluated in random-effect models.A total of 20 studies with 19,064 patients were included. Pooled analysis showed that LPR was associated with an increased bleeding risk (relative risk [RR] 2.80, 95% confidence interval [CI] 1.95-4.02, p < 0.01). Patients with LPR had a lower risk of non-fatal myocardial infarction (RR 0.59, 95% CI 0.38-0.91, p < 0.05) and of serious vascular events (RR 0.50, 95% CI 0.30-0.84, p < 0.01).LPR is associated with an increased bleeding risk of patients who underwent coronary stent implantation. The results suggest possible benefits of this marker in risk stratification, with potential improvement in risk prediction. There are potential advantages using combinations with other factors in prediction models, however, they require further study. PROSPERO registration number: CRD42019136393).}, keywords = {percutaneous coronary intervention; Clopidogrel; acute coronary syndrome; Bleeding risk; Low platelet reactivity}, year = {2023}, eissn = {1898-018X}, pages = {391-400}, orcid-numbers = {Bálint, Alexandra/0000-0002-7267-8633; Hegyi, Péter/0000-0003-0399-7259; Szakács, Zsolt/0000-0002-7035-941X; Garami, András/0000-0003-2493-0571; Varjú-Solymár, Margit/0000-0001-6667-6263; Márta, Katalin/0000-0002-2213-4865} }