TY  - JOUR
AU  - Bálint, Gábor
AU  - Vörös-Horváth, Barbara
AU  - Széchenyi, Aleksandar
TI  - Omicron : increased transmissibility and decreased pathogenicity
JF  - SIGNAL TRANSDUCTION AND TARGETED THERAPY
J2  - SIGNAL TRANSDUCT TAR
VL  - 7
PY  - 2022
IS  - 1
PG  - 3
SN  - 2095-9907
DO  - 10.1038/s41392-022-01009-8
UR  - https://m2.mtmt.hu/api/publication/32819183
ID  - 32819183
N1  - Megosztott első szerzőség
Research Highlight
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vörös-Horváth, Barbara
AU  - Zivkovic, Pavo
AU  - Bánfai, Krisztina
AU  - Bovári-Biri, Judit
AU  - Pongrácz, Judit
AU  - Bálint, Gábor
AU  - Pál, Szilárd
AU  - Széchenyi, Aleksandar
TI  - Preparation and Characterization of ACE2 Receptor Inhibitor-Loaded Chitosan Hydrogels for Nasal Formulation to Reduce the Risk of COVID-19 Viral Infection
JF  - ACS OMEGA
J2  - ACS OMEGA
VL  - 7
PY  - 2022
IS  - 4
SP  - 3240
EP  - 3253
PG  - 14
SN  - 2470-1343
DO  - 10.1021/acsomega.1c05149
UR  - https://m2.mtmt.hu/api/publication/32623813
ID  - 32623813
AB  - The COVID-19 virus is spread by pulmonary droplets. Its high infectivity is caused by the high-affinity binding of the viral spike protein to the ACE2 receptors on the surface of respiratory epithelial cell membranes. The proper hydration of nasal mucosa plays an essential role in defense of bacterial and viral infections. Therefore, a nasal formulation, which can moisture the nasal mucosa and contains the ACE2 receptor inhibitor, can reduce the risk of COVID-19 infection. This article presents a systematic study of the preparation of chitosan hydrogels with dicarboxylic acids (malic and glutaric acid) and their detailed characterization (Fourier transform infrared spectroscopy, deter-mination of cross-linking efficiency, rheological studies, thermal analysis, and swelling kinetics). The results confirm that chemically cross-linked chitosan hydrogels can be synthesized using malic or glutaric acid without additives or catalysts. The adsorption capacity of hydrogels for three different ACE2 inhibitors, as APIs, has also been investigated. The API content of hydrogels and their mucoadhesive property can provide an excellent basis to use the hydrogels for the development of a nasal formulation in order to reduce the risk of SARS-CoV 2 infection.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Salem, Ala'
AU  - Takácsi-Nagy, Anna Erzsébet
AU  - Nagy, Sándor
AU  - Hagymási, Alexandra
AU  - Gősi, Fruzsina
AU  - Vörös-Horváth, Barbara
AU  - Balić, Tomislav
AU  - Pál, Szilárd
AU  - Széchenyi, Aleksandar
TI  - Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid-Sulfamethazine Cocrystals
JF  - PHARMACEUTICS
J2  - PHARMACEUTICS
VL  - 13
PY  - 2021
IS  - 2
PG  - 13
SN  - 1999-4923
DO  - 10.3390/pharmaceutics13020277
UR  - https://m2.mtmt.hu/api/publication/31905073
ID  - 31905073
AB  - Drug-drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Salem, Ala'
AU  - Hagymási, A.
AU  - Vörös-Horváth, Barbara
AU  - Šafarik, T.
AU  - Balić, T.
AU  - Szabó, Péter
AU  - Gősi, F.
AU  - Nagy, Sándor
AU  - Pál, Szilárd
AU  - Kunsági-Máté, Sándor
AU  - Széchenyi, Aleksandar
TI  - Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control
JF  - EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
J2  - EUR J PHARM SCI
VL  - 156
PY  - 2021
PG  - 7
SN  - 0928-0987
DO  - 10.1016/j.ejps.2020.105599
UR  - https://m2.mtmt.hu/api/publication/31646675
ID  - 31646675
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vörös-Horváth, Barbara
AU  - Das, Sourav
AU  - Salem, Ala'
AU  - Nagy, Sándor
AU  - Böszörményi, Andrea
AU  - Kőszegi, Tamás
AU  - Pál, Szilárd
AU  - Széchenyi, Aleksandar
TI  - Formulation of Tioconazole and Melaleuca alternifolia Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment
JF  - MOLECULES
J2  - MOLECULES
VL  - 25
PY  - 2020
IS  - 23
PG  - 17
SN  - 1420-3049
DO  - 10.3390/molecules25235544
UR  - https://m2.mtmt.hu/api/publication/31677449
ID  - 31677449
N1  - * Megosztott szerzőség
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Vörös-Horváth, Barbara
AU  - Nagy, Sándor
AU  - Das, Sourav
AU  - Kőszegi, Tamás
AU  - Pál, Szilárd
AU  - Széchenyi, Aleksandar
TI  - Application of nanotechnology in formulation of tioconazole and tea tree essential oil for onychomycosis topical treatment
JF  - ACTA PHARMACEUTICA HUNGARICA
J2  - ACTA PHARM HUNG
VL  - 90
PY  - 2020
IS  - 2-3
SP  - 150
EP  - 150
PG  - 1
SN  - 0001-6659
UR  - https://m2.mtmt.hu/api/publication/31613607
ID  - 31613607
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Balázs, Viktória Lilla
AU  - Vörös-Horváth, Barbara
AU  - Simonics, D.
AU  - Varga, A.
AU  - Kerekes, E.
AU  - Ács, Kamilla
AU  - Kocsis, Béla
AU  - Krisch, Judit
AU  - Széchenyi, Aleksandar
AU  - Horváth, Györgyi
TI  - Antibiofilm effect of pickering nano-emulsion of clove essential oil against Pseudomonas aeruginosa and Streptococcus pneumoniae
JF  - ACTA PHARMACEUTICA HUNGARICA
J2  - ACTA PHARM HUNG
VL  - 90
PY  - 2020
IS  - 2-3
SP  - 105
EP  - 106
PG  - 2
SN  - 0001-6659
UR  - https://m2.mtmt.hu/api/publication/31613408
ID  - 31613408
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Széchenyi, Aleksandar
AU  - Vörös-Horváth, Barbara
AU  - Nagy, Sándor
AU  - Das, S.
AU  - Kőszegi, Tamás
AU  - Horváth, Györgyi
AU  - Balázs, Viktória Lilla
AU  - Varga, A.
AU  - Kocsis, Béla
AU  - Pál, Szilárd
TI  - Targeted delivery of essential oils for pharmaceutical applications
JF  - ACTA PHARMACEUTICA HUNGARICA
J2  - ACTA PHARM HUNG
VL  - 90
PY  - 2020
IS  - 2-3
SP  - 76
EP  - 76
PG  - 1
SN  - 0001-6659
UR  - https://m2.mtmt.hu/api/publication/31613161
ID  - 31613161
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Das, Sourav
AU  - Vörös-Horváth, Barbara
AU  - Bencsik, Tímea
AU  - Micalizzi, Giuseppe
AU  - Mondello, Luigi
AU  - Horváth, Györgyi
AU  - Kőszegi, Tamás
AU  - Széchenyi, Aleksandar
TI  - Antimicrobial Activity of Different Artemisia Essential Oil Formulations
JF  - MOLECULES
J2  - MOLECULES
VL  - 25
PY  - 2020
IS  - 10
PG  - 27
SN  - 1420-3049
DO  - 10.3390/molecules25102390
UR  - https://m2.mtmt.hu/api/publication/31323123
ID  - 31323123
N1  - * Megosztott szerzőség
LA  - English
DB  - MTMT
ER  - 

TY  - GEN
AU  - Vörös-Horváth, Barbara
AU  - Salem, Ala'
AU  - Tatjana, Šafarik
AU  - Szilárd, Pál
AU  - Széchenyi, Aleksandar
TI  - Systematic study of reaction conditions for size controlled synthesis of silica nanoparticles
PY  - 2019
UR  - https://m2.mtmt.hu/api/publication/31385085
ID  - 31385085
LA  - English
DB  - MTMT
ER  -