@article{MTMT:32819183, title = {Omicron : increased transmissibility and decreased pathogenicity}, url = {https://m2.mtmt.hu/api/publication/32819183}, author = {Bálint, Gábor and Vörös-Horváth, Barbara and Széchenyi, Aleksandar}, doi = {10.1038/s41392-022-01009-8}, journal-iso = {SIGNAL TRANSDUCT TAR}, journal = {SIGNAL TRANSDUCTION AND TARGETED THERAPY}, volume = {7}, unique-id = {32819183}, issn = {2095-9907}, year = {2022}, eissn = {2059-3635}, orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551} } @article{MTMT:32623813, title = {Preparation and Characterization of ACE2 Receptor Inhibitor-Loaded Chitosan Hydrogels for Nasal Formulation to Reduce the Risk of COVID-19 Viral Infection}, url = {https://m2.mtmt.hu/api/publication/32623813}, author = {Vörös-Horváth, Barbara and Zivkovic, Pavo and Bánfai, Krisztina and Bovári-Biri, Judit and Pongrácz, Judit and Bálint, Gábor and Pál, Szilárd and Széchenyi, Aleksandar}, doi = {10.1021/acsomega.1c05149}, journal-iso = {ACS OMEGA}, journal = {ACS OMEGA}, volume = {7}, unique-id = {32623813}, issn = {2470-1343}, abstract = {The COVID-19 virus is spread by pulmonary droplets. Its high infectivity is caused by the high-affinity binding of the viral spike protein to the ACE2 receptors on the surface of respiratory epithelial cell membranes. The proper hydration of nasal mucosa plays an essential role in defense of bacterial and viral infections. Therefore, a nasal formulation, which can moisture the nasal mucosa and contains the ACE2 receptor inhibitor, can reduce the risk of COVID-19 infection. This article presents a systematic study of the preparation of chitosan hydrogels with dicarboxylic acids (malic and glutaric acid) and their detailed characterization (Fourier transform infrared spectroscopy, deter-mination of cross-linking efficiency, rheological studies, thermal analysis, and swelling kinetics). The results confirm that chemically cross-linked chitosan hydrogels can be synthesized using malic or glutaric acid without additives or catalysts. The adsorption capacity of hydrogels for three different ACE2 inhibitors, as APIs, has also been investigated. The API content of hydrogels and their mucoadhesive property can provide an excellent basis to use the hydrogels for the development of a nasal formulation in order to reduce the risk of SARS-CoV 2 infection.}, keywords = {DERIVATIVES; PROTEIN; antiviral activity; DRUG-DELIVERY; Chitin; Inserts; SARS coronavirus}, year = {2022}, eissn = {2470-1343}, pages = {3240-3253}, orcid-numbers = {Pongrácz, Judit/0000-0002-0278-5556; Széchenyi, Aleksandar/0000-0001-9207-2551} } @article{MTMT:31905073, title = {Synthesis and Characterization of Nano-Sized 4-Aminosalicylic Acid-Sulfamethazine Cocrystals}, url = {https://m2.mtmt.hu/api/publication/31905073}, author = {Salem, Ala' and Takácsi-Nagy, Anna Erzsébet and Nagy, Sándor and Hagymási, Alexandra and Gősi, Fruzsina and Vörös-Horváth, Barbara and Balić, Tomislav and Pál, Szilárd and Széchenyi, Aleksandar}, doi = {10.3390/pharmaceutics13020277}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {13}, unique-id = {31905073}, issn = {1999-4923}, abstract = {Drug-drug cocrystals are formulated to produce combined medication, not just to modulate active pharmaceutical ingredient (API) properties. Nano-crystals adjust the pharmacokinetic properties and enhance the dissolution of APIs. Nano-cocrystals seem to enhance API properties by combining the benefits of both technologies. Despite the promising opportunities of nano-sized cocrystals, the research at the interface of nano-technology and cocrystals has, however, been described to be in its infancy. In this study, high-pressure homogenization (HPH) and high-power ultrasound were used to prepare nano-sized cocrystals of 4-aminosalysilic acid and sulfamethazine in order to establish differences between the two methods in terms of cocrystal size, morphology, polymorphic form, and dissolution rate enhancement. It was found that both methods resulted in the formation of form I cocrystals with a high degree of crystallinity. HPH yielded nano-sized cocrystals, while those prepared by high-power ultrasound were in the micro-size range. Furthermore, HPH produced smaller-size cocrystals with a narrow size distribution when a higher pressure was used. Cocrystals appeared to be needle-like when prepared by HPH compared to those prepared by high-power ultrasound, which had a different morphology. The highest dissolution enhancement was observed in cocrystals prepared by HPH; however, both micro- and nano-sized cocrystals enhanced the dissolution of sulfamethazine.}, keywords = {COCRYSTALS; High-pressure homogenization; Sulfamethazine; 4-aminosalicylic acid; high-power ultrasound; nano-drugs}, year = {2021}, eissn = {1999-4923}, orcid-numbers = {Takácsi-Nagy, Anna Erzsébet/0000-0002-4756-9136; Széchenyi, Aleksandar/0000-0001-9207-2551} } @article{MTMT:31646675, title = {Solvent dependent 4-aminosalicylic acid-sulfamethazine co-crystal polymorph control}, url = {https://m2.mtmt.hu/api/publication/31646675}, author = {Salem, Ala' and Hagymási, A. and Vörös-Horváth, Barbara and Šafarik, T. and Balić, T. and Szabó, Péter and Gősi, F. and Nagy, Sándor and Pál, Szilárd and Kunsági-Máté, Sándor and Széchenyi, Aleksandar}, doi = {10.1016/j.ejps.2020.105599}, journal-iso = {EUR J PHARM SCI}, journal = {EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES}, volume = {156}, unique-id = {31646675}, issn = {0928-0987}, year = {2021}, eissn = {1879-0720}, orcid-numbers = {Szabó, Péter/0000-0003-0827-3583; Széchenyi, Aleksandar/0000-0001-9207-2551} } @article{MTMT:31677449, title = {Formulation of Tioconazole and Melaleuca alternifolia Essential Oil Pickering Emulsions for Onychomycosis Topical Treatment}, url = {https://m2.mtmt.hu/api/publication/31677449}, author = {Vörös-Horváth, Barbara and Das, Sourav and Salem, Ala' and Nagy, Sándor and Böszörményi, Andrea and Kőszegi, Tamás and Pál, Szilárd and Széchenyi, Aleksandar}, doi = {10.3390/molecules25235544}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {25}, unique-id = {31677449}, issn = {1420-3049}, year = {2020}, eissn = {1420-3049}, orcid-numbers = {Das, Sourav/0000-0002-3753-9689; Böszörményi, Andrea/0000-0003-3982-7059; Széchenyi, Aleksandar/0000-0001-9207-2551} } @article{MTMT:31613607, title = {Application of nanotechnology in formulation of tioconazole and tea tree essential oil for onychomycosis topical treatment}, url = {https://m2.mtmt.hu/api/publication/31613607}, author = {Vörös-Horváth, Barbara and Nagy, Sándor and Das, Sourav and Kőszegi, Tamás and Pál, Szilárd and Széchenyi, Aleksandar}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {90}, unique-id = {31613607}, issn = {0001-6659}, year = {2020}, eissn = {1587-1495}, pages = {150-150}, orcid-numbers = {Das, Sourav/0000-0002-3753-9689; Széchenyi, Aleksandar/0000-0001-9207-2551} } @article{MTMT:31613408, title = {Antibiofilm effect of pickering nano-emulsion of clove essential oil against Pseudomonas aeruginosa and Streptococcus pneumoniae}, url = {https://m2.mtmt.hu/api/publication/31613408}, author = {Balázs, Viktória Lilla and Vörös-Horváth, Barbara and Simonics, D. and Varga, A. and Kerekes, E. and Ács, Kamilla and Kocsis, Béla and Krisch, Judit and Széchenyi, Aleksandar and Horváth, Györgyi}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {90}, unique-id = {31613408}, issn = {0001-6659}, year = {2020}, eissn = {1587-1495}, pages = {105-106}, orcid-numbers = {Krisch, Judit/0000-0002-6164-7794; Széchenyi, Aleksandar/0000-0001-9207-2551; Horváth, Györgyi/0000-0001-5344-0294} } @article{MTMT:31613161, title = {Targeted delivery of essential oils for pharmaceutical applications}, url = {https://m2.mtmt.hu/api/publication/31613161}, author = {Széchenyi, Aleksandar and Vörös-Horváth, Barbara and Nagy, Sándor and Das, S. and Kőszegi, Tamás and Horváth, Györgyi and Balázs, Viktória Lilla and Varga, A. and Kocsis, Béla and Pál, Szilárd}, journal-iso = {ACTA PHARM HUNG}, journal = {ACTA PHARMACEUTICA HUNGARICA}, volume = {90}, unique-id = {31613161}, issn = {0001-6659}, year = {2020}, eissn = {1587-1495}, pages = {76-76}, orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551; Horváth, Györgyi/0000-0001-5344-0294} } @article{MTMT:31323123, title = {Antimicrobial Activity of Different Artemisia Essential Oil Formulations}, url = {https://m2.mtmt.hu/api/publication/31323123}, author = {Das, Sourav and Vörös-Horváth, Barbara and Bencsik, Tímea and Micalizzi, Giuseppe and Mondello, Luigi and Horváth, Györgyi and Kőszegi, Tamás and Széchenyi, Aleksandar}, doi = {10.3390/molecules25102390}, journal-iso = {MOLECULES}, journal = {MOLECULES}, volume = {25}, unique-id = {31323123}, issn = {1420-3049}, keywords = {Pickering emulsion; Candida biofilms; Antimicrobial activities; cell oxidative stress; Artemisia essential oil}, year = {2020}, eissn = {1420-3049}, orcid-numbers = {Das, Sourav/0000-0002-3753-9689; Horváth, Györgyi/0000-0001-5344-0294; Széchenyi, Aleksandar/0000-0001-9207-2551} } @misc{MTMT:31385085, title = {Systematic study of reaction conditions for size controlled synthesis of silica nanoparticles}, url = {https://m2.mtmt.hu/api/publication/31385085}, author = {Vörös-Horváth, Barbara and Salem, Ala' and Tatjana, Šafarik and Szilárd, Pál and Széchenyi, Aleksandar}, unique-id = {31385085}, year = {2019}, orcid-numbers = {Széchenyi, Aleksandar/0000-0001-9207-2551} }